Prof. Christian Pilarsky

2023

• Al-Fatlawi, A., Rusadze, E., Shmelkin, A., Malekian, N., Ozen, C., Pilarsky, C., & Schroeder, M. (2023). Netrank: network-based approach for biomarker discovery. BMC Bioinformatics, 24(1). https://dx.doi.org/10.1186/s12859-023-05418-6
• Daunke, T., Beckinger, S., Rahn, S., Krüger, S., Heckl, S., Schäfer, H.,... Sebens, S. (2023). Expression and role of the immune checkpoint regulator PD-L1 in the tumor-stroma interplay of pancreatic ductal adenocarcinoma. Frontiers in Immunology, 14. https://dx.doi.org/10.3389/fimmu.2023.1157397
• Dinter, J., Friedrich, R.P., Yang, H., Pilarsky, C., Mangge, H., Pöttler, M.,... Lyer, S. (2023). Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids. Materials, 16(7). https://dx.doi.org/10.3390/ma16072906
• Geyer, M., Schreyer, D., Gaul, L.M., Pfeffer, S., Pilarsky, C., & Queiroz, K. (2023). A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment. Cell Death Discovery, 9(1). https://dx.doi.org/10.1038/s41420-023-01334-z
• Han, Y., Drobisch, P., Krüger, A., William, D., Grützmann, K., Böthig, L.,... Kahlert, C. (2023). Plasma extracellular vesicle messenger RNA profiling identifies prognostic EV signature for non-invasive risk stratification for survival prediction of patients with pancreatic ductal adenocarcinoma. Journal of Hematology & Oncology, 16(1). https://dx.doi.org/10.1186/s13045-023-01404-w
• He, H., Zhang, S., Yang, H., Xu, P., Kutschick, I., Pfeffer, S.,... Pilarsky, C. (2023). Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator. Cancers, 15(1). https://dx.doi.org/10.3390/cancers15010241
• Krug, J., Rodrian, G., Petter, K., Yang, H., Khoziainova, S., Guo, W.,... Britzen-Laurent, N. (2023). N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy. Gastroenterology. https://dx.doi.org/10.1053/j.gastro.2022.11.018
• Zhang, J., Zhang, S., Dörflein, I., Ren, X., Pfeffer, S., Britzen-Laurent, N.,... Pilarsky, C. (2023). Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer. Cancers, 15(19). https://dx.doi.org/10.3390/cancers15194842

2022

• Chen, X.-Z., Guo, R., Zhao, C., Xu, J., Song, H., Yu, H.,... Zhang, J.-Y. (2022). A Novel Anti-Cancer Therapy: CRISPR/Cas9 Gene Editing. Frontiers in Pharmacology, 13. https://dx.doi.org/10.3389/fphar.2022.939090
• De Andres, M.P., Jackson, R.J., Felipe, I., Zagorac, S., Pilarsky, C., Schlitter, A.M.,... Real, F.X. (2022). GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma. Gut. https://dx.doi.org/10.1136/gutjnl-2021-325803
• Fan, X.Y., Deng, Z.F., Yan, Y.Y., E Orel, V., Shypko, A., B Orel, V.,... Zhang, J.Y. (2022). Application of microfluidic chips in anticancer drug screening. Bosnian Journal of Basic Medical Sciences, 22(3), 302-314. https://dx.doi.org/10.17305/bjbms.2021.6484
• Lan, B., Zeng, S., Zhang, S., Ren, X., Xing, Y., Kutschick, I.,... Pilarsky, C. (2022). CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Cancers, 14(2). https://dx.doi.org/10.3390/cancers14020326
• Mahajan, U.M., Oehrle, B., Sirtl, S., Alnatsha, A., Goni, E., Regel, I.,... Mayerle, J. (2022). Independent Validation and Assay Standardization of Improved Metabolic Biomarker Signature to Differentiate Pancreatic Ductal Adenocarcinoma From Chronic Pancreatitis. Gastroenterology, 163(5), 1407-1422. https://dx.doi.org/10.1053/j.gastro.2022.07.047
• Sankarasubramanian, S., Niethard, M., Pilarsky, C., Regenbrecht, C., & Wedeken, L. (2022). Meeting Medical Need - Development of a High-Throughput Assay Using Pancreatic Cancer Patient Derived Organoids as a Tool for Personalized Medicine. In ONCOLOGY RESEARCH AND TREATMENT (pp. 87-88). BASEL: KARGER.
• Wu, Y., Wang, Y., Lu, Y., Luo, X., Huang, Y., Xie, T.,... Zhang, J. (2022). Microfluidic Technology for the Isolation and Analysis of Exosomes. Micromachines, 13(10). https://dx.doi.org/10.3390/mi13101571
• Yang, H., Liu, B., Liu, D., Yang, Z., Zhang, S., Xu, P.,... Pilarsky, C. (2022). Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer. Cancers, 14(13). https://dx.doi.org/10.3390/cancers14133152
• Yun, D., Yang, Z., Zhang, S., Yang, H., Liu, D., Grützmann, R.,... Britzen-Laurent, N. (2022). An m5C methylation regulator-associated signature predicts prognosis and therapy response in pancreatic cancer. Frontiers in Cell and Developmental Biology, 10. https://dx.doi.org/10.3389/fcell.2022.975684
• Zeng, S., Lan, B., Ren, X., Zhang, S., Schreyer, D., Eckstein, M.,... Pilarsky, C. (2022). CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer. Journal of Experimental & Clinical Cancer Research, 41(1). https://dx.doi.org/10.1186/s13046-022-02443-w

2021

• Adam, M.G., Beyer, G., Christiansen, N., Kamlage, B., Pilarsky, C., Distler, M.,... Lerch, M.M. (2021). Identification and validation of a multivariable prediction model based on blood plasma and serum metabolomics for the distinction of chronic pancreatitis subjects from non-pancreas disease control subjects. Gut, 70(11), 2150-2158. https://doi.org/10.1136/gutjnl-2020-320723
• Al-Fatlawi, A., Malekian, N., García, S., Henschel, A., Kim, I., Dahl, A.,... Schroeder, M. (2021). Deep learning improves pancreatic cancer diagnosis using rna-based variants. Cancers, 13(11). https://dx.doi.org/10.3390/cancers13112654
• Dreyer, S.B., Upstill-Goddard, R., Paulus-Hock, V., Paris, C., Lampraki, E.M., Dray, E.,... Sansom, O.J. (2021). Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer. Gastroenterology, 160(1), 362-377.e13. https://dx.doi.org/10.1053/j.gastro.2020.09.043
• Gollavilli, P.N., Parma, B., Siddiqui, A., Yang, H., Ramesh, V., Napoli, F.,... Ceppi, P. (2021). The role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter. Oncogene. https://dx.doi.org/10.1038/s41388-021-01708-6
• Mahajan, U.M., Alnatsha, A., Li, Q., Oehrle, B., Weiss, F.-U., Sendler, M.,... Mayerle, J. (2021). Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma. Cells, 10(7). https://dx.doi.org/10.3390/cells10071821
• Mahajan, U.M., Alnatsha, A., Li, Q., Oehrle, B., Weiss, U., Sendler, M.,... Mayerle, J. (2021). Plasma Metabolic Profiling Identify Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma. In PANCREAS (pp. 1079-1079). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
• Miquel Sedo, M., Zhang, S., & Pilarsky, C. (2021). Pre-clinical Models of Metastasis in Pancreatic Cancer. Frontiers in Cell and Developmental Biology, 9. https://dx.doi.org/10.3389/fcell.2021.748631
• Parma, B., Ramesh, V., Gollavilli, P.N., Siddiqui, A., Pinna, L., Schwab, A.,... Ceppi, P. (2021). Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting. Journal of Experimental & Clinical Cancer Research, 40(1). https://dx.doi.org/10.1186/s13046-021-02049-8
• Schwappacher, R., Dieterich, W., Reljic, D., Pilarsky, C., Mukhopadhyay, D., Chang, D.K.,... Zopf, Y. (2021). Muscle‐derived cytokines reduce growth, viability and migratory activity of pancreatic cancer cells. Cancers, 13(15). https://dx.doi.org/10.3390/cancers13153820
• Zhou, W.-M., Yan, Y.-Y., Guo, Q.-R., Ji, H., Wang, H., Xu, T.-T.,... Zhang, J.-Y. (2021). Microfluidics applications for high-throughput single cell sequencing. Journal of Nanobiotechnology, 19(1). https://dx.doi.org/10.1186/s12951-021-01045-6

2020

• Beyer, G., Adam, M.G., Christiansen, N., Kamlage, B., Pilarsky, C., Distler, M.,... Lerch, M.M. (2020). Development and Validation of a Multivariable Prediction Model Based on Blood Plasma and Serum Metabolomics for the Diagnosis of Chronic Pancreatitis. In PANCREAS (pp. 1401-1401). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
• Brunton, H., Caligiuri, G., Cunningham, R., Upstill-Goddard, R., Bailey, U.M., Garner, I.M.,... Bailey, P.J. (2020). HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer. Cell Reports, 31(6). https://dx.doi.org/10.1016/j.celrep.2020.107625
• Friedrich, R.P., Schreiber, E., Tietze, R., Yang, H., Pilarsky, C., & Alexiou, C. (2020). Intracellular Quantification and Localization of Label-Free Iron Oxide Nanoparticles by Holotomographic Microscopy. Nanotechnology, Science and Applications, 13, 119-130. https://dx.doi.org/10.2147/NSA.S282204
• Langheinrich, M., Wirtz, S., Kneis, B., Gittler, M.M., Tyc, O., Schierwagen, R.,... Weber, G. (2020). Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development. Journal of Clinical Medicine, 9(9). https://dx.doi.org/10.3390/jcm9092785
• Mziaut, H., Henniger, G., Ganss, K., Hempel, S., Wolk, S., McChord, J.,... Kersting, S. (2020). MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling. Molecular Metabolism, 31, 150-162. https://dx.doi.org/10.1016/j.molmet.2019.11.012