Prof. Dr. Anja Boßerhoff

2023

• Stäbler, S., Lichtblau, A., Gurbiel, S., Schubert, T., Riechers, A., Rottensteiner-Brandl, U., & Boßerhoff, A.K. (2023). MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy. Cells, 12(2). https://dx.doi.org/10.3390/cells12020229

2022

• Arndt, S., Unger, P., Boßerhoff, A.K., Berneburg, M., & Karrer, S. (2022). The anti-fibrotic effect of cold atmospheric plasma on localized scleroderma in vitro and in vivo. In EXPERIMENTAL DERMATOLOGY (pp. E83-E83). HOBOKEN: WILEY.
• Böhme-Schäfer, I., Lörentz, S., & Boßerhoff, A.K. (2022). Role of Amino Acid Transporter SNAT1/SLC38A1 in Human Melanoma. Cancers, 14(9). https://dx.doi.org/10.3390/cancers14092151
• Chiheb, C., Böhme-Schäfer, I., & Boßerhoff, A.K. (2022). Extracellular acidosis leads to the formation of a senescence-like subpopulation in malignant melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 103-103). HOBOKEN: WILEY.
• Ertekin, Ö., Monavari, M., Krüger, R., Fuentes Chandia, M.A., Parma, B., Letort, G.,... Leal-Egaña, A. (2022). 3D hydrogel-based microcapsules as an in vitro model to study tumorigenicity, cell migration and drug resistance. Acta Biomaterialia. https://dx.doi.org/10.1016/j.actbio.2022.02.010
• Heppt, M., Wessely, A., Hornig, E., Kammerbauer, C., Graf, S.A., Besch, R.,... Berking, C. (2022). HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma. International Journal of Molecular Sciences, 23(2). https://dx.doi.org/10.3390/ijms23020849
• Kluge, V., Zimmermann, T., Pommer, M., Kuphal, S., & Boßerhoff, A.K. (2022). Molecular mechanisms of OIS breakdown in the context of melanoma formation. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 37-37). HOBOKEN: WILEY.
• Linck-Paulus, L., Horn, A., Matthies, A.O., Fischer, S., Meister, G., Sticht, H.,... Boßerhoff, A.K. (2022). A novel splice variant of Argonaut 2 affects microRNA target genes and cell viability of melanoma cells. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 36-36). HOBOKEN: WILEY.
• Linck-Paulus, L., Kappelmann-Fenzl, M., Meister, G., & Boßerhoff, A.K. (2022). An AGO2 variant affects the function of miRNAs and influences the viability of melanoma cells. In EXPERIMENTAL DERMATOLOGY (pp. E100-E100). HOBOKEN: WILEY.
• Linck-Paulus, L., Meißgeier, T., Pieger, K., Horn, A., Matthies, A.O., Fischer, S.,... Boßerhoff, A.K. (2022). A previously unknown Argonaute 2 variant positively modulates the viability of melanoma cells. Cellular and Molecular Life Sciences, 79(9). https://dx.doi.org/10.1007/s00018-022-04496-8
• Lämmerhirt, L., Kappelmann-Fenzl, M., Fischer, S., Pommer, M., Zimmermann, T., Kluge, V.,... Boßerhoff, A.K. (2022). Knockdown of Lamin B1 and the Corresponding Lamin B Receptor Leads to Changes in Heterochromatin State and Senescence Induction in Malignant Melanoma. Cells, 11(14). https://dx.doi.org/10.3390/cells11142154
• Lämmerhirt, L., Pommer, M., Zimmermann, T., Kluge, V., Kuphal, S., & Boßerhoff, A.K. (2022). The Nuclear Envelope Proteins LMNB1 and LBR influence the Chromatin Structure and Senescence Processes in Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 35-35). HOBOKEN: WILEY.
• Lörentz, S., Böhme-Schäfer, I., & Boßerhoff, A.K. (2022). Importance of the Amino Acid Transporter SNAT1/SLC38A1 in malignant Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 80-80). HOBOKEN: WILEY.
• Meissgeier, T., Linck-Paulus, L., & Boßerhoff, A.K. (2022). The splicing factor PHF5A influences the growth and variability of melanoma cells. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 102-102). HOBOKEN: WILEY.
• Peschl, V., Seitz, T., Sommer, J., Thasler, W., Boßerhoff, A.K., & Hellerbrand, C. (2022). Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis. Journal of Cellular Biochemistry. https://dx.doi.org/10.1002/jcb.30248
• Rachinger, N., Mittag, N., Böhme-Schäfer, I., Xiang, W., Kuphal, S., & Boßerhoff, A.K. (2022). Alpha-Synuclein and Its Role in Melanocytes. Cells, 11(13). https://dx.doi.org/10.3390/cells11132087
• Richter, M., Loth, Y., Weisenstein, C., Wigger, A.K., Schaar, D., Boßerhoff, A.K., & Bolivar, P.H. (2022). Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics. Frequenz, 76(11-12), 627-637. https://dx.doi.org/10.1515/freq-2022-0092
• Richter, M., Weisenstein, C., Wigger, A.K., Boßerhoff, A.K., & Bolivar, P.H. (2022). Design Aspects for Sensitive Metasurface-Based THz Biosensing in Aqueous Solutions. In 2022 47TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER AND TERAHERTZ WAVES (IRMMW-THZ 2022). Delft, NL: NEW YORK: IEEE.
• Schmid, R., Schmidt, S., Detsch, R., Horder, H., Blunk, T., Schrüfer, S.,... Kengelbach-Weigand, A. (2022). A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models. Advanced Functional Materials, Volume 32(Issue 2). https://dx.doi.org/10.1002/adfm.202107993
• Schmidt, S., Fischer, S., Schmid, R., Arkudas, A., Kengel-Bach-Weigand, A., Kappelmann-Fenzl, M., & Boßerhoff, A.K. (2022). Molecular analysis of tumor dormancy of the malignant 3D printed model of melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 101-102). HOBOKEN: WILEY.
• Schott, M., Kappelmann-Fenz, M., Fischer, S., Fernandez-Barrena, M.G., Pineda-Lucena, A., Ávila, M.A.,... Boßerhoff, A.K. (2022). Impact of CYLD on chromatin structure and histone methylation in malignant melanoma. International Journal of Molecular Medicine, 49(5). https://dx.doi.org/10.3892/ijmm.2022.5122
• Seefried, F., Haller, L., Fukuda, S., Thongmao, A., Schneider, N., Utikal, J.,... Kuphal, S. (2022). Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma. International Journal of Cancer. https://dx.doi.org/10.1002/ijc.34254
• Seitz, T., John, N., Sommer, J., Dietrich, P., Thasler, W.E., Hartmann, A.,... Hellerbrand, C. (2022). Role of Fibroblast Growth Factors in the Crosstalk of Hepatic Stellate Cells and Uveal Melanoma Cells in the Liver Metastatic Niche. International Journal of Molecular Sciences, 23(19). https://dx.doi.org/10.3390/ijms231911524
• Stüfchen, I., Beckervordersandforth, R., Fischer, S., Kappelmann-Fenzl, M., Boßerhoff, A.K., & Beyer, F. (2022). Two novel CreERT2 transgenic mouse lines to study melanocytic cells in vivo. Pigment Cell & Melanoma Research. https://dx.doi.org/10.1111/pcmr.13061
• Söderberg, A., Meißgeier, T., Boßerhoff, A.K., & Linck-Paulus, L. (2022). MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A. Cells, 11(23). https://dx.doi.org/10.3390/cells11233859
• Weisenstein, C., Richter, M., Wigger, A.K., Boßerhoff, A.K., & Bolivar, P.H. (2022). Multifrequency Investigation of Single-and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors. Biosensors, 12(7). https://dx.doi.org/10.3390/bios12070483
• Weisenstein, C., Richter, M., Wigger, A.K., Boßerhoff, A.K., & Haring Bolivar, P. (2022). Substrate-integrated microfluidics for sensitive biosensing with complementary THz metamaterials in water. Applied Physics Letters, 120(5). https://dx.doi.org/10.1063/5.0076379
• Zimmermann, T., Pommer, M., Kluge, V., Chiheb, C., Mühlich, S., & Boßerhoff, A.K. (2022). Detection and quantification of cellular senescence in human melanocytes and melanoma cell lines. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 104-105). HOBOKEN: WILEY.
• Zimmermann, T., Pommer, M., Kluge, V., Chiheb, C., Mühlich, S., & Boßerhoff, A.K. (2022). Detection of Cellular Senescence in Human Primary Melanocytes and Malignant Melanoma Cells In Vitro. Cells, 11(9). https://dx.doi.org/10.3390/cells11091489

2021

• Arndt, S., Fadil, F., Dettmer, K., Unger, P., Boskovic, M., Samol, C.,... Karrer, S. (2021). Cold atmospheric plasma changes the amino acid composition of solutions and influences the anti‐tumor effect on melanoma cells. International Journal of Molecular Sciences, 22(15). https://dx.doi.org/10.3390/ijms22157886
• Arndt, S., Fadil, F., Dettmer, K., Unger, P., Boskovic, M., Samol, C.,... Karrer, S. (2021). Cold Atmospheric Plasma Changes the Amino Acid Composition of Solutions and Influences the Anti-Tumor Effect on Melanoma Cells. International Journal of Molecular Sciences, 22(15). https://dx.doi.org/10.3390/ijms22157886
• Arndt, S., Unger, P., Boßerhoff, A.K., Berneburg, M., & Karrer, S. (2021). The anti-fibrotic effect of cold atmospheric plasma on localized scleroderma in vitro and in vivo. Biomedicines, 9(11). https://dx.doi.org/10.3390/biomedicines9111545
• Arndt, S., Unger, P., Schneider, C., Boßerhoff, A.K., & Karrer, S. (2021). Cold atmospheric plasma (CAP) for the selective control of tumor cells. In EXPERIMENTAL DERMATOLOGY (pp. E99-E100). HOBOKEN: WILEY.
• Boßerhoff, A.K., & Kappelmann-Fenzl, M. (2021). Next Generation Sequencing (NGS): What Can Be Sequenced? In Kappelmann-Fenzl, Melanie (Eds.), Next Generation Sequencing and Data Analysis. (pp. 1-15). Cham, Schweiz: Springer.
• Böhme-Schäfer, I., Schoenherr, R., Eberle, J., & Boßerhoff, A.K. (2021). Membrane Transporters and Channels in Melanoma. Reviews of Physiology Biochemistry and Pharmacology, 181, 269-374. https://dx.doi.org/10.1007/112_2020_17
• Fritz, V., Malek, L., Gaza, A., Wormser, L., Appel, M., Kremer, A.,... Siebler, J. (2021). Combined de‐repression of chemoresistance associated mitogen‐activated protein kinase 14 and activating transcription factor 2 by loss of microrna‐622 in hepatocellular carcinoma. Cancers, 13(5), 1-14. https://dx.doi.org/10.3390/cancers13051183
• Fuentes-Chandía, M., Vierling, A., Kappelmann-Fenzl, M., Monavari, M., Letort, G., Höne, L.,... Leal-Egaña, A. (2021). 3D Spheroids Versus 3D Tumor-Like Microcapsules: Confinement and Mechanical Stress May Lead to the Expression of Malignant Responses in Cancer Cells. Advanced Biology, 5(7), e2000349. https://dx.doi.org/10.1002/adbi.202000349
• Gaza, A., Fritz, V., Malek, L., Wormser, L., Treiber, N., Danner, J.,... Dietrich, P. (2021). Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11. Neoplasia, 23(5), 502-514. https://dx.doi.org/10.1016/j.neo.2021.04.001
• Haller, L., Reichelt, J., Boßerhoff, A.K., & Kuphal, S. (2021). The Role of NRN1 in the Development and Progression of malignant Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 70-70). HOBOKEN: WILEY.
• Heppt, M., Wessely, A., Hornig, E., Kammerbauer, C., Graf, S., Besch, R.,... Berking, C. (2021). Brn3a expression is epigenetically controlled by HDAC2 in melanocytes and melanoma. In EXPERIMENTAL DERMATOLOGY (pp. E96-E96). HOBOKEN: WILEY.
• Herr, F., Schmidt, S., Böhme, I., & Boßerhoff, A.K. (2021). Analysis of Glucose Concentration in Melanoma cells under physiological and nutrient-deficient Conditions. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 35-35). HOBOKEN: WILEY.
• Kappelmann-Fenzl, M., Schmidt, S., Fischer, S., Schmid, R., Lämmerhirt, L., Fischer, L.,... Boßerhoff, A.K. (2021). Molecular changes induced in melanoma by cell culturing in 3D alginate hydrogels. Cancers, 13(16), 72-72. https://dx.doi.org/10.3390/cancers13164111
• Kupke, L.S., Arndt, S., Lenzer, S., Metz, S., Unger, P., Zimmermann, J.L.,... Karrer, S. (2021). Cold atmospheric plasma promotes the immunoreactivity of granulocytes in vitro. Biomolecules, 11(6). https://dx.doi.org/10.3390/biom11060902
• Kyjacova, L., Saup, R., Rothley, M., Schmaus, A., Wagner, T., Boßerhoff, A.K.,... Sleeman, J.P. (2021). Quantitative detection of disseminated melanoma cells by trp-1 transcript analysis reveals stochastic distribution of pulmonary metastases. Journal of Clinical Medicine, 10(22). https://dx.doi.org/10.3390/jcm10225459
• Linck-Paulus, L., Lämmerhirt, L., Voeller, D., Meyer, K., Engelmann, J.C., Spang, R.,... Boßerhoff, A.K. (2021). Learning from Embryogenesis-A Comparative Expression Analysis in Melanoblast Differentiation and Tumorigenesis Reveals miRNAs Driving Melanoma Development. Journal of Clinical Medicine, 10(11). https://dx.doi.org/10.3390/jcm10112259
• Pommer, M., Kuphal, S., & Boßerhoff, A.K. (2021). Amphiregulin Regulates Melanocytic Senescence. Cells, 10(2). https://dx.doi.org/10.3390/cells10020326
• Rachinger, N., Boßerhoff, A.K., & Kuphal, S. (2021). Sox21-transcriptional Regulation in malignant Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 36-36). HOBOKEN: WILEY.
• Rachinger, N., Fischer, S., Böhme, I., Linck-Paulus, L., Kuphal, S., Kappelmann-Fenzl, M., & Boßerhoff, A.K. (2021). Loss of gene information: Discrepancies between rna sequencing, cdna microarray, and qrt-pcr. International Journal of Molecular Sciences, 22(17). https://dx.doi.org/10.3390/ijms22179349
• Sasahira, T., Kurihara-Shimomura, M., Shimomura, H., Boßerhoff, A.K., & Kirita, T. (2021). Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO. Journal of Cancer Research and Clinical Oncology. https://dx.doi.org/10.1007/s00432-021-03568-9
• Schmid, R., Schmidt, S., Detsch, R., Horder, H., Blunk, T., Schrüfer, S.,... Kengelbach-Weigand, A. (2021). A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models. Advanced Functional Materials. https://dx.doi.org/10.1002/adfm.202107993
• Schmid, R., Schmidt, S., Detsch, R., Horder, H., Blunk, T., Schrüfer, S.,... Kengelbach-Weigand, A. (2021). A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models. Advanced Functional Materials. https://dx.doi.org/10.1002/adfm.202107993
• Seitz, T., Hackl, C., Freese, K., Dietrich, P., Mahli, A., Thasler, R.M.,... Hellerbrand, C. (2021). Xanthohumol, a prenylated chalcone derived from hops, inhibits growth and metastasis of melanoma cells. Cancers, 13(3), 1-12. https://dx.doi.org/10.3390/cancers13030511
• Stabler, S., Rottensteiner-Brandl, U., & Boßerhoff, A.K. (2021). The Role of the Transcription Factor AP2e in the Development of malignant Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 12-12). HOBOKEN: WILEY.
• Weisenstein, C., Wigger, A.K., Richter, M., Sczech, R., Boßerhoff, A.K., & Bolivar, P.H. (2021). THz Detection of Biomolecules in Aqueous Environments-Status and Perspectives for Analysis Under Physiological Conditions and Clinical use. Journal of Infrared, Millimeter, and Terahertz Waves. https://dx.doi.org/10.1007/s10762-021-00792-9
• Zimmermann, T., Gebhardt, L., Kreiß, L., Schneider, C., Arndt, S., Karrer, S.,... Boßerhoff, A.K. (2021). Acidified nitrite contributes to the antitumor effect of cold atmospheric plasma on melanoma cells. International Journal of Molecular Sciences, 22(7). https://dx.doi.org/10.3390/ijms22073757

2020

• Arnold, J., Engelmann, J.C., Schneider, N., Boßerhoff, A.K., & Kuphal, S. (2020). miR-488-5p and its role in melanoma. Experimental and Molecular Pathology, 112. https://dx.doi.org/10.1016/j.yexmp.2019.104348
• Dietrich, P., Wormser, L., Fritz, V., Seitz, T., de Maria, M., Schambony, A.,... Hellerbrand, C. (2020). Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer. Journal of Clinical Investigation, 130(5), 2509-2526. https://dx.doi.org/10.1172/JCI131919
• Günther, C., Dietrich, P., Wormser, L., Fritz, V., Seitz, T., de Maria, M.,... Hellerbrand, C. (2020). Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer. Journal of Clinical Investigation, 130(5), 2509-2526. https://dx.doi.org/10.1172/JCI131919
• Koch, A., Ebert, E.V., Seitz, T., Dietrich, P., Berneburg, M., Boßerhoff, A.K., & Hellerbrand, C. (2020). Characterization of glycolysis-related gene expression in malignant melanoma. Pathology Research and Practice, 216(1). https://dx.doi.org/10.1016/j.prp.2019.152752
• Kurihara–Shimomura, M., Sasahira, T., Shimomura, H., Boßerhoff, A.K., & Kirita, T. (2020). Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. International Journal of Oncology, 56(5), 1093-1100. https://dx.doi.org/10.3892/ijo.2020.4996
• Liebig, J., Kuphal, S., & Boßerhoff, A.K. (2020). Hurdling senescence: hur breaks braf-induced senescence in melanocytes and supports melanoma growth. Cancers, 12(5). https://dx.doi.org/10.3390/cancers12051299
• Linck-Paulus, L., Hellerbrand, C., Boßerhoff, A.K., & Dietrich, P. (2020). Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma. Cells, 9(1). https://dx.doi.org/10.3390/cells9010114
• Penas, C., Apraiz, A., Muñoa, I., Arroyo-Berdugo, Y., Rasero, J., Ezkurra, P.A.,... Boyano, M.D. (2020). RKIP regulates differentiation-related features in melanocytic cells. Cancers, 12(6), 1-22. https://dx.doi.org/10.3390/cancers12061451
• Petzer, V., Tymoszuk, P., Asshoff, M., Carvalho, J., Papworth, J., Deantonio, C.,... Theurl, I. (2020). A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease. Blood, 136(9), 1080-1090. https://dx.doi.org/10.1182/blood.2019004653
• Schmid, R., Schmidt, S., Hazur, J., Detsch, R., Maurer, E., Boccaccini, A.R.,... Kengelbach-Weigand, A. (2020). Comparison of hydrogels for the development of well-defined 3d cancer models of breast cancer and melanoma. Cancers, 12(8), 1-21. https://dx.doi.org/10.3390/cancers12082320
• Schmidt, S., Schmid, R., Arkudas, A., Kengelbach-Weigand, A., & Boßerhoff, A.K. (2020). 3D Bioprinting of Melanoma Cells with commercially available Bio Inks. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 28-29). HOBOKEN: WILEY.
• Seitz, T., Freese, K., Dietrich, P., Thasler, W.E., Boßerhoff, A.K., & Hellerbrand, C. (2020). Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma. Scientific Reports, 10(1). https://dx.doi.org/10.1038/s41598-020-61510-4
• Sommer, J., Dorn, C., Gaebele, E., Bataille, F., Freese, K., Seitz, T.,... Hellerbrand, C. (2020). Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury. Cells, 9(1). https://dx.doi.org/10.3390/cells9010248
• Weisenstein, C., Schaar, D., Wigger, A.K., Schäfer-Eberwein, H., Boßerhoff, A.K., & Bolívar, P.H. (2020). Ultrasensitive THz biosensor for PCR-free cDNA detection based on frequency selective surfaces. Biomedical Optics Express, 11(1), 448-460. https://dx.doi.org/10.1364/BOE.380818
• Zimmermann, T., Schneider, C., Gebhardt, L., Arndt, S., Karrer, S., Zimmermann, J.L.,... Boßerhoff, A.K. (2020). The molecular Effects of cold atmospheric Plasma on malignant Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 18-18). HOBOKEN: WILEY.