The institute’s research focuses on questions concerning the eye, in particular the anatomy, immunology and pathophysiology of the ocular surface, the tear film and tear drainage mechanisms. Furthermore, the pathomechanisms that lead to dry eye disease such as lacrimal gland insufficiency and meibomian gland dysfunction are investigated. This involves, among other things, lacrimal gland and meibomian gland replacement by means of stem cell therapy. Other research topics include surface-active proteins, in particular surfactant proteins, osteoarthritis, brain mechanics, SARS-CoV-2, microplastics in the human body, various anatomical questions and questions on the health of medical students..
Research projects
Antimicrobial peptides at the ocular surface
Insights into Meibomian Gland (dys)function
Lacrimal gland stem cells
Tear drainage mechanisms
Mechanisms of corneal regeneration
Function of newly described surfactant proteins
Microplastic in the body
Engineering brain mechanics
Drug depots for the eye
Health of medical students
Corneal wound healing
TFF peptides and other peptides in osteoarthritis
Analysis of mucus on the ocular surface and in the larynx
Current projects Current projects
Recent publications Recent publications
2023
Englisch, C.N., Paulsen, F., & Tschernig, T. (2023). TRPC Channels in the Physiology and Pathophysiology of the Renal Tubular System: What Do We Know? International Journal of Molecular Sciences , 24 (1). https://dx.doi.org/10.3390/ijms24010181
Ramsperger, A.F., Bergamaschi, E., Panizzolo, M., Fenoglio, I., Barbero, F., Peters, R.,... Laforsch, C. (2023). Nano- and microplastics: a comprehensive review on their exposure routes, translocation, and fate in humans . NanoImpact , 29 . https://dx.doi.org/10.1016/j.impact.2022.100441
Singh, S., Hammer, C., & Paulsen, F. (2023). Urea and ocular surface: Synthesis, secretion and its role in tear film homeostasis . Ocular Surface , 27 , 41-47. https://dx.doi.org/10.1016/j.jtos.2022.11.003
2022
Baehren, C., Buedding, E., Bellm, A., Schult, F., Pembaur, A., Wirth, S.,... Aydin, M. (2022). The Relevance of the Bacterial Microbiome, Archaeome and Mycobiome in Pediatric Asthma and Respiratory Disorders . Cells , 11 (8). https://dx.doi.org/10.3390/cells11081287
Dąbrowski, P., Kulus, M.J., Grzelak, J., Olchowy, C., Staniowski, T., & Paulsen, F. (2022). Nutritional reconstruction in an early modern population: Searching for a relationship between dental microwear and bone element composition . Annals of Anatomy-Anatomischer Anzeiger , 240 . https://dx.doi.org/10.1016/j.aanat.2021.151884
Feldt, J., Donaubauer, A.-J., Welss, J., Schneider, U., Gaipl, U., & Paulsen, F. (2022). Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients . Scientific Reports , 12 (1), 3560-. https://dx.doi.org/10.1038/s41598-022-07187-3
Feldt, J., Schicht, M., Welss, J., Gelse, K., Sesselmann, S., Tsokos, M.,... Paulsen, F. (2022). Production and Secretion of Gelsolin by Both Human Macrophage- and Fibroblast-like Synoviocytes and GSN Modulation in the Synovial Fluid of Patients with Various Forms of Arthritis . Biomedicines , 10 , 723. https://dx.doi.org/10.3390/biomedicines10030723
Gonera, B., Borowski, A., Zielinska, N., Palac, W., Paulsen, F., & Olewnik, L. (2022). Embryological approach to the morphology of the ligamentum mucosum of the human knee joint . Annals of Anatomy-Anatomischer Anzeiger , 244 . https://dx.doi.org/10.1016/j.aanat.2022.151983
Iwanaga, J., Singh, V., Takeda, S., Ogeng'O, J., Kim, H.-J., Morys, J.,... Tubbs, R.S. (2022). Standardized statement for the ethical use of human cadaveric tissues in anatomy research papers: Recommendations from Anatomical Journal Editors-in-Chief . Clinical Anatomy . https://dx.doi.org/10.1002/ca.23849
Jäger, F., Paulsen, F., Bergua, A., Jungbauer, R., & Hammer, C. (2022). Immunohistochemical detection of urea transporter-A in the tear- producing part of the lacrimal system . Annals of Anatomy-Anatomischer Anzeiger , 244 . https://dx.doi.org/10.1016/j.aanat.2022.151991
Jäger, F., Paulsen, F., Bergua, A., Jungbauer, R., & Hammer, C. (2022). Urea transporter-B expression on the ocular surface and in the lacrimal glands . Annals of Anatomy-Anatomischer Anzeiger , 243 . https://dx.doi.org/10.1016/j.aanat.2022.151954
Jüngert, K., Paulsen, F., Jacobi, C., Horwath-Winter, J., & Garreis, F. (2022). Prolactin Inducible Protein, but Not Prolactin, Is Present in Human Tears, Is Involved in Tear Film Quality, and Influences Evaporative Dry Eye Disease . Frontiers in Medicine , 9 . https://dx.doi.org/10.3389/fmed.2022.892831
Karauda, P., Paulsen, F., Polguj, M., Diogo, R., & Olewnik, L. (2022). Morphological variability of the fibularis tertius tendon in human foetuses. Folia Morphologica , 81 (2), 451-457. https://dx.doi.org/10.5603/FM.a2021.0039
Kuth, S., Karakaya, E., Reiter, N., Schmidt, L.-P., Paulsen, F., Tessmar, J.,... Boccaccini, A.R. (2022). Oxidized Hyaluronic Acid-Gelatin-Based Hydrogels for Tissue Engineering and Soft Tissue Mimicking . Tissue Engineering - Part C: Methods . https://dx.doi.org/10.1089/ten.tec.2022.0004
Moxham, B.J., Brenner, E., Plaisant, O., Pais, D., Stabile, I., Scholz, M.,... Chirculescu, A.R.M. (2022). The Attitudes of European Medical Students towards the Clinical Importance of Neuroanatomy . Annals of Anatomy-Anatomischer Anzeiger , 239 . https://dx.doi.org/10.1016/j.aanat.2021.151832
Olewnik, L., Zielinska, N., Ruzik, K., Podgorski, M., Paulsen, F., Diogo, R., & Polguj, M. (2022). Morphological variability of the fibularis longus tendon in human fetuses . Annals of Anatomy-Anatomischer Anzeiger , 239 . https://dx.doi.org/10.1016/j.aanat.2021.151838
Ovsepyan, A.L., Smirnov, A.A., Pustozerov, E.A., Mokhov, D.E., Mokhova, E.S., Trunin, E.M.,... Starchik, D.A. (2022). Biomechanical analysis of the cervical spine segment as a method for studying the functional and dynamic anatomy of the human neck . Annals of Anatomy-Anatomischer Anzeiger , 240 . https://dx.doi.org/10.1016/j.aanat.2021.151856
Ritter, P., Cai, A., Reischl, B., Fiedler, M., Prölß, G., Frie, B.,... Haug, M. (2022). MyoBio: An automated bioreactor system technology for standardized perfusion-decellularization of whole skeletal muscle . IEEE transactions on bio-medical engineering . https://dx.doi.org/10.1109/TBME.2022.3142317
Ruzik, K., Westrych, K., Zielinska, N., Podgórski, M., Karauda, P., Diogo, R.,... Olewnik, . (2022). The morphological variability of fibularis tertius origin in human foetuses . Annals of Anatomy-Anatomischer Anzeiger , 243 . https://dx.doi.org/10.1016/j.aanat.2022.151920
Schicht, M., Riedlova, K., Kukulka, M., Li, W., Scheer, A., Garreis, F.,... Bräuer, L. (2022). The Potential Role of SP-G as Surface Tension Regulator in Tear Film: From Molecular Simulations to Experimental Observations . International Journal of Molecular Sciences , 23 (10). https://dx.doi.org/10.3390/ijms23105783
Seselja, K., Bazina, I., Vrecl, M., Welss, J., Schicht, M., Mihalj, M.,... Loncar, M.B. (2022). Tff3 Deficiency Protects against Hepatic Fat Accumulation after Prolonged High-Fat Diet . Life , 12 (8). https://dx.doi.org/10.3390/life12081288
Socher, E., Heger, L., Paulsen, F., Zunke, F., & Arnold, P. (2022). Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike – ACE2 complexes reveal distinct changes between both variants . Computational and Structural Biotechnology Journal , 20 , 1168-1176. https://dx.doi.org/10.1016/j.csbj.2022.02.015
Trujillo-Vargas, C.M., Mauk, K.E., Hernandez, H., de Souza, R.G., Yu, Z., Galletti, J.G.,... de Paiva, C.S. (2022). Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands . GeroScience . https://dx.doi.org/10.1007/s11357-022-00529-z
Vučinić, N., Paulsen, F., Milinkov, M., Nikolić, M.B., Todorović, S.T., Knezi, N., & Nikolić, U. (2022). A survey of pelvic types on computed tomography images . Annals of Anatomy-Anatomischer Anzeiger , 243 . https://dx.doi.org/10.1016/j.aanat.2022.151942
Weizel, A., Distler, T., Detsch, R., Boccaccini, A.R., Paulsen, F., Seitz, H.,... Bräuer, L. (2022). Hyperelastic parameter identification of human articular cartilage and substitute materials . Journal of the Mechanical Behavior of Biomedical Materials , 133 . https://dx.doi.org/10.1016/j.jmbbm.2022.105292
Westrych, K., Ruzik, K., Zielinska, N., Paulsen, F., Georgiev, G.P., Olewnik, L., & Labetowicz, P. (2022). Common trunk of the internal thoracic artery, inferior thyroid artery and thyrocervical trunk from the subclavian artery: a rare arterial variant . Surgical and Radiologic Anatomy . https://dx.doi.org/10.1007/s00276-022-02977-w
Willershausen, I., Krautkremer, F., Hilbert, T., Seidel, C.L., Geppert, C., Ghanaati, S.,... Scholz, M. (2022). The comparison of the morphology of the mid-palatal suture between edentulous individuals and dentate jaws shows morphological differences . Annals of Anatomy-Anatomischer Anzeiger , 243 . https://dx.doi.org/10.1016/j.aanat.2022.151948
Wozniak, S., Pawlus, A., Grzelak, J., Chobotow, S., Paulsen, F., Olchowy, C., & Zaleska-Dorobisz, U. (2022). Acute colonic flexures: the basis for developing an artificial intelligence-based tool for predicting the course of colonoscopy . Anatomical Science International . https://dx.doi.org/10.1007/s12565-022-00681-8
Wozniak, S., Pawlus, A., Grzelak, J., Chobotow, S., Paulsen, F., Olchowy, C., & Zaleska-Dorobisz, U. (2022). Descending-sigmoid colon flexure – An important but surprisingly ignored landmark . Annals of Anatomy-Anatomischer Anzeiger , 239 . https://dx.doi.org/10.1016/j.aanat.2021.151821
Wozniak, S., Quondamatteo, F., & Paulsen, F. (2022). "Flexures and bends of the large intestine: Current terminology and a suggestion to simplify it" . Journal of Anatomy . https://dx.doi.org/10.1111/joa.13800
Zahn, I., Garreis, F., Schicht, M., Rötzer, V., Waschke, J., Liu, Y.,... Dietrich, J. (2022). A New Organotypic 3D Slice Culture of Mouse Meibomian Glands Reveals Impact of Melanocortins . International Journal of Molecular Sciences , 23 (23). https://dx.doi.org/10.3390/ijms232314947
2021
Aleshkina, O., Suetenkov, D., Dydykin, S., Vasil'ev, Y., Paulsen, F., Firsova, I.,... Polkovova, I. (2021). Determination of sex dimorphisms of the thickness of the hard palate in adolescence using computed tomography: Pilot study . Annals of Anatomy-Anatomischer Anzeiger , 238 . https://dx.doi.org/10.1016/j.aanat.2021.151764
Aydin, M., Dietrich, J., Witt, J., Finkbeiner, M.S., Park, J.J., Wirth, S.,... Ehrhardt, A. (2021). The communication between ocular surface and nasal epithelia in 3d cell culture technology for translational research: A narrative review . International Journal of Molecular Sciences , 22 (23). https://dx.doi.org/10.3390/ijms222312994
Aydin, M., Naumova, E.A., Bellm, A., Behrendt, A.K., Giachero, F., Bahlmann, N.,... Paulsen, F. (2021). The mystery behind the nostrils – technical clues for successful nasal epithelial cell cultivation . Annals of Anatomy-Anatomischer Anzeiger , 238 . https://dx.doi.org/10.1016/j.aanat.2021.151748
Aydin, M., Naumova, E.A., Bellm, A., Behrendt, A.K., Giachero, F., Bahlmann, N.,... Ehrhardt, A. (2021). From Submerged Cultures to 3D Cell Culture Models: Evolution of Nasal Epithelial Cells in Asthma Research and Virus Infection . Viruses , 13 (3). https://dx.doi.org/10.3390/v13030387
Bischofsberger, L., Burger, P.H., Hammer, A., Paulsen, F., Scholz, M., & Hammer, C. (2021). Prevalence and characteristics of test anxiety in first year anatomy students . Annals of Anatomy-Anatomischer Anzeiger , 236 . https://dx.doi.org/10.1016/j.aanat.2021.151719
Claassen, H., Busch, C., May, M., Schicht, M., Scholz, M., Schulze, M.,... Wree, A. (2021). Cor Triatriatum Sinistrum Combined with Changes in Atrial Septum and Right Atrium in a 60-Year-Old Woman . Medicina , 57 (8). https://dx.doi.org/10.3390/medicina57080777
Dabrowski, P., Kulus, M.J., Furmanek, M., Paulsen, F., Grzelak, J., & Domagala, Z. (2021). Estimation of age at onset of linear enamel hypoplasia. New calculation tool, description and comparison of current methods . Journal of Anatomy . https://dx.doi.org/10.1111/joa.13462
Dietrich, J., Garreis, F., & Paulsen, F. (2021). Pathophysiology of Meibomian Glands - An Overview . Ocular Immunology and Inflammation . https://dx.doi.org/10.1080/09273948.2021.1905856
Dydykin, S., Paulsen, F., Khorobykh, T., Mishchenko, N., Kapitonova, M., Gupalo, S.,... Salikhov, P. (2021). Mediastinal anatomical landmarks, their variants and tips for video-assisted thoracoscopic navigation during oesophageal extirpation . Surgical and Radiologic Anatomy . https://dx.doi.org/10.1007/s00276-021-02820-8
Feldt, J., Welss, J., Schneider, U., & Paulsen, F. (2021). Gold-based blood serum treatment promotes wound closure of corneal epithelial cell defects in primary in vitro experiments . Annals of Anatomy-Anatomischer Anzeiger , 237 . https://dx.doi.org/10.1016/j.aanat.2021.151745
Gonera, B., Kurtys, K., Paulsen, F., Polguj, M., LaPrade, R.F., Grzelecki, D.,... Olewnik, Ł. (2021). The plantaris muscle – Anatomical curiosity or a structure with important clinical value? – A comprehensive review of the current literature . Annals of Anatomy-Anatomischer Anzeiger , 235 . https://dx.doi.org/10.1016/j.aanat.2021.151681
Grajewski, R.S., Rokohl, A.C., Becker, M., Paulsen, F., & Heindl, L.M. (2021). Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases . Annals of Anatomy-Anatomischer Anzeiger , 234 . https://dx.doi.org/10.1016/j.aanat.2020.151661
Greiner, A., Reiter, N., Paulsen, F., Holzapfel, G.A., Steinmann, P., Comellas Sanfeliu, E., & Budday, S. (2021). Poro-Viscoelastic Effects During Biomechanical Testing of Human Brain Tissue . Frontiers in Mechanical Engineering , 7 . https://dx.doi.org/10.3389/fmech.2021.708350
Heichel, J., Struck, H.G., Paulsen, F., Javed Ali, M., & Viestenz, A. (2021). Tiefes periokuläres Trauma mit Tränenwegsbeteiligung durch Kaiserschnittentbindung . HNO . https://dx.doi.org/10.1007/s00106-021-01039-8
Himmler, M., Garreis, F., Paulsen, F., Schubert, D.W., & Fuchsluger, T. (2021). Analyzing the transmission of visible light through electrospun nanofibrous PCL scaffolds .
Himmler, M., Garreis, F., Paulsen, F., Schubert, D.W., & Fuchsluger, T.A. (2021). Optimization of polycaprolactone - based nanofiber matrices for the cultivation of corneal endothelial cells . Scientific Reports , 11 (1). https://dx.doi.org/10.1038/s41598-021-98426-6
Jungbauer, R., Al-Burghol, P., Rosentritt, M., Kirschneck, C., Proff, P., Paulsen, F., & Hammer, C. (2021). Curvature-dependent shear bond strength of different attachment materials for orthodontic lingual indirect bonding . Scientific Reports , 11 (1). https://dx.doi.org/10.1038/s41598-021-96164-3
Linka, K., Reiter, N., Würges, J., Schicht, M., Cyron, C.J., Paulsen, F.,... Bräuer, L. (2021). Unraveling the Local Relation Between Tissue Composition and Human Brain Mechanics Through Machine Learning . Frontiers in Bioengineering and Biotechnology , 9 . https://dx.doi.org/10.3389/fbioe.2021.704738
Luibl, L., Traversari, J., Paulsen, F., Scholz, M., & Burger, P. (2021). Resilience and sense of coherence in first year medical students - a cross-sectional study . BMC Medical Education , 21 (1). https://dx.doi.org/10.1186/s12909-021-02571-5
Mahajan, A., Hasíková, L., Hampel, U., Grüneboom, A., Shan, X., Herrmann, I.,... Schauer, C. (2021). Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation . Ocular Surface , 20 , 1-12. https://dx.doi.org/10.1016/j.jtos.2020.12.005
Olewnik, L., Laprade, R.F., Paulsen, F., Gonera, B., Kurtys, K., Podgorski, M.,... Polguj, M. (2021). A proposal for a new morphological classification of the popliteus muscle tendon with potential clinical and biomechanical significance . Scientific Reports , 11 (1). https://dx.doi.org/10.1038/s41598-021-93778-5
Olewnik, L., Paulsen, F., Tubbs, R.S., Zielinska, N., Szewczyk, B., Karauda, P., & Polguj, M. (2021). Potential compression of the musculocutaneous, median and ulnar nerves by a very rare variant of the coracobrachialis longus muscle . Folia Morphologica , 80 (3), 707-713. https://dx.doi.org/10.5603/FM.a2020.0085
Olewnik, Ł., Karauda, P., Gonera, B., Kurtys, K., Tubbs, R.S., Paulsen, F.,... Polguj, M. (2021). Impact of plantaris ligamentous tendon . Scientific Reports , 11 (1). https://dx.doi.org/10.1038/s41598-021-84186-w
Reiter, N., Roy, B., Paulsen, F., & Budday, S. (2021). Insights into the Microstructural Origin of Brain Viscoelasticity . Journal of Elasticity , 145 , 99-116. https://dx.doi.org/10.1007/s10659-021-09814-y
Sañudo, J.R., Vázquez, T., Talarico, E.F., Duparc, F., Paulsen, F., Macchi, V.,... Konschake, M. (2021). Practical postgraduate teaching in Human Anatomy: A review . European Journal of Anatomy , 25 (S1), 91-99. https://dx.doi.org/10.52083/ZDGE3745
Schicht, M., Reichle, A., Schapher, M., Garreis, F., Kleinsasser, B., Aydin, M.,... Paulsen, F. (2021). The Translational Role of MUC8 in Salivary Glands: A Potential Biomarker for Salivary Stone Disease? Diagnostics , 11 (12). https://dx.doi.org/10.3390/diagnostics11122330
Socher, E., Conrad, M., Heger, L., Paulsen, F., Sticht, H., Zunke, F., & Arnold, P. (2021). Computational decomposition reveals reshaping of the SARS‐CoV‐2–ACE2 interface among viral variants expressing the N501Y mutation . Journal of Cellular Biochemistry . https://dx.doi.org/10.1002/jcb.30142
Socher, E., Conrad, M., Heger, L., Paulsen, F., Sticht, H., Zunke, F., & Arnold, P. (2021). Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion Peptide . Biomedicines , 9 (5). https://dx.doi.org/10.3390/biomedicines9050525
Szewczyk, B., Polguj, M., Paulsen, F., Podgorski, M., Duparc, F., Karauda, P., & Olewnik, L. (2021). A proposal for a new classification of coracobrachialis muscle morphology . Surgical and Radiologic Anatomy , 43 (5), 679-688. https://dx.doi.org/10.1007/s00276-021-02700-1
Topka, M., Zhang, Y., Bock, A., Riedel, P., Lörner, J., Hammer, A.,... Hammer, C. (2021). Usability of abattoir-acquired pig eyes for refractive excimer laser research . Scientific Reports , 11 (1). https://dx.doi.org/10.1038/s41598-021-98635-z
Tschernig, T., Bechmann, I., Meier, C., Paulsen, F., Waschke, J., Westermann, J., & Bräuer, L. (2021). Anatomy in times of pandemia – Impact on teaching and body donations . Annals of Anatomy-Anatomischer Anzeiger . https://dx.doi.org/10.1016/j.aanat.2021.151792
Waśniewska-Włodarczyk, A., Paulsen, F., Olewnik, Ł., & Polguj, M. (2021). Morphological variability of the plantaris tendon in the human fetus . Scientific Reports , 11 (1). https://dx.doi.org/10.1038/s41598-021-96391-8
Welss, J., Punchago, N., Feldt, J., & Paulsen, F. (2021). The distribution of conjunctival goblet cells in mice . Annals of Anatomy-Anatomischer Anzeiger , 234 . https://dx.doi.org/10.1016/j.aanat.2020.151664
Wozniak, S., Florjanski, J., Piatek, A., Tomialowicz, M., Zazga, M., Szymocha, M.,... Paulsen, F. (2021). Diameters of umbilical and portal veins and ductus venosus in the human foetuses after 20 weeks of gestation in an ultrasound examination . In JOURNAL OF ANATOMY (pp. 211-211). HOBOKEN: WILEY.
Wozniak, S., Kempinski, R., Pytrus, T., Zazga, M., Szymocha, M., Domagala, Z.,... Paulsen, F. (2021). New anatomy-related ratios describing the risk of incomplete colonoscopy in human patients . In JOURNAL OF ANATOMY (pp. 210-210). HOBOKEN: WILEY.
Wozniak, S., Szpotowicz, G., Bienias, M., Kedzierski, B., Sosnowska, D., Szymocha, M.,... Paulsen, F. (2021). Human wrist anatomy: anatomical features important for treatment of palmar dislocation of the lunate bone . In JOURNAL OF ANATOMY (pp. 211-211). HOBOKEN: WILEY.
Wozniak, S., Zazga, M., Kurc-Darak, B., Tomialowicz, M., Paulsen, F., & Florjanski, J. (2021). Fetal sigmoid colon mesentery made visible by routine ultrasound in the first and second trimester of pregnancy . Annals of Anatomy-Anatomischer Anzeiger , 235 . https://dx.doi.org/10.1016/j.aanat.2021.151676
Zielinska, N., Tubbs, R.S., Paulsen, F., Szewczyk, B., Podgórski, M., Borowski, A., & Olewnik, Ł. (2021). Anatomical variations of the tibialis anterior tendon insertion: An updated and comprehensive review . Journal of Clinical Medicine , 10 (16). https://dx.doi.org/10.3390/jcm10163684
2020
Ali, M.J., & Paulsen, F. (2020). Human Lacrimal Drainage System Reconstruction, Recanalization, and Regeneration . Current Eye Research , 45 (3), 241-252. https://dx.doi.org/10.1080/02713683.2019.1580376
Ali, M.J., Zetzsche, M., Scholz, M., Hahn, D., Gaffling, S., Heichel, J.,... Paulsen, F. (2020). New insights into the lacrimal pump . Ocular Surface , 18 (4), 689-698. https://dx.doi.org/10.1016/j.jtos.2020.07.013
Aydin, M., Naumova, E.A., Paulsen, F., Zhang, W., Gopon, F., Theis, C.,... Ehrhardt, A. (2020). House dust mite exposure causes increased susceptibility of nasal epithelial cells to adenovirus infection . Viruses , 12 (10). https://dx.doi.org/10.3390/v12101151
Bründl, M., Garreis, F., Schicht, M., Dietrich, J., & Paulsen, F. (2020). Characterization of the innervation of the meibomian glands in humans, rats and mice . Annals of Anatomy-Anatomischer Anzeiger . https://dx.doi.org/10.1016/j.aanat.2020.151609
Budday, S., Sarem, M., Starck, L., Sommer, G., Pfefferle, J., Phunchago, N.,... Holzapfel, G.A. (2020). Towards microstructure-informed material models for human brain tissue . Acta Biomaterialia , 104 , 53-65. https://dx.doi.org/10.1016/j.actbio.2019.12.030
Feldt, J., Welss, J., Schropp, V., Gelse, K., Tsokos, M., & Paulsen, F. (2020). Recombinant human gelsolin promotes the migration of human articular cartilage chondrocytes by regulating gene expression in vitro. Osteoarthritis and Cartilage Open , 2 (4). https://dx.doi.org/10.1016/j.ocarto.2020.100124
Guntinas-Lichius, O., Ihrler, S., Freesmeyer, M., Guehne, F., Kluge, R., Bräuer, L.,... Bechmann, I. (2020). Gibt es eine neue Kopfspeicheldrüse? – Eher nicht! Laryngo-Rhino-Otologie . https://dx.doi.org/10.1055/a-1307-3872
Hammer, C., Scholz, M., Bischofsberger, L., Paulsen, F., & Burger, P.H.M. (2020). Feasibility of Clinical Hypnosis for Test Anxiety in First-Year Medical Students . International Journal of Clinical and Experimental Hypnosis . https://dx.doi.org/10.1080/00207144.2020.1799379
Hampel, U., Chinnery, H.R., Garreis, F., Paulsen, F., de Iongh, R., Bui, B.V.,... Chen, H.L. (2020). Ocular Phenotype of Relaxin Gene Knockout (Rln-/-) Mice . Current Eye Research . https://dx.doi.org/10.1080/02713683.2020.1737714
Iwanaga, J., Singh, V., Ohtsuka, A., Hwang, Y., Kim, H.J., Moryś, J.,... Tubbs, R.S. (2020). Acknowledging the use of human cadaveric tissues in research papers: Recommendations from anatomical journal editors . Clinical Anatomy . https://dx.doi.org/10.1002/ca.23671
Kanewska, A., Ito, M., Karasawa, Y., Inada, M., Garreis, F., Paulsen, F., & Takeuchi, M. (2020). Developmental change in the gene expression of transient receptor potential melastatin channel 3 (TRPM3) in murine lacrimal gland . Annals of Anatomy-Anatomischer Anzeiger , 231 . https://dx.doi.org/10.1016/j.aanat.2020.151551
Karauda, P., Podgórski, M., Paulsen, F., Polguj, M., & Olewnik, Ł. (2020). Anatomical variations of the tibialis anterior tendon . Clinical Anatomy . https://dx.doi.org/10.1002/ca.23663
Mohammad, J.A., Heichel, J., Singh, S., & Paulsen, F. (2020). Electron Microscopic Features of Canalicular Concretions . Ophthalmic Plastic and Reconstructive Surgery , 36 (5), 485-489. https://dx.doi.org/10.1097/IOP.0000000000001618
Mohammad, J.A., & Paulsen, F. (2020). Horner's Muscle or Horner-Duverney's Muscle . Ophthalmic Plastic and Reconstructive Surgery , 36 (2), 208-. https://dx.doi.org/10.1097/IOP.0000000000001574
Mohammad, J.A., Scholz, M., Singh, S., Heichel, J., & Paulsen, F. (2020). Etiopathogenesis of lacrimal sac mucopeptide concretions: insights from cinematic rendering techniques . Graefes Archive For Clinical and Experimental Ophthalmology . https://dx.doi.org/10.1007/s00417-020-04793-7
Musayeva, A., Gericke, A., Jäger, F., Paulsen, F., Braun, M., Fabry, B.,... Zierhut, M. (2020). Ergebnisse der Sicca-Forschungsförderung 2016 . Ophthalmologe . https://dx.doi.org/10.1007/s00347-020-01163-w
Olewnik, Ł., Karauda, P., Gonera, B., Kurtys, K., Haładaj, R., Tubbs, R.S.,... Polguj, M. (2020). Intramuscular innervation of plantaris muscle evaluated using a modified Sihler's staining protocol — Proposal for a new classification . Annals of Anatomy-Anatomischer Anzeiger , 230 . https://dx.doi.org/10.1016/j.aanat.2020.151504
Olewnik, Ł., Zielinska, N., Paulsen, F., Podgórski, M., Haładaj, R., Karauda, P., & Polguj, M. (2020). A proposal for a new classification of soleus muscle morphology . Annals of Anatomy-Anatomischer Anzeiger , 232 . https://dx.doi.org/10.1016/j.aanat.2020.151584
Paulsen, F., & Tillmann, B. (2020). Structure, Function and Insertion of the Human Vocal Folds . Advances in Oto-Rhino-Laryngology , 85 , 1-9. https://dx.doi.org/10.1159/000456678
Schneider, E., Paulsen, F., & Jacobi, C. (2020). Messung der Dichte der Langerhans-Zellen als Verlaufsparameter bei Patienten mit Keratoconjunctivitis sicca unter topischer antiinflammatorischer Therapie mit Ciclosporin A 0,05% Augentropfen. Klinische Monatsblätter für Augenheilkunde , 237 (5), 669-674. https://dx.doi.org/10.1055/a-1155-6519
Singh, S., Mohammad, J.A., Mittal, V., Brabletz, S., & Paulsen, F. (2020). Immunohistological Study of Palpebral Lobe of the Lacrimal Gland in Severe Dry Eyes Secondary to Stevens–Johnson Syndrome . Current Eye Research . https://dx.doi.org/10.1080/02713683.2020.1836227
Steffen, U., Koeleman, C.A., Sokolova, M.V., Bang, H., Kleyer, A., Rech, J.,... Hartmann, F. (2020). IgA subclasses have different effector functions associated with distinct glycosylation profiles . Nature Communications , 11 (1). https://dx.doi.org/10.1038/s41467-019-13992-8
Vasil'ev, Y., Paulsen, F., & Dydykin, S. (2020). Anatomical and radiological features of the bone organization of the anterior part of the mandible . Annals of Anatomy-Anatomischer Anzeiger , 231 . https://dx.doi.org/10.1016/j.aanat.2020.151512
Vasil'ev, Y., Paulsen, F., Dydykin, S., Bogoyavlenskaya, T., & Kashtanov, A. (2020). Structural features of the anterior region of the mandible . Annals of Anatomy-Anatomischer Anzeiger . https://dx.doi.org/10.1016/j.aanat.2020.151589
Weizel, A., Distler, T., Schneidereit, D., Friedrich, O., Bräuer, L., Paulsen, F.,... Seitz, H. (2020). Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair . Acta Biomaterialia . https://dx.doi.org/10.1016/j.actbio.2020.10.025
Wozniak, S., Kempinski, R., Grzelak, J., Domagala, Z., & Paulsen, F. (2020). Anatomy-related ratios predict colonoscopy incompleteness in similar examination conditions . Advances in Clinical and Experimental Medicine , 29 (5), 573-580. https://dx.doi.org/10.17219/acem/118847
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The institute’s research focuses on questions concerning the eye, in particular the anatomy, immunology and pathophysiology of the ocular surface, the tear film and tear drainage mechanisms. Furthermore, the pathomechanisms that lead to dry eye disease such as lacrimal gland insufficiency and meibomian gland dysfunction are investigated. This involves, among other things, lacrimal gland and meibomian gland replacement by means of stem cell therapy. Other research topics include surface-active proteins, in particular surfactant proteins, osteoarthritis, brain mechanics, SARS-CoV-2, microplastics in the human body, various anatomical questions and questions on the health of medical students..
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