Advanced imaging in gastroenterology.
Research projects
molecular endoscopy optoacoustics near infraved imaging
Current projects Current projects
Recent publications Recent publications
2024
Neurath, M. (2024). Strategies for targeting cytokines in inflammatory bowel disease . Nature reviews. Immunology . https://dx.doi.org/10.1038/s41577-024-01008-6
Neurath, M. (2024). The Proteomic Signature of Tissue Remodeling in Chronic Intestinal Inflammation . Cellular and Molecular Gastroenterology and Hepatology , 17 (4), 660-661. https://dx.doi.org/10.1016/j.jcmgh.2024.01.019
Overbeek, K.A., Poulsen, J.L., Lanzillotta, M., Vinge-Holmquist, O., Macinga, P., Demirci, A.F.,... Gubergrits, N. (2024). Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment . Clinical Gastroenterology and Hepatology . https://dx.doi.org/10.1016/j.cgh.2023.12.010
Regensburger, A., Eckstein, M., Wetzl, M., Raming, R., Paulus, L.-P., Bühler, A.,... Knieling, F. (2024). Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease . Photoacoustics , 35 . https://doi.org/10.1016/j.pacs.2023.100578
Thoma, O.-M., Naschberger, E., Kubánková, M., Larafa, I., Kramer, V., Menchicchi, B.,... Waldner, M. (2024). p21 Prevents the Exhaustion of CD4+ T Cells Within the Antitumor Immune Response Against Colorectal Cancer . Gastroenterology , 166 (2), 284-297.e11. https://doi.org/10.1053/j.gastro.2023.09.017
Träger, A.P., Günther, J., Raming, R., Paulus, L.-P., Lang, W., Meyer, A.,... Rother, U. (2024). Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease . Photoacoustics , 35 . https://doi.org/10.1016/j.pacs.2023.100579
Vitali, F., Rath, T., Klenske, E., Vögele, A.-L., Ganzleben, I., Zundler, S.,... Atreya, R. (2024). Long-term outcomes of cyclosporin induction and ustekinumab maintenance combination therapy in patients with steroid-refractory acute severe ulcerative colitis . Therapeutic Advances in Gastroenterology , 17 . https://doi.org/10.1177/17562848231218555
Wiendl, M., Dedden, M., Liu, L., Schweda, A., Paap, E.-M., Ullrich, K.,... Zundler, S. (2024). Etrolizumab-s fails to control E-Cadherin-dependent co-stimulation of highly activated cytotoxic T cells . Nature Communications , 15 (1). https://doi.org/10.1038/s41467-024-45352-6
2023
Atreya, R., & Neurath, M. (2023). Further efficacy and safety data for maintenance upadacitinib in ulcerative colitis . Lancet Gastroenterology and Hepatology . https://dx.doi.org/10.1016/S2468-1253(23)00271-6
Atreya, R., & Neurath, M. (2023). The sphingosine-1-phosphate receptor agonist etrasimod in ulcerative colitis . Lancet . https://dx.doi.org/10.1016/S0140-6736(23)00228-3
Baronetto, A., Graf, L., Fischer, S., Neurath, M., & Amft, O. (2023). Segment-Based Spotting of Bowel Sounds Using Pretrained Models in Continuous Data Streams . IEEE Journal of Biomedical and Health Informatics , 1-12. https://dx.doi.org/10.1109/JBHI.2023.3269910
Bühler, A., Brown, E., Paulus, L.-P., Eckstein, M., Thoma, O.-M., Oraiopoulou, M.-E.,... Regensburger, A. (2023). Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free In Vivo Assessment of Colitis . Advanced Science . https://doi.org/10.1002/advs.202300564
Chiriac, M.-T., Hracsko, Z., Becker, C., & Neurath, M. (2023). STAT2 Controls Colorectal Tumorigenesis and Resistance to Anti-Cancer Drugs . Cancers , 15 (22). https://dx.doi.org/10.3390/cancers15225423
Chiriac, M.-T., Hracsko, Z., Günther, C., Gonzalez Acera, M., Atreya, R., Stolzer, I.,... Neurath, M. (2023). IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling . Gut . https://doi.org/10.1136/gutjnl-2023-329628
Danko, V., Jüngert, J.M., Schüssler, S., Bühler, A., Klett, D., Federle, A.,... Wagner, A. (2023). Hybrid reflected-ultrasound computed tomography versus B-mode-ultrasound for muscle scoring in spinal muscular atrophy . Journal of Neuroimaging . https://doi.org/10.1111/jon.13081
De Boer, N.K., Simsek, M., Meijer, B., Neurath, M., Van Bodegraven, A., & Mulder, C.J. (2023). Drug rediscovery in gastroenterology: From off-label to on-label use of thioguanine in inflammatory bowel disease . Gut . https://dx.doi.org/10.1136/gutjnl-2023-329679
Dedden, M., Wiendl, M., Müller, T., Neurath, M., & Zundler, S. (2023). Manual cell selection in single cell transcriptomics using scSELpy supports the analysis of immune cell subsets . Frontiers in Immunology , 14 . https://doi.org/10.3389/fimmu.2023.1027346
Günther, J., Knieling, F., Träger, A.P., Lang, W., Meyer, A., Regensburger, A.,... Rother, U. (2023). Targeting Muscular Hemoglobin Content for Classification of Peripheral Arterial Disease by Noninvasive Multispectral Optoacoustic Tomography . Journal of the American College of Cardiology : Cardiovascular imaging , 16 (5), 719-721. https://doi.org/10.1016/j.jcmg.2022.11.010
Hardt, L., Herrmann, H.J., Reljic, D., Jaensch, P., Zerth, J., Neurath, M., & Zopf, Y. (2023). Are Guideline Recommendations on Supportive Nutrition and Exercise Therapy for Cancer Patients Implemented in Clinical Routine? A National Survey with Real-Life Data . Nutrients , 15 (14). https://dx.doi.org/10.3390/nu15143172
Heidbreder, K., Sommer, K., Wiendl, M., Müller, T., Atreya, I., Hildner, K.,... Zundler, S. (2023). Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine . Frontiers in Immunology , 13 . https://doi.org/10.3389/fimmu.2022.1040775
Jefremow, A., & Neurath, M. (2023). Novel Small Molecules in IBD: Current State and Future Perspectives . Cells , 12 (13). https://dx.doi.org/10.3390/cells12131730
Koop, K., Enderle, K., Hillmann, M., Ruspeckhofer, L., Vieth, M., Sturm, G.,... Neufert, C. (2023). Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis . Frontiers in Immunology , 14 . https://doi.org/10.3389/fimmu.2023.1163198
Lindemann, A., Roth, D., Koop, K., Neufert, C., Zundler, S., Atreya, R.,... Leppkes, M. (2023). Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis . Frontiers in Medicine , 10 . https://doi.org/10.3389/fmed.2023.1177450
Matthe, D., Dinkel, M., Schmid, B., Vogler, T., Neurath, M., Poeck, H.,... Hildner, K. (2023). Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease . Frontiers in Immunology , 14 . https://doi.org/10.3389/fimmu.2023.1253514
Müller, T., Liu, L., Czerwinski, T., Wiesinger, M., Dedden, M., Paap, E.-M.,... Bosch-Voskens, C. (2023). Increased Motility and Suppression of Ex Vivo–Expanded Regulatory T Cells Designed for Adoptive Transfer Therapy in Ulcerative Colitis . Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2023.04.002
Neurath, M., & Vieth, M. (2023). Different levels of healing in inflammatory bowel diseases: mucosal, histological, transmural, barrier and complete healing . Gut . https://dx.doi.org/10.1136/gutjnl-2023-329964
Paulus, L.-P., Bühler, A., Wagner, A., Raming, R., Jüngert, J., Simon, D.,... Knieling, F. (2023). Contrast-Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract . Advanced Science . https://doi.org/10.1002/advs.202302562
Paulus, L.-P., Wagner, A., Buehler, A., Raming, R., Jüngert, J., Simon, D.,... Regensburger, A. (2023). Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow . Photoacoustics , 30 . https://doi.org/10.1016/j.pacs.2023.100457
Pietschner, R., Rath, T., Neurath, M., & Atreya, R. (2023). Current and Emerging Targeted Therapies for Ulcerative Colitis. Visceral Medicine , 39 (2), 46-53. https://dx.doi.org/10.1159/000530983
Rath, T., Atreya, R., Bodenschatz, J., Uter, W., Geppert, C.-I., Vitali, F.,... Neurath, M. (2023). Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial . Gastroenterology , 164 (2), 241-255. https://dx.doi.org/10.1053/j.gastro.2022.10.014
Rath, T., Atreya, R., Bodenschatz, J., Uter, W., Geppert, C.-I., Vitali, F.,... Neurath, M. (2023). Healing of the epithelial barrier in the ileum is superior to endoscopic and histologic remission for predicting major adverse outcomes in ulcerative colitis . Frontiers in Medicine , 10 . https://doi.org/10.3389/fmed.2023.1221449
Rath, T., Atreya, R., & Neurath, M. (2023). A spotlight on intestinal permeability and inflammatory bowel diseases . Expert Review of Gastroenterology and Hepatology , 17 (9), 893-902. https://dx.doi.org/10.1080/17474124.2023.2242772
Reljic, D., Frenk, F., Herrmann, H.J., Neurath, M., & Zopf, Y. (2023). Maximum Heart Rate- and Lactate Threshold-Based Low-Volume High-Intensity Interval Training Prescriptions Provide Similar Health Benefits in Metabolic Syndrome Patients . Healthcare , 11 (5). https://dx.doi.org/10.3390/healthcare11050711
Reljic, D., Koller, A., Herrmann, H.J., Ekici, A.B., Neurath, M., & Zopf, Y. (2023). Differential Effects of Very-Low-Volume Exercise Modalities on Telomere Length, Inflammation, and Cardiometabolic Health in Obese Metabolic Syndrome Patients: A Subanalysis from Two Randomized Controlled Trials . Antioxidants , 12 (10). https://dx.doi.org/10.3390/antiox12101847
Schnell, A., Jüngert, J.M., Klett, D., Hober, H., Kaiser, N., Ruppel, R.,... Regensburger, A. (2023). Increase of liver stiffness and altered bile acid metabolism after triple CFTR modulator initiation in children and young adults with cystic fibrosis . Liver International . https://doi.org/10.1111/liv.15544
Schulze, L., Becker, E., Dedden, M., Liu, L., Van Passen, C., Mohamed Abdou, M.,... Zundler, S. (2023). Differential Effects of Ontamalimab Versus Vedolizumab on Immune Cell Trafficking in Intestinal Inflammation and Inflammatory Bowel Disease . Journal of Crohns & Colitis , 17 (11), 1817-1832. https://doi.org/10.1093/ecco-jcc/jjad088
Sommer, K., Heidbreder, K., Kreiß, L., Dedden, M., Paap, E.-M., Wiendl, M.,... Zundler, S. (2023). Anti-beta 7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing . Clinical and Translational Medicine , 13 (4). https://dx.doi.org/10.1002/ctm2.1233
Soteriou, D., Kubankova, M., Schweitzer, C., Lopez Posadas, R., Pradhan, R., Thoma, O.-M.,... Guck, J. (2023). Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies . Nature Biomedical Engineering . https://doi.org/10.1038/s41551-023-01015-3
Stolzer, I., Scherer, E., Süß, P., Rothhammer, V., Winner, B., Neurath, M., & Günther, C. (2023). Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration . International Journal of Molecular Sciences , 24 (19). https://dx.doi.org/10.3390/ijms241914925
Ullrich, K., Derdau, J., Baltes, C., Battistella, A., Rosso, G., Uderhardt, S.,... Zundler, S. (2023). IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells. Gut , 72 (11), 2081-2094. https://doi.org/10.1136/gutjnl-2023-329818
Verstockt, B., Salas, A., Sands, B.E., Abraham, C., Leibovitzh, H., Neurath, M., & Vande Casteele, N. (2023). IL-12 and IL-23 pathway inhibition in inflammatory bowel disease . Nature Reviews Gastroenterology & Hepatology . https://dx.doi.org/10.1038/s41575-023-00768-1
Vetter, M., Waldner, M., Zundler, S., Klett, D., Bocklitz, T., Neurath, M.,... Jesper, D. (2023). Artificial intelligence for the classification of focal liver lesions in ultrasound - a systematic review. Ultraschall in der Medizin , 44 (4), 395-407. https://doi.org/10.1055/a-2066-9372
Vitali, F., Zundler, S., Jesper, D., Strobel, D., Wildner, D., De Pretis, N.,... Neurath, M. (2023). Endoscopic Ultrasound in Pancreatology: Focus on Inflammatory Diseases and Interventions . Visceral Medicine . https://doi.org/10.1159/000533433
Vitali, F., Zundler, S., Jesper, D., Wildner, D., Strobel, D., Frulloni, L., & Neurath, M. (2023). Diagnostic Endoscopic Ultrasound in Pancreatology: Focus on Normal Variants and Pancreatic Masses . Visceral Medicine , 39 (5), 121-130. https://doi.org/10.1159/000533432
Waldner, M., & Neurath, M. (2023). TGFβ and the Tumor Microenvironment in Colorectal Cancer . Cells , 12 (8). https://dx.doi.org/10.3390/cells12081139
Weber, S., Sitte, S., Vögele, A.-L., Sologub, L., Wilfer, A., Rath, T.,... Atreya, R. (2023). NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases . Journal of Crohns & Colitis . https://doi.org/10.1093/ecco-jcc/jjad164
Wittner, L., Wagener, L., Wiese, J.J., Stolzer, I., Krug, S.M., Naschberger, E.,... Günther, C. (2023). Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing . International Journal of Molecular Sciences , 24 (8). https://dx.doi.org/10.3390/ijms24087402
Zundler, S., Vitali, F., Kharboutli, S., Völkl, S., Polifka, I., Mackensen, A.,... Mougiakakos, D. (2023). Case Report: IBD-like colitis following CAR T cell therapy for diffuse large B cell lymphoma . Frontiers in Oncology , 13 . https://doi.org/10.3389/fonc.2023.1149450
2022
Atreya, I., & Neurath, M. (2022). How the Tumor Micromilieu Modulates the Recruitment and Activation of Colorectal Cancer-Infiltrating Lymphocytes . Biomedicines , 10 (11). https://dx.doi.org/10.3390/biomedicines10112940
Atreya, R., Bojarski, C., Kühl, A.A., Trajanoski, Z., Neurath, M., & Siegmund, B. (2022). Ileal and colonic Crohn's disease: Does location makes a difference in therapy efficacy? Current Research in Pharmacology and Drug Discovery , 3 . https://doi.org/10.1016/j.crphar.2022.100097
Atreya, R., & Neurath, M. (2022). Deciphering Novel Mechanistic and Pharmacokinetic Effects of Tofacitinib in Intestinal Inflammation: Expect the Unexpected . Cellular and Molecular Gastroenterology and Hepatology , 13 (2), 672-673. https://dx.doi.org/10.1016/j.jcmgh.2021.10.003
Atreya, R., & Neurath, M. (2022). IL-23 Blockade in Anti-TNF Refractory IBD: From Mechanisms to Clinical Reality . Journal of Crohns & Colitis , 16 (SUPPL 2). https://dx.doi.org/10.1093/ecco-jcc/jjac007
Atreya, R., & Neurath, M. (2022). Induction of microRNA-124 as a novel therapeutic concept in ulcerative colitis . Lancet Gastroenterology and Hepatology , 7 (11), 977-978. https://dx.doi.org/10.1016/S2468-1253(22)00249-7
Atreya, R., & Neurath, M. (2022). Inflammatory bowel diseases - therapy update 2022 Chronisch-entzündliche Darmerkrankungen . Deutsche Medizinische Wochenschrift , 147 (6), 295-300. https://dx.doi.org/10.1055/a-1585-4026
Becker, E., Schweda, A., Ullrich, K., Voskens, C., Atreya, R., Müller, T.,... Zundler, S. (2022). Limited Dose-Dependent Effects of Vedolizumab on Various Leukocyte Subsets . Clinical and Translational Gastroenterology , 13 (6), e00494-. https://doi.org/10.14309/ctg.0000000000000494
Besendorf, L., Müller, T., Geppert, C.-I., Schneider, I., Mühl, L., Atreya, I.,... Zundler, S. (2022). Vedolizumab blocks alpha 4 beta 7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis . Therapeutic Advances in Gastroenterology , 15 . https://doi.org/10.1177/17562848221098899
Beyna, T., Moreels, T., Arvanitakis, M., Pioche, M., Saurin, J.-C., May, A.,... Neuhaus, H. (2022). Motorized spiral enteroscopy: Results of an international multicenter prospective observational clinical study in patients with normal and altered gastrointestinal anatomy . Endoscopy . https://dx.doi.org/10.1055/a-1831-6215
Casadei-Gardini, A., Rimini, M., Kudo, M., Shimose, S., Tada, T., Suda, G.,... Cascinu, S. (2022). Real Life Study of Lenvatinib Therapy for Hepatocellular Carcinoma: RELEVANT Study . Liver Cancer , 11 (6), 527-539. https://dx.doi.org/10.1159/000525145
Denk, D., Petrocelli, V., Conche, C., Drachsler, M., Ziegler, P.K., Braun, A.,... Greten, F.R. (2022). Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy . Immunity , 55 (11), 2059-2073.e8. https://dx.doi.org/10.1016/j.immuni.2022.09.014
Dieterich, W., Schuster, C., Gundel, P., Scherf, K.A., Pronin, D., Geisslitz, S.,... Zopf, Y. (2022). Proteins from Modern and Ancient Wheat Cultivars: Impact on Immune Cells of Healthy Individuals and Patients with NCGS . Nutrients , 14 (20). https://dx.doi.org/10.3390/nu14204257
Dubinsky, M.C., Magro, F., Steinwurz, F., Hudesman, D.P., Kinnucan, J.A., Ungaro, R.C.,... Regueiro, M. (2022). Association of C-reactive Protein and Partial Mayo Score With Response to Tofacitinib Induction Therapy: Results From the Ulcerative Colitis Clinical Program . Inflammatory Bowel Diseases . https://dx.doi.org/10.1093/ibd/izac061
Düll, M., Karlen, V., Vetter, M., Dietrich, P., Kupfer, J., Neurath, M., & Kremer, A. (2022). Chronic pruritus represents a major burden in non-cholestatic hepatobiliary disorders . In JOURNAL OF HEPATOLOGY (pp. S163-S163). AMSTERDAM: ELSEVIER.
Gabel, M., Knauß, A., Fischer, D., Neurath, M., & Weigmann, B. (2022). Surface Design Options in Polymer- and Lipid-Based siRNA Nanoparticles Using Antibodies . International Journal of Molecular Sciences , 23 (22). https://dx.doi.org/10.3390/ijms232213929
Ganzleben, I., Klett, D., Hartz, W., Götzfried, L., Vitali, F., Neurath, M., & Waldner, M. (2022). Multispectral optoacoustic tomography for the non-invasive identification of patients with severe anemia in vivo . Photoacoustics , 28 . https://dx.doi.org/10.1016/j.pacs.2022.100414
Gerlach, K., Popp, V., Wirtz, S., Al-Saifi, R., Gonzalez Acera, M., Atreya, R.,... Neurath, M. (2022). PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells . Journal of Crohns & Colitis . https://dx.doi.org/10.1093/ecco-jcc/jjac097
Gerner, M., Vuillerme, N., Aubourg, T., Messner, E.M., Terhorst, Y., Hörmann, V.,... Orlemann, T. (2022). Review and Analysis of German Mobile Apps for Inflammatory Bowel Disease Management Using the Mobile Application Rating Scale: Systematic Search in App Stores and Content Analysis . JMIR mHealth and uHealth , 10 (5). https://doi.org/10.2196/31102
Gámez Belmonte, M.d.l.R., Mahapatro, M., Erkert, L., Gonzalez Acera, M., Naschberger, E., Yu, Y.,... Becker, C. (2022). Epithelial presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling . Gut . https://dx.doi.org/10.1136/gutjnl-2022-327323
Gähler, A., Trufa, D., Chiriac, M.-T., Tausche, P., Hohenberger, K., Brunst, A.-K.,... Neurath-Finotto, S. (2022). Glucose-Restricted Diet Regulates the Tumor Immune Microenvironment and Prevents Tumor Growth in Lung Adenocarcinoma . Frontiers in Oncology , 12 . https://doi.org/10.3389/fonc.2022.873293
Günther, C., Winner, B., Neurath, M., & Stappenbeck, T.S. (2022). Organoids in gastrointestinal diseases: from experimental models to clinical translation . Gut . https://dx.doi.org/10.1136/gutjnl-2021-326560
Heichler, C., Schmied, A., Enderle, K., Scheibe, K., Murawska, M., Schmid, B.,... Neufert, C. (2022). Targeting STAT3 Signaling in COL1+ Fibroblasts Controls Colitis-Associated Cancer in Mice . Cancers , 14 (6). https://doi.org/10.3390/cancers14061472
Heim, L., Yang, Z., Tausche, P., Hohenberger, K., Chiriac, M.-T., Kölle, J.,... Neurath-Finotto, S. (2022). IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer . Frontiers in Immunology , 13 . https://doi.org/10.3389/fimmu.2022.859738
Hohmann, M., Ganzleben, I., Grünberg, A., Menezes, J.G., Klämpfl, F., Lengenfelder, B.,... Schmidt, M. (2022). In vivo multi spectral colonoscopy in mice . Scientific Reports , 12 (1). https://doi.org/10.1038/s41598-022-12794-1
Klett, D., Jesper, D., Vitali, F., Federle, A., Atreya, R., Strobel, D.,... Waldner, M. (2022). Non-invasive assessment of intestinal inflammatory activity in Ulcerative Colitis by Multispectral Optoacoustic Tomography (MSOT) . In JOURNAL OF CROHNS & COLITIS (pp. I062-I062). OXFORD: OXFORD UNIV PRESS.
Kliem, T., Strobel, D., Heinke, F., Pavel, M.E., Neurath, M., & Neufert, C. (2022). Case report: persistent fever after SARS-CoV-2 infection Fallbericht: Persistierendes Fieber nach SARS-CoV-2-Infektion . Internist . https://doi.org/10.1007/s00108-022-01315-x
Knauß, A., Gabel, M., Neurath, M., & Weigmann, B. (2022). The Memory T Cell “Communication Web” in Context with Gastrointestinal Disorders—How Memory T Cells Affect Their Surroundings and How They Are Influenced by It . Cells , 11 (18). https://dx.doi.org/10.3390/cells11182780
Kreiß, L., Ganzleben, I., Mühlberg, A., Ritter, P., Schneidereit, D., Becker, C.,... Waldner, M. (2022). Label-free analysis of inflammatory tissue remodeling in murine lung tissue based on multiphoton microscopy, Raman spectroscopy and machine learning . Journal of Biophotonics . https://doi.org/10.1002/jbio.202200073
Kreiß, L., Thoma, O.-M., Lemire, S., Lechner, K., Carlé, B.-E., Dilipkumar, A.,... Waldner, M. (2022). Label-Free Characterization and Quantification of Mucosal Inflammation in Common Murine Colitis Models With Multiphoton Imaging . Inflammatory Bowel Diseases . https://doi.org/10.1093/ibd/izac114
Lanfer, J., Winner, B., Kaindl, J., Krumm, L., Acera, M.G., Neurath, M.,... Krach, F. (2022). Efficient and Easy Conversion of Human iPSCs into Functional Induced Microglia-like Cells . International Journal of Molecular Sciences , 23 (9). https://dx.doi.org/10.3390/ijms23094526
Lechner, K., Zeeshan, M., Noack, M., Ali, H., Neurath, M., & Weigmann, B. (2022). Small but powerful: will nanoparticles be the future state‐of‐the‐art therapy for IBD? Expert Opinion on Drug Delivery . https://dx.doi.org/10.1080/17425247.2022.2043847
Lemire, S., Thoma, O.-M., Kreiß, L., Völkl, S., Friedrich, O., Neurath, M.,... Waldner, M. (2022). Natural NADH and FAD Autofluorescence as Label-Free Biomarkers for Discriminating Subtypes and Functional States of Immune Cells . International Journal of Molecular Sciences , 23 (4). https://doi.org/10.3390/ijms23042338
Leppkes, M., Lindemann, A., Goesswein, S., Paulus, S., Roth, D., Hartung, A.,... Neurath, M. (2022). Neutrophils prevent rectal bleeding in Ulcerative Colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis . In JOURNAL OF CROHNS & COLITIS (pp. I178-I179). OXFORD: OXFORD UNIV PRESS.
Leppkes, M., & Neurath, M. (2022). Rear Window—What Can the Gut Tell Us About Long-COVID? Gastroenterology , 163 (2), 376-378. https://dx.doi.org/10.1053/j.gastro.2022.05.044
Martínez Sánchez, L.d.C., Phuong Anh Ngo, ., Pradhan, R., Becker, L.S., Böhringer, D., Soteriou, D.,... Lopez Posadas, R. (2022). Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation . Gut . https://doi.org/10.1136/gutjnl-2021-325520
Matthe, D., Thoma, O.-M., Sperka, T., Neurath, M., & Waldner, M. (2022). Telomerase deficiency reflects age-associated changes in CD4+T cells . Immunity & Ageing , 19 (1). https://dx.doi.org/10.1186/s12979-022-00273-0
Monteleone, G., Stolfi, C., Marafini, I., Atreya, R., & Neurath, M. (2022). Smad7 Antisense Oligonucleotide-Based Therapy in Crohn's Disease: Is it Time to Re-Evaluate? Molecular Diagnosis & Therapy . https://dx.doi.org/10.1007/s40291-022-00606-1
Neurath, M. (2022). Targeting cytokines in inflammatory bowel disease. Science Translational Medicine , 14 (675). https://dx.doi.org/10.1126/scitranslmed.abq4473
Neurath, M., & Vieth, M. (2022). Is non-invasive Cytosponge the holy grail for Barrett's neoplasia? Lancet Oncology , 23 (2), 190-191. https://dx.doi.org/10.1016/S1470-2045(21)00755-5
Ngo, P.A., Neurath, M., & Lopez Posadas, R. (2022). Impact of Epithelial Cell Shedding on Intestinal Homeostasis . International Journal of Molecular Sciences , 23 (8). https://doi.org/10.3390/ijms23084160
Regensburger, A., Wagner, A., Danko, V., Jüngert, J.M., Federle, A., Klett, D.,... Knieling, F. (2022). Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients . Photoacoustics , 25 . https://doi.org/10.1016/j.pacs.2021.100315
Reljic, D., Dieterich, W., Herrmann, H.J., Neurath, M., & Zopf, Y. (2022). “HIIT the Inflammation”: Comparative Effects of Low-Volume Interval Training and Resistance Exercises on Inflammatory Indices in Obese Metabolic Syndrome Patients Undergoing Caloric Restriction . Nutrients , 14 (10). https://dx.doi.org/10.3390/nu14101996
Reljic, D., Eichhorn, A., Herrmann, H.J., Neurath, M., & Zopf, Y. (2022). Very Low-Volume, High-Intensity Interval Training Mitigates Negative Health Impacts of COVID-19 Pandemic-Induced Physical Inactivity . International Journal of Environmental Research and Public Health , 19 (19). https://dx.doi.org/10.3390/ijerph191912308
Reljic, D., Herrmann, H.J., Jakobs, B., Dieterich, W., Mougiakakos, D., Neurath, M., & Zopf, Y. (2022). Feasibility, Safety, and Preliminary Efficacy of Very Low-Volume Interval Training in Advanced Cancer Patients . Medicine and science in sports and exercise , 54 (11), 1817-1830. https://doi.org/10.1249/MSS.0000000000002989
Reljic, D., Zieseniss, N., Herrmann, H.J., Neurath, M., & Zopf, Y. (2022). Protein Supplementation Does Not Maximize Adaptations to Low-Volume High-Intensity Interval Training in Sedentary, Healthy Adults: A Placebo-Controlled Double-Blind Randomized Study . Nutrients , 14 (19). https://dx.doi.org/10.3390/nu14193883
Schmalzl, A., Leupold, T., Kreiß, L., Waldner, M., Schürmann, S., Neurath, M.,... Wirtz, S. (2022). Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection . Nature Communications , 13 (1). https://doi.org/10.1038/s41467-022-33326-5
Schneider, I., Allner, C., Mühl, L., Melde, M., Lissner, D., Mantzivi, E.,... Zundler, S. (2022). Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease . Translational Research . https://doi.org/10.1016/j.trsl.2022.10.003
Schweda, A., Becker, E., Wiendl, M., Atreya, R., Atreya, I., Müller, T.,... Zundler, S. (2022). Etrolizumab-s Does Not Induce Residual Trafficking of Regulatory T Cells . Inflammatory Bowel Diseases . https://doi.org/10.1093/ibd/izac137
Simon, D., Tascilar, K., Fagni, F., Kleyer, A., Krönke, G., Meder, C.,... Hartmann, F. (2022). Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study. The Lancet Rheumatology , 4 (9), e614-e625. https://doi.org/10.1016/S2665-9913(22)00191-6
Simon, D., Tascilar, K., Kleyer, A., Fagni, F., Krönke, G., Meder, C.,... Schett, G. (2022). Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort . Arthritis and Rheumatology . https://doi.org/10.1002/art.42035
Tascilar, K., Fagni, F., Kleyer, A., Bayat, S., Heidemann, R., Steiger, F.,... Simon, D. (2022). NON-INVASIVE IN VIVO METABOLIC PROFILING OF INFLAMMATION IN JOINTS AND ENTHESES BY OPTOACOUSTIC IMAGING . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1032-1032). LONDON: BMJ PUBLISHING GROUP.
Tascilar, K., Fagni, F., Kleyer, A., Bayat, S., Heidemann, R., Steiger, F.,... Simon, D. (2022). Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography . Rheumatology . https://doi.org/10.1093/rheumatology/keac346
Tascilar, K., Simon, D., Kleyer, A., Fagni, F., Krönke, G., Meder, C.,... Schett, G. (2022). LONG-TERM HUMORAL RESPONSE TO SARS-COV-2 VACCINATION IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASE . In ANNALS OF THE RHEUMATIC DISEASES (pp. 371-372). LONDON: BMJ PUBLISHING GROUP.
Vieth, M., & Neurath, M. (2022). Cold or hot snare in endoscopy - that is the question . Endoscopy International Open , 10 (05), E580-E581. https://dx.doi.org/10.1055/a-1776-7685
Vitali, F., Morgenstern, N., Eckstein, M., Atreya, R., Waldner, M., Hartmann, A.,... Rath, T. (2022). Endocytoscopy for assessing histologic inflammation in ulcerative colitis: development and prospective validation of the ELECT (ErLangen Endocytoscopy in ColiTis) score (with videos) . Gastrointestinal Endoscopy . https://dx.doi.org/10.1016/j.gie.2022.08.023
Voskens, C., Stoica, D., Rosenberg, M., Vitali, F., Zundler, S., Ganslmayer, M.,... Neurath, M. (2022). Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis . Gut . https://doi.org/10.1136/gutjnl-2022-327075
Waldner, M., & Neurath, M. (2022). Molecular Endoscopy for the Diagnosis and Therapeutic Monitoring of Colorectal Cancer . Frontiers in Oncology , 12 . https://doi.org/10.3389/fonc.2022.835256
Wildner, D., Pfeifer, L., Vitali, F., Neurath, M., & Albrecht, H. (2022). Transabdominal ultrasonography for confirmation of accurate percutaneous endoscopic gastrostomy tube placement: analysis of patient- and procedure-related complications . Medical Ultrasonography , 24 (4), 399-405. https://dx.doi.org/10.11152/mu-3672
Yu, Y., Herrmann, A., Thonn, V., Cordsmeier, A., Neurath, M., Enßer, A., & Becker, C. (2022). SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial Cells . Cells , 11 (8). https://dx.doi.org/10.3390/cells11081262
Yu, Y., Thonn, V., Patankar, J., Thoma, O.-M., Waldner, M., Zielinska, M.,... Becker, C. (2022). SMYD2 targets RIPK1 and restricts TNF-induced apoptosis and necroptosis to support colon tumor growth . Cell Death & Disease , 13 (1). https://doi.org/10.1038/s41419-021-04483-0
Zundler, S., Günther, C., Kremer, A.E., Rothhammer, V., Neurath, M., & Zaiss, M. (2022). Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation . Nature Reviews Gastroenterology & Hepatology . https://doi.org/10.1038/s41575-022-00663-1
Zundler, S., Mardin, C., Bertz, S., Vitali, F., Strauss, R., Fürst, J.,... Strobel, D. (2022). Rectal Cancer Presenting with Absceding Infection Due to Fusobacterium nucleatum . Pathogens , 11 (10). https://doi.org/10.3390/pathogens11101113
Zundler, S., Schulze, L., & Neurath, M. (2022). Controlling in and out - the future of interfering with immune cell trafficking in inflammatory bowel disease . Expert Review of Clinical Immunology . https://doi.org/10.1080/1744666X.2023.2152794
2021
Al-Zaher, N., Vitali, F., Neurath, M., & Görtz, R. (2021). The Positive Rate of Pulmonary Embolism by CT Pulmonary Angiography Is High in an Emergency Department, even in Low-Risk or Young Patients . Medical Principles and Practice , 30 (1), 37-44. https://dx.doi.org/10.1159/000511464
Atreya, R., & Neurath, M. (2021). Can Serum Proteomic Profiling Annunciate Individual Disease Progression in Newly Diagnosed Inflammatory Bowel Disease Patients? Journal of Crohns & Colitis , 15 (5), 697-698. https://dx.doi.org/10.1093/ecco-jcc/jjab009
Baumgartner, M., Lang, M., Holley, H., Crepaz, D., Hausmann, B., Pjevac, P.,... Gasche, C. (2021). Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis . Gastroenterology . https://doi.org/10.1053/j.gastro.2021.06.024
Becker, E., Dedden, M., Gall, C., Wiendl, M., Ekici, A.B., Schulz-Kuhnt, A.,... Zundler, S. (2021). Residual homing of alpha 4 beta 7-expressing beta 1(+)PI16(+) regulatory T cells with potent suppressive activity correlates with exposure-efficacy of vedolizumab . Gut . https://doi.org/10.1136/gutjnl-2021-324868
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Bittel, M., Reichert, P., Sarfati, I., Dressel, A., Leikam, S., Uderhardt, S.,... Momma, S. (2021). Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo . Journal of Extracellular Vesicles , 10 (12). https://dx.doi.org/10.1002/jev2.12159
Bojarski, C., Waldner, M., Rath, T., Schürmann, S., Neurath, M., Atreya, R., & Siegmund, B. (2021). Innovative Diagnostic Endoscopy in Inflammatory Bowel Diseases: From High-Definition to Molecular Endoscopy . Frontiers in Medicine , 8 . https://doi.org/10.3389/fmed.2021.655404
Boutrid, N., Rahmoune, H., Schett, G., McInnes, I., & Neurath, M. (2021). Reframing immune-mediated inflammatory diseases . New England Journal of Medicine , 385 (21). https://doi.org/10.1056/NEJMc2114894
Buchbender, M., Fehlhofer, J.P., Proff, P., Möst, T., Ries, J., Hannig, M.,... Kesting, M.R. (2021). Expression of inflammatory mediators in biofilm samples and clinical association in inflammatory bowel disease patients—a preliminary study . Clinical Oral Investigations . https://doi.org/10.1007/s00784-021-04093-2
Buchele, V., Konein, P., Vogler, T., Kunert, T., Enderle, K., Khan, H.,... Hildner, K. (2021). Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner . Frontiers in Immunology , 11 . https://doi.org/10.3389/fimmu.2020.590893
Dieterich, W., Tietz, E., Kohl, M., Konturek, P.C., Rath, T., Neurath, M., & Zopf, Y. (2021). Food Intolerance of Unknown Origin: Caused by Mucosal Inflammation? A Pilot Study . Clinical and Translational Gastroenterology , 12 (2), e00312-. https://dx.doi.org/10.14309/ctg.0000000000000312
Drobny, A., Ngo, P.A., Neurath, M., Zunke, F., & Lopez-Posadas, R. (2021). Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease . Frontiers in Medicine , 8 . https://dx.doi.org/10.3389/fmed.2021.655123
Düll, M., Wolf, K., Vetter, M., Dietrich, P., Neurath, M., & Kremer, A. (2021). Endogenous Opioid Levels Do Not Correlate With Itch Intensity and Therapeutic Interventions in Hepatic Pruritus . Frontiers in Medicine , 8 . https://doi.org/10.3389/fmed.2021.641163
Dürr, P., Schlichtig, K., Kelz, C., Deutsch, B., Maas, R., Eckart, M.J.,... Fromm, M. (2021). The Randomized AMBORA Trial: Impact of Pharmacological/Pharmaceutical Care on Medication Safety and Patient-Reported Outcomes During Treatment With New Oral Anticancer Agents . Journal of Clinical Oncology , 39 (18), 1983-1994. https://doi.org/10.1200/JCO.20.03088
Elias, M., Zhao, S., Le, H.T., Wang, J., Neurath, M., Neufert, C.,... Rieder, F. (2021). IL-36 in chronic inflammation and fibrosis - bridging the gap? Journal of Clinical Investigation , 131 (2). https://doi.org/10.1172/JCI144336
Enderle, K., Dinkel, M., Spath, E.-M., Schmid, B., Zundler, S., Tripal, P.,... Neufert, C. (2021). Dynamic imaging of iel-iec co-cultures allows for quantification of cd103-dependent t cell migration . International Journal of Molecular Sciences , 22 (10). https://doi.org/10.3390/ijms22105148
Fagni, F., Simon, D., Tascilar, K., Schoenau, V., Sticherling, M., Neurath, M., & Schett, G. (2021). COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses . The Lancet Rheumatology , 3 (10), e724-e736. https://doi.org/10.1016/S2665-9913(21)00247-2
Fischer, S., Cohnen, S., Klenske, E., Schmitt, H., Vitali, F., Hirschmann, S.,... Atreya, R. (2021). Long-term effectiveness, safety and immunogenicity of the biosimilar SB2 in inflammatory bowel disease patients after switching from originator infliximab . Therapeutic Advances in Gastroenterology , 14 . https://doi.org/10.1177/1756284820982802
Fritz, V., Malek, L., Gaza, A., Wormser, L., Appel, M., Kremer, A.,... Siebler, J. (2021). Combined de‐repression of chemoresistance associated mitogen‐activated protein kinase 14 and activating transcription factor 2 by loss of microrna‐622 in hepatocellular carcinoma . Cancers , 13 (5), 1-14. https://doi.org/10.3390/cancers13051183
Ganzleben, I., Kreiß, L., Mühlberg, A., Friedrich, O., Neurath, M., Schürmann, S., & Waldner, M. (2021). Label-free analysis of experimental lung fibrosis using multiphoton microscopy and Raman spectroscopy . In EUROPEAN RESPIRATORY JOURNAL . SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD.
Ganzleben, I., Neurath, M., & Becker, C. (2021). Autophagy in cancer therapy—molecular mechanisms and current clinical advances . Cancers , 13 (21). https://dx.doi.org/10.3390/cancers13215575
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Gonzalez Acera, M., Patankar, J., Diemand, L., Siegmund, B., Neurath, M., Wirtz, S., & Becker, C. (2021). Comparative Transcriptomics of IBD Patients Indicates Induction of Type 2 Immunity Irrespective of the Disease Ideotype . Frontiers in Medicine , 8 . https://dx.doi.org/10.3389/fmed.2021.664045
Günther, C., Rothhammer, V., Karow, M., Neurath, M., & Winner, B. (2021). The gut-brain axis in inflammatory bowel disease—current and future perspectives . International Journal of Molecular Sciences , 22 (16). https://dx.doi.org/10.3390/ijms22168870
Haberman, R., Herati, R., Simon, D., Samanovic, M., Tuen, M., Blank, R.,... Scher, J. (2021). Methotrexate Hampers Immunogenicity to BNT162b2 mRNA COVID-19 Vaccine in Immune-Mediated Inflammatory Disease . In ARTHRITIS & RHEUMATOLOGY (pp. 3205-3208). HOBOKEN: WILEY.
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Hirschmann, S., Fischer, S., Klenske, E., Dechant, K., Distler, J., Treutlein, C.,... Atreya, R. (2021). Case report of severe constrictive perimyocarditis and ischemic hepatitis in a Crohn’s disease patient upon infliximab-induced lupus-like syndrome . Therapeutic Advances in Gastroenterology , 14 . https://doi.org/10.1177/17562848211044033
Hoffman, A., Atreya, R., Rath, T., & Neurath, M. (2021). Current Endoscopic Resection Techniques for Gastrointestinal Lesions: Endoscopic Mucosal Resection, Submucosal Dissection, and Full-Thickness Resection . Visceral Medicine . https://dx.doi.org/10.1159/000515354
Jefremow, A., & Neurath, M. (2021). New agents for immunosuppression . Best Practice & Research in Clinical Gastroenterology . https://doi.org/10.1016/j.bpg.2021.101763
Jefremow, A., Neurath, M., & Waldner, M. (2021). CRISPR/Cas9 in Gastrointestinal Malignancies . Frontiers in Cell and Developmental Biology , 9 . https://doi.org/10.3389/fcell.2021.727217
Jesper, D., Fiedler, S., Klett, D., Waldner, M., Schellhaas, B., Zundler, S.,... Pfeifer, L. (2021). Shear Wave Dispersion Imaging for the Characterization of Focal Liver Lesions - A Pilot study . Ultraschall in der Medizin . https://doi.org/10.1055/a-1610-9171
Kang, L., Schmalzl, A., Leupold, T., Gonzalez-Acera, M., Atreya, R., Neurath, M.,... Wirtz, S. (2021). CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-γ Producing Innate Lymphoid CelIs and Protects From Experimental Colitis . Frontiers in Immunology , 11 . https://dx.doi.org/10.3389/fimmu.2020.609400
Kremer, A., Kremer, A., Willam, C., Verhagen, J., Achenbach, S., Van Der Meiden, E.,... Völkl, S. (2021). Successful treatment of COVID-19 with convalescent plasma in B-cell depleted patients may promote cellular immunity . In ONCOLOGY RESEARCH AND TREATMENT (pp. 294-294). BASEL: KARGER.
Kremer, A.E., Kremer, A., Willam, C., Völkl, S., Verhagen, J., Achenbach, S.,... Hackstein, H. (2021). Successful treatment of COVID-19 infection with convalescent plasma in B-cell-depleted patients may promote cellular immunity . European Journal of Immunology . https://doi.org/10.1002/eji.202149277
Lang-Schwarz, C., Angeloni, M., Agaimy, A., Atreya, R., Becker, C., Dregelies, T.,... Vieth, M. (2021). Validation of the 'Inflammatory Bowel Disease-Distribution, Chronicity, Activity [IBD-DCA] Score' for Ulcerative Colitis and Crohn ' s Disease . Journal of Crohns & Colitis , 15 (10), 1621-1630. https://doi.org/10.1093/ecco-jcc/jjab055
Lechner-Grimm, K., Mott, S., Al-Saifi, R., Knipfer, L., Wirtz, S., Atreya, R.,... Neurath, M. (2021). Targeting of the Tec Kinase ITK Drives Resolution of T Cell–Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis . Gastroenterology . https://dx.doi.org/10.1053/j.gastro.2021.06.072
Leppkes, M., Lindemann, A., Goesswein, S., Paulus, S., Roth, D., Hartung, A.,... Neurath, M. (2021). Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis . Gut . https://doi.org/10.1136/gutjnl-2021-324725
Melde, M., Müller, T., Schneider, I.H.F., Geppert, C.-I., Mühl, L., Besendorf, L.,... Zundler, S. (2021). α4β7 integrin-dependent adhesion of T cells to MAdCAM-1 is blocked by vedolizumab in patients with chronic refractory pouchitis . Therapeutic Advances in Gastroenterology , 14 . https://doi.org/10.1177/17562848211054707
Mühl, L., Becker, E., Müller, T., Atreya, R., Atreya, I., Neurath, M., & Zundler, S. (2021). Clinical experiences and predictors of success of treatment with vedolizumab in IBD patients: a cohort study . BMC Gastroenterology , 21 (1). https://doi.org/10.1186/s12876-021-01604-z
Müller, T., Becker, E., Wiendl, M., Schulze, L., Voskens, C., Kremer, A.,... Völkl, S. (2021). Circulating Adaptive Immune Cells Expressing the Gut Homing Marker α4β7 Integrin Are Decreased in COVID-19 . Frontiers in Immunology , 12 . https://doi.org/10.3389/fimmu.2021.639329
Neurath, M. (2021). COVID-19: biologic and immunosuppressive therapy in gastroenterology and hepatology . Nature Reviews Gastroenterology & Hepatology . https://dx.doi.org/10.1038/s41575-021-00480-y
Neurath, M. (2021). Drug Therapy in Gastroenterology: Molecular Basis of IBD . Drug Research , 71 , S15-S15. https://dx.doi.org/10.1055/a-1606-5844
Neurath, M., & Vieth, M. (2021). Gastric hyperplastic polyps (hyperplasiogenic polyps): a constant debate! Endoscopy , 53 (01), 100-100. https://doi.org/10.1055/a-1217-0521
Neurath, M., & Vieth, M. (2021). Issues in histopathological reporting: A crucial crossroad between surgeons and pathologists after oesophago-gastrectomy . Diseases of the Esophagus , 34 (8). https://dx.doi.org/10.1093/dote/doab038
Neurath, M., Überla, K., & Ng, S.C. (2021). Gut as viral reservoir: Lessons from gut viromes, HIV and COVID-19 . Gut . https://dx.doi.org/10.1136/gutjnl-2021-324622
Paap, E.-M., Müller, T., Sommer, K., Neurath, M., & Zundler, S. (2021). Total Recall: Intestinal T-RM Cells in Health and Disease . Frontiers in Immunology , 11 . https://doi.org/10.3389/fimmu.2020.623072
Patankar, J., Muller, T.M., Kantham, S., Acera, M.G., Mascia, F., Scheibe, K.,... Becker, C. (2021). E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis . Nature Cell Biology , 23 (7), 796-807. https://doi.org/10.1038/s41556-021-00708-8
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Pfeifer, L., Neufert, C., Leppkes, M., Waldner, M., Hafner, M., Beyer, A.,... Rath, T. (2021). Computer-aided detection of colorectal polyps using a newly generated deep convolutional neural network: from development to first clinical experience . European Journal of Gastroenterology & Hepatology , 33 , E662-E669. https://doi.org/10.1097/MEG.0000000000002209
Pradhan, R., Ngo, P.A., Martínez Sánchez, L.d.C., Neurath, M., & Lopez Posadas, R. (2021). Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases . Cells , 10 (1). https://doi.org/10.3390/cells10010066
Rath, T., Atreya, R., & Neurath, M. (2021). Is histological healing a feasible endpoint in ulcerative colitis? Expert Review of Gastroenterology and Hepatology . https://dx.doi.org/10.1080/17474124.2021.1880892
Rath, T., Dieterich, W., Kätscher-Murad, C., Neurath, M., & Zopf, Y. (2021). Cross-sectional imaging of intestinal barrier dysfunction by confocal laser endomicroscopy can identify patients with food allergy in vivo with high sensitivity . Scientific Reports , 11 (1). https://dx.doi.org/10.1038/s41598-021-92262-4
Rath, T., Neurath, M., & Atreya, R. (2021). Molecular Endoscopic Imaging in Cancer .
Rath, T., Neurath, M., & Atreya, R. (2021). Molecular Imaging and its Applications in Selected GI Diseases . Techniques and Innovations in Gastrointestinal Endoscopy , 23 (1), 87-98. https://dx.doi.org/10.1016/j.tige.2020.09.003
Rath, T., Vitali, F., Naegel, A., & Neurath, M. (2021). Endoscopic management of buried bumper syndrome using a novel grasping-type scissor forceps . Endoscopy , 53 (01), E21-E22. https://dx.doi.org/10.1055/a-1173-7494
Reljic, D., Frenk, F., Herrmann, H.J., Neurath, M., & Zopf, Y. (2021). Effects of very low volume high intensity versus moderate intensity interval training in obese metabolic syndrome patients: a randomized controlled study . Scientific Reports , 11 (1). https://dx.doi.org/10.1038/s41598-021-82372-4
Reljic, D., Herrmann, H.J., Neurath, M., & Zopf, Y. (2021). Iron beats electricity: Resistance training but not whole-body electromyostimulation improves cardiometabolic health in obese metabolic syndrome patients during caloric restriction—a randomized-controlled study . Nutrients , 13 (5). https://dx.doi.org/10.3390/nu13051640
Reljic, D., Konturek, P.C., Herrmann, H.J., Siebler, J., Neurath, M., & Zopf, Y. (2021). VERY LOW-VOLUME INTERVAL TRAINING IMPROVES NONALCOHOLIC FATTY LIVER DISEASE FIBROSIS SCORE AND CARDIOMETABOLIC HEALTH IN ADULTS WITH OBESITY AND METABOLIC SYNDROME . Journal of Physiology and Pharmacology , 72 (6), 927-938. https://dx.doi.org/10.26402/jpp.2021.6.10
Roth, D., Lindemann, A., Goesswein, S., Neurath, M., Armbruster, F.P., & Leppkes, M. (2021). Detection of Crohn's typical Anti-Yeast Glycan Antibodies by a novel Assay based on Flow Cytometry . Mycoses , 23-24.
Schett, G., Mcinnes, I.B., & Neurath, M. (2021). Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs . New England Journal of Medicine , 385 (7), 628-639. https://doi.org/10.1056/NEJMra1909094
Schmitt, H., Neurath, M., & Atreya, R. (2021). Role of the IL23/IL17 Pathway in Crohn’s Disease . Frontiers in Immunology , 12 . https://dx.doi.org/10.3389/fimmu.2021.622934
Schulz-Kuhnt, A., Neurath, M., Wirtz, S., & Atreya, I. (2021). Innate Lymphoid Cells as Regulators of Epithelial Integrity: Therapeutic Implications for Inflammatory Bowel Diseases . Frontiers in Medicine , 8 . https://dx.doi.org/10.3389/fmed.2021.656745
Schwappacher, R., Dieterich, W., Reljic, D., Pilarsky, C., Mukhopadhyay, D., Chang, D.K.,... Zopf, Y. (2021). Muscle‐derived cytokines reduce growth, viability and migratory activity of pancreatic cancer cells . Cancers , 13 (15). https://dx.doi.org/10.3390/cancers13153820
Sommer, K., Wiendl, M., Müller, T., Heidbreder, K., Voskens, C., Neurath, M., & Zundler, S. (2021). Intestinal Mucosal Wound Healing and Barrier Integrity in IBD–Crosstalk and Trafficking of Cellular Players . Frontiers in Medicine , 8 . https://doi.org/10.3389/fmed.2021.643973
Spoerl, S., Kremer, A., Aigner, M., Eisenhauer, N., Koch, P., Meretuk, L.,... Völkl, S. (2021). Upregulation of CCR4 in activated CD8(+) T cells indicates enhanced lung homing in patients with severe acute SARS-CoV-2 infection . European Journal of Immunology . https://doi.org/10.1002/eji.202049135
Stolzer, I., Dressel, A., Neurath, M., Günther, C., & Chiriac, M.-T. (2021). An IFN-STAT Axis Augments Tissue Damage and Inflammation in a Mouse Model of Crohn's Disease . Frontiers in Medicine , 8 . https://dx.doi.org/10.3389/fmed.2021.644244
Stolzer, I., Ruder, B., Neurath, M., & Günther, C. (2021). Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection . International Journal of Medical Microbiology , 311 (3). https://dx.doi.org/10.1016/j.ijmm.2021.151491
Stolzer, I., Schickedanz, L., Chiriac, M.T., López-Posadas, R., Grassl, G.A., Mattner, J.,... Winner, B. (2021). STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8 . Mucosal Immunology , 15 (1), 130-142. https://dx.doi.org/10.1038/s41385-021-00450-2
Tascilar, K., Simon, D., Krönke, G., Kleyer, A., Ramming, A., Atreya, R.,... Schett, G. (2021). PATIENTS WITH IMMUNE MEDIATED INFLAMMATORY DISEASES ARE OVERREPRESENTED IN LOW-FREQUENCY VIRAL SYMPTOM CLUSTERS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 996-997). LONDON: BMJ PUBLISHING GROUP.
Thoma, O.-M., Neurath, M., & Waldner, M. (2021). Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment . Frontiers in Pharmacology , 12 . https://dx.doi.org/10.3389/fphar.2021.757120
Thoma, O.-M., Neurath, M., & Waldner, M. (2021). T cell aging in patients with colorectal cancer—what do we know so far? Cancers , 13 (24). https://doi.org/10.3390/cancers13246227
Vetter, M., Kaufmann, M., Neurath, M., & Kremer, A. (2021). Purple urine in a patient after recovery from a SARS-CoV-2 infection . International Journal of Infectious Diseases , 105 , 472-473. https://doi.org/10.1016/j.ijid.2021.02.083
Vetter, M., Kremer, A., Agaimy, A., Konturek, P.C., Pfeifer, L., Neurath, M.,... Siebler, J. (2021). THE AMOUNT OF LIVER TISSUE IS ESSENTIAL FOR ACCURATE HISTOLOGICAL STAGING IN PATIENTS WITH AUTOIMMUNE HEPATITIS . Journal of Physiology and Pharmacology , 72 (1), 119-127. https://doi.org/10.26402/jpp.2021.1.13
Vetter, M., Rath, T., Siebler, J., Waldner, M., Neurath, M., & Pfeifer, L. (2021). The Ominous Ouzo Party - A Case Series of Four Patients with Accidental Alkali Ingestion . Clinical and Experimental Gastroenterology , 14 , 303-308. https://doi.org/10.2147/CEG.S320047
Vitali, F., Naegel, A., Pfeifer, L., Goetz, M., Neurath, M., Rath, T., & Siebler, J. (2021). Endoscopic recanalization of complete esophageal obstruction . Surgical Endoscopy . https://dx.doi.org/10.1007/s00464-021-08313-4
Vitali, F., Simon, D., Neurath, M., Schett, G., & Zundler, S. (2021). Vedolizumab-associated enthesitis: correlation or causality? Rheumatology , 60 (12), 5491-5492. https://doi.org/10.1093/rheumatology/keab396
Vitali, F., Wein, A., Rath, T., Eckstein, M., Neufert, C., Siebler, J.,... Merkel, S. (2021). The outcome of patients with inflammatory bowel disease-associated colorectal cancer is not worse than that of patients with sporadic colorectal cancer-a matched-pair analysis of survival . International Journal of Colorectal Disease . https://doi.org/10.1007/s00384-021-04072-9
Voskens, C., Stoica, D., Roessner, S., Vitali, F., Zundler, S., Rosenberg, M.,... Neurath, M. (2021). Safety and tolerability of a single infusion of autologous ex vivo expanded regulatory T cells in adults with ulcerative colitis (ER-TREG 01): protocol of a phase 1, open-label, fast-track dose-escalation clinical trial . BMJ Open , 11 (12). https://doi.org/10.1136/bmjopen-2021-049208
Wagner, A., Danko, V., Federle, A., Klett, D., Simon, D., Heiß, R.,... Knieling, F. (2021). Precision of handheld multispectral optoacoustic tomography for muscle imaging . Photoacoustics , 21 . https://doi.org/10.1016/j.pacs.2020.100220
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Weindl, L., Atreya, I., Dietrich, P., Neubeck, S., Neurath, M., & Pavel, M.E. (2021). Targeted inhibition of the WEE1 kinase as a novel therapeutic strategy in neuroendocrine neoplasms . Endocrine-Related Cancer , 28 (9), 605-620. https://doi.org/10.1530/ERC-20-0500
Wiendl, M., Becker, E., Müller, T., Voskens, C., Neurath, M., & Zundler, S. (2021). Targeting Immune Cell Trafficking – Insights From Research Models and Implications for Future IBD Therapy . Frontiers in Immunology , 12 . https://doi.org/10.3389/fimmu.2021.656452
Wildner, D., Heinzerling, L., Scheulen, M.E., Kämpgen, E., Schuler, G., Strobel, D.,... Knieling, F. (2021). Assessment of sorafenib induced changes in tumor perfusion of uveal melanoma metastases with dynamic contrast-enhanced ultrasound (DCE-US) . Journal of Cancer Research and Clinical Oncology . https://doi.org/10.1007/s00432-021-03666-8
Wirtz, S., Schulz-Kuhnt, A., Neurath, M., & Atreya, I. (2021). Functional Contribution and Targeted Migration of Group-2 Innate Lymphoid Cells in Inflammatory Lung Diseases: Being at the Right Place at the Right Time . Frontiers in Immunology , 12 . https://dx.doi.org/10.3389/fimmu.2021.688879
Wolf, K., Kühn, H., Boehm, F., Gebhardt, L., Glaudo, M., Agelopoulos, K.,... Kremer, A. (2021). A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice . Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2020.12.655
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2020
Abdullah, A., Neurath, M., & Atreya, R. (2020). Mild COVID-19 Symptoms in an Infliximab-Treated Ulcerative Colitis Patient: Can Ongoing Anti-TNF Therapy Protect against the Viral Hyperinflammatory Response and Avoid Aggravated Outcomes? Visceral Medicine . https://doi.org/10.1159/000508740
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Atreya, R., Neurath, M., & Siegmund, B. (2020). Personalizing Treatment in IBD: Hype or Reality in 2020? Can We Predict Response to Anti-TNF? Frontiers in Medicine , 7 . https://doi.org/10.3389/fmed.2020.00517
Atreya, R., Peyrin-Biroulet, L., Klymenko, A., Augustyn, M., Bakulin, I., Slankamenac, D.,... Reinisch, W. (2020). Cobitolimod for Moderate-to-Severe Left-Sided Ulcerative Colitis (CONDUCT): A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Trial . In AMERICAN JOURNAL OF GASTROENTEROLOGY (pp. S322-S322). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
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Baronetto, A., Graf, L., Fischer, S., Neurath, M., & Amft, O. (2020). GastroDigitalShirt: A smart shirt for digestion acoustics monitoring . In Proceedings - International Symposium on Wearable Computers, ISWC (pp. 17-21). Association for Computing Machinery.
Becker, E., Wiendl, M., Schulz-Kuhnt, A., Atreya, I., Atreya, R., Neurath, M., & Zundler, S. (2020). Dose-dependent differential effects of vedolizumab therapy on adhesion of regulatory and effector T cells . In JOURNAL OF CROHNS & COLITIS (pp. S165-S166). OXFORD: OXFORD UNIV PRESS.
Breidert, M., Eftekhari, P., Louis, F., Rotoiu, C., Rath, T., Neurath, M., & Atreya, R. (2020). Functional molecular network analysis enables prediction of response to vedolizumab therapy in anti-TNF refractory IBD patients . Crohn's & Colitis 360 , 2 (2). https://dx.doi.org/10.1093/crocol/otaa037
Danese, S., Neurath, M., Kopoń, A., Zakko, S.F., Simmons, T.C., Fogel, R.,... Chitkara, D. (2020). Effects of Apremilast, an Oral Inhibitor of Phosphodiesterase 4, in a Randomized Trial of Patients With Active Ulcerative Colitis . Clinical Gastroenterology and Hepatology , 18 (11), 2526-2534.e9. https://doi.org/10.1016/j.cgh.2019.12.032
Dieterich, W., Neurath, M., & Zopf, Y. (2020). Intestinal ex vivo organoid culture reveals altered programmed crypt stem cells in patients with celiac disease . Scientific Reports , 10 (1). https://doi.org/10.1038/s41598-020-60521-5
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Fischer, S., & Neurath, M. (2020). „Ich habe Durchfall und Erbrechen“ . MMW Fortschritte der Medizin , 162 (1), 39-43. https://doi.org/10.1007/s15006-020-0059-x
Fournier, A.P., De Lizarrondo, S.M., Rateau, A., Gerard-Brisou, A., Waldner, M., Neurath, M.,... Gauberti, M. (2020). Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice . Science Translational Medicine , 12 (560). https://doi.org/10.1126/scitranslmed.aaz4047
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Görtz, R., Atreya, R., & Neurath, M. (2020). Recurrent Ileal Invagination in Crohn's Disease . Deutsches Ärzteblatt international , 117 (9), 146-146. https://doi.org/10.3238/arztebl.2020.0146
Görtz, R., Hensel, S., Wildner, D., Neurath, M., & Strobel, D. (2020). Bowel wall thickening and hyperemia assessed by high-frequency ultrasound indicate histological inflammation in Crohn's ileitis . Abdominal Radiology . https://doi.org/10.1007/s00261-020-02895-8
Hagel, A., Raithel, M., Hempen, P., Preclik, G., Dauth, W., Neurath, M.,... Albrecht, H. (2020). MULTICENTER ANALYSIS OF ENDOCLOT AS HEMOSTATIC POWDER IN DIFFERENT ENDOSCOPIC SETTINGS OF THE UPPER GASTROINTESTINAL TRACT . Journal of Physiology and Pharmacology , 71 (5). https://dx.doi.org/10.26402/jpp.2020.5.06
Hartmann, L., Siegmund, B., Weidinger, C., Becker, C., Neurath, M., & Günther, C. (2020). An IFN-STAT1-MLKL axis drives programmed necrosis of Paneth cells in Crohn's ileitis . In JOURNAL OF CROHNS & COLITIS (pp. S125-S125). OXFORD: OXFORD UNIV PRESS.
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Jefremow, A., & Neurath, M. (2020). SARS-CoV-2 Virus Manifestations in the Gastrointestinal Tract: Therapeutic Implications . Visceral Medicine . https://dx.doi.org/10.1159/000513180
Jefremow, A., Wiesmüller, M., Rouse, R.A., Dietrich, P., Kremer, A., Waldner, M.,... Siebler, J. (2020). Beyond the border: The use of lenvatinib in advanced hepatocellular carcinoma after different treatment lines: A retrospective analysis . Journal of Physiology and Pharmacology , 71 (5), 717-728. https://doi.org/10.26402/jpp.2020.5.11
Jefremow, A., Wiesmüller, M., Rouse, R.A., Dietrich, P., Kremer, A., Waldner, M.,... Siebler, J. (2020). Efficiency and Toxicity of Lenvatinib in Advanced HCC in Later Treatment Lines . In ONCOLOGY RESEARCH AND TREATMENT (pp. 216-216). BASEL: KARGER.
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Klenske, E., Hartmann, A., Atreya, R., Neurath, M., & Rath, T. (2020). Perforations after routine biopsy in IBD patients, their management and potential risk reductions by microscopic imaging with endocytoscopy . Journal of Gastrointestinal and Liver Diseases , 29 (3), 465-466. https://doi.org/10.15403/jgld-2267
Konturek, P.C., Harsch, I.A., Neurath, M., & Zopf, Y. (2020). COVID-19 - more than respiratory disease: a gastroenterologist's perspective. Journal of Physiology and Pharmacology , 71 (2). https://dx.doi.org/10.26402/jpp.2020.2.02
Konturek, P.C., Konturek, K., Brzozowski, T., Wojcik, D., Magierowski, M., Targosz, A.,... Zopf, Y. (2020). Participation of the intestinal microbiota in the mechanism of beneficial effect of treatment with synbiotic syngut on experimental colitis under stress conditions . Journal of Physiology and Pharmacology , 71 (3), 1-14. https://doi.org/10.26402/jpp.2020.3.03
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Lechner, K.S., Neurath, M., & Weigmann, B. (2020). Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis . Journal of Molecular Medicine . https://doi.org/10.1007/s00109-020-01958-z
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Martínez Sánchez, L.d.C., Pradhan, R., Ngo, P.A., Erkert, L., Becker, L., Watson, A.J.,... Lopez Posadas, R. (2020). An intravital microscopy-based approach to assess intestinal permeability and epithelial cell shedding performance . Journal of Visualized Experiments , 2020 (166), 1-12. https://doi.org/10.3791/60790
Mortier, E., Ma, A., Malynn, B.A., & Neurath, M. (2020). Editorial: Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer . Frontiers in Immunology , 11 . https://dx.doi.org/10.3389/fimmu.2020.608636
Neufert, C., Heichler, C., Brabletz, T., Scheibe, K., Boonsanay, V., Greten, F.R., & Neurath, M. (2020). Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis . Nature Protocols . https://doi.org/10.1038/s41596-020-00412-1
Neurath, M. (2020). Covid-19 and immunomodulation in IBD . Gut . https://doi.org/10.1136/gutjnl-2020-321269
Neurath, M. (2020). IL-36 in chronic inflammation and cancer . Cytokine & Growth Factor Reviews . https://doi.org/10.1016/j.cytogfr.2020.06.006
Rath, T., Morgenstern, N., Vitali, F., Atreya, R., & Neurath, M. (2020). Advanced Endoscopic Imaging in Colonic Neoplasia . Visceral Medicine . https://doi.org/10.1159/000505411
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Reljic, D., Frenk, F., Herrmann, H.J., Neurath, M., & Zopf, Y. (2020). Low-volume high-intensity interval training improves cardiometabolic health, work ability and well-being in severely obese individuals: a randomized-controlled trial sub-study . Journal of Translational Medicine , 18 (1). https://dx.doi.org/10.1186/s12967-020-02592-6
Reljic, D., Konturek, P., Herrmann, H.J., Neurath, M., & Zopf, Y. (2020). Effects of whole-body electromyostimulation exercise and caloric restriction on cardiometabolic risk profile and muscle strength in obese women with the metabolic syndrome: a pilot study . Journal of Physiology and Pharmacology , 71 (1). https://doi.org/10.26402/jpp.2020.1.08
Reljic, D., Zarafat, D., Jensen, B., Herrmann, H.J., Neurath, M., Konturek, P.C., & Zopf, Y. (2020). Phase angle and vector analysis from multifrequency segmental bioelectrical impedance analysis: New reference data for older adults . Journal of Physiology and Pharmacology , 71 (4), 1-9. https://dx.doi.org/10.26402/jpp.2020.4.04
Ruder, B., Günther, C., Stürzl, M., Neurath, M., Cesarman, E., Ballon, G., & Becker, C. (2020). Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo . PLoS ONE , 15 (1). https://doi.org/10.1371/journal.pone.0228441
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Schulz-Kuhnt, A., Wirtz, S., Neurath, M., & Atreya, I. (2020). Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation . Frontiers in Immunology , 11 . https://doi.org/10.3389/fimmu.2020.01062
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