Prof. Dr. Leonhard Möckl

2025

• Brunner, C.M., Pietsch, L., vom Sondern, I., Röhrl, M., Popov, C.R., Trollmann, M.,... Möckl, L. (2025). Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy. Journal of the American Chemical Society, 147(36), 32799-32808. https://doi.org/10.1021/jacs.5c08659
• Fritsche, S., & Möckl, L. (2025). A framework for the simulation of individual glycan coordinates to analyze spatial relationships within the glycocalyx. Frontiers in Cell and Developmental Biology, 12. https://doi.org/10.3389/fcell.2024.1519831
• George, B.M., Eleftheriou, M., Yankova, E., Perr, J., Chai, P., Nestola, G.L.,... Tzelepis, K. (2025). Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein. Nature Biotechnology. https://doi.org/10.1038/s41587-025-02648-2
• Masullo, L.A., Almahayni, K., Pachmayr, I., Honsa, M., Heinze, L., Fritsche, S.,... Möckl, L. (2025). Ångström-resolution imaging of cell-surface glycans. Nature Nanotechnology. https://doi.org/10.1038/s41565-025-01966-5
• Perr, J., Langen, A., Almahayni, K., Nestola, G., Chai, P., Lebedenko, C.G.,... Flynn, R.A. (2025). RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. Cell. https://doi.org/10.1016/j.cell.2025.01.040
• Perr, J., Langen, A., Almahayni, K., Nestola, G., Chai, P., Lebedenko, C.G.,... Flynn, R.A. (2025). RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. Cell, 188(7), 1878-1895.e25. https://doi.org/10.1016/j.cell.2025.01.040

2024

• Almahayni, K., Bachir Salvador, J., Conti, R., Widera, A., Spiekermann, M., Wehner, D.,... Möckl, L. (2024). Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems. ACS Chemical Biology. https://doi.org/10.1021/acschembio.4c00399
• Almahayni, K., Bachir Salvador, J., Moonnukandathil Joseph, D., Yurekli, N., Möllmert, S., & Möckl, L. (2024). From Biophysics to Biomedical Physics. ACS Bio & Med Chem Au, 5, 320-333. https://doi.org/10.1021/acsbiomedchemau.4c00096
• Holler, C., Taylor, R.W., Schambony, A., Möckl, L., & Sandoghdar, V. (2024). A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control. Nature Methods. https://doi.org/10.1038/s41592-024-02177-x
• Rodríguez, C., Arlt, S., Möckl, L., & Krenn, M. (2024). Automated discovery of experimental designs in super-resolution microscopy with XLuminA. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-54696-y

2023

• Almahayni, K., Almahayni, K., Nestola, G., Spiekermann, M., & Möckl, L. (2023). Simple, Economic, and Robust Rail-Based Setup for Super-Resolution Localization Microscopy. Journal of Physical Chemistry A. https://doi.org/10.1021/acs.jpca.3c01351
• Almahayni, K., & Möckl, L. (2023). Setting the stage for universal pharmacological targeting of the glycocalyx. In Ibra S. Fancher, Andreia Z. Chignalia (Eds.), Current Topics in Membranes. (pp. 61-88). Academic Press Inc..

2022

• Almahayni, K., Spiekermann, M., Fiore, A., Yu, G., Pedram, K., & Möckl, L. (2022). Erratum to “Small molecule inhibitors of mammalian glycosylation” [Matrix Biol. Plus 16C (2022) 100108] (Matrix Biology Plus (2022) 16, (S2590028522000084), (10.1016/j.mbplus.2022.100108)). Matrix Biology Plus, 16. https://doi.org/10.1016/j.mbplus.2022.100126
• Almahayni, K., Spiekermann, M., Fiore, A., Yu, G., Pedram, K., & Möckl, L. (2022). Small molecule inhibitors of mammalian glycosylation. Matrix Biology Plus, 16. https://doi.org/10.1016/j.mbplus.2022.100108
• Almahayni, K., Spiekermann, M., & Möckl, L. (2022). Fluorophores’ talk turns them dark. Nature Methods, 19(8), 932-933. https://doi.org/10.1038/s41592-022-01565-5
• Wang, J., Han, M., Roy, A.R., Wang, H., Möckl, L., Zeng, L.,... Qi, L.S. (2022). Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection. Cell Reports: Methods, 2(2). https://doi.org/10.1016/j.crmeth.2022.100170

2021

• Evers, J., Herzog, C., & Möckl, L. (2021). Die Fraunhofer-Gesellschaft: Von kleinen Anfängen zum steilen Aufstieg. Chemie in Unserer Zeit, 55(2), 101-111. https://doi.org/10.1002/ciuz.201900034
• Wisnovsky, S., Möckl, L., Malaker, S.A., Pedram, K., Hess, G.T., Riley, N.M.,... Bertozzi, C.R. (2021). Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. Proceedings of the National Academy of Sciences of the United States of America, 118(5). https://doi.org/10.1073/pnas.2015024118
• Yoshikawa, A.M., Rangel, A., Feagin, T., Chun, E.M., Wan, L., Li, A.,... Soh, H.T. (2021). Discovery of indole-modified aptamers for highly specific recognition of protein glycoforms. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-26933-1

2020

• Debets, M.F., Tastan, O.Y., Wisnovsky, S.P., Malaker, S.A., Angelis, N., Möckl, L.,... Schumann, B. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. Proceedings of the National Academy of Sciences of the United States of America, 117(41), 25293-25301. https://doi.org/10.1073/pnas.2007297117
• Möckl, L. (2020). The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.00253
• Möckl, L., & Moerner, W.E. (2020). Super-resolution Microscopy with Single Molecules in Biology and Beyond-Essentials, Current Trends, and Future Challenges. Journal of the American Chemical Society, 142(42), 17828-17844. https://doi.org/10.1021/jacs.0c08178
• Möckl, L., Roy, A.R., & Moerner, W.E. (2020). Deep learning in single-molecule microscopy: Fundamentals, caveats, and recent developments [Invited]. Biomedical Optics Express, 11(3), 1633-1661. https://doi.org/10.1364/BOE.386361
• Möckl, L., Roy, A.R., Petrov, P.N., & Moerner, W.E. (2020). Accurate and rapid background estimation in single-molecule localization microscopy using the deep neural network BGnet. Proceedings of the National Academy of Sciences of the United States of America, 117(1), 60-67. https://doi.org/10.1073/pnas.1916219117
• Raddaoui, N., Croce, S., Geiger, F., Borodavka, A., Möckl, L., Stazzoni, S.,... Carell, T. (2020). Supersensitive Multifluorophore RNA-FISH for Early Virus Detection and Flow-FISH by Using Click Chemistry. ChemBioChem, 21(15), 2214-2218. https://doi.org/10.1002/cbic.202000081