Prof. Dr. Aldo R. Boccaccini

Institute of Biomaterials

The Institute of Biomaterials develops and characterizes organic and inorganic materials, also in combination for applications in several biomedical fields, including coatings for implants, bone replacement, controlled drug delivery, antibacterial surfaces and wound healing, tissue engineering and tissue models.

Research projects

  • Materials research in the areas such as bone replacement, heart muscle, wound dressings, coatings, porous biomaterials (scaffolds), electrospinning and 3D bioprinting
  • 3D bioprinting will cell laden hydrogels
  • Electroactive biomaterials
  • Nanomaterials for drug delivery
  • Bioactive materials for bone regeneration
  • Flexible fibrous structures for antibacterial wound healing

Current Projects

  • Exploring Brain Mechanics (EBM): Understanding, engineering and exploiting mechanical properties and signals in central nervous system development, physiology and pathology

    (Third Party Funds Group – Overall project)

    Term: 1. January 2023 - 31. December 2026
    Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)

    Thecentral nervous system (CNS) is our most complex organ system. Despite tremendousprogress in our understanding of the biochemical, electrical, and geneticregulation of CNS functioning and malfunctioning, many fundamental processesand diseases are still not fully understood. For example, axon growth patterns inthe developing brain can currently not be well-predicted based solely on thechemical landscape that neurons encounter, several CNS-related diseases cannotbe precisely diagnosed in living patients, and neuronal regeneration can stillnot be promoted after spinal cord injuries.

    Duringmany developmental and pathological processes, neurons and glial cells aremotile. Fundamentally, motion is drivenby forces. Hence, CNS cells mechanicallyinteract with their surrounding tissue. They adhere to neighbouring cells and extracellular matrix using celladhesion molecules, which provide friction, and generate forces usingcytoskeletal proteins.  These forces aretransmitted to the outside world not only to locomote but also to probe themechanical properties of the environment, which has a long overseen huge impacton cell function.

    Onlyrecently, groups of several project leaders in this consortium, and a few other groupsworldwide, have discovered an important contribution of mechanical signalsto regulating CNS cell function. For example, they showed that brain tissuemechanics instructs axon growth and pathfinding in vivo, that mechanicalforces play an important role for cortical folding in the developing humanbrain, that the lack of remyelination in the aged brain is due to an increasein brain stiffness in vivo, and that many neurodegenerative diseases areaccompanied by changes in brain and spinal cord mechanics. These first insights strongly suggest thatmechanics contributes to many other aspects of CNS functioning, and it islikely that chemical and mechanical signals intensely interact at the cellularand tissue levels to regulate many diverse cellular processes.

    The CRC 1540 EBM synergises the expertise of engineers, physicists,biologists, medical researchers, and clinicians in Erlangen to explore mechanicsas an important yet missing puzzle stone in our understanding of CNSdevelopment, homeostasis, and pathology. Our strongly multidisciplinary teamwith unique expertise in CNS mechanics integrates advanced invivo, in vitro, and in silico techniques across time(development, ageing, injury/disease) and length (cell, tissue, organ) scalesto uncover how mechanical forces and mechanical cell and tissue properties,such as stiffness and viscosity, affect CNS function. We especially focus on(A) cerebral, (B) spinal, and (C) cellular mechanics. Invivo and in vitro studies provide a basic understanding ofmechanics-regulated biological and biomedical processes in different regions ofthe CNS. In addition, they help identify key mechano-chemical factors forinclusion in in silico models and provide data for model calibration andvalidation. In silico models, in turn, allow us to test hypotheses without the need of excessive or even inaccessibleexperiments. In addition, they enable the transfer and comparison of mechanics data and findingsacross species and scales. They also empower us to optimise processparameters for the development of in vitro brain tissue-like matricesand in vivo manipulation of mechanical signals, and, eventually, pavethe way for personalised clinical predictions.

    Insummary, we exploit mechanics-based approaches to advance ourunderstanding of CNS function and to provide the foundation for futureimprovement of diagnosis and treatment of neurological disorders.

  • Programm des Projektbezogenen Personenaustauschs Kroatien 2023-2025

    (Third Party Funds Single)

    Term: 1. January 2023 - 31. December 2024
    Funding source: Deutscher Akademischer Austauschdienst (DAAD)
  • Programm des personenbezogenenn Personenaustauschs Brasilien CAPES 2023-2025

    (Third Party Funds Single)

    Term: 1. January 2023 - 31. December 2024
    Funding source: Deutscher Akademischer Austauschdienst (DAAD)

Recent publications

2024

2023

2022

2021

2020

Related Research Fields

 

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