Prof. Dr. Christian Jeleazcov
Department of Anesthesiology
Prof. Dr. Christian Jeleazcov
Department of Anesthesiology
The research is focused on online processing and evaluation of physiological data for open- or closed-loop control of anesthetic drug dosing. A further topic of research is the development and evaluation of pharmacokinetic and pharmacodynamic models using volunteer and patient data. Clinical evaluation of medical devices for patient monitoring and drug dosing supplements the research focus.
Research projects
- Neurophysiologic and Hemodynamic Data Analysis
- Pharmacokinetics and Pharmacodynamics of Anesthetic Drugs
- Efficacy and Safety of Model Based Closed Loop Infusion
No projects found.
2025
- Schmidt, S., Ihmsen, H., Münster, T., Schüttler, J., Jeleazcov, C., & Wehrfritz, A. (2025). Determination of the Long-Term Stability of Propofol in Human Plasma Frozen for Eight Years and Quantified by UHPLC–MS/MS. International Journal of Analytical Chemistry, 2025(1). https://doi.org/10.1155/ianc/7533068
- Wehrfritz, A., Schmidt, S., Ihmsen, H., Schüttler, J., & Jeleazcov, C. (2025). Long-term stability of sufentanil quantified by UPLC-MS-MS in human plasma frozen for 11 years at -20°C. Journal of Analytical Toxicology, 49(1), 59-62. https://doi.org/10.1093/jat/bkae083
2023
- Gao, Y.Q., Ihmsen, H., Hu, Z.Y., Sun, W., Fang, Y.B., Wang, Z.,... Liu, H.C. (2023). Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children. British Journal of Anaesthesia. https://doi.org/10.1016/j.bja.2023.08.019
2022
- Wehrfritz, A., Schmidt, S., Ihmsen, H., Schüttler, J., & Jeleazcov, C. (2022). Long-Term Stability of Hydromorphone in Human Plasma Frozen at-20 degrees C for Three Years Quantified by LC-MS/MS. International Journal of Analytical Chemistry, 2022. https://doi.org/10.1155/2022/3645048
- Wehrfritz, A., Senger, A.-S., Just, P., Albart, M., Münchsmeier, M., Ihmsen, H.,... Jeleazcov, C. (2022). Patient-Controlled Analgesia After Cardiac Surgery With Median Sternotomy: No Advantages of Hydromorphone When Compared to Morphine. Journal of Cardiothoracic and Vascular Anesthesia, 36(9), 3587-3595. https://doi.org/10.1053/j.jvca.2022.04.051
2021
- Ihmsen, H., Schüttler, J., & Jeleazcov, C. (2021). Pharmacokinetics of Morphine and Morphine-6-Glucuronide During Postoperative Pain Therapy in Cardiac Surgery Patients. European Journal of Drug Metabolism and Pharmacokinetics. https://doi.org/10.1007/s13318-020-00663-z
2020
- Eisenried, A., Schüttler, J., Lerch, M., Ihmsen, H., & Jeleazcov, C. (2020). Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers Part II. Pharmacodynamics of Electroencephalogram Effects. Anesthesiology, 132(4), 652-666. https://doi.org/10.1097/ALN.0000000000003102
- Schüttler, J., Eisenried, A., Lerch, M., Fechner, J., Jeleazcov, C., & Ihmsen, H. (2020). Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part I. Pharmacokinetics and Clinical Pharmacodynamics. Anesthesiology, 132(4), 636-651. https://doi.org/10.1097/ALN.0000000000003103
- Wehrfritz, A., Ihmsen, H., Fuchte, T., Kim, M., Kremer, S., Weiss, A.,... Jeleazcov, C. (2020). Postoperative pain therapy with hydromorphone; comparison of patient-controlled analgesia with target-controlled infusion and standard patient-controlled analgesia A randomised controlled trial. European Journal of Anaesthesiology, 37(12), 1168-1175. https://doi.org/10.1097/EJA.0000000000001360