Prof. Vahid Sandoghdar

2026

• Paolini, L., Romano, M., Mangolini, V., Tassoni, S., Jiang, S., Mazzoldi, E.L.,... Radeghieri, A. (2026). Red blood cell-derived extracellular vesicles as biomaterials: the opportunity of freezing-induced accelerated aging. Biomaterials Science, 14(1), 122-139. https://doi.org/10.1039/d5bm01349f

2025

• Brunner, C.M., Pietsch, L., vom Sondern, I., Röhrl, M., Popov, C.R., Trollmann, M.,... Möckl, L. (2025). Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy. Journal of the American Chemical Society, 147(36), 32799-32808. https://doi.org/10.1021/jacs.5c08659
• Ginsberg, N.S., Hsieh, C.L., Kukura, P., Piliarik, M., & Sandoghdar, V. (2025). Interferometric scattering microscopy. Nature Reviews Methods Primers, 5(1). https://doi.org/10.1038/s43586-025-00391-1
• Luo, S., Hebenstreit, T., Shkarin, A., Utikal, T., Renger, J., Sandoghdar, V., & Götzinger, S. (2025). Highly Efficient Organic Single-Photon Source Operating at Cryogenic Temperatures. In 2025 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2025. Munich, DEU: Institute of Electrical and Electronics Engineers Inc..
• Mazal, H., Wieser, F.F., Bollschweiler, D., & Sandoghdar, V. (2025). Cryogenic light microscopy of vitrified samples with angstrom precision. Proceedings of the National Academy of Sciences of the United States of America, 122(49), e2513583122. https://doi.org/10.1073/pnas.2513583122
• Mazal, H., Wieser, F.F., Bollschweiler, D., Schambony, A., & Sandoghdar, V. (2025). Cryo–light microscopy with angstrom precision deciphers structural conformations of PIEZO1 in its native state. Science Advances, 11(34). https://doi.org/10.1126/sciadv.adw4402
• Musavinezhad, M., Shkarin, A., Renger, J., Utikal, T., Götzinger, S., & Sandoghdar, V. (2025). On-Chip Stark Tuning of Molecular Resonances in Nanoprinted Crystals. In 2025 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2025. Munich, DEU: Institute of Electrical and Electronics Engineers Inc..
• Nobakht, J., Pscherer, A., Renger, J., Götzinger, S., & Sandoghdar, V. (2025). Hybridization of molecules via a common photonic mode. Proceedings of the National Academy of Sciences of the United States of America, 122(31). https://doi.org/10.1073/pnas.2505161122
• Pourtalebijahromi, L., Kronast, B., Munkert, J., Sana, L., Koch, M., Danzer, H.,... Fuhrmann, G. (2025). Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome. Small. https://doi.org/10.1002/smll.202502551
• Sant, V., Matthes, D., Mazal, H., Antonschmidt, L., Wieser, F., Movellan, K.T.,... Andreas, L.B. (2025). Lipidic folding pathway of α-Synuclein via a toxic oligomer. Nature Communications, 16(1), 760-. https://doi.org/10.1038/s41467-025-55849-3
• Tuna, Y., Al-Hiyasat, A., Kashkanova, A.D., Dechant, A., Lutz, E., & Sandoghdar, V. (2025). Electrostatic All-Passive Force Clamping of Charged Nanoparticles. ACS nano. https://doi.org/10.1021/acsnano.4c17299
• Tuna, Y., & Sandoghdar, V. (2025). Supported Lipid Bilayers as Stochastic Conveyor Belt for Delivery to the Near Field of Nanoscopic Structures. Journal of Physical Chemistry C, 129(1), 495-499. https://doi.org/10.1021/acs.jpcc.4c06908
• Zhang, X.C., Xue, K., Salvi, M., Schomburg, B., Mehrens, J., Giller, K.,... Griesinger, C. (2025). Mechanism of sensor kinase CitA transmembrane signaling. Nature Communications, 16. https://doi.org/10.1038/s41467-024-55671-3

2024

• Holler, C., Taylor, R.W., Schambony, A., Möckl, L., & Sandoghdar, V. (2024). A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control. Nature Methods. https://doi.org/10.1038/s41592-024-02177-x
• Kasaian, K., Mazaheri, M., & Sandoghdar, V. (2024). Long-Range Three-Dimensional Tracking of Nanoparticles Using Interferometric Scattering Microscopy. ACS nano. https://doi.org/10.1021/acsnano.4c08435
• Kashkanova, A.D., Albrecht, D., Küppers, M., Blessing, M., & Sandoghdar, V. (2024). Measuring Concentration of Nanoparticles in Polydisperse Mixtures Using Interferometric Nanoparticle Tracking Analysis. ACS nano. https://doi.org/10.1021/acsnano.4c04396
• Mazaheri, M., Kasaian, K., Albrecht, D., Renger, J., Utikal, T., Holler, C., & Sandoghdar, V. (2024). iSCAT microscopy and particle tracking with tailored spatial coherence. Optica, 11(7), 1030-1038. https://doi.org/10.1364/OPTICA.523788
• Morales-Inostroza, L., Folz, J., Kühnemuth, R., Felekyan, S., Wieser, F.F., Seidel, C.A.,... Sandoghdar, V. (2024). An optofluidic antenna for enhancing the sensitivity of single-emitter measurements. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-46730-w
• Musavinezhad, M., Renger, J., Zirkelbach, J., Utikal, T., Hail, C.U., Basché, T.,... Sandoghdar, V. (2024). High-Resolution Cryogenic Spectroscopy of Single Molecules in Nanoprinted Crystals. ACS nano. https://doi.org/10.1021/acsnano.4c02003
• Sandoghdar, V. (2024). Essay: Exploring the Physics of Basic Medical Research. Physical Review Letters, 132(9). https://doi.org/10.1103/PhysRevLett.132.090001

2023

• Dahmardeh, M., Dastjerdi, H.M., Mazal, H., Köstler, H., & Sandoghdar, V. (2023). Breaking new ground in protein detection: Self-supervised machine learning and iSCAT enable label-free detection of single proteins below 10 kDa. In Bio-Optics: Design and Application in Proceedings Biophotonics Congress: Optics in the Life Sciences 2023, OMA, NTM, BODA, OMP, BRAIN 2023. Vancouver, BC, CAN: Optical Society of America.
• Dahmardeh, M., Mirzaalian Dastjerdi, H., Mazal, H., Köstler, H., & Sandoghdar, V. (2023). Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa. Nature Methods. https://doi.org/10.1038/s41592-023-01778-2
• Kashkanova, A.D., Blessing, M., Reischke, M., Baur, J.-O., Baur, A., Sandoghdar, V., & Van Deun, J. (2023). Label-free discrimination of extracellular vesicles from large lipoproteins. Journal of Extracellular Vesicles, 12(8). https://doi.org/10.1002/jev2.12348
• Küppers, M., Albrecht, D., Kashkanova, A.D., Lühr, J., & Sandoghdar, V. (2023). Confocal interferometric scattering microscopy reveals 3D nanoscopic structure and dynamics in live cells. Nature Communications, 14(1), 1962-. https://doi.org/10.1038/s41467-023-37497-7
• Mazal, H., Wieser, F.F., & Sandoghdar, V. (2023). Insights into protein structure using cryogenic light microscopy. Biochemical Society Transactions, 51(6), 2041-2059. https://doi.org/10.1042/BST20221246
• Musavinezhad, M., Shkarin, A., Rattenbacher, D., Renger, J., Utikal, T., Götzinger, S., & Sandoghdar, V. (2023). Quantum Efficiency of Single Dibenzoterrylene Molecules in p-Dichlorobenzene at Cryogenic Temperatures. Journal of Physical Chemistry B, 127(23), 5353-5359. https://doi.org/10.1021/acs.jpcb.3c01755
• Rattenbacher, D., Shkarin, A., Renger, J., Utikal, T., Gotzinger, S., & Sandoghdar, V. (2023). On-chip interference of scattering from two individual molecules. Optica, 10(12), 1595-1601. https://doi.org/10.1364/OPTICA.502221
• Zirkelbach, J., Gurlek, B., Mirzaei, M., Shkarin, A., Utikal, T., Götzinger, S., & Sandoghdar, V. (2023). Spectral splitting of a stimulated Raman transition in a single molecule. Physical Review Research, 5(4). https://doi.org/10.1103/PhysRevResearch.5.043244

2022

• Blessing, M., Kashkanova, A.D., Gemeinhardt, A., & Sandoghdar, V. (2022). Next-generation particle sizing: interferometric nanoparticle tracking analysis (iNTA). In Optics InfoBase Conference Papers. Vancouver, BC, CAN: Optica Publishing Group (formerly OSA).
• Gurlek, B., Sandoghdar, V., & Martin-Cano, D. (2022). Engineering long-lived vibrational states for an organic molecule. In Said Zouhdi (Eds.), International Conference on Metamaterials, Photonic Crystals and Plasmonics (pp. 708-). Torremolinos, ES: META Conference.
• Kashkanova, A.D., Blessing, M., Gemeinhardt, A., Soulat, D., & Sandoghdar, V. (2022). Precision size and refractive index analysis of weakly scattering nanoparticles in polydispersions. Nature Methods. https://doi.org/10.1038/s41592-022-01460-z
• Küppers, M., Albrecht, D., Kashkanova, A., Lühr, J., & Sandoghdar, V. (2022). Nanoscale Imaging of Live Cells with Confocal Interferometric Scattering Microscopy (iSCAT). In Optics InfoBase Conference Papers. Fort Lauderdale, FL, USA: Optica Publishing Group (formerly OSA).
• Liu, H.-W., Becker, M.A., Matsuzaki, K., Kumar, R., Götzinger, S., & Sandoghdar, V. (2022). Robust Tipless Positioning Device for Near-Field Investigations: Press and Roll Scan (PROscan). ACS nano. https://doi.org/10.1021/acsnano.2c05047
• Mazaheri, M., Kasaian, K., & Sandoghdar, V. (2022). Long-Range High-Speed 3D Tracking via Interferometric Scattering Microscopy. In Optics InfoBase Conference Papers. Fort Lauderdale, FL, USA: Optica Publishing Group (formerly OSA).
• Mazal, H., Wieser, F.-F., & Sandoghdar, V. (2022). Deciphering a hexameric protein complex with Angstrom optical resolution. eLife, 11. https://doi.org/10.7554/eLife.76308
• Mirzaalian Dastjerdi, H., Dahmardeh, M., Gemeinhardt, A., Mahmoodabadi, R.G., Köstler, H., & Sandoghdar, V. (2022). Optimized analysis for sensitive detection and analysis of single proteins via interferometric scattering microscopy. Journal of Physics D: Applied Physics, 55(5). https://doi.org/10.1088/1361-6463/ac2f68
• Zirkelbach, J., Mirzaei, M., Deperasińska, I., Kozankiewicz, B., Gurlek, B., Shkarin, A.,... Sandoghdar, V. (2022). High-resolution vibronic spectroscopy of a single molecule embedded in a crystal. Journal of Chemical Physics, 156(10). https://doi.org/10.1063/5.0081297

2021

• Böning, D., Wieser, F.F., & Sandoghdar, V. (2021). Polarization-Encoded Colocalization Microscopy at Cryogenic Temperatures. ACS Photonics, 8(1), 194-201. https://doi.org/10.1021/acsphotonics.0c01201
• Gurlek, B., Sandoghdar, V., & Martin-Cano, D. (2021). Engineering Long-Lived Vibrational States for an Organic Molecule. Physical Review Letters, 127(12). https://doi.org/10.1103/PhysRevLett.127.123603
• Kashkanova, A.D., Shkarin, A.B., Mahmoodabadi, R.G., Blessing, M., Tuna, Y., Gemeinhardt, A., & Sandoghdar, V. (2021). Precision single-particle localization using radial variance transform. Optics Express, 27(9), 11070-11083. https://doi.org/10.1364/OE.420670
• Küppers, M., Albrecht, D., Kashkanova, A., Lühr, J., & Sandoghdar, V. (2021). Label-free confocal iSCAT microscopy on live cells. In Optics InfoBase Conference Papers. Virtual, Online, USA: The Optical Society.
• Matsuzaki, K., Liu, H.W., Götzinger, S., & Sandoghdar, V. (2021). On Quantum Efficiency Measurements and Plasmonic Antennas. ACS Photonics. https://doi.org/10.1021/acsphotonics.1c00169
• Pscherer, A., Meierhofer, M., Wang, D., Kelkar, H., Martin-Cano, D., Utikal, T.,... Sandoghdar, V. (2021). Nonlinear optics with one molecule and two photons. In 2021 Conference on Lasers and Electro-Optics, CLEO 2021 - Proceedings. Virtual, Online, USA: Institute of Electrical and Electronics Engineers Inc..
• Pscherer, A., Meierhofer, M., Wang, D., Kelkar, H., Martín-Cano, D., Utikal, T.,... Sandoghdar, V. (2021). Single-Molecule Vacuum Rabi Splitting: Four-Wave Mixing and Optical Switching at the Single-Photon Level. Physical Review Letters, 127(13). https://doi.org/10.1103/PhysRevLett.127.133603
• Shkarin, A., Rattenbacher, D., Renger, J., Hönl, S., Utikal, T., Seidler, P.,... Sandoghdar, V. (2021). Nanoscopic Charge Fluctuations in a Gallium Phosphide Waveguide Measured by Single Molecules. Physical Review Letters, 126(13). https://doi.org/10.1103/PhysRevLett.126.133602

2020

• Alaee, R., Gurlek, B., Albooyeh, M., Martin-Cano, D., & Sandoghdar, V. (2020). Quantum Metamaterials with Magnetic Response at Optical Frequencies. Physical Review Letters, 125(6). https://doi.org/10.1103/PhysRevLett.125.063601
• Alaee, R., Safari, A., Sandoghdar, V., & Boyd, R.W. (2020). Kerker effect, superscattering, and scattering dark states in atomic antennas. Physical Review Research, 2(4). https://doi.org/10.1103/PhysRevResearch.2.043409
• Cutler, T.F., Hamlyn, W.J., Renger, J., Whittaker, K.A., Pizzey, D., Hughes, I.G.,... Adams, C.S. (2020). Nanostructured Alkali-Metal Vapor Cells. Physical Review Applied, 14(3). https://doi.org/10.1103/PhysRevApplied.14.034054
• Gemeinhardt, A., König, K., Dahmardeh, M., & Sandoghdar, V. (2020). A high throughput device for label-free real-time study of cellular secretion with iSCAT microscopy. In Optics InfoBase Conference Papers. Washington, DC, US: OSA - The Optical Society.
• Küppers, M., Kashkanova, A., Lühr, J., Albrecht, D., Schambony, A., & Sandoghdar, V. (2020). Label-free live-cell imaging with interferometric scattering microscopy: Confocal imaging and high-speed 3D single particle tracking. In Optics InfoBase Conference Papers. Washington, DC, US: OSA - The Optical Society.
• Mahmoodabadi, R.G., Taylor, R.W., Kaller, M., Spindler, S., Mazaheri, M., Kasaian, K., & Sandoghdar, V. (2020). Point spread function in interferometric scattering microscopy (iSCAT). Part I: aberrations in defocusing and axial localization. Optics Express, 28(18), 25969-25988. https://doi.org/10.1364/OE.401374
• Mazaheri, M., Ehrig, J., Shkarin, A., Zaburdaev, V., & Sandoghdar, V. (2020). Ultrahigh-Speed Imaging of Rotational Diffusion on a Lipid Bilayer. Nano Letters, 20(10), 7213-7219. https://doi.org/10.1021/acs.nanolett.0c02516
• Mukamel, S., Freyberger, M., Schleich, W., Bellini, M., Zavatta, A., Leuchs, G.,... Laussy, F. (2020). Roadmap on quantum light spectroscopy. Journal of Physics B: Atomic, Molecular and Optical Physics, 53(7). https://doi.org/10.1088/1361-6455/ab69a8
• Reitz, M., Sommer, C., Gurlek, B., Sandoghdar, V., Martin-Cano, D., & Genes, C. (2020). Molecule-photon interactions in phononic environments. Physical Review Research, 2(3). https://doi.org/10.1103/PhysRevResearch.2.033270
• Sandoghdar, V. (2020). Nano-Optics in 2020 ± 20. Nano Letters. https://doi.org/10.1021/acs.nanolett.0c02199
• Schutz, S., Schachenmayer, J., Hagenmuller, D., Brennen, G.K., Volz, T., Sandoghdar, V.,... Pupillo, G. (2020). Ensemble-Induced Strong Light-Matter Coupling of a Single Quantum Emitter. Physical Review Letters, 124(11). https://doi.org/10.1103/PhysRevLett.124.113602
• Taylor, R.W., Holler, C., Mahmoodabadi, R.G., Küppers, M., Mirzaalian Dastjerdi, H., Zaburdaev, V.,... Sandoghdar, V. (2020). High-Precision Protein-Tracking With Interferometric Scattering Microscopy. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.590158
• Witkowska, A., Spindler, S., Mahmoodabadi, R.G., Sandoghdar, V., & Jahn, R. (2020). Differential Diffusional Properties in Loose and Tight Docking Prior to Membrane Fusion. Biophysical Journal. https://doi.org/10.1016/j.bpj.2020.10.033
• Yang, B., Chen, G., Ghafoor, A., Zhang, Y., Zhang, Y., Zhang, Y.,... Hou, J.G. (2020). Sub-nanometre resolution in single-molecule photoluminescence imaging. Nature Photonics, 14(11), 693-699. https://doi.org/10.1038/s41566-020-0677-y
• Zirkelbach, J., Gmeiner, B., Renger, J., Tuerschmann, P., Utikal, T., Götzinger, S., & Sandoghdar, V. (2020). Partial Cloaking of a Gold Particle by a Single Molecule. Physical Review Letters, 125(10). https://doi.org/10.1103/PhysRevLett.125.103603