We are working on the identification and validation of biomarker and target genes for pancreatic cancer. For this, we are handling the biobank of the surgical department and employing CRISPR/Cas9 and organoid technology.
Research projects
CRISPR/Cas9 in human pancreas organoids
Development of new markers
Identification of metastasis-associated genes
Recent publications
2021
Dreyer, S.B., Upstill-Goddard, R., Paulus-Hock, V., Paris, C., Lampraki, E.M., Dray, E.,... Sansom, O.J. (2021). Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer . Gastroenterology , 160 (1), 362-377.e13. https://dx.doi.org/10.1053/j.gastro.2020.09.043
Gollavilli, P.N., Parma, B., Siddiqui, A., Yang, H., Ramesh, V., Napoli, F.,... Ceppi, P. (2021). The role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter . Oncogene . https://dx.doi.org/10.1038/s41388-021-01708-6
2020
Beyer, G., Adam, M.G., Christiansen, N., Kamlage, B., Pilarsky, C., Distler, M.,... Lerch, M.M. (2020). Development and Validation of a Multivariable Prediction Model Based on Blood Plasma and Serum Metabolomics for the Diagnosis of Chronic Pancreatitis . In PANCREAS (pp. 1401-1401). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Brunton, H., Caligiuri, G., Cunningham, R., Upstill-Goddard, R., Bailey, U.M., Garner, I.M.,... Bailey, P.J. (2020). HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer . Cell Reports , 31 (6). https://dx.doi.org/10.1016/j.celrep.2020.107625
Friedrich, R.P., Schreiber, E., Tietze, R., Yang, H., Pilarsky, C., & Alexiou, C. (2020). Intracellular Quantification and Localization of Label-Free Iron Oxide Nanoparticles by Holotomographic Microscopy . Nanotechnology, Science and Applications , 13 , 119-130. https://dx.doi.org/10.2147/NSA.S282204
Langheinrich, M., Wirtz, S., Kneis, B., Gittler, M.M., Tyc, O., Schierwagen, R.,... Kersting, S. (2020). Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development . Journal of Clinical Medicine , 9 (9). https://dx.doi.org/10.3390/jcm9092785
Mziaut, H., Henniger, G., Ganss, K., Hempel, S., Wolk, S., McChord, J.,... Kersting, S. (2020). MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling . Molecular Metabolism , 31 , 150-162. https://dx.doi.org/10.1016/j.molmet.2019.11.012
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We are working on the identification and validation of biomarker and target genes for pancreatic cancer. For this, we are handling the biobank of the surgical department and employing CRISPR/Cas9 and organoid technology.
Research projects
PancREatic Cancer OrganoiDs rEsearch Network
(Third Party Funds Group – Sub project)
Term: 1. October 2019 - 30. September 2023
Funding source: EU - 8. Rahmenprogramm - Horizon 2020
2021
2020
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