Prof. Dr. Anja Boßerhoff
Chair of Biochemistry and Molecular Medicine
Molecular understanding of the basic processes of tumour development and progression, furthermore the translation of the results into clinical practice.
Research projects
- Cancer
- Cell Biology
- Biomedical Science
- Methods: Immunohistochemie, Protein Analyse, PCR, Cell Culture, Cloning
- Growth factor and matrix-induced modulation of the tumor cells and the tumor micro-milieu
- Effects of Cold atmospheric plasma on cancer cells
- Impact of cellular dormancy or senescence on tumor cells and clinical outcome
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SFB 1540 - EBM: Exploring Brain Mechanics (EBM): Understanding, engineering and exploiting mechanical properties and signals in central nervous system development, physiology and pathology
(Third Party Funds Group – Overall project)
Project leader:
Term: 1. January 2023 - 31. December 2026
Acronym: SFB 1540 - EBM
Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)
URL: https://www.crc1540-ebm.research.fau.eu/Thecentral nervous system (CNS) is our most complex organ system. Despite tremendousprogress in our understanding of the biochemical, electrical, and geneticregulation of CNS functioning and malfunctioning, many fundamental processesand diseases are still not fully understood. For example, axon growth patterns inthe developing brain can currently not be well-predicted based solely on thechemical landscape that neurons encounter, several CNS-related diseases cannotbe precisely diagnosed in living patients, and neuronal regeneration can stillnot be promoted after spinal cord injuries.
Duringmany developmental and pathological processes, neurons and glial cells aremotile. Fundamentally, motion is drivenby forces. Hence, CNS cells mechanicallyinteract with their surrounding tissue. They adhere to neighbouring cells and extracellular matrix using celladhesion molecules, which provide friction, and generate forces usingcytoskeletal proteins. These forces aretransmitted to the outside world not only to locomote but also to probe themechanical properties of the environment, which has a long overseen huge impacton cell function.
Onlyrecently, groups of several project leaders in this consortium, and a few other groupsworldwide, have discovered an important contribution of mechanical signalsto regulating CNS cell function. For example, they showed that brain tissuemechanics instructs axon growth and pathfinding in vivo, that mechanicalforces play an important role for cortical folding in the developing humanbrain, that the lack of remyelination in the aged brain is due to an increasein brain stiffness in vivo, and that many neurodegenerative diseases areaccompanied by changes in brain and spinal cord mechanics. These first insights strongly suggest thatmechanics contributes to many other aspects of CNS functioning, and it islikely that chemical and mechanical signals intensely interact at the cellularand tissue levels to regulate many diverse cellular processes.
The CRC 1540 EBM synergises the expertise of engineers, physicists,biologists, medical researchers, and clinicians in Erlangen to explore mechanicsas an important yet missing puzzle stone in our understanding of CNSdevelopment, homeostasis, and pathology. Our strongly multidisciplinary teamwith unique expertise in CNS mechanics integrates advanced invivo, in vitro, and in silico techniques across time(development, ageing, injury/disease) and length (cell, tissue, organ) scalesto uncover how mechanical forces and mechanical cell and tissue properties,such as stiffness and viscosity, affect CNS function. We especially focus on(A) cerebral, (B) spinal, and (C) cellular mechanics. Invivo and in vitro studies provide a basic understanding ofmechanics-regulated biological and biomedical processes in different regions ofthe CNS. In addition, they help identify key mechano-chemical factors forinclusion in in silico models and provide data for model calibration andvalidation. In silico models, in turn, allow us to test hypotheses without the need of excessive or even inaccessibleexperiments. In addition, they enable the transfer and comparison of mechanics data and findingsacross species and scales. They also empower us to optimise processparameters for the development of in vitro brain tissue-like matricesand in vivo manipulation of mechanical signals, and, eventually, pavethe way for personalised clinical predictions.
Insummary, we exploit mechanics-based approaches to advance ourunderstanding of CNS function and to provide the foundation for futureimprovement of diagnosis and treatment of neurological disorders.
2026
- Dieckmann, S.M., Tripp, C.H., Strandt, H., Hornsteiner, F., Schäfer, A.K., Prokopi, A.,... Stoitzner, P. (2026). Metabolic inhibition of glutamate-cysteine ligase increases dendritic cell-mediated antitumor immunity in melanoma. Journal for ImmunoTherapy of Cancer, 14(6). https://doi.org/10.1136/jitc-2026-014808
- Eckert, C., Schmidt, S., Sandor, E., Karimi, T., Arkudas, A., Kengelbach-Weigand, A., & Boßerhoff, A.K. (2026). An alginate-based 3D cell culture model as a useful tool for melanoma drug testing. Biomedicine & Pharmacotherapy, 198. https://doi.org/10.1016/j.biopha.2026.119275
- El Ahmad, Z., Ludwig, K., Matthies, A.O., Boßerhoff, A.K., & Kappelmann-Fenzl, M. (2026). Transcriptional Reprogramming by AP-1-Bound Cis-Regulatory Elements Is Associated with Melanoma Development. International Journal of Molecular Sciences, 27(14). https://doi.org/10.3390/ijms27146459
- Heidenreich, S., Faber, J., Lorke, M., Herrera-Ríos, D., Schmidt, S., Schambony, A.,... Boßerhoff, A.K. (2026). Deciphering melanoma brain metastases: Role of cellular plasticity and metastatic origin. Biomaterials Advances, 188. https://doi.org/10.1016/j.bioadv.2026.214983
- Larue, L., Barral, D.C., Delmas, V., Egea-Rodriguez, S., Aldea, D., Etchevers, H.C.,... Boßerhoff, A.K. (2026). A Short Report on Melanocyte/Melanoma Culture, Senescence, and Reproducibility. Pigment Cell & Melanoma Research, 39(2). https://doi.org/10.1111/pcmr.70084
- Lörentz, S., Böhme-Schäfer, I., König, J., Sticht, H., & Boßerhoff, A.K. (2026). SNAT1 (SLC38A1) Is Not the Main Glutamine Transporter in Melanoma, but Controls Metabolism via Glutamine-Dependent Activation of P62 (SQSTM1)/cMYC-Axis. Cancers, 18(7). https://doi.org/10.3390/cancers18071068
2025
- Chiheb, C., Fischer, S., El Ahmad, Z., Henz, I., Böhme-Schäfer, I., Kappelmann-Fenzl, M., & Boßerhoff, A.K. (2025). Acidic melanoma microenvironment selects for a senescence-like but also migratory-active subpopulation driving metastatic disease. Cell Death Discovery, 11(1). https://doi.org/10.1038/s41420-025-02806-0
- Eckert, C., Schmidt, S., Faber, J., Detsch, R., Vielreicher, M., Lamberger, Z.,... Boßerhoff, A.K. (2025). An alginate-cellulose based bioink mimics the viscoelastic features of the melanoma microenvironment and its influence on cell cycle and invasion. Bioprinting, 46. https://doi.org/10.1016/j.bprint.2024.e00384
- Gantert, B., Karakaya, E., Hofmann, F., Jungst, T., Meinel, L., Boßerhoff, A.K.,... Lühmann, T. (2025). Alginate-Dialdehyde-Based Reporter Ink Enabling Online Detection of Matrix Metalloproteinase Activity of Encapsulated Cells. ACS Biomaterials Science and Engineering. https://doi.org/10.1021/acsbiomaterials.4c02399
- Sandor, E., Karimi, T., Schmid, R., Kulicke, Y., Heltmann-Meyer, S., Eckert, C.,... Arkudas, A. (2025). Biofabrication of 3D-printed, pre-cross-linked alginate dialdehyde–gelatin (ADA–GEL) scaffolds for an in vivo metastatic arteriovenous loop tumor model. Frontiers in Bioengineering and Biotechnology, 13. https://doi.org/10.3389/fbioe.2025.1657653
- Schmidt, S., Fischer, S., El Ahmad, Z., Schmid, R., Metzger, E., Schüle, R.,... Boßerhoff, A.K. (2025). Modeling a mesenchymal cell state by bioprinting for the molecular analysis of dormancy in melanoma. Materials Today Bio, 32. https://doi.org/10.1016/j.mtbio.2025.101674
- Stäbler, S., Pieger, K., Perl, J., Stieglitz, D., Thongmao, A., Schneider, N.,... Kuphal, S. (2025). In long-lasting cellular stress phases of melanoma cells, stress granules are dissolved by HSP70. Cellular and Molecular Life Sciences, 82(1). https://doi.org/10.1007/s00018-025-05939-8
- Tröster, B., Kappelmann-Fenzl, M., Boßerhoff, A.K., & Rachinger, N. (2025). Emerging role of ARHGAP29 in melanoma cell phenotype switching. Molecular Oncology. https://doi.org/10.1002/1878-0261.70114
- Wormser, L., Fritz, V., Kappelmann-Fenzl, M., Rachinger, N., Escudé, P., Enderle, K.,... Dietrich, P. (2025). The liver talks back: NPY orchestrates attraction of cancer cells and CHK2-dependent clonogenicity in the metastatic niche. Proceedings of the National Academy of Sciences of the United States of America, 122(47), e2518418122. https://doi.org/10.1073/pnas.2518418122
2024
- Antonelli, Y., Krüger, R., Bühler, A., Monavari, M., Fuentes Chandia, M.A., Colombo, F.,... Leal-Egaña, A. (2024). When Mechanical Stress Matters: Generation of Polyploid Giant Cancer Cells in Tumor-Like Microcapsules. Advanced Functional Materials. https://doi.org/10.1002/adfm.202311139
- Devitt, L., Westphal, D., Pieger, K., Schneider, N., Boßerhoff, A.K., & Kuphal, S. (2024). NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma. Cell Communication and Signaling, 22(1). https://doi.org/10.1186/s12964-024-01632-8
- Harris, D., Groß, M., Stäbler, S., Ebert, R., Seibel, J., & Boßerhoff, A.K. (2024). Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-d-glucosamine Analogues. Cells, 13(22). https://doi.org/10.3390/cells13221831
- Karrer, S., Unger, P., Gruber, M., Gebhardt, L., Schober, R., Berneburg, M.,... Arndt, S. (2024). In Vitro Safety Study on the Use of Cold Atmospheric Plasma in the Upper Respiratory Tract. Cells, 13(17). https://doi.org/10.3390/cells13171411
- Karrer, S., Unger, P., Spindler, N., Szeimies, R.M., Boßerhoff, A.K., Berneburg, M., & Arndt, S. (2024). Optimization of the Treatment of Squamous Cell Carcinoma Cells by Combining Photodynamic Therapy with Cold Atmospheric Plasma. International Journal of Molecular Sciences, 25(19). https://doi.org/10.3390/ijms251910808
- Kluge, V., Kappelmann-Fenzl, M., Fischer, S., Zimmermann, T., Pommer, M., Kuphal, S., & Boßerhoff, A.K. (2024). Alternative Wnt-signaling axis leads to a break of oncogene-induced senescence. Cell Death & Disease, 15(2). https://doi.org/10.1038/s41419-024-06550-8
- Lämmerhirt, L., Kappelmann-Fenzl, M., Fischer, S., Meier, P., Stäbler, S., Kuphal, S., & Boßerhoff, A.K. (2024). Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention. Cellular & Molecular Biology Letters, 29(1). https://doi.org/10.1186/s11658-024-00552-2
- Meißgeier, T., Kappelmann-Fenzl, M., Stäbler, S., Ahari, A.J., Mertes, C., Gagneur, J.,... Boßerhoff, A.K. (2024). Splicing control by PHF5A is crucial for melanoma cell survival. Cell Proliferation. https://doi.org/10.1111/cpr.13741
- Richter, M., Loth, Y., Rachinger, N., Wigger, A.K., Boßerhoff, A.K., & Bolívar, P.H. (2024). THz Metamaterial Biodetection Platform for Label-Free, Sensitive and Selective DNA-, Protein- or Supermolecular-Based Biomarker Analysis. In Mona Jarrahi, Sascha Preu, Dmitry Turchinovich (Eds.), Proceedings of SPIE - The International Society for Optical Engineering. Strasbourg, FRA: SPIE.
- Schipka, R., Heltmann-Meyer, S., Schneidereit, D., Friedrich, O., Röder, J., Boccaccini, A.R.,... Schmid, R. (2024). Characterization of two different alginate-based bioinks and the influence of melanoma growth within. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-63642-3
- Schmid, R., Schmidt, S., Schrüfer, S., Schubert, D.W., Heltmann-Meyer, S., Schicht, M.,... Arkudas, A. (2024). A vascularized in vivo melanoma model suitable for metastasis research of different tumor stages using fundamentally different bioinks. Materials Today Bio, 26, 101071. https://doi.org/10.1016/j.mtbio.2024.101071
- Stäbler, S., Hoechst, S., Thongmao, A., Schneider, N., Boßerhoff, A.K., & Kuphal, S. (2024). The Role of T-Cadherin (CDH13) in Treatment Options with Garcinol in Melanoma. Cancers, 16(10). https://doi.org/10.3390/cancers16101853
- Stäbler, S., Rottensteiner-Brandl, U., El Ahmad, Z., Kappelmann-Fenzl, M., Arkudas, A., Kengelbach-Weigand, A.,... Schmidt, S. (2024). Transcription factor activating enhancer-binding protein 2ε (AP2ε) modulates phenotypic plasticity and progression of malignant melanoma. Cell Death & Disease, 15(5). https://doi.org/10.1038/s41419-024-06733-3
2023
- Heppt, M., Wessely, A., Hornig, E., Kammerbauer, C., Graf, S., Besch, R.,... Berking, C. (2023). HDAC2 is involved in the regulation of Brn3a in melanocytes and melanoma. In EXPERIMENTAL DERMATOLOGY (pp. E20-E20). HOBOKEN: WILEY.
- Kersten, V., Seitz, T., Sommer, J., Thasler, W.E., Boßerhoff, A.K., & Hellerbrand, C. (2023). Bone Morphogenetic Protein 13 Has Protumorigenic Effects on Hepatocellular Carcinoma Cells In Vitro. International Journal of Molecular Sciences, 24(13). https://doi.org/10.3390/ijms241311059
- Penas, C., Arroyo-Berdugo, Y., Apraiz, A., Rasero, J., Muñoa-Hoyos, I., Andollo, N.,... Boyano, M.D. (2023). Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-36684-2
- Richter, M., Loth, Y., Wigger, A.K., Nordhoff, D., Rachinger, N., Weisenstein, C.,... Bolívar, P.H. (2023). High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-46876-5
- Richter, M., Loth, Y., Wigger, A.K., Rachinger, N., Nordhoff, D., Stock, D.,... Bolivar, P.H. (2023). Selective Biodetection Platform for Melanoma Diagnosis Using Functionalized THz Metamaterials. In International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz. Montreal, QC, CAN: IEEE Computer Society.
- Sommer, J., Ehnis, H., Seitz, T., Schneider, J., Wild, A., Moceri, S.,... Hellerbrand, C. (2023). Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity. International Journal of Molecular Sciences, 24(19). https://doi.org/10.3390/ijms241914943
- Sommer, J., Thasler, W.E., Boßerhoff, A.K., & Hellerbrand, C. (2023). Expression of Bone Morphogenetic Protein 14 in Liver Disease and Cancer. Livers, 3(2), 282-292. https://doi.org/10.3390/livers3020019
- Stäbler, S., Lichtblau, A., Gurbiel, S., Schubert, T., Riechers, A., Rottensteiner-Brandl, U., & Boßerhoff, A.K. (2023). MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy. Cells, 12(2). https://doi.org/10.3390/cells12020229
- Stüfchen, I., Beyer, F., Stäbler, S., Fischer, S., Kappelmann, M., Beckervordersandforth, R., & Boßerhoff, A.K. (2023). Sox9 regulates melanocytic fate decision of adult hair follicle stem cells. iScience, 26(6). https://doi.org/10.1016/j.isci.2023.106919
- Zimmermann, T., Stäbler, S., Taudte, R.V., Ünüvar, S., Groesch, S., Arndt, S.,... Boßerhoff, A.K. (2023). Cold Atmospheric Plasma Triggers Apoptosis via the Unfolded Protein Response in Melanoma Cells. Cancers, 15(4). https://doi.org/10.3390/cancers15041064
2022
- Arndt, S., Unger, P., Boßerhoff, A.K., Berneburg, M., & Karrer, S. (2022). The anti-fibrotic effect of cold atmospheric plasma on localized scleroderma in vitro and in vivo. In EXPERIMENTAL DERMATOLOGY (pp. E83-E83). HOBOKEN: WILEY.
- Böhme-Schäfer, I., Lörentz, S., & Boßerhoff, A.K. (2022). Role of Amino Acid Transporter SNAT1/SLC38A1 in Human Melanoma. Cancers, 14(9). https://doi.org/10.3390/cancers14092151
- Chiheb, C., Böhme-Schäfer, I., & Boßerhoff, A.K. (2022). Extracellular acidosis leads to the formation of a senescence-like subpopulation in malignant melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 103-103). HOBOKEN: WILEY.
- Ertekin, Ö., Monavari, M., Krüger, R., Fuentes Chandia, M.A., Parma, B., Letort, G.,... Leal-Egaña, A. (2022). 3D hydrogel-based microcapsules as an in vitro model to study tumorigenicity, cell migration and drug resistance. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2022.02.010
- Heppt, M., Wessely, A., Hornig, E., Kammerbauer, C., Graf, S.A., Besch, R.,... Berking, C. (2022). HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma. International Journal of Molecular Sciences, 23(2). https://doi.org/10.3390/ijms23020849
- Kluge, V., Zimmermann, T., Pommer, M., Kuphal, S., & Boßerhoff, A.K. (2022). Molecular mechanisms of OIS breakdown in the context of melanoma formation. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 37-37). HOBOKEN: WILEY.
- Linck-Paulus, L., Horn, A., Matthies, A.O., Fischer, S., Meister, G., Sticht, H.,... Boßerhoff, A.K. (2022). A novel splice variant of Argonaut 2 affects microRNA target genes and cell viability of melanoma cells. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 36-36). HOBOKEN: WILEY.
- Linck-Paulus, L., Kappelmann-Fenzl, M., Meister, G., & Boßerhoff, A.K. (2022). An AGO2 variant affects the function of miRNAs and influences the viability of melanoma cells. In EXPERIMENTAL DERMATOLOGY (pp. E100-E100). HOBOKEN: WILEY.
- Linck-Paulus, L., Meißgeier, T., Pieger, K., Horn, A., Matthies, A.O., Fischer, S.,... Boßerhoff, A.K. (2022). A previously unknown Argonaute 2 variant positively modulates the viability of melanoma cells. Cellular and Molecular Life Sciences, 79(9). https://doi.org/10.1007/s00018-022-04496-8
- Lämmerhirt, L., Kappelmann-Fenzl, M., Fischer, S., Pommer, M., Zimmermann, T., Kluge, V.,... Boßerhoff, A.K. (2022). Knockdown of Lamin B1 and the Corresponding Lamin B Receptor Leads to Changes in Heterochromatin State and Senescence Induction in Malignant Melanoma. Cells, 11(14). https://doi.org/10.3390/cells11142154
- Lämmerhirt, L., Pommer, M., Zimmermann, T., Kluge, V., Kuphal, S., & Boßerhoff, A.K. (2022). The Nuclear Envelope Proteins LMNB1 and LBR influence the Chromatin Structure and Senescence Processes in Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 35-35). HOBOKEN: WILEY.
- Lörentz, S., Böhme-Schäfer, I., & Boßerhoff, A.K. (2022). Importance of the Amino Acid Transporter SNAT1/SLC38A1 in malignant Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 80-80). HOBOKEN: WILEY.
- Meissgeier, T., Linck-Paulus, L., & Boßerhoff, A.K. (2022). The splicing factor PHF5A influences the growth and variability of melanoma cells. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 102-102). HOBOKEN: WILEY.
- Peschl, V., Seitz, T., Sommer, J., Thasler, W., Boßerhoff, A.K., & Hellerbrand, C. (2022). Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.30248
- Rachinger, N., Mittag, N., Böhme-Schäfer, I., Xiang, W., Kuphal, S., & Boßerhoff, A.K. (2022). Alpha-Synuclein and Its Role in Melanocytes. Cells, 11(13). https://doi.org/10.3390/cells11132087
- Richter, M., Loth, Y., Weisenstein, C., Wigger, A.K., Schaar, D., Boßerhoff, A.K., & Bolivar, P.H. (2022). Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics. Frequenz, 76(11-12), 627-637. https://doi.org/10.1515/freq-2022-0092
- Richter, M., Weisenstein, C., Wigger, A.K., Boßerhoff, A.K., & Bolivar, P.H. (2022). Design Aspects for Sensitive Metasurface-Based THz Biosensing in Aqueous Solutions. In 2022 47TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER AND TERAHERTZ WAVES (IRMMW-THZ 2022). Delft, NL: NEW YORK: IEEE.
- Schmid, R., Schmidt, S., Detsch, R., Horder, H., Blunk, T., Schrüfer, S.,... Kengelbach-Weigand, A. (2022). A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models. Advanced Functional Materials, Volume 32(Issue 2). https://doi.org/10.1002/adfm.202107993
- Schmidt, S., Fischer, S., Schmid, R., Arkudas, A., Kengel-Bach-Weigand, A., Kappelmann-Fenzl, M., & Boßerhoff, A.K. (2022). Molecular analysis of tumor dormancy of the malignant 3D printed model of melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 101-102). HOBOKEN: WILEY.
- Schott, M., Kappelmann-Fenz, M., Fischer, S., Fernandez-Barrena, M.G., Pineda-Lucena, A., Ávila, M.A.,... Boßerhoff, A.K. (2022). Impact of CYLD on chromatin structure and histone methylation in malignant melanoma. International Journal of Molecular Medicine, 49(5). https://doi.org/10.3892/ijmm.2022.5122
- Seefried, F., Haller, L., Fukuda, S., Thongmao, A., Schneider, N., Utikal, J.,... Kuphal, S. (2022). Nuclear AREG affects a low-proliferative phenotype and contributes to drug resistance of melanoma. International Journal of Cancer. https://doi.org/10.1002/ijc.34254
- Seitz, T., John, N., Sommer, J., Dietrich, P., Thasler, W.E., Hartmann, A.,... Hellerbrand, C. (2022). Role of Fibroblast Growth Factors in the Crosstalk of Hepatic Stellate Cells and Uveal Melanoma Cells in the Liver Metastatic Niche. International Journal of Molecular Sciences, 23(19). https://doi.org/10.3390/ijms231911524
- Stüfchen, I., Beckervordersandforth, R., Fischer, S., Kappelmann-Fenzl, M., Boßerhoff, A.K., & Beyer, F. (2022). Two novel CreERT2 transgenic mouse lines to study melanocytic cells in vivo. Pigment Cell & Melanoma Research. https://doi.org/10.1111/pcmr.13061
- Söderberg, A., Meißgeier, T., Boßerhoff, A.K., & Linck-Paulus, L. (2022). MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A. Cells, 11(23). https://doi.org/10.3390/cells11233859
- Weisenstein, C., Richter, M., Wigger, A.K., Boßerhoff, A.K., & Bolivar, P.H. (2022). Multifrequency Investigation of Single-and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors. Biosensors, 12(7). https://doi.org/10.3390/bios12070483
- Weisenstein, C., Richter, M., Wigger, A.K., Boßerhoff, A.K., & Haring Bolivar, P. (2022). Substrate-integrated microfluidics for sensitive biosensing with complementary THz metamaterials in water. Applied Physics Letters, 120(5). https://doi.org/10.1063/5.0076379
- Zimmermann, T., Pommer, M., Kluge, V., Chiheb, C., Mühlich, S., & Boßerhoff, A.K. (2022). Detection and quantification of cellular senescence in human melanocytes and melanoma cell lines. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 104-105). HOBOKEN: WILEY.
- Zimmermann, T., Pommer, M., Kluge, V., Chiheb, C., Mühlich, S., & Boßerhoff, A.K. (2022). Detection of Cellular Senescence in Human Primary Melanocytes and Malignant Melanoma Cells In Vitro. Cells, 11(9). https://doi.org/10.3390/cells11091489
2021
- Arndt, S., Fadil, F., Dettmer, K., Unger, P., Boskovic, M., Samol, C.,... Karrer, S. (2021). Cold atmospheric plasma changes the amino acid composition of solutions and influences the anti‐tumor effect on melanoma cells. International Journal of Molecular Sciences, 22(15). https://doi.org/10.3390/ijms22157886
- Arndt, S., Fadil, F., Dettmer, K., Unger, P., Boskovic, M., Samol, C.,... Karrer, S. (2021). Cold Atmospheric Plasma Changes the Amino Acid Composition of Solutions and Influences the Anti-Tumor Effect on Melanoma Cells. International Journal of Molecular Sciences, 22(15). https://doi.org/10.3390/ijms22157886
- Arndt, S., Unger, P., Boßerhoff, A.K., Berneburg, M., & Karrer, S. (2021). The anti-fibrotic effect of cold atmospheric plasma on localized scleroderma in vitro and in vivo. Biomedicines, 9(11). https://doi.org/10.3390/biomedicines9111545
- Arndt, S., Unger, P., Schneider, C., Boßerhoff, A.K., & Karrer, S. (2021). Cold atmospheric plasma (CAP) for the selective control of tumor cells. In EXPERIMENTAL DERMATOLOGY (pp. E99-E100). HOBOKEN: WILEY.
- Boßerhoff, A.K., & Kappelmann-Fenzl, M. (2021). Next Generation Sequencing (NGS): What Can Be Sequenced? In Kappelmann-Fenzl, Melanie (Eds.), Next Generation Sequencing and Data Analysis. (pp. 1-15). Cham, Schweiz: Springer.
- Böhme-Schäfer, I., Schoenherr, R., Eberle, J., & Boßerhoff, A.K. (2021). Membrane Transporters and Channels in Melanoma. Reviews of Physiology Biochemistry and Pharmacology, 181, 269-374. https://doi.org/10.1007/112_2020_17
- Fritz, V., Malek, L., Gaza, A., Wormser, L., Appel, M., Kremer, A.,... Siebler, J. (2021). Combined de‐repression of chemoresistance associated mitogen‐activated protein kinase 14 and activating transcription factor 2 by loss of microrna‐622 in hepatocellular carcinoma. Cancers, 13(5), 1-14. https://doi.org/10.3390/cancers13051183
- Fuentes-Chandía, M., Vierling, A., Kappelmann-Fenzl, M., Monavari, M., Letort, G., Höne, L.,... Leal-Egaña, A. (2021). 3D Spheroids Versus 3D Tumor-Like Microcapsules: Confinement and Mechanical Stress May Lead to the Expression of Malignant Responses in Cancer Cells. Advanced Biology, 5(7), e2000349. https://doi.org/10.1002/adbi.202000349
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- Haller, L., Reichelt, J., Boßerhoff, A.K., & Kuphal, S. (2021). The Role of NRN1 in the Development and Progression of malignant Melanoma. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 70-70). HOBOKEN: WILEY.
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- Herr, F., Schmidt, S., Böhme, I., & Boßerhoff, A.K. (2021). Analysis of Glucose Concentration in Melanoma cells under physiological and nutrient-deficient Conditions. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 35-35). HOBOKEN: WILEY.
- Kappelmann-Fenzl, M., Schmidt, S., Fischer, S., Schmid, R., Lämmerhirt, L., Fischer, L.,... Boßerhoff, A.K. (2021). Molecular changes induced in melanoma by cell culturing in 3D alginate hydrogels. Cancers, 13(16), 72-72. https://doi.org/10.3390/cancers13164111
- Kupke, L.S., Arndt, S., Lenzer, S., Metz, S., Unger, P., Zimmermann, J.L.,... Karrer, S. (2021). Cold atmospheric plasma promotes the immunoreactivity of granulocytes in vitro. Biomolecules, 11(6). https://doi.org/10.3390/biom11060902
- Kyjacova, L., Saup, R., Rothley, M., Schmaus, A., Wagner, T., Boßerhoff, A.K.,... Sleeman, J.P. (2021). Quantitative detection of disseminated melanoma cells by trp-1 transcript analysis reveals stochastic distribution of pulmonary metastases. Journal of Clinical Medicine, 10(22). https://doi.org/10.3390/jcm10225459
- Linck-Paulus, L., Lämmerhirt, L., Voeller, D., Meyer, K., Engelmann, J.C., Spang, R.,... Boßerhoff, A.K. (2021). Learning from Embryogenesis-A Comparative Expression Analysis in Melanoblast Differentiation and Tumorigenesis Reveals miRNAs Driving Melanoma Development. Journal of Clinical Medicine, 10(11). https://doi.org/10.3390/jcm10112259
- Pommer, M., Kuphal, S., & Boßerhoff, A.K. (2021). Amphiregulin Regulates Melanocytic Senescence. Cells, 10(2). https://doi.org/10.3390/cells10020326
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- Rachinger, N., Fischer, S., Böhme, I., Linck-Paulus, L., Kuphal, S., Kappelmann-Fenzl, M., & Boßerhoff, A.K. (2021). Loss of gene information: Discrepancies between rna sequencing, cdna microarray, and qrt-pcr. International Journal of Molecular Sciences, 22(17). https://doi.org/10.3390/ijms22179349
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2020
- Arnold, J., Engelmann, J.C., Schneider, N., Boßerhoff, A.K., & Kuphal, S. (2020). miR-488-5p and its role in melanoma. Experimental and Molecular Pathology, 112. https://doi.org/10.1016/j.yexmp.2019.104348
- Dietrich, P., Wormser, L., Fritz, V., Seitz, T., de Maria, M., Schambony, A.,... Hellerbrand, C. (2020). Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer. Journal of Clinical Investigation, 130(5), 2509-2526. https://doi.org/10.1172/JCI131919
- Koch, A., Ebert, E.V., Seitz, T., Dietrich, P., Berneburg, M., Boßerhoff, A.K., & Hellerbrand, C. (2020). Characterization of glycolysis-related gene expression in malignant melanoma. Pathology Research and Practice, 216(1). https://doi.org/10.1016/j.prp.2019.152752
- Kurihara–Shimomura, M., Sasahira, T., Shimomura, H., Boßerhoff, A.K., & Kirita, T. (2020). Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma. International Journal of Oncology, 56(5), 1093-1100. https://doi.org/10.3892/ijo.2020.4996
- Liebig, J., Kuphal, S., & Boßerhoff, A.K. (2020). Hurdling senescence: hur breaks braf-induced senescence in melanocytes and supports melanoma growth. Cancers, 12(5). https://doi.org/10.3390/cancers12051299
- Linck-Paulus, L., Hellerbrand, C., Boßerhoff, A.K., & Dietrich, P. (2020). Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma. Cells, 9(1). https://doi.org/10.3390/cells9010114
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- Schmidt, S., Schmid, R., Arkudas, A., Kengelbach-Weigand, A., & Boßerhoff, A.K. (2020). 3D Bioprinting of Melanoma Cells with commercially available Bio Inks. In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 28-29). HOBOKEN: WILEY.
- Seitz, T., Freese, K., Dietrich, P., Thasler, W.E., Boßerhoff, A.K., & Hellerbrand, C. (2020). Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-61510-4
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