Prof. Dr. Christian Alzheimer
Institute of Physiology and Pathophysiology

Prof. Dr. Christian Alzheimer
Institute of Physiology and Pathophysiology
We study how signaling molecules in the brain, especially activin, affect memory, mood, and stress. Using mouse models, recordings of brain activity, and behavioral studies, we look at the biology behind anxiety, depression, and alcohol-related changes, and at how psychiatric drugs work.
No projects found.
2026
- German, A., Akdas, E.Y., Flügel-Koch, C., Erterek, E., Frischknecht, R., Fejtová, A.,... Zheng, F. (2026). Functional recovery of the adult murine hippocampus after cryopreservation by vitrification. Proceedings of the National Academy of Sciences of the United States of America, 123(10). https://doi.org/10.1073/pnas.2516848123
- Müller, C.P., Chestnykh, D., Lourdusamy, A., Alzheimer, C., Gulbins, E., Kornhuber, J., & Kalinichenko, L. (2026). Sphingolipid mechanisms in schizophrenia and its pharmacotherapy. Current Opinion in Physiology, 49. https://doi.org/10.1016/j.cophys.2026.100972
- Schmuda von Trzebiatowski, P., Alzheimer, C., & Zheng, F. (2026). Tipsy signals: new electrophysiological perspectives on alcohol use and addiction. Current Opinion in Physiology, 49. https://doi.org/10.1016/j.cophys.2026.100970
2025
- Chestnykh, D., Mühle, C., Schumacher, F., Kalinichenko, L., Löber, S., Gmeiner, P.,... Müller, C.P. (2025). Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia. Molecular Psychiatry, 30, 2891-2906. https://doi.org/10.1038/s41380-025-02893-6
- Heininger, H., Feng, X., Altunkaya, A., Zheng, F., Stockinger, F., Wefers, B.,... Huth, T. (2025). BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions. EMBO Reports. https://doi.org/10.1038/s44319-025-00604-4
- Ruxanda, C., Alzheimer, C., & Zheng, F. (2025). Forebrain-Specific B-raf Deficiency Reduces NMDA Current and Enhances Small-Conductance Ca2+-Activated K+ (SK) Current. International Journal of Molecular Sciences, 26(15). https://doi.org/10.3390/ijms26157172
- Stürzenberger, S., Bülow, N., Kalinichenko, L., Licha, R., Eulenburg, V., Dahlmanns, M.,... Alzheimer, C. (2025). Heavy adolescent drinking makes the adult brain more vulnerable to ethanol by permanently altering the age-dependent interplay between alcohol, GIRK channels and activin. Molecular Psychiatry. https://doi.org/10.1038/s41380-025-03210-x
- Wiessler, A.L., Zheng, F., Werner, C., Habib, M., Tuzun, E., Alzheimer, C.,... Villmann, C. (2025). Impaired Presynaptic Function Contributes Significantly to the Pathology of Glycine Receptor Autoantibodies. Neurology, Neuroimmunology and Neuroinflammation, 12(2), e200364-. https://doi.org/10.1212/NXI.0000000000200364
2024
- Zheng, F., Dahlmanns, M., Keßler, P., & Alzheimer, C. (2024). Increase in activin A may counteract decline in synaptic plasticity with age. Frontiers in Aging Neuroscience, 16. https://doi.org/10.3389/fnagi.2024.1382492
2023
- Bertalan, G., Becker, J., Tzschätzsch, H., Morr, A., Herthum, H., Shahryari, M.,... Sack, I. (2023). Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties. Journal of the Mechanical Behavior of Biomedical Materials, 138. https://doi.org/10.1016/j.jmbbm.2022.105613
- Dahlmanns, M., Valero-Aracama, M.J., Dahlmanns, J., Zheng, F., & Alzheimer, C. (2023). Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus. iScience, 26(10). https://doi.org/10.1016/j.isci.2023.108001
- Oikonomou, E., Gruber, T., Achanta, R.C., Höller, S., Alzheimer, C., Wellein, G., & Huth, T. (2023). 2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. Biophysical Journal. https://doi.org/10.1016/j.bpj.2023.02.023
- Valero Aracama, M.J., Zheng, F., & Alzheimer, C. (2023). Dorsal–Ventral Gradient of Activin Regulates Strength of GABAergic Inhibition along Longitudinal Axis of Mouse Hippocampus in an Activity-Dependent Fashion. International Journal of Molecular Sciences, 24(17). https://doi.org/10.3390/ijms241713145
- Zheng, F., Wess, J., & Alzheimer, C. (2023). Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice. Cells, 12(14). https://doi.org/10.3390/cells12141890
2022
- Dahlmanns, M., Dahlmanns, J., Schmidt, C.C., Valero Aracama, M.J., Zheng, F., & Alzheimer, C. (2022). Environmental enrichment recruits activin A to recalibrate neural activity in mouse hippocampus. Cerebral Cortex. https://doi.org/10.1093/cercor/bhac092
- El Hamdaoui, Y., Zheng, F., Fritz, N., Ye, L., Tran, M.A., Schwickert, K.,... Friedland, K. (2022). Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs. Molecular Psychiatry. https://doi.org/10.1038/s41380-022-01804-3
- Schmidt, C., Zheng, F., & Alzheimer, C. (2022). Activin A regulates the excitability of hippocampal mossy cells. Hippocampus. https://doi.org/10.1002/hipo.23415
- Schneider, J., Weigel, J., Wittmann, M.-T., Svehla, P., Ehrt, S., Zheng, F.,... Beckervordersandforth-Bonk, R. (2022). Astrogenesis in the murine dentate gyrus is a life-long and dynamic process. The EMBO Journal. https://doi.org/10.15252/embj.2021110409
- Zheng, F., Valero Aracama, M.J., Schaefer, N., & Alzheimer, C. (2022). Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.920388
2021
- Alzheimer, C. (2021). Commentary on: Bassetti, D., Luhmann, H.J., Kirischuk, S. Presynaptic GABAB receptor-mediated network excitation in the medial prefrontal cortex of Tsc2 + / − mice. Pflügers Archiv: European Journal of Physiology. https://doi.org/10.1007/s00424-021-02584-5
- Lin, C.-H., Kornhuber, J., Zheng, F., & Alzheimer, C. (2021). Tonic Control of Secretory Acid Sphingomyelinase Over Ventral Hippocampal Synaptic Transmission and Neuron Excitability. Frontiers in Cellular Neuroscience, 15. https://doi.org/10.3389/fncel.2021.660561
- Uzuneser, T., Weiss, E.M., Dahlmanns, J., Kalinichenko, L., Amato, D., Kornhuber, J.,... Müller, C.P. (2021). Presynaptic vesicular accumulation is required for antipsychotic efficacy in psychotic-like rats. Journal of Psychopharmacology, 35, 65-77. https://doi.org/10.1177/0269881120965908
- Zheng, F., Nixdorf-Bergweiler, B., van Brederode, J., Alzheimer, C., & Meßlinger, K. (2021). Excitatory effects of calcitonin gene‐related peptide (Cgrp) on superficial sp5c neurons in mouse medullary slices. International Journal of Molecular Sciences, 22(7). https://doi.org/10.3390/ijms22073794