PD Dr. med. Dr. rer. nat. Tobias Huth
Lehrstuhl für Physiologie
We are interested in the functioning of molecular machines such as voltage-gated ion channels or Alzheimer’s Disease protease BACE1. Using patch-clamp recordings or time-resolved optical techniques, the behavior of single proteins is investigated. Subsequent Markov modelling of acquired time series using simulations or Deep Neural Networks provides insight into the molecular composition and function.
Research projects
- Time Series Analysis
- Modelling
- HPC Simulations
- Deep Neural Networks
- Voltage-Gated Ion Channels
- Alzheimer’s Disease Protease BACE1
No projects found.
2025
- Heininger, H., Feng, X., Altunkaya, A., Zheng, F., Stockinger, F., Wefers, B.,... Huth, T. (2025). BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions. EMBO Reports. https://doi.org/10.1038/s44319-025-00604-4
2024
- Oikonomou, E., Juli, Y., Kolan, R.R., Kern, L., Gruber, T., Alzheimer, C.,... Huth, T. (2024). A deep learning approach to real-time Markov modeling of ion channel gating. Communications Chemistry. https://doi.org/10.1038/s42004-024-01369-y
2023
- Oikonomou, E., Gruber, T., Achanta, R.C., Höller, S., Alzheimer, C., Wellein, G., & Huth, T. (2023). 2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. Biophysical Journal. https://doi.org/10.1016/j.bpj.2023.02.023
2021
- Anni, D., Weiss, E.-M., Guhathakurta, D., Akdas, E.Y., Klueva, J., Zeitler, S.,... Fejtová, A. (2021). Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-021-03835-5
2020
- Thull, S., Neacsu, C., O'Reilly, A.O., Bothe, S., Hausmann, R., Huth, T.,... Lampert, A. (2020). Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties. Data in Brief, 31. https://doi.org/10.1016/j.dib.2020.105844
- Thull, S., Neacsu, C., O'Reilly, A.O., Bothe, S., Hausmann, R., Huth, T.,... Lampert, A. (2020). Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5. Toxicology and Applied Pharmacology, 397. https://doi.org/10.1016/j.taap.2020.115010
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