Research projects
Physiology and electrophysiology of the healthy and diseased retina and its significance for visual perception.
Research in human subjects (healthy subjects and well-described patient groups with retinal disorders) and in animals (healthy animals; animal models for human diseases and genetically modified animals).
Interaktionen der fotorezeptor-generierten Signale im Elektroretinogramm von Mäusen Function and dysfunction of rod- and cone-driven pathways: novel approaches for measuring treatment effects Eine neue Sicht der postrezeptoralen Signalverarbeitung in retino-genikulärer Sehbahnen beim Menschen Retina 2.0. Image acquisition from retina to sensors.
Decoding central defects in dystrophinopathies: from diagnostic to remediation Artificial Intelligence for Diagnosing Retinal Diseases
Recent publications
2025
Huchzermeyer, C., Stingl, K., & Kremers, J. (2025). Multidimensional Functional Phenotyping Based on Photoreceptor-Directed Temporal Contrast Sensitivity Defects in Inherited Retinal Diseases . Investigative Ophthalmology & Visual Science , 66 (4). https://doi.org/10.1167/iovs.66.4.25
Joachimsthaler, A., Hauf, K., Armbruster, A., Zayit-Soudry, S., Naaman, E., Perlman, I.,... Eulenburg, V. (2025). Changes in glycinergic neurotransmission alter mammalian retinal information processing . Frontiers in Molecular Neuroscience , 18 . https://doi.org/10.3389/fnmol.2025.1564870
Kremers, J., Aher, A., & Huchzermeyer, C. (2025). ERG responses and the Ferry-Porter law . Journal of the Optical Society of America A: Optics and Image Science, and Vision , 42 (5), B1-B7. https://doi.org/10.1364/JOSAA.538103
Kremers, J., Huchzermeyer, C., & Aher, A. (2025). The consequence of modulating background on the luminance-response function of the human photopic electroretinogram . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-025-10029-y
2024
Huchzermeyer, C., Lämmer, R., Mardin, C.Y., Kruse, F., Kremers, J., & Horn, F. (2024). Pattern electroretinogram, blue-yellow visual evoked potentials and the risk of developing visual field defects in glaucoma suspects: a longitudinal “survival” analysis with a very long follow-up . Graefes Archive For Clinical and Experimental Ophthalmology . https://doi.org/10.1007/s00417-023-06364-y
Kremers, J., & Huchzermeyer, C. (2024). Electroretinographic responses to periodic stimuli in primates and the relevance for visual perception and for clinical studies . Visual Neuroscience , 41 . https://doi.org/10.1017/S0952523824000038
Kulyabin, M., Kremers, J., Holbach, V., Maier, A., & Huchzermeyer, C. (2024). Artificial intelligence for detection of retinal toxicity in chloroquine and hydroxychloroquine therapy using multifocal electroretinogram waveforms . Scientific Reports , 14 (1), 24853. https://doi.org/10.1038/s41598-024-76943-4
Marmoy, O.R., Tekavčič Pompe, M., & Kremers, J. (2024). Chromatic visual evoked potentials: A review of physiology, methods and clinical applications . Progress in Retinal and Eye Research , 101 . https://doi.org/10.1016/j.preteyeres.2024.101272
2023
Crux, K., Huchzermeyer, C., Kremers, J., & Horn, F. (2023). Objective detection of visual field defects with multifrequency VEPs . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-023-09949-4
Huchzermeyer, C., Fars, J., Kremers, J., Kühlewein, L., Kempf, M., Ott, S.,... Stingl, K. (2023). Photoreceptor-Specific Temporal Contrast Sensitivities in RP1L1-Associated Occult Macular Dystrophy . Investigative Ophthalmology & Visual Science , 64 (7), 33-. https://doi.org/10.1167/iovs.64.7.33
Stallwitz, N., Joachimsthaler, A., & Kremers, J. (2023). Single opsin driven white noise ERGs in mice . Frontiers in Neuroscience , 17 . https://doi.org/10.3389/fnins.2023.1211329
Tsay, K., Safari, S., Abu-Samra, A., Kremers, J., & Tzekov, R. (2023). Pre-stimulus bioelectrical activity in light-adapted ERG under blue versus white background . Visual Neuroscience , 40 , E004-. https://doi.org/10.1017/S0952523823000032
2022
Aher, A., Huchzermeyer, C., & Kremers, J. (2022). The effect of sinusoidally modulating backgrounds on flash electroretinograms . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Barboni, M.T.S., Joachimsthaler, A., Roux, M.J., Nagy, Z.Z., Ventura, D.F., Rendon, A.,... Vaillend, C. (2022). Retinal dystrophins and the retinopathy of Duchenne muscular dystrophy . Progress in Retinal and Eye Research . https://doi.org/10.1016/j.preteyeres.2022.101137
Fars, J., Fernandes, T.P., Huchzermeyer, C., Kremers, J., & Paramei, G.V. (2022). Chromatic discrimination measures in mature observers depend on the response window . Scientific Reports , 12 (1). https://doi.org/10.1038/s41598-022-13129-w
Fars, J., Kremers, J., & Huchzermeyer, C. (2022). Complementarity of sensitivity and just noticeable difference in the study of Retinitis Pigmentosa and Stargardt disease . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., & Kremers, J. (2022). Comparing functional defects measured by mfERG and standard automated perimetry in patients under (hydroxy-)chloroquine therapy . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., & Kremers, J. (2022). Selektive Stimulation der verschiedenen Fotorezeptorklassen mittels Silent Substitution bei psychophysischen und elektroretinografischen Messungen . Klinische Monatsblätter für Augenheilkunde , 239 (12), 1433-1439. https://doi.org/10.1055/a-1937-9901
Joachimsthaler, A., Stallwitz, N., & Kremers, J. (2022). How the use of dim red-light pre-recording affects ERG responses of mice with long-wavelength shifted opsin . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Kremers, J., Aher, A., & Huchzermeyer, C. (2022). Modulation of flash ERGs by dynamic backgrounds . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-022-09902-x
Kremers, J., Aher, A., Parry, N., Patel, N.B., & Frishman, L.J. (2022). ERG signals elicited by temporal white noise in macaques . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Kremers, J., Aher, A., Parry, N.R.A., Patel, N.B., & Frishman, L.J. (2022). Electroretinographic responses to luminance and cone-isolating white noise stimuli in macaques . Frontiers in Neuroscience , 16 . https://doi.org/10.3389/fnins.2022.925405
Stallwitz, N., Joachimsthaler, A., & Kremers, J. (2022). A novel approach to analyze white noise ERGs in mice . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Stallwitz, N., Joachimsthaler, A., & Kremers, J. (2022). Luminance white noise electroretinograms (wnERGs) in mice . Frontiers in Neuroscience , 16 . https://doi.org/10.3389/fnins.2022.1075126
Vidal, K.S.M., Decleva, D., Barboni, M.T.S., Nagy, B.V., De Menezes, P.A.H., Aher, A.,... Ventura, D.F. (2022). The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease . Investigative Ophthalmology & Visual Science , 63 (5). https://doi.org/10.1167/iovs.63.5.20
2021
Aher, A., Horn, F., Huchzermeyer, C., Lämmer, R., & Kremers, J. (2021). Responses of postreceptoral pathways elicited by L- And M-cone isolating ON- And OFF-electroretinograms in glaucoma patients . Investigative Ophthalmology & Visual Science , 62 (9). https://doi.org/10.1167/iovs.62.9.14
Aher, A., Horn, F., Huchzermeyer, C., Lämmer, R., & Kremers, J. (2021). Spatial properties of L- and M-cone driven incremental (on-) and decremental (off-) electroretinograms: normal subjects Vs. glaucoma patients . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Assis, J.B., Brasil, A., Loureiro, T.M.G., da Silva, V.G.R., Herculano, A.M., Ventura, D.F.,... Souza, G.S. (2021). Pseudorandom full-field electroretinograms reflect different light adaptation mechanisms . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-021-09822-2
Barboni, M.T.S., Dias, S.L., Silva, L.A., Damico, F.M., Vidal, K.S., Costa, M.F.,... Ventura, D.F. (2021). Correlations between dark-adapted rod threshold elevations and erg response deficits in duchenne muscular dystrophy . Investigative Ophthalmology & Visual Science , 62 (4). https://doi.org/10.1167/iovs.62.4.29
Barboni, M.T.S., Liber, A.M.P., Joachimsthaler, A., Saoudi, A., Goyenvalle, A., Rendon, A.,... Vaillend, C. (2021). Altered visual processing in the mdx52 mouse model of Duchenne muscular dystrophy . Neurobiology of Disease , 152 . https://doi.org/10.1016/j.nbd.2021.105288
Dussan Molinos, L., Huchzermeyer, C., Lämmer, R., Kremers, J., & Horn, F. (2021). Blue-Yellow VEP with Projector-Stimulation in Glaucoma . Graefes Archive For Clinical and Experimental Ophthalmology . https://doi.org/10.1007/s00417-021-05473-w
Fars, J., Fernandes, T.M.P., Huchzermeyer, C., Kremers, J., & Paramei, G.V. (2021). Chromatic discrimination: The response window does matter for veridical measurement in mature observers . In PERCEPTION (pp. 114-114). LONDON: SAGE PUBLICATIONS LTD.
Fars, J., Huchzermeyer, C., & Kremers, J. (2021). Psychometric curves in retinitis pigmentosa patients . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Fars, J., Pasutto, F., Kremers, J., & Huchzermeyer, C. (2021). Perifoveal cone- And rod-mediated temporal contrast sensitivities in stargardt disease/fundus flavimaculatus . Investigative Ophthalmology & Visual Science , 62 (14). https://doi.org/10.1167/iovs.62.14.24
Huchzermeyer, C., Fars, J., & Kremers, J. (2021). Relationship between temporal L-coneflicker sensitivity and established clinical parameters in Stargardt's disease . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., Horn, F., Lämmer, R., Mardin, C., & Kremers, J. (2021). Summation of Temporal L-Cone- and M-Cone-Contrast in the Magno- and Parvocellular Retino-Geniculate Systems in Glaucoma . Investigative Ophthalmology & Visual Science , 62 (6), 17-. https://doi.org/10.1167/iovs.62.6.17
Joachimsthaler, A., Stallwitz, N., & Kremers, J. (2021). Combining temporal white noise stimulation and silent substitution technique: wnERGs driven by single photoreceptor types in LIAIS mice . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Kremers, J., Aher, A., Parry, N.R., Patel, N.B., & Frishman, L.J. (2021). Comparison of macaque and human L- and M-cone driven electroretinograms . Experimental Eye Research , 206 . https://doi.org/10.1016/j.exer.2021.108556
Kremers, J., Aher, A., & Stuewe, K. (2021). Linking ERG recordings to psychophysical data in human subjects . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Lux, U., Ehrenberg, J., Joachimsthaler, A., Atorf, J., Pircher, B., Reim, K.,... Brandstätter, J.H. (2021). Cell types and synapses expressing the snare complex regulating proteins complexin 1 and complexin 2 in mammalian retina . International Journal of Molecular Sciences , 22 (15). https://doi.org/10.3390/ijms22158131
Ryl, M., Urbasik, A., Gierke, K., Babai, N., Joachimsthaler, A., Feigenspan, A.,... Brandstätter, J.H. (2021). Genetic disruption of bassoon in two mutant mouse lines causes divergent retinal phenotypes . The FASEB Journal , 35 (5), e21520-. https://doi.org/10.1096/fj.202001962R
Vidal, K.S., Aher, A., Ventura, D.F., & Kremers, J. (2021). The spatial distribution of ERGs reflecting luminance and L-/M-cone-opponent signals . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-020-09807-7
2020
Barboni, M.T.S., Dias, S., Silva, L., Damico, F.M., Vidal, K.S., Costa, M.F.,... Ventura, D.F. (2020). Dark adapted cone/rod thresholds and ERGs in Duchenne muscular dystrophy . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ONLINE: ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Fars, J., Kremers, J., & Huchzermeyer, C. (2020). Discriminating anomalous trichromacy and cone degeneration in retinitis pigmentosa patients . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ONLINE: ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Gierke, K., von Wittgenstein, J., Hemmerlein, M., Atorf, J., Joachimsthaler, A., Kremers, J.,... Brandstätter, J.H. (2020). Heterogeneous presynaptic distribution of munc13 isoforms at retinal synapses and identification of an unconventional bipolar cell type with dual expression of munc13 isoforms: A study using munc13-exfp knock-in mice . International Journal of Molecular Sciences , 21 (21), 1-20. https://doi.org/10.3390/ijms21217848
Huchzermeyer, C., Fars, J., & Kremers, J. (2020). Photoreceptor-specific loss of perifoveal temporal contrassensitivity in retinitis pigmentosa . Translational Vision Science & Technology , 9 (6), 1-15. https://doi.org/10.1167/TVST.9.6.27
Huchzermeyer, C., Fars, J., Lorenz, B., & Kremers, J. (2020). Patterns of photoreceptor-specific temporal contrast sensitivity losses in patients with different phenotypic variants of retinitis pigmentosa . In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE . ONLINE: ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
Huchzermeyer, C., Fars, J., Stöhr, H., & Kremers, J. (2020). Neue Techniken zur Quantifizierung des Farbsinns bei Störungen der Zapfenfunktion . Ophthalmologe . https://doi.org/10.1007/s00347-020-01119-0
Kremers, J., McKeefry, D.J., Murray, I.J., & Parry, N.R. (2020). Developments in non-invasive visual electrophysiology . Vision research , 174 , 50-56. https://doi.org/10.1016/j.visres.2020.05.003
Nittmann, M.G., Aher, A., Kremers, J., & Tzekov, R. (2020). Relationship between stimulus size and different components of the electroretinogram (ERG) elicited by flashed stimuli . Documenta Ophthalmologica . https://doi.org/10.1007/s10633-020-09797-6
Parry, N.R.A., Mckeefry, D.J., Murray, I.J., & Kremers, J. (2020). New developments in non-invasive visual electrophysiology. Vision research , 174 , 77-78. https://doi.org/10.1016/j.visres.2020.06.002
Salgueiro Barboni, M.T., Vaillend, C., Joachimsthaler, A., Passos Liber, A.M., Khabou, H., Roux, M.J.,... Kremers, J. (2020). Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71 . Investigative Ophthalmology & Visual Science , 61 (2). https://doi.org/10.1167/iovs.61.2.11
Wise, E.N., Foster, M.L., Kremers, J., & Mowat, F.M. (2020). A modified silent substitution electroretinography protocol to separate photoreceptor subclass function in lightly sedated dogs . Veterinary Ophthalmology . https://doi.org/10.1111/vop.12847
Yan, X., Atorf, J., Ramos, D., Thiele, F., Weber, S., Dalke, C.,... Graw, J. (2020). Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice . Investigative Ophthalmology & Visual Science , 61 (2). https://doi.org/10.1167/iovs.61.2.44
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