Protein-protein interactions play a crucial role for the transduction of information in biological systems. The identification of the underlying principles of molecular recognition is important for the understanding of regulatory mechanisms as well as for the prediction of novel, physiologically relevant protein interactions. The bioinformatics group is primarily interested in investigating molecular interactions by a variety of computational tools (e.g. sequence data analysis, molecular modeling, and molecular dynamics).
Research projects
Protein aggregation
Host-pathogen interaction
Molecular communication processes
Current projects Current projects
Recent publications Recent publications
2023
Conrad, M., Horn, A., & Sticht, H. (2023). Computational Analysis of Histamine Protonation Effects on H1R Binding . Molecules , 28 (9). https://dx.doi.org/10.3390/molecules28093774
Deubler, M., Weißenborn, L., Leukel, S., Horn, A., Eichler, J., & Sticht, H. (2023). Computational Characterization of the Binding Properties of the HIV1-Neutralizing Antibody PG16 and Design of PG16-Derived CDRH3 Peptides . Biology , 12 (6). https://dx.doi.org/10.3390/biology12060824
Langhammer, F., Maroofian, R., Badar, R., Gregor, A., Rochman, M., Ratliff, J.B.,... Zweier, C. (2023). Genotype-phenotype correlations in RHOBTB2-associated neurodevelopmental disorders . Genetics in Medicine , 25 (8). https://dx.doi.org/10.1016/j.gim.2023.100885
Reimann, T., Müdsam, C., Schachtler, C., Ince, S., Sticht, H., Herrmann, C.,... Kost, B. (2023). The large GTPase AtGBPL3 links nuclear envelope formation and morphogenesis to transcriptional repression . Nature Plants . https://dx.doi.org/10.1038/s41477-023-01400-5
Schmid, C.M., Gregor, A., Costain, G., Morel, C.F., Massingham, L., Schwab, J.,... Zweier, C. (2023). LHX2 haploinsufficiency causes a variable neurodevelopmental disorder . Genetics in Medicine , 25 (7). https://dx.doi.org/10.1016/j.gim.2023.100839
Zanoni, P., Steindl, K., Sticht, H., Oneda, B., Joset, P., Ivanovski, I.,... Khan, N. (2023). The genetic landscape and clinical implication of pediatric Moyamoya angiopathy in an international cohort . European Journal of Human Genetics . https://dx.doi.org/10.1038/s41431-023-01320-0
Zarzecka, U., Tegtmeyer, N., Sticht, H., & Backert, S. (2023). Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain . Medical Microbiology and Immunology . https://dx.doi.org/10.1007/s00430-023-00766-9
2022
Aillaud, I., Kaniyappan, S., Chandupatla, R.R., Ramirez, L.M., Alkhashrom, S., Eichler, J.,... Funke, S.A. (2022). A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro . Alzheimer's Research and Therapy , 14 (1). https://dx.doi.org/10.1186/s13195-022-00959-z
Beudert, M., Hahn, L., Horn, A., Hauptstein, N., Sticht, H., Meinel, L.,... Luehmann, T. (2022). Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels . Journal of Controlled Release , 347 , 115-126. https://dx.doi.org/10.1016/j.jconrel.2022.04.028
Boonsawat, P., Horn, A.H.C., Steindl, K., Baumer, A., Joset, P., Kraemer, D.,... Rauch, A. (2022). Assessing clinical utility of preconception expanded carrier screening regarding residual risk for neurodevelopmental disorders . npj Genomic Medicine , 7 (1). https://dx.doi.org/10.1038/s41525-022-00316-x
Brand, L., Garkisch, M., Lotter, S., Schäfer, M., Burkovski, A., Sticht, H.,... Schober, R. (2022). Media Modulation based Molecular Communication . IEEE Transactions on Communications , 1-1. https://dx.doi.org/10.1109/TCOMM.2022.3205949
Breitinger, U., Farag, N.S., Sticht, H., & Breitinger, H.G. (2022). Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2 . International Journal of Biochemistry and Cell Biology , 145 . https://dx.doi.org/10.1016/j.biocel.2022.106185
Conrad, M., Söldner, C., & Sticht, H. (2022). Effect of Ions and Sequence Variants on the Antagonist Binding Properties of the Histamine H1 Receptor . International Journal of Molecular Sciences , 23 (3). https://dx.doi.org/10.3390/ijms23031420
Gerber, C.B., Fliedner, A., Bartsch, O., Berland, S., Dewenter, M., Haug, M.,... Zweier, C. (2022). Further characterization of Borjeson-Forssman-Lehmann syndrome in females due to de novo variants in PHF6 . Clinical Genetics . https://dx.doi.org/10.1111/cge.14173
Gregor, A., Meerbrei, T., Gerstner, T., Toutain, A., Lynch, S.A., Stals, K.,... Zweier, C. (2022). De novo missense variants in FBXO11 alter its protein expression and subcellular localization . Human Molecular Genetics , 31 (3), 440-454. https://dx.doi.org/10.1093/hmg/ddab265
Kerker, I., Löhr, S., Uebe, S., Popp, B., Vasileiou, G., Bowes, J.,... Hüffmeier, U. (2022). Common RUNX3 missense variant contributes to psoriatic arthritis by modifying differentiation of CD8(+) T-cells . In EUROPEAN JOURNAL OF HUMAN GENETICS (pp. 554-555). LONDON: SPRINGERNATURE.
Kicuntod, J., Häge, S., Hahn, F., Sticht, H., & Marschall, M. (2022). The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors . Viruses , 14 (5). https://dx.doi.org/10.3390/v14051021
Kloeckner, C., Murray, J.P.F., Tavasoli, M., Sticht, H., Stoltenburg-Didinger, G., Scholle, L.M.,... Platzer, K. (2022). Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly . Brain . https://dx.doi.org/10.1093/brain/awac074
Linck-Paulus, L., Horn, A., Matthies, A.O., Fischer, S., Meister, G., Sticht, H.,... Boßerhoff, A.K. (2022). A novel splice variant of Argonaut 2 affects microRNA target genes and cell viability of melanoma cells . In JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (pp. 36-36). HOBOKEN: WILEY.
Linck-Paulus, L., Meißgeier, T., Pieger, K., Horn, A., Matthies, A.O., Fischer, S.,... Boßerhoff, A.K. (2022). A previously unknown Argonaute 2 variant positively modulates the viability of melanoma cells . Cellular and Molecular Life Sciences , 79 (9). https://dx.doi.org/10.1007/s00018-022-04496-8
Luppe, J., Sticht, H., Lecoquierre, F., Goldenberg, A., Gorman, K.M., Molloy, B.,... Platzer, K. (2022). Heterozygous and homozygous variants in STX1A cause a neurodevelopmental disorder with or without epilepsy . European Journal of Human Genetics . https://dx.doi.org/10.1038/s41431-022-01269-6
Lösing, J., Haege, S., Schütz, M., Wagner, S., Wardin, J., Sticht, H., & Marschall, M. (2022). 'Shared-Hook' and 'Changed-Hook' Binding Activities of Herpesviral Core Nuclear Egress Complexes Identified by Random Mutagenesis . Cells , 11 (24). https://dx.doi.org/10.3390/cells11244030
Peter, A.S., Grüner, E., Socher, E., Fraedrich, K., Richel, E., Müller-Schmucker, S.,... Überla, K. (2022). Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD . International Journal of Molecular Sciences , 23 (15). https://dx.doi.org/10.3390/ijms23158177
Platzer, K., Sticht, H., Bupp, C., Ganapathi, M., Pereira, E.M., Le Guyader, G.,... Wojcik, S.M. (2022). De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission . Annals of Neurology . https://dx.doi.org/10.1002/ana.26485
Popp, B., Bienvenu, T., Giurgea, I., Metreau, J., Kraus, C., Reis, A.,... Zweier, C. (2022). The recurrent TCF4 missense variant p.(Arg389Cys) causes a neurodevelopmental disorder overlapping with but not typical for Pitt-Hopkins syndrome . Clinical Genetics . https://dx.doi.org/10.1111/cge.14206
Rahimi, M.J., Urban, N., Wegler, M., Sticht, H., Schaefer, M., Popp, B.,... Oppermann, H. (2022). De novo variants in ATP2B1 lead to neurodevelopmental delay . American Journal of Human Genetics , 109 (5), 944-952. https://dx.doi.org/10.1016/j.ajhg.2022.03.009
Rosenhahn, E., O'Brien, T.J., Zaki, M.S., Sorge, I., Wieczorek, D., Rostasy, K.,... Platzer, K. (2022). Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications . American Journal of Human Genetics , 109 (8), 1421-1435. https://dx.doi.org/10.1016/j.ajhg.2022.06.008
Schweininger, J., Kriegel, M., Häge, S., Conrad, M., Alkhashrom, S., Lösing, J.,... Muller, Y. (2022). The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity . Journal of Biological Chemistry , 298 (3). https://dx.doi.org/10.1016/j.jbc.2022.101625
Schütz, M., Müller, R., Socher, E., Wangen, C., Full, F., Wyler, E.,... Marschall, M. (2022). Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H . International Journal of Molecular Sciences , 23 , 11814. https://dx.doi.org/10.3390/ijms231911814
Thuma, N., Döhler, D., Mielenz, D., Sticht, H., Radtke, D., Reimann, L.,... Vöhringer, D. (2022). A newly identified secreted larval antigen elicits basophil-dependent protective immunity against N. brasiliensis infection . Frontiers in Immunology , 13 . https://dx.doi.org/10.3389/fimmu.2022.979491
Vintschger, E., Kraemer, D., Joset, P., Horn, A., Rauch, A., Sticht, H., & Bachmann-Gagescu, R. (2022). Challenges for the implementation of next generation sequencing-based expanded carrier screening: Lessons learned from the ciliopathies . European Journal of Human Genetics . https://dx.doi.org/10.1038/s41431-022-01267-8
Wegler, M., Jia, X., Alders, M., Bouman, A., Chen, J., Duan, X.,... Abou Jamra, R. (2022). De novo variants in the PABP domain of PABPC1 lead to developmental delay . Genetics in Medicine . https://dx.doi.org/10.1016/j.gim.2022.04.013
Weißenborn, L., Richel, E., Hueseman, H., Welzer, J., Beck, S., Schäfer, S.,... Eichler, J. (2022). Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein . International Journal of Molecular Sciences , 23 (11). https://dx.doi.org/10.3390/ijms23116309
2021
Appelhof, B., Wagner, M., Hoefele, J., Heinze, A., Roser, T., Koch-Hogrebe, M.,... Abou Jamra, R. (2021). Pontocerebellar hypoplasia due to bi-allelic variants in MINPP1 . European Journal of Human Genetics , 29 (3), 411-421. https://dx.doi.org/10.1038/s41431-020-00749-x
Averdunk, L., Sticht, H., Surowy, H., Luedecke, H.-J., Koch-Hogrebe, M., Alsaif, H.S.,... Wieczorek, D. (2021). Correction to: The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype (Journal of Molecular Medicine, (2021), 10.1007/s00109-021-02124-9) . Journal of Molecular Medicine . https://dx.doi.org/10.1007/s00109-021-02153-4
Averdunk, L., Sticht, H., Surowy, H., Luedecke, H.-J., Koch-Hogrebe, M., Alsaif, H.S.,... Wieczorek, D. (2021). The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype . Journal of Molecular Medicine . https://dx.doi.org/10.1007/s00109-021-02124-9
Bachert, W., Klotz, L., Sticht, H., & Enz, R. (2021). Homodimerization of a proximal region within the C-terminus of the orphan G-protein coupled receptor GPR179 . Neurochemistry International , 149 . https://dx.doi.org/10.1016/j.neuint.2021.105150
Breitinger, U., Ali, N.K., Sticht, H., & Breitinger, H.G. (2021). Inhibition of SARS CoV Envelope Protein by Flavonoids and Classical Viroporin Inhibitors . Frontiers in Microbiology , 12 . https://dx.doi.org/10.3389/fmicb.2021.692423
Breitinger, U., Sticht, H., & Breitinger, H.G. (2021). Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols . Biological Chemistry . https://dx.doi.org/10.1515/hsz-2020-0360
Durmus, H., Mertoğlu, E., Sticht, H., Ceylaner, S., Kulaksızoğlu, I.B., Hashemolhosseini, S.,... Parman, Y. (2021). Episodic psychosis, ataxia, motor neuropathy with pyramidal signs (PAMP sydrome) caused by a novel mutation in ADPRHL2 (AHR3) . Neurological Sciences . https://dx.doi.org/10.1007/s10072-021-05100-w
Höring, C., Conrad, M., Söldner, C., Wang, J., Sticht, H., Strasser, A., & Miao, Y. (2021). Specific engineered G protein coupling to histamine receptors revealed from cellular assay experiments and accelerated molecular dynamics simulations . International Journal of Molecular Sciences , 22 (18). https://dx.doi.org/10.3390/ijms221810047
Kicuntod, J., Alkhashrom, S., Häge, S., Diewald, B., Müller, R., Hahn, F.,... Marschall, M. (2021). Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule . Viruses , 13 (3). https://dx.doi.org/10.3390/v13030462
Klöckner, C., Sticht, H., Zacher, P., Popp, B., Babcock, H.E., Bakker, D.P.,... Platzer, K. (2021). Correction to: De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy (Genetics in Medicine, (2020), 10.1038/s41436-020-01020-w) . Genetics in Medicine . https://dx.doi.org/10.1038/s41436-020-01090-w
Kohrt, S., Strobel, S., Mann, M., Sticht, H., Fleckenstein, B., & Thoma-Kreß, A. (2021). Characterizing the interaction between the htlv-1 transactivator tax-1 with transcription elongation factor ell2 and its impact on viral transactivation . International Journal of Molecular Sciences , 22 (24). https://dx.doi.org/10.3390/ijms222413597
Konieczny, A., Conrad, M., Ertl, F.J., Gleixner, J., Gattor, A.O., Grätz, L.,... Keller, M. (2021). N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide y Y4Receptor Ligands Results in Picomolar Binding Constants . Journal of Medicinal Chemistry , 64 (22), 16746-16769. https://dx.doi.org/10.1021/acs.jmedchem.1c01574
Malhis, M., Kaniyappan, S., Aillaud, I., Chandupatla, R.R., Ramirez, L.M., Zweckstetter, M.,... Funke, S.A. (2021). Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display . ChemBioChem . https://dx.doi.org/10.1002/cbic.202100287
Peter, A.S., Roth, E., Schulz, S., Fraedrich, K., Steinmetz, T., Damm, D.,... Jäck, H.-M. (2021). A pair of non‐competing neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model . European Journal of Immunology . https://dx.doi.org/10.1002/eji.202149374
Regensburger, D., Tenkerian, C., Pürzer, V., Schmid, B., Wohlfahrt, T., Stolzer, I.,... Naschberger, E. (2021). Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease . Inflammatory Bowel Diseases . https://dx.doi.org/10.1093/ibd/izaa346
Richard, E.M., Bakhtiari, S., Marsh, A.P., Kaiyrzhanov, R., Wagner, M., Shetty, S.,... Kruer, M.C. (2021). Bi-allelic variants in SPATA5L1 lead to intellectual disability, spastic-dystonic cerebral palsy, epilepsy, and hearing loss . American Journal of Human Genetics , 108 (10), 2006-2016. https://dx.doi.org/10.1016/j.ajhg.2021.08.003
Schuhmann, S., Koller, H., Sticht, H., Kraus, C., Krumbiegel, M., Uebe, S.,... Thiel, C. (2021). Clinical and molecular delineation of spondylocostal dysostosis type 3 . Clinical Genetics . https://dx.doi.org/10.1111/cge.13952
Schütz, M., Steingruber, M., Socher, E., Müller, R., Wagner, S., Kögel, M.,... Marschall, M. (2021). Functional Relevance of the Interaction between Human Cyclins and the Cytomegalovirus-Encoded CDK-Like Protein Kinase pUL97 . Viruses , 13 , 1248. https://dx.doi.org/10.3390/v13071248
Socher, E., Conrad, M., Heger, L., Paulsen, F., Sticht, H., Zunke, F., & Arnold, P. (2021). Computational decomposition reveals reshaping of the SARS‐CoV‐2–ACE2 interface among viral variants expressing the N501Y mutation . Journal of Cellular Biochemistry . https://dx.doi.org/10.1002/jcb.30142
Socher, E., Conrad, M., Heger, L., Paulsen, F., Sticht, H., Zunke, F., & Arnold, P. (2021). Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide . Biomedicines , 9 (5). https://dx.doi.org/10.3390/biomedicines9050525
Söldner, C., Sticht, H., & Horn, A. (2021). Molecular Simulations and Alzheimer׳s Disease . In Olaf Wolkenhauer (Eds.), Systems Medicine: Integrative, qualitative, and computational approaches. (pp. 54-70). Amsterdam: Elsevier.
Thomas, M., Kropff, B., Schneider, A., Winkler, T., Görzer, I., Sticht, H.,... Reuter, N. (2021). A novel strain-specific neutralizing epitope on glycoprotein H of human cytomegalovirus . Journal of Virology , 95 (18). https://dx.doi.org/10.1128/JVI.00657-21
Zanoni, P., Steindl, K., Sengupta, D., Joset, P., Bahr, A., Sticht, H.,... Rauch, A. (2021). Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype . Genetics in Medicine . https://dx.doi.org/10.1038/s41436-021-01158-1
2020
Abdelfattah, F., Kariminejad, A., Kahlert, A.K., Morrison, P.J., Gumus, E., Mathews, K.D.,... Schanze, D. (2020). Expanding the genotypic and phenotypic spectrum of severe serine biosynthesis disorders . Human Mutation . https://dx.doi.org/10.1002/humu.24067
Begemann, A., Sticht, H., Begtrup, A., Vitobello, A., Faivre, L., Banka, S.,... Rauch, A. (2020). New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated actin dynamics . Genetics in Medicine . https://dx.doi.org/10.1038/s41436-020-01011-x
Begemann, A., Sticht, H., Mcwalter, K., Vitobello, A., Faivre, L., Alhaddad, B.,... Rauch, A. (2020). Expanding the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and functional proof of aberrant WRC-mediated actin dynamics . In EUROPEAN JOURNAL OF HUMAN GENETICS (pp. 329-331). LONDON: SPRINGERNATURE.
Breitinger, U., Weinländer, K., Pechmann, Y., Langlhofer, G., Enz, R., Becker, C.-M.,... Breitinger, H.G. (2020). A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin . Journal of Advanced Research . https://dx.doi.org/10.1016/j.jare.2020.09.009
Conrad, M., Söldner, C., Miao, Y., & Sticht, H. (2020). Agonist binding and g protein coupling in histamine h2 receptor: A molecular dynamics study . International Journal of Molecular Sciences , 21 (18), 1-18. https://dx.doi.org/10.3390/ijms21186693
Donhauser, N., Socher, E., Millen, S., Heym, S., Sticht, H., & Thoma-Kreß, A. (2020). Transfer of htlv-1 p8 and gag to target t-cells depends on vasp, a novel interaction partner of p8 . PLoS Pathogens , 16 (9). https://dx.doi.org/10.1371/journal.ppat.1008879
Durmus, H., Sticht, H., Ceylaner, S., Hashemolhosseini, S., & Deymeer, F. (2020). Rare slow channel congenital myasthenic syndromes without repetitive compound muscle action potential and dramatic response to low dose fluoxetine . Acta Neurologica Belgica . https://dx.doi.org/10.1007/s13760-020-01505-0
Durmus, H., Sticht, H., Ceylaner, S., Hashemolhosseini, S., & Parmn, Y. (2020). EPISODIC PSYCHOSIS, ATAXIA, MOTOR NEUROPATHY CAUSED BY A NOVEL MUTATION IN ADPRHL2 . In NEUROLOGY . Toronto, CANADA: PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Fliedner, A., Gregor, A., Ferrazzi, F., Ekici, A.B., Sticht, H., & Zweier, C. (2020). Loss of PHF6 leads to aberrant development of human neuron-like cells . Scientific Reports , 10 (1). https://dx.doi.org/10.1038/s41598-020-75999-2
Frey, S., Sticht, H., Wilsmann-Theis, D., Gerschütz, A., Wolf, K., Löhr, S.,... Hüffmeier, U. (2020). Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis . Journal of Investigative Dermatology . https://dx.doi.org/10.1016/j.jid.2019.11.024
Grosche, L., Knippertz, I., König, C., Royzman, D., Wild, A., Zinser, E.,... Lechmann, M. (2020). The CD83 Molecule – An Important Immune Checkpoint . Frontiers in Immunology , 11 . https://dx.doi.org/10.3389/fimmu.2020.00721
Haskamp, S., Bruns, H., Hahn, M., Hoffmann, M., Gregor, A., Löhr, S.,... Schauer, C. (2020). Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases . American Journal of Human Genetics , 107 (3), 527-538. https://dx.doi.org/10.1016/j.ajhg.2020.07.001
Hussein, R.A., Ahmed, M., Sticht, H., Breitinger, H.G., & Breitinger, U. (2020). Fine-Tuning of Neuronal Ion Channels-Mapping of Residues Involved in Glucose Sensitivity of Recombinant Human Glycine Receptors . ACS Chemical Neuroscience . https://dx.doi.org/10.1021/acschemneuro.0c00566
Hüffmeier, U., Löhr, S., Uebe, S., Popp, B., Bowes, J., Kirchner, P.,... Reis, A. (2020). Common RUNX3 missense variant contributes to psoriatic arthritis by affecting splicing and modifying signaling, activation and differentiation of T-cells . In EUROPEAN JOURNAL OF HUMAN GENETICS (pp. 314-315). LONDON: SPRINGERNATURE.
Kloeckner, C., Sticht, H., Zacher, P., Popp, B., Babcock, H.E., Bakker, D.P.,... Platzer, K. (2020). De novo variants in SNAP25 cause an early-onset developmental and epileptic encephalopathy . Genetics in Medicine . https://dx.doi.org/10.1038/s41436-020-01020-w
Marschall, M., Häge, S., Conrad, M., Alkhashrom, S., Kicuntod, J., Schweininger, J.,... Sticht, H. (2020). Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties . Viruses , 12 (6). https://dx.doi.org/10.3390/v12060683
Muller, Y., Häge, S., Alkhashrom, S., Höllriegl, T., Weigert, S., Dolles, S.,... Marschall, M. (2020). High-resolution crystal structures of two prototypical β- And γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity . Journal of Biological Chemistry , 295 (10), 3189-3201. https://dx.doi.org/10.1074/jbc.RA119.011546
Schuhmann, S., Koller, H., Sticht, H., Kraus, C., Krumbiegel, M., Uebe, S.,... Thiel, C.T. (2020). Further clinical and molecular delineation of spondylocostal dysostosis type 3 . In EUROPEAN JOURNAL OF HUMAN GENETICS (pp. 841-841). LONDON: SPRINGERNATURE.
Schütz, M., Thomas, M., Wangen, C., Wagner, S., Rauschert, L., Errerd, T.,... Marschall, M. (2020). The peptidyl-prolyl cis/trans isomerase Pin1 interacts with three early regulatory proteins of human cytomegalovirus . Virus Research , 285 . https://dx.doi.org/10.1016/j.virusres.2020.198023
Sharafutdinov, I., Soltan Esmaeili, D., Harrer, A., Tegtmeyer, N., Sticht, H., & Backert, S. (2020). Campylobacter jejuni Serine Protease HtrA Cleaves the Tight Junction Component Claudin-8 . Frontiers in Cellular and Infection Microbiology , 10 . https://dx.doi.org/10.3389/fcimb.2020.590186
Söldner, C., Socher, E., Jamali, V., Wicke, W., Ahmadzadeh, A., Breitinger, H.G.,... Sticht, H. (2020). A Survey of Biological Building Blocks for Synthetic Molecular Communication Systems . IEEE Communications Surveys & Tutorials , 22 (4), 2765-2800. https://dx.doi.org/10.1109/COMST.2020.3008819
Tegtmeyer, N., Neddermann, M., Lind, J., Suneesh Kumar, P., Sharafutdinov, I., Gutiérrez-Escobar, A.J.,... Vieth, M. (2020). Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori . Cell Reports , 32 (11). https://dx.doi.org/10.1016/j.celrep.2020.108159
Thiel, C.T., Hauer, N., Vogl, C., Uebe, S., Sticht, H., Ekici, A.B.,... Reis, A. (2020). Mono-allelic deleterious variants in autosomal recessive skeletal dysplasia genes are strongly associated with idiopathic short stature . In EUROPEAN JOURNAL OF HUMAN GENETICS (pp. 240-240). LONDON: SPRINGERNATURE.
Zanoni, P., Steindl, K., Sengupta, D., Sticht, H., Joset, P., Baar, A.,... Rauch, A. (2020). Loss-of-function truncating and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct neurodevelopmental phenotype . In EUROPEAN JOURNAL OF HUMAN GENETICS (pp. 355-356). LONDON: SPRINGERNATURE.
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Protein-protein interactions play a crucial role for the transduction of information in biological systems. The identification of the underlying principles of molecular recognition is important for the understanding of regulatory mechanisms as well as for the prediction of novel, physiologically relevant protein interactions. The bioinformatics group is primarily interested in investigating molecular interactions by a variety of computational tools (e.g. sequence data analysis, molecular modeling, and molecular dynamics).
Research projects
Current projects
Deciphering Autosomal Recessive Neurodevelopmental Disorders
(FAU Funds)
Recent publications
2023
2022
2021
2020
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