PD Dr. med. Dr. rer. nat. Tobias Huth

We are interested in the functioning of molecular machines such as voltage-gated ion channels or Alzheimer’s Disease protease BACE1. Using patch-clamp recordings or time-resolved optical techniques, the behavior of single proteins is investigated. Subsequent Markov modelling of acquired time series using simulations or Deep Neural Networks provides insight into the molecular composition and function.

Research projects

Time Series Analysis
Modelling
HPC Simulations
Deep Neural Networks
Voltage-Gated Ion Channels
Alzheimer’s Disease Protease BACE1

Current Projects

No projects found.

Recent publications

2023

Oikonomou, E., Gruber, T., Achanta, R.C., Höller, S., Alzheimer, C., Wellein, G., & Huth, T. (2023). 2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. Biophysical Journal. https://dx.doi.org/10.1016/j.bpj.2023.02.023

2021

Anni, D., Weiss, E.-M., Guhathakurta, D., Akdas, E.Y., Klueva, J., Zeitler, S.,... Fejtová, A. (2021). Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-021-03835-5

2020

Thull, S., Neacsu, C., O'Reilly, A.O., Bothe, S., Hausmann, R., Huth, T.,... Lampert, A. (2020). Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties. Data in Brief, 31. https://dx.doi.org/10.1016/j.dib.2020.105844
Thull, S., Neacsu, C., O'Reilly, A.O., Bothe, S., Hausmann, R., Huth, T.,... Lampert, A. (2020). Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5. Toxicology and Applied Pharmacology, 397. https://doi.org/10.1016/j.taap.2020.115010

Related Research Fields

Biomaterials