Research projects
DFG-Project: MicroRNA mediated regulation of key components of the Mediator Complex (MED) and its functional role in CRPC EU-EIT Health Project (PI Karolinska Institute)
Imaging in prostate cancer diagnosis BMBF (PI Prof. Bauer/Dermatology)
Diagnostics with biomarker patterns from plasma extra-cellular vesicles (pEV) using artificial intelligence (AI) methods
Identification of biomarkers in urologic cancers for diagnosis, prognosis or therapieprediction/monitoring.
Characterization of (cancer) stem cell-associated gene-/protein expression.
Focus on microRNA-expression profiles in tumors and liquid biopsies.
Current projects Current projects
Recent publications Recent publications
2022
Fichte, A., Neumann, A.-D., Weigelt, K., Guzman, J., Jansen, T., Keinert, J.,... Lieb, V. (2022). Combined miR-486 and GP88 (Progranulin) Serum Levels Are Suggested as Supportive Biomarkers for Therapy Decision in Elderly Prostate Cancer Patients . Life , 12 (5). https://dx.doi.org/10.3390/life12050732
Jasinski-Bergner, S., Eckstein, M., Taubert, H., Wach, S., Fiebig, C., Strick, R.,... Seliger, B. (2022). The Human Leukocyte Antigen G as an Immune Escape Mechanism and Novel Therapeutic Target in Urological Tumors . Frontiers in Immunology , 13 , 811200-. https://dx.doi.org/10.3389/fimmu.2022.811200
2021
Greither, T., Steiner, T., Bache, M., Serrero, G., Otto, S., Taubert, H.,... Kappler, M. (2021). Gp88/pgrn serum levels are associated with prognosis for oral squamous cell carcinoma patients . Biology , 10 (5). https://dx.doi.org/10.3390/biology10050400
Offermann, A., Kang, D., Watermann, C., Weingart, A., Hupe, M.C., Saraji, A.,... Perner, S. (2021). Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases . Carcinogenesis , 42 (12), 1475-1484. https://dx.doi.org/10.1093/carcin/bgab083
Taubert, H., & Eckstein, M. (2021). Ist die Expression des GP88-Proteins (Progranulin) ein klinisch relevanter Prognosefaktor für Prostatakarzinompatienten? Journal für Urologie und Urogynäkologie . https://dx.doi.org/10.1007/s41972-021-00129-7
Taubert, H., Eckstein, M., Epple, E., Jung, R., Weigelt, K., Lieb, V.,... Wach, S. (2021). Immune Cell-Associated Protein Expression Helps to Predict Survival in Muscle-Invasive Urothelial Bladder Cancer Patients after Radical Cystectomy and Optional Adjuvant Chemotherapy . Cells , 10 (1). https://dx.doi.org/10.3390/cells10010159
Tully, K.H., Jütte, H., Wirtz, R.M., Jarczyk, J., Santiago-Walker, A., Zengerling, F.,... Eckstein, M. (2021). Prognostic Role of FGFR Alterations and FGFR mRNA Expression in Metastatic Urothelial Cancer Undergoing Checkpoint Inhibitor Therapy . Urology . https://dx.doi.org/10.1016/j.urology.2021.05.055
Weyerer, V., Eckstein, M., Strissel, P., Wullweber, A., Lange, F., Tögel, L.,... Giedl, J. (2021). Tert promoter mutation analysis of whole-organ mapping bladder cancers . Genes , 12 (2), 1-10. https://dx.doi.org/10.3390/genes12020230
Weyerer, V., Strissel, P., Stohr, C., Eckstein, M., Wach, S., Taubert, H.,... Strick, R. (2021). Endogenous Retroviral-K Envelope Is a Novel Tumor Antigen and Prognostic Indicator of Renal Cell Carcinoma . Frontiers in Oncology , 11 . https://dx.doi.org/10.3389/fonc.2021.657187
Weyerer, V., Strissel, P., Strick, R., Sikic, D., Geppert, C., Bertz, S.,... Eckstein, M. (2021). Integration of spatial pd-l1 expression with the tumor immune microenvironment outperforms standard pd-l1 scoring in outcome prediction of urothelial cancer patients . Cancers , 13 (10). https://dx.doi.org/10.3390/cancers13102327
Wullweber, A., Strick, R., Lange, F., Sikic, D., Taubert, H., Wach, S.,... Eckstein, M. (2021). Bladder Tumor Subtype Commitment Occurs in Carcinoma In Situ Driven by Key Signaling Pathways Including ECM Remodeling . Cancer Research , 81 (6), 1552-1566. https://dx.doi.org/10.1158/0008-5472.CAN-20-2336
2020
Eckstein, M., Epple, E., Jung, R., Weigelt, K., Lieb, V., Sikic, D.,... Wach, S. (2020). CCL2 expression in tumor cells and tumor-infiltrating immune cells shows divergent prognostic potential for bladder cancer patients depending on lymph node stage . Cancers , 12 (5). https://dx.doi.org/10.3390/cancers12051253
Eckstein, M., Strissel, P., Strick, R., Weyerer, V., Wirtz, R., Pfannstiel, C.,... Sikic, D. (2020). Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy . Journal for ImmunoTherapy of Cancer , 8 (1). https://dx.doi.org/10.1136/jitc-2019-000162
Eckstein, M., Strissel, P., Strick, R., Weyerer, V., Wirtz, R.M., Pfannstiel, C.,... Sikic, D. (2020). Immune Cell Gene Expression Signature is Associated with Improved Outcome in Muscle-Invasive Urothelial Bladder Cancer Patients Treated with Radical Cystectomy . In ONCOLOGY RESEARCH AND TREATMENT (pp. 70-70). BASEL: KARGER.
Erber, R., Meyer, J., Taubert, H., Fasching, P., Wach, S., Häberle, L.,... Rübner, M. (2020). Piwi-like 1 and piwi-like 2 expression in breast cancer . Cancers , 12 (10), 1-17. https://dx.doi.org/10.3390/cancers12102742
Friedrich, M., Heimer, N., Stoehr, C., Steven, A., Wach, S., Taubert, H.,... Seliger, B. (2020). CREB1 is affected by the microRNAs miR-22-3p, miR-26a-5p, miR-27a-3p, and miR-221-3p and correlates with adverse clinicopathological features in renal cell carcinoma . Scientific Reports , 10 (1). https://dx.doi.org/10.1038/s41598-020-63403-y
Greither, T., Koser, F., Holzhausen, H.J., Güttler, A., Würl, P., Kappler, M.,... Taubert, H. (2020). Mir-155-5p and mir-203a-3p are prognostic factors in soft tissue sarcoma . Cancers , 12 (8), 1-13. https://dx.doi.org/10.3390/cancers12082254
Kubon, J., Sikic, D., Eckstein, M., Weyerer, V., Stöhr, R., Neumann, A.,... Wach, S. (2020). Analysis of CXCL9, PD1 and PD-L1 mRNA in stage T1 non-muscle invasive bladder cancer and their association with prognosis . Cancers , 12 (10), 1-13. https://dx.doi.org/10.3390/cancers12102794
Kunz, M., Brandl, M., Bhattacharya, A., Nobereit-Siegel, L., Ewe, A., Weirauch, U.,... Aigner, A. (2020). Nanoparticle-complexed antimiRs for inhibiting tumor growth and metastasis in prostate carcinoma and melanoma . Journal of Nanobiotechnology , 18 (1). https://dx.doi.org/10.1186/s12951-020-00728-w
König, P., Eckstein, M., Jung, R., Abdulrahman, A., Guzman, J., Weigelt, K.,... Lieb, V. (2020). Expression of AR-V7 (Androgen receptor variant 7) protein in granular cytoplasmic structures is an independent prognostic factor in prostate cancer patients . Cancers , 12 (9), 1-15. https://dx.doi.org/10.3390/cancers12092639
Simon, A.G., Tolkach, Y., Esser, L.K., Ellinger, J., Stoehr, C., Ritter, M.,... Toma, M.I. (2020). Mitophagy-associated genes PINK1 and PARK2 are independent prognostic markers of survival in papillary renal cell carcinoma and associated with aggressive tumor behavior . Scientific Reports , 10 (1). https://dx.doi.org/10.1038/s41598-020-75258-4
Taubert, H., Abdulrahman, A., Eckstein, M., Jung, R., Guzman, J., Weigelt, K.,... Wach, S. (2020). Progranulin (GP88) is an independent prognostic factor for prostate cancer patients . In CANCER RESEARCH . PHILADELPHIA: AMER ASSOC CANCER RESEARCH.
Wach, S., Taubert, H., Weigelt, K., Hase, N., Köhn, M., Misiak, D.,... Lai, X. (2020). RNA sequencing of collecting duct renal cell carcinoma suggests an interaction between miRNA and target genes and a predominance of deregulated solute carrier genes . Cancers , 12 (1). https://dx.doi.org/10.3390/cancers12010064
Weyerer, V., Lange, F., Wullweber, A., Stöhr, R., Bertz, S., Wach, S.,... Eckstein, M. (2020). Heterogeneity-analysis of molecular subtypes of muscle-invasive bladder cancer and their precursor lesions in multiregion mapped whole-organ bladders . In UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (pp. 907-907). NEW YORK: ELSEVIER SCIENCE INC.
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2022
2021
2020
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