Prof. Dr. Benoit Ladoux
Professor of Biophysics

My research focuses on regulating basic biological processes such as morphogenesis, tumor metastasis and tissue repair. Cell adhesions, coupled to the contractile cytoskeleton, are major sites of force transmission in cells. This mechanical coupling enables cells to sense, signal, and respond to physical changes in the environment. In this context, we are studying the cooperation between adhesion, mechanical and biochemical signaling for the adaptation of living cells to changes in their physical environment at various scales, from single molecules to tissues.
Research projects
- Cell rigidity sensing
- Cell/Extra-cellular matrix interactions
- Collective cell migration
- The mechanical imprints of cell extrusion and apoptosis
No projects found.
2027
- Le Toquin, Y., Dubey, S., Ardaševa, A., Balasubramaniam, L., Delaune, E., Morin, V.,... Ladoux, B. (2027). Mechanical stresses govern myoblast fusion and myotube growth. (Unpublished, In review).
2026
- Anger, L., Schoenit, A., Wodrascka, F., Rossé, C., Mège, R.M., Ladoux, B., & Marcq, P. (2026). Tissue stress measurements with Bayesian inversion stress microscopy. European Physical Journal E, 49(1-2). https://doi.org/10.1140/epje/s10189-025-00542-y
- Destrian, O., Moisan, N., Mège, R.M., Ladoux, B., Goyeau, B., & Chabanon, M. (2026). Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion. Proceedings of the National Academy of Sciences of the United States of America, 123(4). https://doi.org/10.1073/pnas.2519599123
- Schoenit, A., Mège, R.M., & Ladoux, B. (2026). Adhesion-mediated force transmission regulates cell competition in epithelia. Comptes Rendus Biologies, 349, 77-84. https://doi.org/10.5802/crbiol.194
- Schoenit, A., Mège, R.M., & Ladoux, B. (2026). Biophysical principles of cell competition and elimination. Trends in Cell Biology. https://doi.org/10.1016/j.tcb.2026.04.009
- Shen, Y., Xi, W., Mège, R.M., Kob, W., & Ladoux, B. (2026). Dynamic heterogeneity and hidden fluidity in dense epithelial tissues. Science Advances, 12(18), eaec3773-. https://doi.org/10.1126/sciadv.aec3773
2025
- Fardin, M.A., & Ladoux, B. (2025). The shifting reign of force in active nematics. Newton, 1(8). https://doi.org/10.1016/j.newton.2025.100259
- Wu, H., Duclut, C., Arkowitz, G., Chilupuri, R., Dang, T., Prost, J.,... Mège, R.M. (2025). Regulation of epithelial tissue homeostasis by active transepithelial transport. Proceedings of the National Academy of Sciences of the United States of America, 122(46). https://doi.org/10.1073/pnas.2503156122
2024
- Balasubramaniam, L., Jain, S., Dang, T., Lagoutte, E., Marc Mège, R., Chavrier, P.,... Rossé, C. (2024). Different Biomechanical Cell Behaviors in an Epithelium Drive Collective Epithelial Cell Extrusion. Advanced Science. https://doi.org/10.1002/advs.202401573
2023
- Eckert, J., Ladoux, B., Mège, R.M., Giomi, L., & Schmidt, T. (2023). Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-41449-6
- Kawaue, T., Yow, I., Pan, Y., Le, A.P., Lou, Y., Loberas, M.,... Toyama, Y. (2023). Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation. Developmental Cell, 58(4), 267-277.e5. https://doi.org/10.1016/j.devcel.2023.01.005
- Monteiro, P., Remy, D., Lemerle, E., Routet, F., Macé, A.S., Guedj, C.,... Chavrier, P. (2023). A mechanosensitive caveolae–invadosome interplay drives matrix remodelling for cancer cell invasion. Nature Cell Biology, 25(12), 1787-1803. https://doi.org/10.1038/s41556-023-01272-z
- Ron, J.E., d'Alessandro, J., Cellerin, V., Voituriez, R., Ladoux, B., & Gov, N.S. (2023). Polarization and motility of one-dimensional multi-cellular trains. Biophysical Journal, 122(23), 4598-4613. https://doi.org/10.1016/j.bpj.2023.11.003
- Rose, N., Estrada Chavez, B., Sonam, S., Nguyen, T., Grenci, G., Bigot, A.,... Trichet, L. (2023). Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies. Biomaterials, 293. https://doi.org/10.1016/j.biomaterials.2022.121935
- Sonam, S., Balasubramaniam, L., Lin, S.Z., Ivan, Y.M.Y., Pi-Jaumà, I., Jebane, C.,... Ladoux, B. (2023). Mechanical stress driven by rigidity sensing governs epithelial stability. Nature Physics, 19(1), 132-141. https://doi.org/10.1038/s41567-022-01826-2
2022
- Balasubramaniam, L., Mège, R.M., & Ladoux, B. (2022). Active nematics across scales from cytoskeleton organization to tissue morphogenesis. Current Opinion in Genetics & Development, 73. https://doi.org/10.1016/j.gde.2021.101897
- D'alessandro, J., Barbier-Chebbah, A., Voituriez, R., & Ladoux, B. (2022). Cells as « Tom Thumbs » of living tissues Les cellules, « Petits Poucets » des tissus vivants. M S-Medecine Sciences, 38(11), 861-863. https://doi.org/10.1051/medsci/2022138
- Doostmohammadi, A., & Ladoux, B. (2022). Physics of liquid crystals in cell biology. Trends in Cell Biology, 32(2), 140-150. https://doi.org/10.1016/j.tcb.2021.09.012
- Glentis, A., Blanch-Mercader, C., Balasubramaniam, L., Saw, T.B., d'Alessandro, J., Janel, S.,... Ladoux, B. (2022). The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces. Science Advances, 8(37). https://doi.org/10.1126/sciadv.abn5406
- Kabla, A., Ladoux, B., & Di Meglio, J.M. (2022). Tissue mechanics. European Physical Journal E, 45(11). https://doi.org/10.1140/epje/s10189-022-00240-z
- Petracchini, S., Hamaoui, D., Doye, A., Asnacios, A., Fage, F., Vitiello, E.,... Mettouchi, A. (2022). Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33803-x
- Yang, Y.A., Nguyen, E., Narayana, G.H.N.S., Heuzé, M., Fu, C., Yu, H.,... Sheetz, M.P. (2022). Local contractions regulate E-cadherin rigidity sensing. Science Advances, 8(4). https://doi.org/10.1126/sciadv.abk0387
2021
- Balasubramaniam, L., Doostmohammadi, A., Saw, T.B., Narayana, G.H.N.S., Mueller, R., Dang, T.,... Ladoux, B. (2021). Author Correction: Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers (Nature Materials, (2021), 20, 8, (1156-1166), 10.1038/s41563-021-00919-2). Nature Materials, 20(8), 1167-. https://doi.org/10.1038/s41563-021-00974-9
- Balasubramaniam, L., Doostmohammadi, A., Saw, T.B., Narayana, G.H.N.S., Mueller, R., Dang, T.,... Ladoux, B. (2021). Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers. Nature Materials, 20(8), 1156-1166. https://doi.org/10.1038/s41563-021-00919-2
- Balasubramaniam, L., Mège, R.M., & Ladoux, B. (2021). Active forces modulate collective behaviour and cellular organization Des forces actives modulent le comportement collectif et l'organisation cellulaire. Comptes Rendus Biologies, 344(4), 325-335. https://doi.org/10.5802/crbiol.65
- Fardin, M.A., & Ladoux, B. (2021). Living proof of effective defects. Nature Physics, 17(2), 172-173. https://doi.org/10.1038/s41567-020-01084-0
- Gaston, C., De Beco, S., Doss, B., Pan, M., Gauquelin, E., D’Alessandro, J.,... Delacour, D. (2021). EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22482-9
- Jain, S., Ladoux, B., & Mège, R.M. (2021). Mechanical plasticity in collective cell migration. Current Opinion in Cell Biology, 72, 54-62. https://doi.org/10.1016/j.ceb.2021.04.006
- Latorre, E., Kale, S., Casares, L., Gómez-González, M., Uroz, M., Valon, L.,... Trepat, X. (2021). Erratum: Addendum: Active superelasticity in three-dimensional epithelia of controlled shape (Nature (2018) 563 7730 (203-208)). Nature, 592(7856), E30-. https://doi.org/10.1038/s41586-021-03281-0
- Le, A.P., Rupprecht, J.F., Mège, R.M., Toyama, Y., Lim, C.T., & Ladoux, B. (2021). Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion. Nature Communications, 12(1). https://doi.org/10.1038/s41467-020-20563-9
- Sonam, S., Vigouroux, C., Jégou, A., Romet-Lemonne, G., Le Clainche, C., Ladoux, B., & Mège, R.M. (2021). Direct measurement of near-nano-Newton forces developed by self-organizing actomyosin fibers bound α-catenin. Biology of the Cell, 113(11), 441-449. https://doi.org/10.1111/boc.202100014
- d’Alessandro, J., Barbier--Chebbah, A., Cellerin, V., Benichou, O., Mège, R.M., Voituriez, R., & Ladoux, B. (2021). Cell migration guided by long-lived spatial memory. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24249-8
2020
- Balcioglu, H.E., Balasubramaniam, L., Stirbat, T.V., Doss, B.L., Fardin, M.A., Mège, R.M., & Ladoux, B. (2020). A subtle relationship between substrate stiffness and collective migration of cell clusters. Soft Matter, 16(7), 1825-1839. https://doi.org/10.1039/c9sm01893j
- Beauchesne, C.C., Chabanon, M., Smaniotto, B., Ladoux, B., Goyeau, B., & David, B. (2020). Channeling Effect and Tissue Morphology in a Perfusion Bioreactor Imaged by X-Ray Microtomography. Tissue Engineering and Regenerative Medicine, 17(3), 301-311. https://doi.org/10.1007/s13770-020-00246-8
- Doss, B.L., Pan, M., Gupta, M., Grenci, G., Mège, R.M., Lim, C.T.,... Ladoux, B. (2020). Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12817-12825. https://doi.org/10.1073/pnas.1917555117
- Jain, S., Cachoux, V.M., Narayana, G.H., de Beco, S., D’Alessandro, J., Cellerin, V.,... Ladoux, B. (2020). The role of single-cell mechanical behaviour and polarity in driving collective cell migration. Nature Physics, 16(7), 802-809. https://doi.org/10.1038/s41567-020-0875-z
- Teo, J.L., Gomez, G.A., Weeratunga, S., Davies, E.M., Noordstra, I., Budnar, S.,... Yap, A.S. (2020). Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells. Developmental Cell, 54(1), 75-91.e7. https://doi.org/10.1016/j.devcel.2020.05.002
- Thomas, M., Ladoux, B., & Toyama, Y. (2020). Desmosomal Junctions Govern Tissue Integrity and Actomyosin Contractility in Apoptotic Cell Extrusion. Current Biology, 30(4), 682-690.e5. https://doi.org/10.1016/j.cub.2020.01.002
- Tlili, S., Durande, M., Gay, C., Ladoux, B., Graner, F., & Delanoë-Ayari, H. (2020). Migrating Epithelial Monolayer Flows like a Maxwell Viscoelastic Liquid. Physical Review Letters, 125(8). https://doi.org/10.1103/PhysRevLett.125.088102
- Xi, W., Delacour, D., & Ladoux, B. (2020). Designer substrates and devices for mechanobiology study. Journal of Semiconductors, 41(4). https://doi.org/10.1088/1674-4926/41/4/041607