The research is focused on online processing and evaluation of physiological data for open- or closed-loop control of anesthetic drug dosing. A further topic of research is the development and evaluation of pharmacokinetic and pharmacodynamic models using volunteer and patient data. Clinical evaluation of medical devices for patient monitoring and drug dosing supplements the research focus.
Research projects
Neurophysiologic and Hemodynamic Data Analysis
Pharmacokinetics and Pharmacodynamics of Anesthetic Drugs
Efficacy and Safety of Model Based Closed Loop Infusion
Recent publications
2025
Wehrfritz, A., Schmidt, S., Ihmsen, H., Schüttler, J., & Jeleazcov, C. (2025). Long-term stability of sufentanil quantified by UPLC-MS-MS in human plasma frozen for 11 years at -20°C. Journal of Analytical Toxicology , 49 (1), 59-62. https://doi.org/10.1093/jat/bkae083
2023
Gao, Y.Q., Ihmsen, H., Hu, Z.Y., Sun, W., Fang, Y.B., Wang, Z.,... Liu, H.C. (2023). Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children . British Journal of Anaesthesia . https://doi.org/10.1016/j.bja.2023.08.019
2022
Wehrfritz, A., Schmidt, S., Ihmsen, H., Schüttler, J., & Jeleazcov, C. (2022). Long-Term Stability of Hydromorphone in Human Plasma Frozen at-20 degrees C for Three Years Quantified by LC-MS/MS . International Journal of Analytical Chemistry , 2022 . https://doi.org/10.1155/2022/3645048
Wehrfritz, A., Senger, A.-S., Just, P., Albart, M., Münchsmeier, M., Ihmsen, H.,... Jeleazcov, C. (2022). Patient-Controlled Analgesia After Cardiac Surgery With Median Sternotomy: No Advantages of Hydromorphone When Compared to Morphine . Journal of Cardiothoracic and Vascular Anesthesia , 36 (9), 3587-3595. https://doi.org/10.1053/j.jvca.2022.04.051
2021
2020
Eisenried, A., Schüttler, J., Lerch, M., Ihmsen, H., & Jeleazcov, C. (2020). Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers Part II. Pharmacodynamics of Electroencephalogram Effects . Anesthesiology , 132 (4), 652-666. https://doi.org/10.1097/ALN.0000000000003102
Schüttler, J., Eisenried, A., Lerch, M., Fechner, J., Jeleazcov, C., & Ihmsen, H. (2020). Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part I. Pharmacokinetics and Clinical Pharmacodynamics . Anesthesiology , 132 (4), 636-651. https://doi.org/10.1097/ALN.0000000000003103
Wehrfritz, A., Ihmsen, H., Fuchte, T., Kim, M., Kremer, S., Weiss, A.,... Jeleazcov, C. (2020). Postoperative pain therapy with hydromorphone; comparison of patient-controlled analgesia with target-controlled infusion and standard patient-controlled analgesia A randomised controlled trial . European Journal of Anaesthesiology , 37 (12), 1168-1175. https://doi.org/10.1097/EJA.0000000000001360
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The research is focused on online processing and evaluation of physiological data for open- or closed-loop control of anesthetic drug dosing. A further topic of research is the development and evaluation of pharmacokinetic and pharmacodynamic models using volunteer and patient data. Clinical evaluation of medical devices for patient monitoring and drug dosing supplements the research focus.
Research projects
No projects found.
2025
2023
2022
2021
2020
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