Molecular understanding of the basic processes of tumour development and progression, furthermore the translation of the results into clinical practice.
Research projects
Cancer
Cell Biology
Biomedical Science
Methods: Immunohistochemie, Protein Analyse, PCR, Cell Culture, Cloning
Growth factor and matrix-induced modulation of the tumor cells and the tumor micro-milieu
Effects of Cold atmospheric plasma on cancer cells
Impact of cellular dormancy or senescence on tumor cells and clinical outcome
Current projects Current projects
MGluR7 in the cochlea: molecular composition and protective function at ribbon synapses of inner hair cells
(FAU Funds)
Term: 1. September 2021 - 31. August 2022
Modulation of oncogene-induced senescence by cell-matrix adhesion
(FAU Funds)
Term: 16. March 2020 - 15. September 2022
Oncogene-induced senescence (OIS) was recently introduced as a strong tumor suppressive mechanism seen e.g. in development of nevi out of melanocytes after BRAF mutation. Tumor cells like melanoma obviously can overcome these limiting mechanisms by further changes, however the molecular mechanisms leading to and overcoming OIS are just being started to be understood. We aim to understand the role of cell adhesion processes and mechanotransduction in induction and overcoming OIS.
Ultrasensitive marker-free biomolecular THz-detection for tumor related analytics: PCR-free sensitivity, biomolecular extension and biological relevance
(Third Party Funds Group – Sub project)
Overall project: SPP 1857: Elektromagnetische Sensoren für Life Sciences (ESSENCE)Term: 1. January 2015 - 30. September 2022Funding source: DFG / Schwerpunktprogramm (SPP)
Recent publications Recent publications
2022
Arndt, S., Unger, P., Boßerhoff, A.K., Berneburg, M., & Karrer, S. (2022). The anti-fibrotic effect of cold atmospheric plasma on localized scleroderma in vitro and in vivo . In EXPERIMENTAL DERMATOLOGY (pp. E83-E83). HOBOKEN: WILEY.
Böhme-Schäfer, I., Lörentz, S., & Boßerhoff, A.K. (2022). Role of Amino Acid Transporter SNAT1/SLC38A1 in Human Melanoma . Cancers , 14 (9). https://dx.doi.org/10.3390/cancers14092151
Ertekin, Ö., Monavari, M., Krüger, R., Fuentes Chandia, M.A., Parma, B., Letort, G.,... Leal-Egaña, A. (2022). 3D hydrogel-based microcapsules as an in vitro model to study tumorigenicity, cell migration and drug resistance. Acta Biomaterialia . https://dx.doi.org/10.1016/j.actbio.2022.02.010
Heppt, M., Wessely, A., Hornig, E., Kammerbauer, C., Graf, S.A., Besch, R.,... Berking, C. (2022). HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma . International Journal of Molecular Sciences , 23 (2). https://dx.doi.org/10.3390/ijms23020849
Klotz-Weigand, L., & Enz, R. (2022). Metabotropic Glutamate Receptors at Ribbon Synapses in the Retina and Cochlea . Cells , 11 (7). https://dx.doi.org/10.3390/cells11071097
Linck-Paulus, L., Kappelmann-Fenzl, M., Meister, G., & Boßerhoff, A.K. (2022). An AGO2 variant affects the function of miRNAs and influences the viability of melanoma cells . In EXPERIMENTAL DERMATOLOGY (pp. E100-E100). HOBOKEN: WILEY.
Peschl, V., Seitz, T., Sommer, J., Thasler, W., Boßerhoff, A.K., & Hellerbrand, C. (2022). Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis . Journal of Cellular Biochemistry . https://dx.doi.org/10.1002/jcb.30248
Quinn, J., Jeninga, M., Limm, K., Pareek, K., Meißgeier, T., Bachmann, A.,... Petter, M. (2022). The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite Plasmodium Falciparum Cooperates With PfBDP1 in the Silencing of Variant Surface Antigen Expression . Frontiers in Cell and Developmental Biology , 10 . https://dx.doi.org/10.3389/fcell.2022.816558
Schmid, R., Schmidt, S., Detsch, R., Horder, H., Blunk, T., Schrüfer, S.,... Kengelbach-Weigand, A. (2022). A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models . Advanced Functional Materials , Volume 32 (Issue 2). https://dx.doi.org/10.1002/adfm.202107993
Schott, M., Kappelmann-Fenz, M., Fischer, S., Fernandez-Barrena, M.G., Pineda-Lucena, A., Ávila, M.A.,... Boßerhoff, A.K. (2022). Impact of CYLD on chromatin structure and histone methylation in malignant melanoma . International Journal of Molecular Medicine , 49 (5). https://dx.doi.org/10.3892/ijmm.2022.5122
Sörgel, C., Schmid, R., Stadelmann, N., Weisbach, V.G., Distel, L., Horch, R.E., & Kengelbach-Weigand, A. (2022). IGF-I and Hyaluronic Acid Mitigate the Negative Effect of Irradiation on Human Skin Keratinocytes . Cancers , 14 (3). https://dx.doi.org/10.3390/cancers14030588
Weisenstein, C., Richter, M., Wigger, A.K., Boßerhoff, A.K., & Haring Bolivar, P. (2022). Substrate-integrated microfluidics for sensitive biosensing with complementary THz metamaterials in water . Applied Physics Letters , 120 (5). https://dx.doi.org/10.1063/5.0076379
Zimmermann, T., Pommer, M., Kluge, V., Chiheb, C., Mühlich, S., & Boßerhoff, A.K. (2022). Detection of Cellular Senescence in Human Primary Melanocytes and Malignant Melanoma Cells In Vitro . Cells , 11 (9). https://dx.doi.org/10.3390/cells11091489
2021
Arndt, S., Fadil, F., Dettmer, K., Unger, P., Boskovic, M., Samol, C.,... Karrer, S. (2021). Cold Atmospheric Plasma Changes the Amino Acid Composition of Solutions and Influences the Anti-Tumor Effect on Melanoma Cells . International Journal of Molecular Sciences , 22 (15). https://dx.doi.org/10.3390/ijms22157886
Arndt, S., Fadil, F., Dettmer, K., Unger, P., Boskovic, M., Samol, C.,... Karrer, S. (2021). Cold atmospheric plasma changes the amino acid composition of solutions and influences the anti‐tumor effect on melanoma cells . International Journal of Molecular Sciences , 22 (15). https://dx.doi.org/10.3390/ijms22157886
Arndt, S., Unger, P., Boßerhoff, A.K., Berneburg, M., & Karrer, S. (2021). The anti-fibrotic effect of cold atmospheric plasma on localized scleroderma in vitro and in vivo . Biomedicines , 9 (11). https://dx.doi.org/10.3390/biomedicines9111545
Arndt, S., Unger, P., Schneider, C., Boßerhoff, A.K., & Karrer, S. (2021). Cold atmospheric plasma (CAP) for the selective control of tumor cells . In EXPERIMENTAL DERMATOLOGY (pp. E99-E100). HOBOKEN: WILEY.
Bachert, W., Klotz, L., Sticht, H., & Enz, R. (2021). Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179 . Neurochemistry International , 149 . https://dx.doi.org/10.1016/j.neuint.2021.105150
Beyer, F., Lüdje, W., Karpf, J., Saher, G., & Beckervordersandforth, R. (2021). Distribution of Aldh1L1-CreERT2 Recombination in Astrocytes Versus Neural Stem Cells in the Neurogenic Niches of the Adult Mouse Brain . Frontiers in Neuroscience , 15 . https://dx.doi.org/10.3389/fnins.2021.713077
Boßerhoff, A.K., & Kappelmann-Fenzl, M. (2021). Next Generation Sequencing (NGS): What Can Be Sequenced? In Kappelmann-Fenzl, Melanie (Eds.), Next Generation Sequencing and Data Analysis. (pp. 1-15). Cham, Schweiz: Springer.
Böhme-Schäfer, I., Schoenherr, R., Eberle, J., & Boßerhoff, A.K. (2021). Membrane Transporters and Channels in Melanoma . Reviews of Physiology Biochemistry and Pharmacology , 181 , 269-374. https://dx.doi.org/10.1007/112_2020_17
Faas, M., Ipseiz, N., Ackermann, J., Culemann, S., Grüneboom, A., Schröder, F.,... Krönke, G. (2021). IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation . Immunity , 54 (11), 2531-2546.e5. https://dx.doi.org/10.1016/j.immuni.2021.09.010
Fritz, V., Malek, L., Gaza, A., Wormser, L., Appel, M., Kremer, A.,... Dietrich, P. (2021). Combined de‐repression of chemoresistance associated mitogen‐activated protein kinase 14 and activating transcription factor 2 by loss of microrna‐622 in hepatocellular carcinoma . Cancers , 13 (5), 1-14. https://dx.doi.org/10.3390/cancers13051183
Fuentes Chandia, M.A., Vierling, A., Kappelmann-Fenzl, M., Monavari, M., Letort, G., Höne, L.,... Leal-Egaña, A. (2021). 3D Spheroids Versus 3D Tumor-Like Microcapsules: Confinement and Mechanical Stress May Lead to the Expression of Malignant Responses in Cancer Cells . Advanced Biology , 5 (7), e2000349. https://dx.doi.org/10.1002/adbi.202000349
Fuentes-Chandía, M., Vierling, A., Kappelmann-Fenzl, M., Monavari, M., Letort, G., Höne, L.,... Leal-Egaña, A. (2021). 3D Spheroids Versus 3D Tumor-Like Microcapsules: Confinement and Mechanical Stress May Lead to the Expression of Malignant Responses in Cancer Cells . Advanced Biology , 5 . https://dx.doi.org/10.1002/adbi.202000349
Gaza, A., Fritz, V., Malek, L., Wormser, L., Treiber, N., Danner, J.,... Dietrich, P. (2021). Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11 . Neoplasia , 23 (5), 502-514. https://dx.doi.org/10.1016/j.neo.2021.04.001
Haller, L., Reichelt, J., Boßerhoff, A.K., & Kuphal, S. (2021). The Role of NRN1 in the Development and Progression of malignant Melanoma . In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 70-70). HOBOKEN: WILEY.
Hartlage-Rübsamen, M., Bluhm, A., Moceri, S., Machner, L., Köppen, J., Schenk, M.,... Roßner, S. (2021). A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies . Acta Neuropathologica . https://dx.doi.org/10.1007/s00401-021-02349-5
Heppt, M., Wessely, A., Hornig, E., Kammerbauer, C., Graf, S., Besch, R.,... Berking, C. (2021). Brn3a expression is epigenetically controlled by HDAC2 in melanocytes and melanoma . In EXPERIMENTAL DERMATOLOGY (pp. E96-E96). HOBOKEN: WILEY.
Herr, F., Schmidt, S., Böhme, I., & Boßerhoff, A.K. (2021). Analysis of Glucose Concentration in Melanoma cells under physiological and nutrient-deficient Conditions . In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 35-35). HOBOKEN: WILEY.
Kappelmann-Fenzl, M., Schmidt, S., Fischer, S., Schmid, R., Lämmerhirt, L., Fischer, L.,... Boßerhoff, A.K. (2021). Molecular changes induced in melanoma by cell culturing in 3D alginate hydrogels . Cancers , 13 (16). https://dx.doi.org/10.3390/cancers13164111
Kappelmann-Fenzl, M., Schmidt, S., Fischer, S., Schmid, R., Lämmerhirt, L., Fischer, L.,... Boßerhoff, A.K. (2021). Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels. Cancers , 13 (16). https://dx.doi.org/10.3390/cancers13164111
Kappelmann-Fenzl, M., Schmidt, S., Fischer, S., Schmid, R., Lämmerhirt, L., Fischer, L.,... Boßerhoff, A.K. (2021). Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels . Cancers , 72-72. https://dx.doi.org/10.3390/cancers13164111
Klotz, L., & Enz, R. (2021). MGluR7 is a presynaptic metabotropic glutamate receptor at ribbon synapses of inner hair cells . The FASEB Journal , 35 (11). https://dx.doi.org/10.1096/fj.202100672R
Krumm, L., Pozner, T., Kaindl, J., Regensburger, M., Günther, C., Turan, S.,... Winner, B. (2021). Genetically Single Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in . Stem Cell Research , 56 . https://dx.doi.org/10.1016/j.scr.2021.102520
Kupke, L.S., Arndt, S., Lenzer, S., Metz, S., Unger, P., Zimmermann, J.L.,... Karrer, S. (2021). Cold atmospheric plasma promotes the immunoreactivity of granulocytes in vitro . Biomolecules , 11 (6). https://dx.doi.org/10.3390/biom11060902
Kyjacova, L., Saup, R., Rothley, M., Schmaus, A., Wagner, T., Boßerhoff, A.K.,... Sleeman, J.P. (2021). Quantitative detection of disseminated melanoma cells by trp-1 transcript analysis reveals stochastic distribution of pulmonary metastases . Journal of Clinical Medicine , 10 (22). https://dx.doi.org/10.3390/jcm10225459
Linck-Paulus, L., Lämmerhirt, L., Voeller, D., Meyer, K., Engelmann, J.C., Spang, R.,... Boßerhoff, A.K. (2021). Learning from Embryogenesis-A Comparative Expression Analysis in Melanoblast Differentiation and Tumorigenesis Reveals miRNAs Driving Melanoma Development . Journal of Clinical Medicine , 10 (11). https://dx.doi.org/10.3390/jcm10112259
Mahli, A., Sommer, J., Koch, A., & Hellerbrand, C. (2021). STEATOSIS: A LUBRICANT FOR THE DEVELOPMENT AND PROGRESSION OF ALCOHOLIC LIVER DISEASE . In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (pp. 28A-28A). HOBOKEN: WILEY.
Mougiakakos, D., Bach, C., Böttcher, M., Beier, F., Röhner, L., Stoll, A.,... Bruns, H. (2021). The IKZF1–IRF4/IRF5 axis controls polarization of myeloma-associated macrophages . Cancer Immunology Research , 9 (3), 265-278. https://dx.doi.org/10.1158/2326-6066.CIR-20-0555
Pommer, M., Kuphal, S., & Boßerhoff, A.K. (2021). Amphiregulin Regulates Melanocytic Senescence . Cells , 10 (2). https://dx.doi.org/10.3390/cells10020326
Rachinger, N., Boßerhoff, A.K., & Kuphal, S. (2021). Sox21-transcriptional Regulation in malignant Melanoma . In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 36-36). HOBOKEN: WILEY.
Rachinger, N., Fischer, S., Böhme, I., Linck-Paulus, L., Kuphal, S., Kappelmann-Fenzl, M., & Boßerhoff, A.K. (2021). Loss of gene information: Discrepancies between rna sequencing, cdna microarray, and qrt-pcr . International Journal of Molecular Sciences , 22 (17). https://dx.doi.org/10.3390/ijms22179349
Sasahira, T., Kurihara-Shimomura, M., Shimomura, H., Boßerhoff, A.K., & Kirita, T. (2021). Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO . Journal of Cancer Research and Clinical Oncology . https://dx.doi.org/10.1007/s00432-021-03568-9
Schmid, R., Schmidt, S., Detsch, R., Horder, H., Blunk, T., Schrüfer, S.,... Kengelbach-Weigand, A. (2021). A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models . Advanced Functional Materials . https://dx.doi.org/10.1002/adfm.202107993
Seitz, T., Hackl, C., Freese, K., Dietrich, P., Mahli, A., Thasler, R.M.,... Hellerbrand, C. (2021). Xanthohumol, a prenylated chalcone derived from hops, inhibits growth and metastasis of melanoma cells . Cancers , 13 (3), 1-12. https://dx.doi.org/10.3390/cancers13030511
Stabler, S., Rottensteiner-Brandl, U., & Boßerhoff, A.K. (2021). The Role of the Transcription Factor AP2e in the Development of malignant Melanoma . In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 12-12). HOBOKEN: WILEY.
Weisenstein, C., Wigger, A.K., Richter, M., Sczech, R., Boßerhoff, A.K., & Bolivar, P.H. (2021). THz Detection of Biomolecules in Aqueous Environments-Status and Perspectives for Analysis Under Physiological Conditions and Clinical use . Journal of Infrared, Millimeter, and Terahertz Waves . https://dx.doi.org/10.1007/s10762-021-00792-9
Winner, B., Krumm, L., Pozner, T., Kaindl, J., Regensburger, M., Günther, C.,... Rauch, A. (2021). Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in . Stem Cell Research , 56 , 102520. https://dx.doi.org/10.1016/j.scr.2021.102520
Zimmermann, T., Gebhardt, L., Kreiß, L., Schneider, C., Arndt, S., Karrer, S.,... Boßerhoff, A.K. (2021). Acidified nitrite contributes to the antitumor effect of cold atmospheric plasma on melanoma cells . International Journal of Molecular Sciences , 22 (7). https://dx.doi.org/10.3390/ijms22073757
2020
Agrelo, I.S., Schira-Heinen, J., Beyer, F., Groh, J., Bütermann, C., Estrada, V.,... Küry, P. (2020). Secretome analysis of mesenchymal stem cell factors fostering oligodendroglial differentiation of neural stem cells in vivo . International Journal of Molecular Sciences , 21 (12), 1-25. https://dx.doi.org/10.3390/ijms21124350
Arnold, J., Engelmann, J.C., Schneider, N., Boßerhoff, A.K., & Kuphal, S. (2020). miR-488-5p and its role in melanoma . Experimental and Molecular Pathology , 112 . https://dx.doi.org/10.1016/j.yexmp.2019.104348
Breitinger, U., Weinländer, K., Pechmann, Y., Langlhofer, G., Enz, R., Becker, C.-M.,... Breitinger, H.G. (2020). A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin . Journal of Advanced Research . https://dx.doi.org/10.1016/j.jare.2020.09.009
Börstler, T., Wend, H., Krumbiegel, M., Kavyanifar, A., Reis, A., Lie, D.C.,... Turan, S. (2020). CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome . Stem Cell Research , 47 . https://dx.doi.org/10.1016/j.scr.2020.101889
Börstler, T., Wend, H., Krumbiegel, M., Kavyanifar, A., Wiesmann da Silva Reis, A., Lie, D.C.,... Turan, S. (2020). CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome . Stem Cell Research , 47 . https://dx.doi.org/10.1016/j.scr.2020.101889
Dietrich, P., Wormser, L., Fritz, V., Seitz, T., de Maria, M., Schambony, A.,... Hellerbrand, C. (2020). Molecular cross-talk between Y5-receptor and neuropeptide Y drives liver cancer . Journal of Clinical Investigation , 130 (5), 2509-2526. https://dx.doi.org/10.1172/JCI131919
Grosche, L., Knippertz, I., König, C., Royzman, D., Wild, A., Zinser, E.,... Lechmann, M. (2020). The CD83 Molecule – An Important Immune Checkpoint . Frontiers in Immunology , 11 . https://dx.doi.org/10.3389/fimmu.2020.00721
Hauf, K., Barsch, L., Bauer, D., Buchert, R., Armbruster, A., Frauenfeld, L.,... Eulenburg, V. (2020). GlyT1 encephalopathy: Characterization of presumably disease causing GlyT1 mutations . Neurochemistry International , 139 . https://dx.doi.org/10.1016/j.neuint.2020.104813
Koch, A., Ebert, E.V., Seitz, T., Dietrich, P., Berneburg, M., Boßerhoff, A.K., & Hellerbrand, C. (2020). Characterization of glycolysis-related gene expression in malignant melanoma . Pathology Research and Practice , 216 (1). https://dx.doi.org/10.1016/j.prp.2019.152752
Kurihara–Shimomura, M., Sasahira, T., Shimomura, H., Boßerhoff, A.K., & Kirita, T. (2020). Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma . International Journal of Oncology , 56 (5), 1093-1100. https://dx.doi.org/10.3892/ijo.2020.4996
Liebig, J., Kuphal, S., & Boßerhoff, A.K. (2020). Hurdling senescence: hur breaks braf-induced senescence in melanocytes and supports melanoma growth . Cancers , 12 (5). https://dx.doi.org/10.3390/cancers12051299
Linck-Paulus, L., Hellerbrand, C., Boßerhoff, A.K., & Dietrich, P. (2020). Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma . Cells , 9 (1). https://dx.doi.org/10.3390/cells9010114
Penas, C., Apraiz, A., Muñoa, I., Arroyo-Berdugo, Y., Rasero, J., Ezkurra, P.A.,... Boyano, M.D. (2020). RKIP regulates differentiation-related features in melanocytic cells . Cancers , 12 (6), 1-22. https://dx.doi.org/10.3390/cancers12061451
Petzer, V., Tymoszuk, P., Asshoff, M., Carvalho, J., Papworth, J., Deantonio, C.,... Theurl, I. (2020). A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease . Blood , 136 (9), 1080-1090. https://dx.doi.org/10.1182/blood.2019004653
Rauschenberger, V., Von Wardenburg, N., Schaefer, N., Ogino, K., Hirata, H., Lillesaar, C.,... Villmann, C. (2020). Glycine ReceptorAutoantibodies Impair Receptor Function and Induce Motor Dysfunction . Annals of Neurology . https://dx.doi.org/10.1002/ana.25832
Schierwagen, R., Dietrich, P., Klein, S., Uschner, F.E., Ortiz, C., Tyc, O.,... Trebicka, J. (2020). β-Arrestin2 is increased in liver fibrosis in humans and rodents . Proceedings of the National Academy of Sciences of the United States of America , 117 (44), 27082-27084. https://dx.doi.org/10.1073/pnas.2014337117
Schmid, R., Schmidt, S., Hazur, J., Detsch, R., Maurer, E., Boccaccini, A.R.,... Kengelbach-Weigand, A. (2020). Comparison of hydrogels for the development of well-defined 3d cancer models of breast cancer and melanoma . Cancers , 12 (8), 1-21. https://dx.doi.org/10.3390/cancers12082320
Schmidt, S., Schmid, R., Arkudas, A., Kengelbach-Weigand, A., & Boßerhoff, A.K. (2020). 3D Bioprinting of Melanoma Cells with commercially available Bio Inks . In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 28-29). HOBOKEN: WILEY.
Seitz, T., Freese, K., Dietrich, P., Thasler, W.E., Boßerhoff, A.K., & Hellerbrand, C. (2020). Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma . Scientific Reports , 10 (1). https://dx.doi.org/10.1038/s41598-020-61510-4
Singh, N., Eberhardt, M., Wolkenhauer, O., Vera, J., & Gupta, S.K. (2020). An integrative network-driven pipeline for systematic identification of lncRNA-associated regulatory network motifs in metastatic melanoma . BMC Bioinformatics , 21 (1), 329-. https://dx.doi.org/10.1186/s12859-020-03656-6
Sommer, J., Dorn, C., Gaebele, E., Bataille, F., Freese, K., Seitz, T.,... Hellerbrand, C. (2020). Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury . Cells , 9 (1). https://dx.doi.org/10.3390/cells9010248
Stemick, J., Gauer, C., Wihan, J., Moceri, S., Xiang, W., von Hörsten, S.,... Winkler, J. (2020). Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease . Brain Research , 1748 . https://dx.doi.org/10.1016/j.brainres.2020.147119
Weisenstein, C., Schaar, D., Wigger, A.K., Schäfer-Eberwein, H., Boßerhoff, A.K., & Bolívar, P.H. (2020). Ultrasensitive THz biosensor for PCR-free cDNA detection based on frequency selective surfaces . Biomedical Optics Express , 11 (1), 448-460. https://dx.doi.org/10.1364/BOE.380818
Zimmermann, T., Schneider, C., Gebhardt, L., Arndt, S., Karrer, S., Zimmermann, J.L.,... Boßerhoff, A.K. (2020). The molecular Effects of cold atmospheric Plasma on malignant Melanoma . In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 18-18). HOBOKEN: WILEY.
Related Research Fields
Contact:
Molecular understanding of the basic processes of tumour development and progression, furthermore the translation of the results into clinical practice.
Research projects
Current projects
MGluR7 in the cochlea: molecular composition and protective function at ribbon synapses of inner hair cells
(FAU Funds)
Modulation of oncogene-induced senescence by cell-matrix adhesion
(FAU Funds)
Ultrasensitive marker-free biomolecular THz-detection for tumor related analytics: PCR-free sensitivity, biomolecular extension and biological relevance
(Third Party Funds Group – Sub project)
Term: 1. January 2015 - 30. September 2022
Funding source: DFG / Schwerpunktprogramm (SPP)
Recent publications
2022
2021
2020
Related Research Fields
Contact: