Prof. Dr. Julio Vera González

Laboratory of Systems Tumor Immunology / Department of Dermatology

I am a physicist working in systems and precision medicine applied to cancer and autoimmune diseases. I lead an interdisciplinary team that combines computational modeling, bioinformatics, multi-criteria decision algorithms, and network biology to cancer diagnostics and therapy.

Research projects

  • Molecular data-driven engineering of immunotherapy
  • Omics, network and machine learning-based classification of skin and prostate cancer patients
  • Multi-layered data-based drug repurposing in therapy-resistant cancer patients

  • E033: Deubiquitinase Otud7b in oligodendrocyte differentiation and CNS myelination

    (FAU Funds)

    Project leader:
    Term: 1. July 2023 - 30. June 2026
    Specific regulation of protein degradation by the ubiquitin-proteasome system plays important roles in myelination, remyelination and neurodegenerative diseases. I want to analyse the functions of the deubiquitinase Otud7b in oligodendrocytes in vitro and in vivo in an oligodendrocyte-specific Otud7b knockout mouse model and identify functional targets of Otud7b in oligodendrocytes to deepen the understanding of posttranscriptional regulatory events during OL differentiation and CNS myelination.
  • E037: CtBP1 in oligodendroglial development and myelination

    (FAU Funds)

    Project leader: ,
    Term: 1. February 2023 - 30. June 2026
    Mutations in transcriptional corepressor CtBP1 cause the neurodevelopmental disorder HADDTS. Functional CtBP1 studies in the central nervous system so far focused on neurons. We recently found that CtBP1 is also important in oligodendrocytes. Here we will characterize the oligodendroglial functions of CtBP1 and the underlying cellular and molecular mechanisms in mice and a human ES cell-derived cellular disease model to show that defects in oligodendrogenesis and myelination contribute to HADDTS

2026

2025

2024

2023

2022

2021

2020

Related Research Fields

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