Prof. Dr. Friedrich Paulsen

Institute of Functional and Clinical Anatomy

The institute’s research focuses on questions concerning the eye, in particular the anatomy, immunology and pathophysiology of the ocular surface, the tear film and tear drainage mechanisms. Furthermore, the pathomechanisms that lead to dry eye disease such as lacrimal gland insufficiency and meibomian gland dysfunction are investigated. This involves, among other things, lacrimal gland and meibomian gland replacement by means of stem cell therapy. Other research topics include surface-active proteins, in particular surfactant proteins, osteoarthritis, brain mechanics, SARS-CoV-2, microplastics in the human body, various anatomical questions and questions on the health of medical students..

Research projects

  • Antimicrobial peptides at the ocular surface
  • Insights into Meibomian Gland (dys)function
  • Lacrimal gland stem cells
  • Tear drainage mechanisms
  • Mechanisms of corneal regeneration
  • Function of newly described surfactant proteins
  • Microplastic in the body
  • Engineering brain mechanics
  • Drug depots for the eye
  • Health of medical students
  • Corneal wound healing
  • TFF peptides and other peptides in osteoarthritis
  • Analysis of mucus on the ocular surface and in the larynx

  • Novel Biopolymer Hydrogels for Understanding Complex Soft Tissue Biomechanics

    (FAU Funds)

    Term: 1. April 2019 - 31. March 2022
    URL: https://www.biohydrogels.forschung.fau.de/

    Biological tissues such as blood vessels, skin, cartilage or nervous tissue provide vital functionality
    to living organisms. Novel computational simulations of these tissues can provide insights
    into their biomechanics during injury and disease that go far beyond traditional approaches. This
    is of ever increasing importance in industrial and medical applications as numerical models will
    enable early diagnostics of diseases, detailed planning and optimization of surgical procedures,
    and not least will reduce the necessity of animal and human experimentation. However, the extreme
    compliance of these, from a mechanical perspective, particular soft tissues stretches conventional
    modeling and testing approaches to their limits. Furthermore, the diverse microstructure
    has, to date, hindered their systematic mechanical characterization. In this project, we will, as a
    novel perspective, categorize biological tissues according to their mechanical behavior and identify
    biofabricated proxy (substitute) materials with similar properties to reduce challenges related
    to experimental characterization of living tissues. We will further develop appropriate mathematical
    models that allow us to computationally predict the tissue response based on these proxy
    materials. Collectively, we will provide a catalogue of biopolymeric proxy materials for different
    soft tissues with corresponding modeling approaches. As a prospect, this will significantly facilitate
    the choice of appropriate materials for 3D biofabrication of artificial organs, as well as modeling
    approaches for predictive simulations. These form the cornerstone of advanced medical
    treatment strategies and engineering design processes, leveraging virtual prototyping.

2021

2020

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