We develop, refine, and evaluate new paradigms for assessing visual function in patients with retinal and optic nerve diseases, building on our continuously expanding understanding of retinal signal processing. In addition, we apply machine learning and advanced data analysis methods to enhance the evaluation of established assessment techniques.
Research projects
Bridging Physiology, Electrophysiology, and Clinical Innovation in Diseases of the retina and the optic nerve
Application of Artificial Intelligence and Data Analytics to Assess Visual Function in Retinal and Optic Nerve Diseases
Recent publications
2026
Kremers, J., Barboni, M.T., Zele, A.J., Feigl, B., McAnany, J.J., Robson, A.G.,... Huchzermeyer, C. (2026). ISCEV extended protocol for the photoreceptor directed ERG using full-field silent substitution stimuli identification . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-026-10087-w
2025
Huchzermeyer, C., Stingl, K., & Kremers, J. (2025). Multidimensional Functional Phenotyping Based on Photoreceptor-Directed Temporal Contrast Sensitivity Defects in Inherited Retinal Diseases . Investigative Ophthalmology & Visual Science , 66 (4). https://doi.org/10.1167/iovs.66.4.25
Kremers, J., Aher, A., & Huchzermeyer, C. (2025). ERG responses and the Ferry-Porter law . Journal of the Optical Society of America A: Optics and Image Science, and Vision , 42 (5), B1-B7. https://doi.org/10.1364/JOSAA.538103
Kremers, J., Huchzermeyer, C., & Aher, A. (2025). The consequence of modulating background on the luminance-response function of the human photopic electroretinogram . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-025-10029-y
Merle, D.A., Hertens, L., Dimopoulos, S., Kohl, S., Van Haute, M., De Baere, E.,... Stingl, K. (2025). Short-Term Outcomes of Pediatric Patients With Mild Autosomal Recessive RPE65-Associated Retinal Dystrophy Treated With Voretigene Neparvovec . Translational Vision Science & Technology , 14 (8). https://doi.org/10.1167/tvst.14.8.8
2024
Huchzermeyer, C., Lämmer, R., Mardin, C., Kruse, F., Kremers, J., & Horn, F. (2024). Pattern electroretinogram, blue-yellow visual evoked potentials and the risk of developing visual field defects in glaucoma suspects: a longitudinal “survival” analysis with a very long follow-up . Graefes Archive For Clinical and Experimental Ophthalmology . https://doi.org/10.1007/s00417-023-06364-y
Kiel, C., Biasella, F., Stöhr, H., Rating, P., Spital, G., Kellner, U.,... Weber, B.H. (2024). 18-Years of single-centre DNA testing in over 7000 index cases with inherited retinal dystrophies and optic neuropathies . Scientific Reports , 14 (1). https://doi.org/10.1038/s41598-024-77014-4
Kremers, J., & Huchzermeyer, C. (2024). Electroretinographic responses to periodic stimuli in primates and the relevance for visual perception and for clinical studies . Visual Neuroscience , 41 . https://doi.org/10.1017/S0952523824000038
Kulyabin, M., Kremers, J., Holbach, V., Maier, A., & Huchzermeyer, C. (2024). Artificial intelligence for detection of retinal toxicity in chloroquine and hydroxychloroquine therapy using multifocal electroretinogram waveforms . Scientific Reports , 14 (1), 24853. https://doi.org/10.1038/s41598-024-76943-4
2023
Crux, K., Huchzermeyer, C., Kremers, J., & Horn, F. (2023). Objective detection of visual field defects with multifrequency VEPs . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-023-09949-4
Huchzermeyer, C. (2023). Chromatische Pupillometrie – ein neuer Weg zur funktionellen Glaukomdiagnostik? Klinische Monatsblätter für Augenheilkunde . https://doi.org/10.1055/a-2130-0546
Huchzermeyer, C., Fars, J., Kremers, J., Kühlewein, L., Kempf, M., Ott, S.,... Stingl, K. (2023). Photoreceptor-Specific Temporal Contrast Sensitivities in RP1L1-Associated Occult Macular Dystrophy . Investigative Ophthalmology & Visual Science , 64 (7), 33-. https://doi.org/10.1167/iovs.64.7.33
2022
Aher, A., Huchzermeyer, C., & Kremers, J. (2022). The effect of sinusoidally modulating backgrounds on flash electroretinograms . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Fars, J., Fernandes, T.P., Huchzermeyer, C., Kremers, J., & Paramei, G.V. (2022). Chromatic discrimination measures in mature observers depend on the response window . Scientific Reports , 12 (1). https://doi.org/10.1038/s41598-022-13129-w
Fars, J., Kremers, J., & Huchzermeyer, C. (2022). Complementarity of sensitivity and just noticeable difference in the study of Retinitis Pigmentosa and Stargardt disease . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., & Kremers, J. (2022). Comparing functional defects measured by mfERG and standard automated perimetry in patients under (hydroxy-)chloroquine therapy . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., & Kremers, J. (2022). Selektive Stimulation der verschiedenen Fotorezeptorklassen mittels Silent Substitution bei psychophysischen und elektroretinografischen Messungen . Klinische Monatsblätter für Augenheilkunde , 239 (12), 1433-1439. https://doi.org/10.1055/a-1937-9901
Kremers, J., Aher, A., & Huchzermeyer, C. (2022). Modulation of flash ERGs by dynamic backgrounds . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-022-09902-x
Rieger, M., Türk, M., Kraus, C., Uebe, S., Ekici, A.B., Krumbiegel, M.,... Thiel, C. (2022). SRD5A3-CDG: Twins with an intragenic tandem duplication . European Journal of Medical Genetics , 65 (5). https://doi.org/10.1016/j.ejmg.2022.104492
2021
Aher, A., Horn, F., Huchzermeyer, C., Lämmer, R., & Kremers, J. (2021). Responses of postreceptoral pathways elicited by L- And M-cone isolating ON- And OFF-electroretinograms in glaucoma patients . Investigative Ophthalmology & Visual Science , 62 (9). https://doi.org/10.1167/iovs.62.9.14
Aher, A., Horn, F., Huchzermeyer, C., Lämmer, R., & Kremers, J. (2021). Spatial properties of L- and M-cone driven incremental (on-) and decremental (off-) electroretinograms: normal subjects Vs. glaucoma patients . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Dussan Molinos, L., Huchzermeyer, C., Lämmer, R., Kremers, J., & Horn, F. (2021). Blue-Yellow VEP with Projector-Stimulation in Glaucoma . Graefes Archive For Clinical and Experimental Ophthalmology . https://doi.org/10.1007/s00417-021-05473-w
Fars, J., Fernandes, T.M.P., Huchzermeyer, C., Kremers, J., & Paramei, G.V. (2021). Chromatic discrimination: The response window does matter for veridical measurement in mature observers . In PERCEPTION (pp. 114-114). LONDON: SAGE PUBLICATIONS LTD.
Fars, J., Huchzermeyer, C., & Kremers, J. (2021). Psychometric curves in retinitis pigmentosa patients . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Fars, J., Pasutto, F., Kremers, J., & Huchzermeyer, C. (2021). Perifoveal cone- And rod-mediated temporal contrast sensitivities in stargardt disease/fundus flavimaculatus . Investigative Ophthalmology & Visual Science , 62 (14). https://doi.org/10.1167/iovs.62.14.24
Huchzermeyer, C., Fars, J., & Kremers, J. (2021). Relationship between temporal L-coneflicker sensitivity and established clinical parameters in Stargardt's disease . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., Horn, F., Lämmer, R., Mardin, C., & Kremers, J. (2021). Summation of Temporal L-Cone- and M-Cone-Contrast in the Magno- and Parvocellular Retino-Geniculate Systems in Glaucoma . Investigative Ophthalmology & Visual Science , 62 (6), 17-. https://doi.org/10.1167/iovs.62.6.17
Lämmer, R., & Huchzermeyer, C. (2021). Perimetrie in der Glaukomdiagnostik . Klinische Monatsblätter für Augenheilkunde . https://doi.org/10.1055/a-1351-9080
Lämmer, R., & Huchzermeyer, C. (2021). Perimetry in the Diagnosis of Glaucoma . Augenheilkunde up2date , 11 (01), 51-60. https://doi.org/10.1055/a-1065-2889
2020
Fars, J., Kremers, J., & Huchzermeyer, C. (2020). Discriminating anomalous trichromacy and cone degeneration in retinitis pigmentosa patients . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ONLINE: ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., Fars, J., & Kremers, J. (2020). Photoreceptor-specific loss of perifoveal temporal contrassensitivity in retinitis pigmentosa . Translational Vision Science & Technology , 9 (6), 1-15. https://doi.org/10.1167/TVST.9.6.27
Huchzermeyer, C., Fars, J., Lorenz, B., & Kremers, J. (2020). Patterns of photoreceptor-specific temporal contrast sensitivity losses in patients with different phenotypic variants of retinitis pigmentosa . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ONLINE: ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., Fars, J., Stöhr, H., & Kremers, J. (2020). Neue Techniken zur Quantifizierung des Farbsinns bei Störungen der Zapfenfunktion . Ophthalmologe . https://doi.org/10.1007/s00347-020-01119-0
König, Y., Huchzermeyer, C., & Drexler, H. (2020). Blaulichtgefährdung der Augen durch Lichtemittierende Dioden (LED)? Arbeitsmedizin, Sozialmedizin, Umweltmedizin , 2020 (2), 109-113. https://doi.org/10.17147/ASU-2002-8657
Regensburger, M., Minakaki, G., Kettwig, M., Huchzermeyer, C., Eisenhut, F., Haack, T.B.,... Winkler, J. (2020). Novel Biallelic CTSD Gene Variants Cause Late-Onset Ataxia and Retinitis Pigmentosa . Movement Disorders . https://doi.org/10.1002/mds.28106
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We develop, refine, and evaluate new paradigms for assessing visual function in patients with retinal and optic nerve diseases, building on our continuously expanding understanding of retinal signal processing. In addition, we apply machine learning and advanced data analysis methods to enhance the evaluation of established assessment techniques.
Research projects
No projects found.
2026
2025
2024
2023
2022
2021
2020
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