One focus of our research is data acquisition (e.g. data from imaging MRI or CT, basic research, clinical trial data, digital applications Apps) and the distribution of data for analysis using AI methods to improve early diagnosis, differential diagnosis and prediction of the course of the disease of rheumatic diseases such as rheumatoid arthritis or psoriatic arthritis.
Research projects
Emerging Fields Initiative: MIRACLE – MR-based Immune-metabolic Redefinition of Arthritis and MusCuloskletaL DisEase (2018)
BMBF Consortium: Mascara Molecular Assessment of Signatures ChAracterizing the Remission of Arthritis (2019)
planned SFB: EmpkinS Empathokinästethische Sensorik (2020)
Imaging and deep learning: implementation of AI methods on radiological images such as CT/MRT in patients with rheumatic diseases (RMD)
Digital Health: Evaluation of the use of digital applications (APPs) for recording disease activity and differential diagnosis of rheumatic diseases in patients with RMDs
Use of sensor technology in rheumatology. Development and evaluation of sensor technologies for the analysis of movement patterns and hand function in patients with RMDs
Current Projects
Umfassende Charakterisierung von Patienten mit entzündlichen Knochenerkrankungen durch serologisches Profiling und Bildgebung (Z01)
(Third Party Funds Group – Sub project)
Overall project: TRR 369: DIONE Entzündungsbedingte KnochendegenerationTerm: 1. April 2024 - 31. December 2027Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)
Die Rolle von Typ-I-Interferon bei entzündlichen Knochenerkrankungen (C06)
(Third Party Funds Group – Sub project)
Overall project: TRR 369: DIONE Entzündungsbedingte KnochendegenerationTerm: 1. April 2024 - 31. December 2027Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)
Im Projekt C06 wird untersucht, wie ungebremstes Typ-I-IFN den entzündlichen Knochenverlust antreibt. Primäre Fibroblasten von Patienten mit IFIH1-Mutationen sezernieren große Mengen von VEGF, einem wichtigen Regulator des Knochens, was auf eine bisher nicht erkannte Verbindung zwischen Typ-I-IFN und VEGF in der Knochenhomöostase hindeutet. Ziel dieses Projekts ist es, einen Einblick in die Mechanismen der durch Typ-I-IFN vermittelten entzündlichen Knochenerkrankung zu gewinnen und neue Wege aufzuzeigen, die für therapeutische Eingriffe genutzt werden können.
Bewegungsmuster der Hand aus empathokinästhetischen Sensordaten als diagnostische Größe für Krankheitsaktivität bei Patienten mit rheumatischen Erkrankungen
(Third Party Funds Group – Sub project)
Overall project: Empathokinästhetische Sensorik
Term: 1. July 2021 - 30. June 2025
Funding source: DFG / Sonderforschungsbereich (SFB)
URL: https://www.empkins.de/
Unter standardisierten Bedingungen wird in D01 ein umfassender Datensatz zum aktuellen Erkrankungsstatus von Patienten (N = 150) mit RA und PsA in Kombination mit einer umfangreichen klinischen Testbatterie von Handfunktion sowie auch Vergleichsdaten einer gesunden Kohorte (N = 75) erhoben. Die parallele Erfassung von Handfunktion mittels „state-of-the-art“ Motion-Capture-Sensorik bietet eine kritische Grundlage für die experimentelle Evaluation und integrierte Dateninterpretation der neuartigen Sensordaten (TPe A01, A02 und A03), die bei der Erfassung von Handfunktion mittels EmpkinS in der 2. Hälfte der 1. Förderperiode erfasst werden.
Recent publications
2025
Bartenschlager, S., Cavallaro, A.J., Pogarell, T., Uder, M., Chaudry, O., Schett, G., & Engelke, K. (2025). Impact of intravenous CT contrast agents on internal calibration techniques to determine trabecular BMD of the lumbar spine . European Journal of Radiology , 183 . https://doi.org/10.1016/j.ejrad.2025.111923
Coppers, B., Heinrich, S., Tascilar, K., Phutane, U., Kleyer, A., Simon, D.,... Liphardt, A.-M. (2025). Sensor-assessed grasping time as a biomarker of functional impairment in rheumatoid arthritis . Scientific Reports , 15 (1). https://doi.org/10.1038/s41598-025-90295-7
Hong, X., Xiao, Y., Xu, L., Shen, L., Neelagar, R., Devakumar, V.,... Matei, A.E. (2025). Combination therapies of porcupine inhibition with ruxolitinib, ibrutinib, or belumosudil in murine sclerodermatous GVHD . Blood Advances , 9 (6), 1261-1266. https://doi.org/10.1182/bloodadvances.2024014387
Junt, T., Calzascia, T., Traggiai, E., da Costa, A.N., Gergely, P., Schett, G.,... Siegel, R.M. (2025). Defining immune reset: achieving sustained remission in autoimmune diseases . Nature Reviews Immunology . https://doi.org/10.1038/s41577-025-01141-w
Mougiakakos, D., Meyer, E.H., & Schett, G. (2025). CAR T cells in autoimmunity: game changer or stepping stone? Blood . https://doi.org/10.1182/blood.2024025413
Pfeuffer, N., Hartmann, F., Grahammer, M., Simon, D., Schuster, L., Kuhn, S.,... Kleyer, A. (2025). Early detection of rheumatoid arthritis through patient empowerment by tailored digital monitoring and education: a feasibility study . Rheumatology International , 45 (2), 43-. https://doi.org/10.1007/s00296-025-05793-8
Port, H., Coppers, B., Tragl, S., Manger, E., Niemiec, L.M., Bayat, S.,... Liphardt, A.-M. (2025). Serum extracellular matrix biomarkers in rheumatoid arthritis, psoriatic arthritis and psoriasis and their association with hand function . Scientific Reports , 15 . https://doi.org/10.1038/s41598-025-98395-0
Port, H., Coppers, B., Tragl, S., Manger, E., Niemiec, L.M., Bayat, S.,... Liphardt, A.-M. (2025). Serum extracellular matrix biomarkers in rheumatoid arthritis, psoriatic arthritis and psoriasis and their association with hand function . Scientific Reports , 15 . https://doi.org/10.1038/s41598-025-98395-0
Ramiro, S., Schett, G., Marzo-Ortega, H., & Schmidt, W.A. (2025). The Impact of IL-17A Inhibition in Rheumatic and Musculoskeletal Diseases: Current Insights and Future Prospects . Rheumatology and Therapy . https://doi.org/10.1007/s40744-025-00754-w
Zhu, L., Wang, Y., Shan, L., Xue, Y., Schett, G., Herrmann, M., & Liu, L. (2025). Colchicine inhibits monosodium urate crystal-mediated inflammation by influencing F-actin formation . Biochimica et Biophysica Acta - Molecular Basis of Disease , 1871 (3). https://doi.org/10.1016/j.bbadis.2024.167602
2024
Abir, A.H., Weckwerth, L., Wilhelm, A., Thomas, J., Reichardt, C., Munoz, L.E.,... Mielenz, D. (2024). Metabolic profiling of single cells by exploiting NADH and FAD fluorescence via flow cytometry . Molecular Metabolism , 87 . https://doi.org/10.1016/j.molmet.2024.101981
Alsuliman, T., Marjanovic, Z., Rimar, D., Tarte, K., Avcin, T., Hagen, M.,... Farge, D. (2024). Harnessing the potential of CAR-T cell in lupus treatment: From theory to practice . Autoimmunity Reviews , 23 (12). https://doi.org/10.1016/j.autrev.2024.103687
Andreev, D., Kachler, K., Liu, M., Chen, Z., Krishnacoumar, B., Ringer, M.,... Bozec, A. (2024). Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase. Nature Communications , 15 (1). https://doi.org/10.1038/s41467-024-45261-8
Auger, J.-P., Zimmermann, M., Faas, M., Stifel, U., Chambers, D., Krishnacoumar, B.,... Krönke, G. (2024). Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids . Nature . https://doi.org/10.1038/s41586-024-07282-7
Auth, J., Müller, F., Völkl, S., Bayerl, N., Distler, J.H., Tur, C.,... Bergmann, C. (2024). CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series . The Lancet Rheumatology . https://doi.org/10.1016/S2665-9913(24)00282-0
Bartenschlager, S., Cavallaro, A.J., Pogarell, T., Chaudry, O., Uder, M., Khosla, S.,... Engelke, K. (2024). Response to the editor of JBMR regarding the letter related to "Opportunistic screening with CT: comparison of phantomless BMD calibration methods". Journal of Bone and Mineral Research , 39 (6), 804-805. https://doi.org/10.1093/jbmr/zjae037
Bartsch, V., Fagni, F., Krieter, M., Ibrahim, M., Temiz, S.A., Yalcin-Mutlu, M.,... Hueber, A. (2024). Screening for psoriatic arthritis in dermatological settings-are handheld ultrasound devices the gamechangers we hoped for? Rheumatology , 63 (11), e294-e296. https://doi.org/10.1093/rheumatology/kead592
Bergmann, C., Chenguiti Fakhouri, S., Trinh-Minh, T., Filla, T., Rius Rigau, A.R., Ekici, A.B.,... Distler, J.H. (2024). Mutual Amplification of GLI2/Hedgehog and Transcription Factor JUN/AP-1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies . Arthritis and Rheumatology . https://doi.org/10.1002/art.42979
Blazek, V., Loy, N., Jukic, E., Coppers, B., Fleischmann, M.E., Hübner, J.,... Liphardt, A.-M. (2024). AB0930 Towards Objective Measurement Of Spinal Mobility In Axial Spondyloarthritis – Benchmarking An Inertial Measurement Unit System With An Optical Measurement System . Annals of the Rheumatic Diseases , 1774-1775. https://doi.org/10.1136/annrheumdis-2024-eular.5778
Boy, K., May, S., Labinsky, H., Morf, H., Heinze, M., Leipe, J.,... Muehlensiepen, F. (2024). Back on track – digital health applications to treat back pain of rheumatic patients? Results of a qualitative interview study . Rheumatology International . https://doi.org/10.1007/s00296-024-05726-x
Boy, K., May, S., Labinsky, H., Morf, H., Heinze, M., Leipe, J.,... Muehlensiepen, F. (2024). Correction to: Back on track – digital health applications to treat back pain of rheumatic patients? Results of a qualitative interview study (Rheumatology International, (2024), 10.1007/s00296-024-05726-x) . Rheumatology International . https://doi.org/10.1007/s00296-024-05747-6
Boy, K., von Rohr-Wahlen-Jürgaß, S., May, S., Kuhn, S., Schett, G., Labinsky, H.,... Muehlensiepen, F. (2024). Pre-assessment of patients with suspected axial spondyloarthritis combining student-led clinics and telemedicine: a qualitative study . Rheumatology International . https://doi.org/10.1007/s00296-023-05522-z
Bucci, L., Hagen, M., Rothe, T., Raimondo, M.G., Fagni, F., Tur, C.,... Grieshaber Bouyer, R. (2024). Bispecific T cell engager therapy for refractory rheumatoid arthritis . Nature Medicine , 30 (6), 1593-1601. https://doi.org/10.1038/s41591-024-02964-1
Bugatti, S., & Schett, G. (2024). Prevention of seronegative rheumatoid arthritis: an entity of its own . The Lancet Rheumatology . https://doi.org/10.1016/S2665-9913(24)00226-1
Coates, L.C., Schett, G., Wang, C., & Weiss, P.F. (2024). Unmet Needs in Spondyloarthritis: Pathogenesis, Clinical Trial Design, and Nonpharmacologic Therapy . Journal of Rheumatology , 51 (12), 1254-1258. https://doi.org/10.3899/jrheum.2024-0939
Coppers, B., Heinrich, S., Bayat, S., Tascilar, K., Kleyer, A., Simon, D.,... Liphardt, A.-M. (2024). AB0208 Reduced Hand Function Indicates Higher Disease Activity In Patients With Rheumatoid And Psoriatic Arthritis . Annals of the Rheumatic Diseases , 1342.1-1342. https://doi.org/10.1136/annrheumdis-2024-eular.1112
Corte, G., Atzinger, A., Temiz, S.A., Noversa de Sousa, R., Mutlu, M.Y., Schönau, V.,... Fagni, F. (2024). Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritis . RMD Open , 10 (2). https://doi.org/10.1136/rmdopen-2024-004294
Deane, K.D., Michael Holers, V., Emery, P., Mankia, K., El Gabalawy, H., Sparks, J.A.,... Cope, A.P. (2024). Therapeutic interception in individuals at risk of rheumatoid arthritis to prevent clinically impactful disease . Annals of the Rheumatic Diseases . https://doi.org/10.1136/ard-2023-224211
Dingfelder, J., Aigner, M., Taubmann, J., Minopoulou, I., Park, S., Kaplan, C.D.,... Lutzny-Geier, G. (2024). Fully Human Anti-CD19 CAR T Cells Derived from Systemic Lupus Erythematosus Patients Exhibit Cytotoxicity with Reduced Inflammatory Cytokine Production . Transplantation and Cellular Therapy . https://doi.org/10.1016/j.jtct.2024.03.023
Fagni, F., Motta, F., Schett, G., & Selmi, C. (2024). Difficult-to-Treat Psoriatic Arthritis: A Conceptual Approach. Arthritis and Rheumatology , 76 (5), 670-674. https://doi.org/10.1002/art.42780
Fagni, F., Tascilar, K., Noversa de Sousa, R., Bayat, S., Sollfrank, L., Kleyer, A.,... Simon, D. (2024). Unveiling Metabolic Similarities of Entheses in Patients with Psoriasis and Psoriatic Arthritis Using Noninvasive In Vivo Molecular Imaging: Results From a Cross-sectional Exploratory Study . Arthritis and Rheumatology , 76 (9), 1387-1396. https://doi.org/10.1002/art.42917
Fleischmann, S., Holzwarth Correa, V., Coppers, B., Sadeghi, M., Richer, R., Kleyer, A.,... Liphardt, A.-M. (2024). Classification of rheumatoid arthritis from hand motion capture data using machine learning . In Proceedings of the 13. Kongress der Deutschen Gesellschaft für Biomechanik (DGfB) . Heidelberg.
Gossec, L., Kerschbaumer, A., Ferreira, R.J., Aletaha, D., Baraliakos, X., Bertheussen, H.,... Smolen, J.S. (2024). EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update . Annals of the Rheumatic Diseases . https://doi.org/10.1136/ard-2024-225531
Greco, R., Alexander, T., Del Papa, N., Müller, F., Saccardi, R., Sanchez-Guijo, F.,... Farge, D. (2024). Innovative cellular therapies for autoimmune diseases: expert-based position statement and clinical practice recommendations from the EBMT practice harmonization and guidelines committee. EClinicalMedicine , 69 . https://doi.org/10.1016/j.eclinm.2024.102476
Grube, L., Petit, P., Vuillerme, N., Nitschke, M., Nwosu, O.B., Knitza, J.,... Morf, H. (2024). Complementary App-Based Yoga Home Exercise Therapy for Patients With Axial Spondyloarthritis: Usability Study . JMIR Formative Research , 8 . https://doi.org/10.2196/57185
Györfi, A.H., Filla, T., Dickel, N., Möller, F., Li, Y.N., Bergmann, C.,... Distler, J.H. (2024). Performance of serum biomarkers reflective of different pathogenic processes in systemic sclerosis-associated interstitial lung disease. Rheumatology , 63 (4), 962-969. https://doi.org/10.1093/rheumatology/kead332
Hagen, M., Müller, F., Wirsching, A., Kharboutli, S., Spörl, S., Aigner, M.,... Schett, G. (2024). Treatment of CNS systemic lupus erythematosus with CD19 CAR T cells . The Lancet , 404 (10468), 2158-2160. https://doi.org/10.1016/S0140-6736(24)02265-7
Hagen, M., Wirsching, A., Bohr, D., Taubmann, J., Müller, F., Mackensen, A.,... Schett, G. (2024). CAR-T-Zell-Therapie in der Rheumatologie – Was wissen wir bisher? Zeitschrift für Rheumatologie . https://doi.org/10.1007/s00393-024-01514-x
Haghikia, A., Hegelmaier, T., Wolleschak, D., Böttcher, M., Pappa, V., Motte, J.,... Mougiakakos, D. (2024). Clinical efficacy and autoantibody seroconversion with CD19-CAR T cell therapy in a patient with rheumatoid arthritis and coexisting myasthenia gravis . Annals of the Rheumatic Diseases . https://doi.org/10.1136/ard-2024-226017
Haghikia, A., Schett, G., & Mougiakakos, D. (2024). B cell-targeting chimeric antigen receptor T cells as an emerging therapy in neuroimmunological diseases . Lancet Neurology , 23 (6), 615-624. https://doi.org/10.1016/S1474-4422(24)00140-6
Heinrich, S., Michaelis, J., Reiher, I., Coppers, B., Lohmayer, M., Fleischmann, M.E.,... Liphardt, A.-M. (2024). Comparison and Improvement of CyberGlove III calibration methods . IEEE Sensors , 24 (9). https://doi.org/10.1109/JSEN.2024.3376606
Jia, Y., Zhang, F., Meng, X., Andreev, D., Lyu, P., Zhang, W.,... Bozec, A. (2024). Osteocytes support bone metastasis of melanoma cells by CXCL5 . Cancer Letters , 590 . https://doi.org/10.1016/j.canlet.2024.216866
Kachler, K., Andreev, D., Thapa, S., Royzman, D., Gießl, A., Karuppusamy, S.,... Bozec, A. (2024). Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis . Annals of the Rheumatic Diseases . https://doi.org/10.1136/ard-2023-224774
Kaeley, G.S., Schett, G., Conaghan, P.G., McGonagle, D., Behrens, F., Goupille, P.,... Bakewell, C. (2024). Enthesitis in patients with psoriatic arthritis treated with secukinumab or adalimumab: a post hoc analysis of the EXCEED study. Rheumatology , 63 (1), 41-49. https://doi.org/10.1093/rheumatology/kead181
Knitza, J., Hasanaj, R., Beyer, J., Ganzer, F., Slagman, A., Bolanaki, M.,... Dechant, K. (2024). Comparison of Two Symptom Checkers (Ada and Symptoma) in the Emergency Department: Randomized, Crossover, Head-to-Head, Double-Blinded Study . Journal of Medical Internet Research , 26 . https://doi.org/10.2196/56514
Knitza, J., Tascilar, K., Fuchs, F., Mohn, J., Kuhn, S., Bohr, D.,... Hueber, A. (2024). Diagnostic Accuracy of a Mobile AI-Based Symptom Checker and a Web-Based Self-Referral Tool in Rheumatology: Multicenter Randomized Controlled Trial . Journal of Medical Internet Research , 26 . https://doi.org/10.2196/55542
Krickau, T., Naumann-Bartsch, N., Aigner, M., Kharboutli, S., Kretschmann, S., Spörl, S.,... Müller, F. (2024). CAR T-cell therapy rescues adolescent with rapidly progressive lupus nephritis from haemodialysis . The Lancet , 403 (10437), 1627-1630. https://doi.org/10.1016/S0140-6736(24)00424-0
Krishnacoumar, B., Stenzel, M., Garibagaoglu, H., Omata, Y., Sworn, R.L., Hofmann, T.,... Scholtysek, C. (2024). Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors . Bone Research , 12 (1). https://doi.org/10.1038/s41413-024-00338-4
Labinsky, H., May, S., Boy, K., von Rohr, S., Grahammer, M., Kuhn, S.,... Knitza, J. (2024). Evaluation of a hybrid telehealth care pathway for patients with axial spondyloarthritis including self-sampling at home: results of a longitudinal proof-of-concept mixed-methods study (TeleSpactive) . Rheumatology International , 44 , 1133-1142. https://doi.org/10.1007/s00296-024-05581-w
Liang, M., Dickel, N., Györfi, A.H., SafakTümerdem, B., Li, Y.N., Rius Rigau, A.R.,... Distler, J.H. (2024). Attenuation of fibroblast activation and fibrosis by adropin in systemic sclerosis . Science Translational Medicine , 16 (740). https://doi.org/10.1126/scitranslmed.add6570
Loy, N., Blazek, V., Jukic, E., Fleischmann, M.E., Coppers, B., Hübner, J.,... Liphardt, A.-M. (2024). POS0494 Fear Of Movement Affects Range Of Motion During Repeated Basmi Exercises Assessed By State-Of-The-Art Motion Capture Techniques . Annals of the Rheumatic Diseases , 936.3-937. https://doi.org/10.1136/annrheumdis-2024-eular.5298
Lyu, P., Wen, J., Zhang, W., Liu, N., Stolzer, I., Gießl, A.,... Bozec, A. (2024). Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery . Annals of the Rheumatic Diseases . https://doi.org/10.1136/ard-2023-224491
Manger, B., & Schett, G. (2024). Bessel’s disease—the first report of an IgG4-related disorder . Zeitschrift für Rheumatologie , 83 (8), 661-663. https://doi.org/10.1007/s00393-024-01502-1
Manger, B., & Schett, G. (2024). Magnesium Disorders . New England Journal of Medicine , 391 (7), 668-669. https://doi.org/10.1056/NEJMc2408312
Meng, X., Asadi Asadabad, S., Cao, S., Song, R., Lin, Z., Safhi, M.,... Bozec, A. (2024). Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation . Cellular & Molecular Immunology . https://doi.org/10.1038/s41423-024-01233-y
Minopoulou, I., Tascilar, K., Corte, G., Mutlu, M.Y., Schmidt, K., Bohr, D.,... Fagni, F. (2024). Tixagevimab/cilgavimab for the prevention of COVID-19 in vaccine-refractory patients with autoimmune diseases: a prospective cohort study. Rheumatology , 63 (5), 1377-1383. https://doi.org/10.1093/rheumatology/kead391
Mougiakakos, D., Sengupta, R., Gold, R., Schroers, R., Haghikia, A., Lorente, M.,... Walker, K. (2024). Successful generation of fully human, second generation, anti-CD19 CAR T cells for clinical use in patients with diverse autoimmune disorders . Cytotherapy . https://doi.org/10.1016/j.jcyt.2024.09.008
Müller, F., Taubmann, J., Bucci, L., Wilhelm, A., Bergmann, C., Völkl, S.,... Schett, G. (2024). CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up. New England Journal of Medicine , 390 (8), 687-700. https://doi.org/10.1056/NEJMoa2308917
Neurath, L., Sticherling, M., Schett, G., & Fagni, F. (2024). Targeting cytokines in psoriatic arthritis . Cytokine & Growth Factor Reviews , 78 , 1-13. https://doi.org/10.1016/j.cytogfr.2024.06.001
Noversa de Sousa, R., Tascilar, K., Corte, G., Atzinger, A., Minopoulou, I., Ohrndorf, S.,... Corte, G. (2024). Metabolic and molecular imaging in inflammatory arthritis . RMD Open , 10 (1). https://doi.org/10.1136/rmdopen-2023-003880
Pachowsky, M., Söllner, S., Gelse, K., Sambale, J., Nagel, A.M., Schett, G.,... Heiß, R. (2024). Primary anterior cruciate ligament repair-morphological and quantitative assessment by 7-T MRI and clinical outcome after 1.5 years. European Radiology , 34 (8), 5007-5015. https://doi.org/10.1007/s00330-024-10603-z
Palm von Alten Blaskowitz, P.A., Liphardt, A.-M., Bouzas, C., Coppers, B., Petit, P., Vuillerme, N.,... Morf, H. (2024). Impact of the digital health application ViViRA on spinal mobility, physical function, quality of life and pain perception in spondyloarthritides patients: a randomized controlled trial . Arthritis Research & Therapy , 26 (1). https://doi.org/10.1186/s13075-024-03443-1
Pedersen, R.S., Thorlacius-Ussing, J., Raimondo, M.G., Langholm, L.L., Schett, G., Ramming, A.,... Willumsen, N. (2024). Fibroblast Activation Protein (FAP)-Mediated Cleavage of Type III Collagen Reveals Serum Biomarker Potential in Non-Small Cell Lung Cancer and Spondyloarthritis . Biomedicines , 12 (3). https://doi.org/10.3390/biomedicines12030545
Pfeil, A., Klemm, P., Hueber, A.J., Hoffmann, T., Weise, T., Oelzner, P.,... Kleyer, A. (2024). Enhancing student understanding of rheumatic disease pathologies through augmented reality: findings from a multicentre trial. Rheumatology , 63 (7), 1949-1956. https://doi.org/10.1093/rheumatology/kead508
Rahman, P., McInnes, I.B., Deodhar, A., Schett, G., Mease, P.J., Shawi, M.,... McGonagle, D. (2024). Association between enthesitis/dactylitis resolution and patient-reported outcomes in guselkumab-treated patients with psoriatic arthritis . Clinical Rheumatology . https://doi.org/10.1007/s10067-024-06921-8
Rauber, S., Mohammadian, H., Schmidkonz, C., Atzinger, A., Soare, A., Treutlein, C.,... Ramming, A. (2024). CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis . Nature Immunology . https://doi.org/10.1038/s41590-024-01774-4
Raulien, N., Friedrich, K., Strobel, S., Raps, S., Hecker, F., Pierer, M.,... Wagner, U. (2024). Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes . Science Signaling , 17 (845). https://doi.org/10.1126/scisignal.add89
Rech, J., Schett, G., Tufan, A., Kuemmerle-Deschner, J.B., Özen, S., Tascilar, K.,... Vetterli, M. (2024). Patient Experiences and Challenges in the Management of Autoinflammatory Diseases—Data from the International FMF & AID Global Association Survey . Journal of Clinical Medicine , 13 (5). https://doi.org/10.3390/jcm13051199
Rech, J., Tascilar, K., Hagen, M., Kleyer, A., Manger, B., Schönau, V.,... Schett, G. (2024). Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial . The Lancet . https://doi.org/10.1016/S0140-6736(23)02650-8
Regierer, A.C., Kiefer, D., Schett, G., Krause, A., Weiß, A., Sewerin, P., & Strangfeld, A. (2024). No difference in clinical parameters and drug retention in PsA patients receiving b/tsDMARD monotherapy versus combination with methotrexate: data from the RABBIT-SpA registry . RMD Open , 10 (3). https://doi.org/10.1136/rmdopen-2024-004389
Reichardt, C., Munoz Becerra, M., Rius Rigau, A.R., Rückert, M., Fietkau, R., Schett, G.,... Munoz Becerra, L. (2024). Neutrophils seeking new neighbors: radiotherapy affects the cellular framework and the spatial organization in a murine breast cancer model . Cancer Immunology, Immunotherapy , 73 (4). https://doi.org/10.1007/s00262-024-03653-1
Rius Rigau, A.R., Li, Y.N., Matei, A.-E., Györfi, A.H., Bruch, P.M., Koziel, S.,... Liang, M. (2024). Characterization of Vascular Niche in Systemic Sclerosis by Spatial Proteomics . Circulation Research , 134 (7), 875-891. https://doi.org/10.1161/CIRCRESAHA.123.323299
Schett, G., & June, C.H. (2024). CAR T cells in autoimmune disease: On the road to remission . Immunity . https://doi.org/10.1016/j.immuni.2024.10.011
Schett, G., Mackensen, A., & Mougiakakos, D. (2024). CAR T-cell perspectives in lupus – Authors' reply . The Lancet , 404 (10450), 336-337. https://doi.org/10.1016/S0140-6736(24)01266-2
Schett, G., Müller, F., Taubmann, J., Mackensen, A., Wang, W., Furie, R.A.,... Mougiakakos, D. (2024). Advancements and challenges in CAR T cell therapy in autoimmune diseases . Nature Reviews Rheumatology . https://doi.org/10.1038/s41584-024-01139-z
Schlereth, M., Yalcin-Mutlu, M., Utz, J., Bayat, S., Heimann, T., Qiu, J.,... Fagni, F. (2024). Deep learning-based classification of erosion, synovitis and osteitis in hand MRI of patients with inflammatory arthritis . RMD Open , 10 (2). https://doi.org/10.1136/rmdopen-2024-004273
Schuster, L., Henes, J., Diener, M., Mühlensiepen, F., Andreica, I., Hueber, A.,... Knitza, J. (2024). Messung des krankheitsbezogenen Wissens von Patient*innen mit axialer Spondyloarthritis – Entwicklung und Anwendung des G-ASKQ7-Fragebogens . Zeitschrift für Rheumatologie . https://doi.org/10.1007/s00393-024-01584-x
Schweiger, I., Koschinsky, J., Elie-Tino, G., Tascilar, K., Coppers, B., Kleyer, A.,... Liphardt, A.-M. (2024). AB0929 THE IMPACT OF KINESIOPHOBIA ON GAIT KINEMATICS IN PATIENTS WITH SPONDYLOARTHROPATHIES . Annals of the Rheumatic Diseases , 1773.2-1774. https://doi.org/10.1136/annrheumdis-2024-eular.5381
Schälter, F., Azizov, V., Frech, M., Dürholz, K., Schmid, E., Hendel, A.,... Zaiss, M. (2024). CCL19‐positive lymph node stromal cells govern the onset of inflammatory arthritis via tropomyosin receptor kinase . Arthritis and Rheumatology . https://doi.org/10.1002/art.42807
Siebert, S., Coates, L.C., Schett, G., Raychaudhuri, S.P., Chen, W., Gao, S.,... Deodhar, A. (2024). Modulation of Interleukin-23 Signaling With Guselkumab in Biologic-Naive Patients Versus Tumor Necrosis Factor Inhibitor–Inadequate Responders With Active Psoriatic Arthritis . Arthritis and Rheumatology . https://doi.org/10.1002/art.42803
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Singh, J., Zlatar, L., Munoz Becerra, M., Lochnit, G., Herrmann, I., Pfister, F.,... Mahajan, A. (2024). Calpain-1 weakens the nuclear envelope and promotes the release of neutrophil extracellular traps . Cell Communication and Signaling , 22 (1). https://doi.org/10.1186/s12964-024-01785-6
Taubmann, J., Knitza, J., Müller, F., Völkl, S., Aigner, M., Kleyer, A.,... Schett, G. (2024). Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies . Rheumatology , 63 (1), e12-e14. https://doi.org/10.1093/rheumatology/kead330
Taubmann, J., Knitza, J., Müller, F., Völkl, S., Aigner, M., Kretschmann, S.,... Schett, G. (2024). Comment on: Rescue therapy of anti-synthetase syndrome with CD19-targeted CART cells after failure of several B cell-depleting antibodies: reply. Rheumatology , 63 (11), e312-e314. https://doi.org/10.1093/rheumatology/kead669
Taubmann, J., Müller, F., Mutlu, M.Y., Völkl, S., Aigner, M., Bozec, A.,... Schett, G. (2024). CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus. Arthritis and Rheumatology , 76 (4), 497-504. https://doi.org/10.1002/art.42784
Taylor, P.C., Schett, G., Huizinga, T.W., Wang, Q., Ibrahim, F., Zhou, B.,... Fei, K. (2024). Nipocalimab, an anti-FcRn monoclonal antibody, in participants with moderate to severe active rheumatoid arthritis and inadequate response or intolerance to anti-TNF therapy: results from the phase 2a IRIS-RA study . RMD Open , 10 (2). https://doi.org/10.1136/rmdopen-2024-004278
Thies, M., Wagner, F., Gu, M., Mei, S., Huang, Y., Pechmann, S.,... Maier, A. (2024). Exploring Epipolar Consistency Conditions for Rigid Motion Compensation in In-vivo X-ray Microscopy . In Andreas Maier, Thomas M. Deserno, Heinz Handels, Klaus Maier-Hein, Christoph Palm, Thomas Tolxdorff (Eds.), Bildverarbeitung für die Medizin 2024. BVM 2024 (pp. 211-216). Erlangen, DE: Wiesbaden: Springer Vieweg.
Trinh-Minh, T., Chen, C.-W., Tran-Manh, C., Li, Y.N., Zhu, H., Zhou, X.,... Distler, J.H.W. (2024). Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis . Journal of Clinical Investigation , 134 (10). https://doi.org/10.1172/JCI159884
Tur, C., Eckstein, M., Velden, J., Rauber, S., Bergmann, C., Auth, J.,... Raimondo, M.G. (2024). CD19-CAR T-cell therapy induces deep tissue depletion of B cells . Annals of the Rheumatic Diseases . https://doi.org/10.1136/ard-2024-226142
Wilhelm, A., Chambers, D., Müller, F., Bozec, A., Grieshaber Bouyer, R., Winkler, T.,... Krönke, G. (2024). Selective CAR T cell–mediated B cell depletion suppresses IFN signature in SLE . JCI Insight , 9 (12). https://doi.org/10.1172/jci.insight.179433
Yalcin-Mutlu, M., Icacan, O.C., Yildirim, F., Temiz, S.A., Fagni, F., Schett, G.,... Bes, C. (2024). IL-1 Inhibitors in the Treatment of Familial Mediterranean Fever: Treatment Indications and Clinical Features in a Large Real-World Cohort . Journal of Clinical Medicine , 13 (12). https://doi.org/10.3390/jcm13123375
Yaykasli, K.O., van Schie, K.A., Toes, R.E., Wuhrer, M., Koeleman, C.A., Bila, G.,... Bilyy, R. (2024). Neutrophil Depletion Changes the N-Glycosylation Pattern of IgG in Experimental Murine Sepsis . International Journal of Molecular Sciences , 25 (12). https://doi.org/10.3390/ijms25126478
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Zhu, H., Luo, H., Skaug, B., Tabib, T., Li, Y., Tao, Y.,... Distler, J. (2024). Fibroblast Subpopulations in Systemic Sclerosis: Functional Implications of Individual Subpopulations and Correlations with Clinical Features . Journal of Investigative Dermatology . https://doi.org/10.1016/j.jid.2023.09.288
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2023
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Kaaij, M.H., Van Hamburg, J.P., Van Rooijen, C.C.N., Grüneboom, A., Kan, Y.Y., Pots, D.,... Tas, S.W. (2023). Contribution of Type H Blood Vessels to Pathologic Osteogenesis and Inflammation in an Experimental Spondyloarthritis Model . Arthritis and Rheumatology . https://doi.org/10.1002/art.42449
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Mutlu, M.Y., Tascilar, K., & Schett, G. (2023). Rationnel, état des lieux et perspectives des combinaisons de traitements de fond biologiques dans la prise en charge de la polyarthrite rhumatoïde et du rhumatisme psoriasique . Revue du Rhumatisme (Edition Francaise) . https://doi.org/10.1016/j.rhum.2023.07.019
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Schett, G., Chen, W., Gao, S., Chakravarty, S.D., Shawi, M., Lavie, F.,... Siebert, S. (2023). Effect of guselkumab on serum biomarkers in patients with active psoriatic arthritis and inadequate response to tumor necrosis factor inhibitors: results from the COSMOS phase 3b study . Arthritis Research & Therapy , 25 (1). https://doi.org/10.1186/s13075-023-03125-4
Schett, G., Mackensen, A., & Mougiakakos, D. (2023). CAR T-cell therapy in autoimmune diseases . The Lancet . https://doi.org/10.1016/S0140-6736(23)01126-1
Schmidt, K., Harrer, E., Schönau, V., Simon, D., Kleyer, A., Steininger, P.,... Harrer, T. (2023). Detection of pre-existing neutralizing antibodies against Ad26 in HIV-1-infected individuals not responding to the Ad26.COV2.S vaccine . Infection . https://doi.org/10.1007/s15010-023-02035-6
Schuster, L., Valor-Mendez, L., Wacker, J., Dannhardt-Thiem, V., Schmidt, A., Knitza, J.,... Kleyer, A. (2023). „Rheuma (be-)greifen“ – ein multimodales Lehrkonzept zur Verbesserung der rheumatologischen Lehre für Studierende der Humanmedizin . Zeitschrift für Rheumatologie . https://doi.org/10.1007/s00393-023-01391-w
Seeling, M., Pöhnl, M., Kara, S., Horstmann, N., Riemer, C., Wöhner, M.,... Nimmerjahn, F. (2023). Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1 . Immunity , 56 (5), 1046-1063.e7. https://doi.org/10.1016/j.immuni.2023.02.019
Simon, D., Minopoulou, I., Kemenes, S., Bayat, S., Tascilar, K., Mutlu, M.Y.,... Kleyer, A. (2023). Baricitinib Improves Bone Properties and Biomechanics in Patients With Rheumatoid Arthritis: Results of the Prospective Interventional BARE BONE Trial . Arthritis and Rheumatology . https://doi.org/10.1002/art.42617
Singh, J., Boettcher, M., Dölling, M., Heuer, A., Hohberger, B., Leppkes, M.,... Knopf, J. (2023). Moonlighting chromatin: when DNA escapes nuclear control . Cell Death and Differentiation . https://doi.org/10.1038/s41418-023-01124-1
Sokolova, M., Hartmann, F., Sieghart, D., Bang, H., Steiner, G., Kleyer, A.,... Steffen, U. (2023). Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk. RMD Open , 9 (1). https://doi.org/10.1136/rmdopen-2022-002705
Sonomoto, K., Song, R., Eriksson, D., Hahn, A.M., Meng, X., Lyu, P.,... Bozec, A. (2023). High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production . Cell Reports , 42 (7). https://doi.org/10.1016/j.celrep.2023.112713
Stephan, M., Tascilar, K., Yalcin-Mutlu, M., Hagen, M., Haschka, J., Reiser, M.,... Rech, J. (2023). Physical Function of RA patients Tapering Treatment—A Post Hoc Analysis of the Randomized Controlled RETRO Trial . Journal of Clinical Medicine , 12 (11). https://doi.org/10.3390/jcm12113723
Valor-Mendez, L., Atzinger, A., Reis, P., Manger, B., & Schett, G. (2023). Clinical Images: Increased bone metabolism in secondary hyperparathyroidism . Arthritis and Rheumatology . https://doi.org/10.1002/art.42458
Valor-Mendez, L., Sticherling, M., Zeschick, M., Atreya, R., Schmidt, D., Waldfahrer, F.,... Rech, J. (2023). VEXAS syndrome mimicking lupus-like disease . Rheumatology . https://doi.org/10.1093/rheumatology/kead076
Valor-Mendez, L., Türk, M., Schett, G., Manger, B., & Knitza, J. (2023). Misdiagnosis of polymyositis in a young female patient with occult limb-girdle muscular dystrophy . Rheumatology Advances in Practice , 7 (2). https://doi.org/10.1093/rap/rkad061
Weiß, M., Holzer, M.T., Muehlensiepen, F., Ignatyev, Y., Fiehn, C., Bauhammer, J.,... Knitza, J. (2023). Healthcare utilization and unmet needs of patients with antisynthetase syndrome: An international patient survey . Rheumatology International , 43 (10), 1925-1934. https://doi.org/10.1007/s00296-023-05372-9
Wirth, V., Liphardt, A.-M., Coppers, B., Bräunig, J., Heinrich, S., Leyendecker, S.,... Stamminger, M. (2023). Markerless RGB-D Hand Pose Estimation for Activity Monitoring of Musculoskeletal Diseases .
Wirth, V., Liphardt, A.-M., Coppers, B., Bräunig, J., Heinrich, S., Leyendecker, S.,... Stamminger, M. (2023). ShaRPy: Shape Reconstruction and Hand Pose Estimation from RGB-D with Uncertainty . In Proceedings of the IEEE/CVF International Conference on Computer Vision (ICCV) Workshops (pp. 2625-2633). Paris, FR.
Zabotti, A., De Marco, G., Gossec, L., Baraliakos, X., Aletaha, D., Iagnocco, A.,... McGonagle, D.G. (2023). EULAR points to consider for the definition of clinical and imaging features suspicious for progression from psoriasis to psoriatic arthritis . Annals of the Rheumatic Diseases . https://doi.org/10.1136/ard-2023-224148
Zhou, X., Trinh-Minh, T., Matei, A.-E., Györfi, A.H., Hong, X., Bergmann, C.,... Distler, J.H. (2023). Amelioration of Fibrotic Remodeling of Human 3-Dimensional Full-Thickness Skin by Transglutamase 2 Inhibition . Arthritis and Rheumatology . https://doi.org/10.1002/art.42518
Zlatar, L., Mahajan, A., Munoz Becerra, M., Weidner, D., Bila, G., Bilyy, R.,... Knopf, J. (2023). Suppression of neutrophils by sodium exacerbates oxidative stress and arthritis . Frontiers in Immunology , 14 . https://doi.org/10.3389/fimmu.2023.1174537
Zlatar, L., Timm, T., Lochnit, G., Bilyy, R., Bäuerle, T., Munoz Becerra, M.,... Herrmann, M. (2023). Neutrophil Extracellular Traps Drive Dacryolithiasis . Cells , 12 (14). https://doi.org/10.3390/cells12141857
von Rohr, S., Knitza, J., Grahammer, M., Schmalzing, M., Kuhn, S., Schett, G.,... Labinsky, H. (2023). Student-led clinics and ePROs to accelerate diagnosis and treatment of patients with axial spondyloarthritis: results from a prospective pilot study . Rheumatology International . https://doi.org/10.1007/s00296-023-05392-5
2022
Andreev, D., Kachler, K., Bozec, A., & Schett, G. (2022). Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism . Bone , 162 . https://doi.org/10.1016/j.bone.2022.116468
Bayat, S., Tascilar, K., Bohr, D., Krönke, G., Simon, D., Knitza, J.,... Kleyer, A. (2022). Efficacy and drug persistence of baricitinib monotherapy is similar to combination therapy in patients with active RA: a prospective observational study . RMD Open , 8 (2). https://doi.org/10.1136/rmdopen-2022-002674
Bayat, S., Tascilar, K., Bohr, D., Simon, D., Kronke, G., Hartmann, F.,... Kleyer, A. (2022, June). SIMILAR EFFICACY AND DRUG SURVIVAL RATES OF BARICITINIB MONOTHERAPY AND BARICITINIB/METHOTREXATE COMBINATION THERAPY IN REAL-LIFE TREATMENT OF RHEUMATOID ARTHRITIS - RESULTS FROM A PROSPECTIVE COHORT OF BARICITINIB-TREATED PATIENTS .
Birkner, B., Rech, J., Edelmann, E., Verheyen, F., Schett, G., & Stargardt, T. (2022). Patient-individual tapering of DMARDs in rheumatoid arthritis patients in a real-world setting . Rheumatology . https://doi.org/10.1093/rheumatology/keac472
Cao, S., Song, R., Meng, X., Kachler, K., Fuchs, M., Meng, X.,... Bozec, A. (2022). L-ARGININE REPROGRAMS OSTEOCLAST PURINE METABOLISM AMELIORATING BONE LOSS IN RHEUMATOID ARTHRITIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 52-52). LONDON: BMJ PUBLISHING GROUP.
Coppers, B., Heinrich, S., Phutane, U., Berisha, D., Tascilar, K., Kleyer, A.,... Liphardt, A.-M. (2022). Feasibility of using optoelectronic measurement of hand movement for characterizing hand function in rheumatoid arthritis .
Coppers, B., Heinrich, S., Phutane, U., Berisha, D., Tascilar, K., Kleyer, A.,... Liphardt, A.-M. (2022). Evaluation of marker-based motion capturing to charactherize basic hand movements in rheumatic patients .
Coppers, B., Phutane, U., Berisha, D., Tascilar, K., Kleyer, A., Simon, D.,... Liphardt, A.-M. (2022). Establishment and evaluation of a sensor-based method to assess hand function in patients with rheumatoid arthritis . In Proceedings of the conference, World Biomechanics Congress 2022 . Taipei (online), TW.
D'Agostino, M.A., Boers, M., Gaillez, C., Gamez, C., Ventura, L., Padovano, J.R.I.,... Schett, G. (2022). RESPONSIVENESS OF A COMBINED POWER DOPPLER AND GREYSCALE ULTRASOUND SCORE FOR ASSESSING SYNOVITIS AT JOINT LEVEL IN PSORIATIC ARTHRITIS PATIENTS WITH INADEQUATE RESPONSE TO CSDMARDS: DATA FROM THE ULTIMATE TRIAL . In ANNALS OF THE RHEUMATIC DISEASES (pp. 171-172). LONDON: BMJ PUBLISHING GROUP.
D'Agostino, M.A., Boers, M., Schett, G., Conaghan, P.G., Naredo, E., Mandl, P.,... Bao, W. (2022). REDUCED JOINT SYNOVITIS ASSESSMENT VERSUS THE GLOBAL EULAR OMERACT SYNOVITIS SCORE (GLOESS) TO PREDICT THE RESPONSE TO SECUKINUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND INADEQUATE RESPONSE TO CONVENTIONAL DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS: EXPLORATORY RESULTS FROM THE ULTIMATE TRIAL . In ANNALS OF THE RHEUMATIC DISEASES (pp. 195-196). LONDON: BMJ PUBLISHING GROUP.
D'Agostino, M.-A., Conaghan, P.G., Gaillez, C., Naredo, E., Mandl, P., Carron, P.,... Boers, M. (2022). How Well Does Ultrasound-assessed Synovitis in Reduced Joint Sets Predict the Response to Secukinumab in Patients with Active Psoriatic Arthritis and Inadequate Response to Conventional DMARDs? - Exploratory Results from a Phase 3b Study . In ARTHRITIS & RHEUMATOLOGY (pp. 4246-4248). HOBOKEN: WILEY.
Degboe, Y., Sunzini, F., Sood, S., Bozec, A., Sokolova, M., Zekovic, A.,... Goodyear, C.S. (2022). Apremilast inhibits inflammatory osteoclastogenesis . Rheumatology , 61 (1), 452-461. https://doi.org/10.1093/rheumatology/keab315
Dölling, M., Eckstein, M., Singh, J., Schoen, J., Shan, X., Bozec, A.,... Schauer, C. (2022). Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction . Frontiers in Immunology , 13 . https://doi.org/10.3389/fimmu.2022.726153
Dürholz, K., Lucas, S., Schmid, E., Schaelter, F., Frech, M., Azizov, V.,... Zaiss, M. (2022). Propionate induced bacterial-derived histamine promotes resolution of synovial inflammation . In EUROPEAN JOURNAL OF IMMUNOLOGY (pp. 29-30). HOBOKEN: WILEY.
Dürholz, K., Schmid, E., Frech, M., Azizov, V., Otterbein, N., Lucas, S.,... Zaiss, M. (2022). Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function . Frontiers in Immunology , 13 . https://doi.org/10.3389/fimmu.2022.908174
Fagni, F., Schmidt, K., Bohr, D., Valor, L., Hartmann, F., Tascilar, K.,... Harrer, T. (2022). PRE-EXPOSURE PROPHYLAXIS FOR SARS-COV-2 INFECTION WITH SUBCUTANEOUS CASIRIVIMAB/IMDEVIMAB IN PATIENTS WITH IMMUNE MEDIATED INFLAMMATORY DISEASES. In ANNALS OF THE RHEUMATIC DISEASES (pp. 968-969). LONDON: BMJ PUBLISHING GROUP.
Fagni, F., Schmidt, K., Bohr, D., Valor-Mendez, L., Tascilar, K., Manger, K.,... Hartmann, F. (2022). Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccination . RMD Open , 8 (1). https://doi.org/10.1136/rmdopen-2022-002323
Fagni, F., Simon, D., Kleyer, A., Tascilar, K., Taubmann, J., Bayat, S.,... Schmidkonz, C. (2022). Fibroblast Activation in Psoriasis Patients Assessed by Ga-68-FAPI-04 PET-CT Is Associated with Progression to Psoriatic Arthritis . In ARTHRITIS & RHEUMATOLOGY (pp. 2425-2427). HOBOKEN: WILEY.
Feurstein, J., Behanova, M., Haschka, J., Roetzer, K., Uyanik, G., Hadzimuratovic, B.,... Kocijan, R. (2022). Identifying adult hypophosphatasia in the rheumatology unit . Orphanet Journal of Rare Diseases , 17 (1). https://doi.org/10.1186/s13023-022-02572-7
Folle, L., Bayat, S., Kleyer, A., Fagni, F., Kapsner, L., Schlereth, M.,... Schett, G. (2022, June). CLASSIFICATION OF PSORIATIC ARTHRITIS, SERONEGATIVE RHEUMATOID ARTHRITIS, AND SEROPOSITIVE RHEUMATOID ARTHRITIS USING DEEP LEARNING ON MAGNETIC RESONANCE IMAGING .
Folle, L., Bayat, S., Kleyer, A., Fagni, F., Kapsner, L., Schlereth, M.,... Simon, D. (2022). Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis . Rheumatology . https://doi.org/10.1093/rheumatology/keac197
Folle, L., Bayat, S., Kleyer, A., Fagni, F., Kapsner, L., Schlereth, M.,... Simon, D. (2022, November). Neural Networks for Distinguishing Rheumatoid Arthritis from Psoriatic Arthritis by Using Magnetic Resonance Imaging .
Folle, L., Meinderink, T., Simon, D., Liphardt, A.-M., Thies, M., Krönke, G.,... Maier, A. (2022, June). Automated Bone Density Measurements using Deep Learning .
Folle, L., Simon, D., Tascilar, K., Krönke, G., Liphardt, A.-M., Maier, A.,... Kleyer, A. (2022). Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns—How Neural Networks Can Tell Us Where to “Deep Dive” Clinically . Frontiers in Medicine , 9 . https://doi.org/10.3389/fmed.2022.850552
Frech, M., Omata, Y., Schmalzl, A., Wirtz, S., Taher, L., Schett, G.,... Sarter, K. (2022). Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses . Frontiers in Immunology , 13 . https://doi.org/10.3389/fimmu.2022.757436
Fuchs, F., Morf, H., Mohn, J., Muehlensiepen, F., Ignatyev, Y., Bohr, D.,... Knitza, J. (2022). Diagnostic delay stages and pre-diagnostic treatment in patients with suspected rheumatic diseases before special care consultation: results of a multicenter-based study . Rheumatology International . https://doi.org/10.1007/s00296-022-05223-z
Gasperi, N., Schreiber, N., Bosch, P., Adinolfi, A., Kleyer, A., Hagen, M.,... Dejaco, C. (2022). Ultrasound-detected inflammation is more common in clinically manifest hand osteoarthritis than in painless bony enlarged finger joints: subanalysis of the population-based Bruneck study . Therapeutic Advances in Musculoskeletal Disease , 14 . https://doi.org/10.1177/1759720X221096382
Gerner, M., Vuillerme, N., Aubourg, T., Messner, E.M., Terhorst, Y., Hörmann, V.,... Orlemann, T. (2022). Review and Analysis of German Mobile Apps for Inflammatory Bowel Disease Management Using the Mobile Application Rating Scale: Systematic Search in App Stores and Content Analysis . JMIR mHealth and uHealth , 10 (5). https://doi.org/10.2196/31102
Gimpel, A., Maccataio, A., Unterweger, H., Sokolova, M., Schett, G., & Steffen, U. (2022). IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes . Frontiers in Immunology , 12 . https://doi.org/10.3389/fimmu.2021.761816
Gouze, H., Aegerter, P., Said-Nahal, R., Zins, M., Goldberg, M., Morelle, G.,... D'Agostino, M.A. (2022). Rheumatoid arthritis, as a clinical disease, but not rheumatoid arthritis-associated autoimmunity, is linked to cardiovascular events . Arthritis Research & Therapy , 24 (1). https://doi.org/10.1186/s13075-022-02722-z
Gregoric, G., Gaculenko, A., Nagel, L., Popp, V., Maschauer, S., Prante, O.,... Bäuerle, T. (2022). Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT . Cancers , 14 (10). https://doi.org/10.3390/cancers14102482
Groetsch, J., Tascilar, K., Schett, G., Foell, D., & Rech, J. (2022). BASELINE CLINICAL DISEASE ACTIVITY IS NOT CRITICAL FOR PREDICTING REMISSION OF ADULTS ONSET STILL'S DISEASE . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1008-1008). LONDON: BMJ PUBLISHING GROUP.
Gräf, M., Knitza, J., Leipe, J., Krusche, M., Welcker, M., Kuhn, S.,... Callhoff, J. (2022). A Symptom Checker App Is Better at Classifying Inflammatory Disease Than Physicians Who Are Presented Identical Information . In ARTHRITIS & RHEUMATOLOGY (pp. 3511-3513). HOBOKEN: WILEY.
Gräf, M., Knitza, J., Leipe, J., Krusche, M., Welcker, M., Kuhn, S.,... Callhoff, J. (2022). Comparison of physician and artificial intelligence-based symptom checker diagnostic accuracy . Rheumatology International . https://doi.org/10.1007/s00296-022-05202-4
Grötsch, B., Schachtschabel, E., Tripal, P., Schmid, B., Smith, A.-S., Schett, G., & Bozec, A. (2022). Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts . Frontiers in Immunology , 13 . https://doi.org/10.3389/fimmu.2022.958974
Györfi, A.-H., Schett, G., & Distler, J. (2022). Response to: 'Correspondence on 'Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis'' by Jeny et al. Annals of the Rheumatic Diseases , 81 (12). https://doi.org/10.1136/annrheumdis-2020-218983
Haschka, J., Simon, D., Bayat, S., Messner, Z., Kampylafka, E., Fagni, F.,... Rech, J. (2022, June). IDENTIFICATION OF CIRCULATING MICRORNA SIGNATURES IN PATIENTS WITH PSORIASIS WITH SUBCLINICAL JOINT DISEASE AND PATIENTS WITH PSORIATIC ARTHRITIS .
Kemenes, S., Bayat, S., Simon, D., Krönke, G., Bohr, D., Valor, L.,... Kleyer, A. (2022). BARICITINIB LEADS TO RAPID AND PERSISTENT RESOLUTION OF SYNOVITIS AS MEASURED BY HAND MRI IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS (RA) FAILING CS/BDMARD THERAPY . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1320-1321). LONDON: BMJ PUBLISHING GROUP.
Kemenes, S., Hartmann, F., Tascilar, K., Simon, D., Bayat, S., Krönke, G.,... Kleyer, A. (2022). Baricitinib Improves Bone Biomechanical Properties in Rheumatoid Arthritis (RA) - Results of a Prospective Interventional Study . In ARTHRITIS & RHEUMATOLOGY (pp. 3931-3933). HOBOKEN: WILEY.
Kerker, I., Löhr, S., Uebe, S., Popp, B., Vasileiou, G., Bowes, J.,... Hüffmeier, U. (2022). Common RUNX3 missense variant contributes to psoriatic arthritis by modifying differentiation of CD8(+) T-cells . In EUROPEAN JOURNAL OF HUMAN GENETICS (pp. 554-555). LONDON: SPRINGERNATURE.
Knevel, R., Knitza, J., Hensvold, A., Circiumaru, A., Bruce, T., Evans, S.,... Catrina, A. (2022). Rheumatic?—A Digital Diagnostic Decision Support Tool for Individuals Suspecting Rheumatic Diseases: A Multicenter Pilot Validation Study . Frontiers in Medicine , 9 . https://doi.org/10.3389/fmed.2022.774945
Knitza, J., Grahammer, M., Böltz, S., Lang, J., Detert, M., Bader, M.,... Detert, J. (2022). DIGITALLY ENHANCED TREAT-TO-TARGET AND SHARED DECISION-MAKING APPROACH WITH A DIGITAL HEALTH APPLICATION: INTERIM RESULTS FROM A RANDOMIZED CONTROLLED TRIAL . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1088-1089). LONDON: BMJ PUBLISHING GROUP.
Knitza, J., Janousek, L., Kluge, F., Von Der Decken, C.B., Kleinert, S., Vorbrueggen, W.,... Bartz-Bazzanella, P. (2022). Machine learning-based improvement of an online rheumatology referral and triage system . Frontiers in Medicine , 9 . https://doi.org/10.3389/fmed.2022.954056
Knitza, J., Muehlensiepen, F., Ignatyev, Y., Fuchs, F., Mohn, J., Simon, D.,... Hueber, A. (2022). Patient's Perception of Digital Symptom Assessment Technologies in Rheumatology: Results From a Multicentre Study . Frontiers in Public Health , 10 . https://doi.org/10.3389/fpubh.2022.844669
Knitza, J., Tascilar, K., Vuillerme, N., Eimer, E., Matusewicz, P., Corte, G.,... Simon, D. (2022). Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients-results from a randomized controlled trial . Arthritis Research & Therapy , 24 (1). https://doi.org/10.1186/s13075-022-02809-7
Knitza, J., Tascilar, K., Vuillerme, N., Vogt, E., Matusewicz, P., Corte, G.,... Simon, D. (2022). PATIENT SELF-SAMPLING IN RHEUMATOID ARTHRITIS: RESULTS FROM A RANDOMIZED CONTROLLED TRIAL . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1117-1117). LONDON: BMJ PUBLISHING GROUP.
Kretschmann, S., Völkl, S., Reimann, H., Krönke, G., Schett, G., Achenbach, S.,... Aigner, M. (2022). Successful Generation of CD19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus . Transplantation and Cellular Therapy . https://doi.org/10.1016/j.jtct.2022.10.004
Kuwert, T., Schmidkonz, C., Prante, O., Schett, G., & Ramming, A. (2022). FAPI PET Opens a New Window to Understanding Immune-Mediated Inflammatory Diseases . Journal of Nuclear Medicine , 63 (8), 1136-1137. https://doi.org/10.2967/jnumed.122.263922
Labinsky, H., Von Rohr, S., Raimondo, M.G., Vogt, E., Horstmann, B., Gehring, I.,... Knitza, J. (2022). Accelerating AxSpA Diagnosis: Exploring At-home Self-sampling, Symptom Checkers, Medical Student-visits and Asynchronous Reportbased Assessment . In ARTHRITIS & RHEUMATOLOGY (pp. 94-95). HOBOKEN: WILEY.
Lai, C., Heinemann, J., Schleicher, U., Schett, G., Bogdan, C., Bozec, A., & Soulat, D. (2022). Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass . Journal of Bone and Mineral Research . https://doi.org/10.1002/jbmr.4733
Leppkes, M., Lindemann, A., Goesswein, S., Paulus, S., Roth, D., Hartung, A.,... Neurath, M. (2022). Neutrophils prevent rectal bleeding in Ulcerative Colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis . In JOURNAL OF CROHNS & COLITIS (pp. I178-I179). OXFORD: OXFORD UNIV PRESS.
Li, Y., Chen, C.-W., Trinh, M.T., Honglin, Z., Hubel, P., Pfannstiel, J.,... Distler, J. (2022). O-GLCNACYLATION ON NUP153 REGULATES THE EARLY STAGES OF OSTEOCLASTOGENESIS THROUGH MYC NUCLEAR TRANSLOCATION . In ANNALS OF THE RHEUMATIC DISEASES (pp. 426-426). LONDON: BMJ PUBLISHING GROUP.
Li, Y.-N., Chen, C.-W., Trinh, M.T., Zhu, H., Matei, A.-E., Györfi, A.-H.,... Distler, J. (2022). Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153 . Bone Research , 10 (1). https://doi.org/10.1038/s41413-022-00218-9
Liphardt, A.-M., Tascilar, K., Coppers, B., Manger, E., Liehr, S., Bieniek, L.M.,... Kleyer, A. (2022). SUBJECTIVE ASSESSMENT OF PHYSICAL FUNCTION DOES NOT SUFFICIENTLY EXPLAIN VARIANCE OF MEASURED HAND FUNCTION AND GRIP STRENGTH IN ARTHRITIS PATIENTS AND NON-ARTHRITIS CONTROLS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 218-218). LONDON: BMJ PUBLISHING GROUP.
Lyu, P., Wen, J., Stolzer, I., Gießl, A., Song, R., Meng, X.,... Bozec, A. (2022). INTESTINAL HIF1 alpha EXPRESSION PROTECTS AGAINST EPITHELIAL CELL DEATH IN ARTHRITIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 460-460). LONDON: BMJ PUBLISHING GROUP.
Mackensen, A., Müller, F., Mougiakakos, D., Böltz, S., Wilhelm, A., Aigner, M.,... Schett, G. (2022). Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus . Nature Medicine . https://doi.org/10.1038/s41591-022-02017-5
Marzo-Ortega, H., Theander, E., Neuhold, M., Bergmans, P., Shawi, M., Perate, M.,... Schett, G. (2022). GUSELKUMAB IMPROVES DACTYLITIS IN PSA PATIENTS WITH INADEQUATE RESPONSE TO TNFI: DATA FROM THE PHASE 3B COSMOS TRIAL . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1577-1578). LONDON: BMJ PUBLISHING GROUP.
Matei, A.-E., Marketa, K., Xu, L., Györfi, A.-H., Boxberger, E., Soteriou, D.,... Distler, J. (2022, June). BIOPHYSICAL PROPERTIES OF MONOCYTES INDICATE DISEASE ACTIVITY, SEVERITY OF FIBROTIC OR MICROVASCULAR MANIFESTATIONS AND THE RISK FOR PROGRESSION IN SYSTEMIC SCLEROSIS .
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Fagni, F., Simon, D., Tascilar, K., Schoenau, V., Sticherling, M., Neurath, M., & Schett, G. (2021). COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses . The Lancet Rheumatology , 3 (10), e724-e736. https://doi.org/10.1016/S2665-9913(21)00247-2
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Frech, M., Schuster, G., Andes, F.T., Schett, G., Zaiss, M., & Sarter, K. (2021). RANKL-Induced Btn2a2 – A T Cell Immunomodulatory Molecule – During Osteoclast Differentiation Fine-Tunes Bone Resorption . Frontiers in Endocrinology , 12 . https://doi.org/10.3389/fendo.2021.685060
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Gaculenko, A., Gregoric, G., Popp, V., Seyler, L., Ringer, M., Kachler, K.,... Bozec, A. (2021). Systemic PPAR gamma Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents . Journal of Bone and Mineral Research . https://doi.org/10.1002/jbmr.4422
Genovese, M.C., Buckley, C.D., Saurigny, D., Schett, G., Davy, K., Gupta, A.,... Tak, P.P. (2021). Targeting GM-CSF in rheumatological conditions: risk of PAP – Authors' reply . The Lancet Rheumatology , 3 (7), e473-e474. https://doi.org/10.1016/S2665-9913(21)00146-6
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Haberman, R., Herati, R., Simon, D., Samanovic, M., Tuen, M., Blank, R.,... Scher, J. (2021). Methotrexate Hampers Immunogenicity to BNT162b2 mRNA COVID-19 Vaccine in Immune-Mediated Inflammatory Disease . In ARTHRITIS & RHEUMATOLOGY (pp. 3205-3208). HOBOKEN: WILEY.
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Kleyer, A., Roemer, F., Schett, G., & Manger, B. (2021). Differenzialdiagnose Rückenschmerzen mit Entzündungsparametern: Fallvorstellung: Manifestation einer CPPD als Crowned Dens Syndrom mit Befall peripherer Gelenke . Aktuelle Rheumatologie , 46 (1), 76-79. https://doi.org/10.1055/a-1327-1424
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Kolbinger, F., Di Padova, F., Deodhar, A., Hawkes, J.E., Huppertz, C., Kuiper, T.,... Bruin, G. (2021). Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and safety . Pharmacology & Therapeutics . https://doi.org/10.1016/j.pharmthera.2021.107925
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Manger, B., & Schett, G. (2021). 80 Meilensteine der Rheumatologie aus 80 Jahren – I: 1940–1960 . Zeitschrift für Rheumatologie . https://doi.org/10.1007/s00393-021-01031-1
Martinsson, K., Dürholz, K., Schett, G., Zaiss, M., & Kastbom, A. (2021). Higher serum levels of short-chain fatty acids are associated with non-progression to arthritis in individuals at increased risk of RA . Annals of the Rheumatic Diseases . https://doi.org/10.1136/annrheumdis-2021-221386
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Mcgonagle, D., Mcinnes, I.B., Deodhar, A., Schett, G., Shawi, M., Kafka, S.,... Mease, P.J. (2021). Resolution of enthesitis by guselkumab and relationships to disease burden: 1-year results of two phase 3 psoriatic arthritis studies. Rheumatology , 60 (11), 5337-5350. https://doi.org/10.1093/rheumatology/keab285
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Michaelis, J., Reiher, I., Heinrich, S., Coppers, B., Schett, G., Kleyer, A.,... Liphardt, A.-M. (2021). CyberGlove for clinical use?
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Mougiakakos, D., Krönke, G., & Schett, G. (2021). More on CD19-CAR T Cells in Systemic Lupus Erythematosus . New England Journal of Medicine , 385 (19). https://doi.org/10.1056/nejmc2114593
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Nagy, G., Roodenrijs, N.M., Welsing, P.M., Kedves, M., Hamar, A., Van Der Goes, M.C.,... Van Laar, J.M. (2021). EULAR definition of difficult-To-Treat rheumatoid arthritis . Annals of the Rheumatic Diseases , 80 (1), 31-35. https://doi.org/10.1136/annrheumdis-2020-217344
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O'Neil, L.J., Hu, P., Liu, Q., Islam, M.M., Spicer, V., Rech, J.,... Wilkins, J.A. (2021). Proteomic Approaches to Defining Remission and the Risk of Relapse in Rheumatoid Arthritis . Frontiers in Immunology , 12 . https://doi.org/10.3389/fimmu.2021.729681
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Pachowsky, M., Söllner, S., Kleyer, A., Welsch, G., & Schett, G. (2021). CARTILAGE LESIONS OF THE KNEE: GAGCEST IMAGING AT 3 T MRI AND INTRAOPERATIVE VALIDATION . In ANNALS OF THE RHEUMATIC DISEASES (pp. 60-61). LONDON: BMJ PUBLISHING GROUP.
Pfeifle, R., Kittler, J., Wuhrer, M., Schett, G., & Krönke, G. (2021). THE IMPACT OF IL-17A THERAPY ON IGG SIALYLATION IN HUMANS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1042-1043). LONDON: BMJ PUBLISHING GROUP.
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Pfeil, A., Franz, M., Hoffmann, T., Klemm, P., Oelzner, P., Müller-Ladner, U.,... Kleyer, A. (2021). Virtual teaching for medical students during SARS-CoV-2 pandemic. Clinical and Experimental Rheumatology , 39 (6), 1447-1448. https://doi.org/10.55563/clinexprheumatol/0dbnx5
Pfeil, A., Marcus, F., Hoffmann, T., Klemm, P., Oelzner, P., Muller-Ladner, U.,... Kleyer, A. (2021). EVALUATION OF A VIRTUAL REALITY TEACHING CONCEPT FOR MEDICAL STUDENTS DURING THE SARS-COV-2 PANDEMIC . In ANNALS OF THE RHEUMATIC DISEASES (pp. 40-40). LONDON: BMJ PUBLISHING GROUP.
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Rahman, P., Mcinnes, I., Deodhar, A., Schett, G., Mease, P., Shawi, M.,... Mcgonagle, D. (2021). Guselkumab (TREMFYA (R)) Maintains Resolution of Dactylitis and Enthesitis in Patients with Active Psoriatic Arthritis: Results Through 2 Years from a Phase 3 Study . In ARTHRITIS & RHEUMATOLOGY (pp. 2757-2760). HOBOKEN: WILEY.
Rech, J., Hueber, A., Ostergaard, M., Tascilar, K., Hagen, M., Mendez, L.V.,... Schett, G. (2021). Abatacept Reverses Subclinical Arthritis in Patients with High-risk to Develop Rheumatoid Arthritis -results from the Randomized, Placebo-controlled ARIAA Study in RA-at Risk Patients . In ARTHRITIS & RHEUMATOLOGY (pp. 939-941). HOBOKEN: WILEY.
Regierer, A., Weiss, A., Bohl-Buehler, M., Baraliakos, X., Behrens, F., Schett, G., & Strangfeld, A. (2021). DEPRESSIVE SYMPTOMS IN PSA: A CROSS-SECTIONAL ANALYSIS FROM THE NATIONAL GERMAN RABBIT-SPA REGISTRY . Annals of the Rheumatic Diseases , 135-136. https://doi.org/10.1136/annrheumdis-2021-eular.2130
Regierer, A.C., Weiss, A., Poddubnyy, D., Kellner, H., Behrens, F., Schett, G.,... Strangfeld, A. (2021). DOSING OF BDMARDS IN AXSPA AND PSA IN A REAL WORLD SETTING . In ANNALS OF THE RHEUMATIC DISEASES (pp. 373-373). LONDON: BMJ PUBLISHING GROUP.
Schaelter, F., Dürholz, K., Bucci, L., Burmester, G., Caporali, R., Figuereido, C.,... Schett, G. (2021). Does methotrexate influence COVID-19 infection? Case series and mechanistic data . Arthritis Research & Therapy , 23 (1). https://doi.org/10.1186/s13075-021-02464-4
Schenker, H., Hagen, M., Simon, D., Schett, G., & Manger, B. (2021). Reactive arthritis and cutaneous vasculitis after SARS-CoV-2 infection . Rheumatology , 60 (1), 479-480. https://doi.org/10.1093/rheumatology/keaa689
Schenker, H., Tascilar, K., Konerth, L., Sergeeva, M., Prade, J., Strobelt, S.,... Rech, J. (2021). Prediction of response to Certolizumab-Pegol in rheumatoid arthritis (PreCePRA) by functional MRI of the brain – Study protocol for a randomized double-blind controlled study . Contemporary Clinical Trials Communications , 22 . https://doi.org/10.1016/j.conctc.2021.100770
Schett, G. (2021). GUT MICROBIOME, BONE AND JOINT . In OSTEOPOROSIS INTERNATIONAL (pp. S39-S39). LONDON: SPRINGER LONDON LTD.
Schett, G. (2021). The role of IL-23 in joint disease . Rheumatology , 60 (11), 5486-5487. https://doi.org/10.1093/rheumatology/keab073
Schett, G., Baraliakos, X., Van Den Bosch, F., Deodhar, A., Ostergaard, M., Das Gupta, A.,... Gensler, L.S. (2021). Secukinumab Efficacy on Enthesitis in Patients With Ankylosing Spondylitis: Pooled Analysis of Four Pivotal Phase III Studies . Journal of Rheumatology , 48 (8), 1251-1258. https://doi.org/10.3899/jrheum.201111
Schett, G., Kalden, J., & Manger, B. (2021). 80 Meilensteine der Rheumatologie aus 80 Jahren – II: 1961–1980 . Zeitschrift für Rheumatologie . https://doi.org/10.1007/s00393-021-01032-0
Schett, G., Loza, M.J., Palanichamy, A., Fitzgerald, O., Ritchlin, C., Baribaud, F., & Sweet, K. (2021). COLLAGEN TURNOVER MARKERS ASSOCIATE WITH ACTIVE PSORIATIC ARTHRITIS AND DECREASE WITH GUSELKUMAB TREATMENT . Clinical and Experimental Rheumatology , 1217-1218.
Schett, G., Mcinnes, I.B., & Neurath, M. (2021). Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs . New England Journal of Medicine , 385 (7), 628-639. https://doi.org/10.1056/NEJMra1909094
Schmidkonz, C., Distler, J., Treutlein, C., Atzinger, A., Prante, O., Ritt, P.,... Bergmann, C. (2021). Ga-68-FAPI-04 PET/CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-related interstitial lung disease . European Journal of Nuclear Medicine and Molecular Imaging , S158-S159. https://doi.org/10.1055/s-0041-1726695
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Schälter, F., Dürholz, K., Bucci, L., Burmester, G.R., Caporali, R., Figuereido, C.,... Schett, G. (2021). Does methotrexate influence COVID-19 infection? Case series and mechanistic data . Arthritis Research & Therapy . https://doi.org/10.1186/s13075-021-02464-4
Schönau, V., Roth, J., Tascilar, K., Corte, G., Manger, B., Rech, J.,... Muratore, F. (2021). Resolution of vascular inflammation in patients with new-onset giant cell arteritis: data from the RIGA study . Rheumatology , 60 (8), 3851-3861. https://doi.org/10.1093/rheumatology/keab332
Simon, D., Kleyer, A., Bayat, S., Knitza, J., Valor, L., Schweiger, M.,... Hueber, A. (2021). BIOMECHANICAL STRESS IN THE CONTEXT OF COMPETITIVE SPORTS TRAINING TRIGGERS ENTHESITIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1275-1275). LONDON: BMJ PUBLISHING GROUP.
Simon, D., Kleyer, A., Bayat, S., Knitza, J., Valor-Mendez, L., Schweiger, M.,... Hueber, A. (2021). Biomechanical stress in the context of competitive sports training triggers enthesitis . Arthritis Research & Therapy , 23 (1). https://doi.org/10.1186/s13075-021-02530-x
Simon, D., Tascilar, K., Fagni, F., Krönke, G., Kleyer, A., Meder, C.,... Ramming, A. (2021). SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases . Annals of the Rheumatic Diseases . https://doi.org/10.1136/annrheumdis-2021-220461
Simon, D., Tascilar, K., Fagni, F., Schmidt, K., Krönke, G., Kleyer, A.,... Schett, G. (2021). Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease . Annals of the Rheumatic Diseases . https://doi.org/10.1136/annrheumdis-2021-221554
Simon, D., Tascilar, K., Kleyer, A., Bayat, S., Kampylafka, E., Sokolova, M.,... Schett, G. (2021). Association of Structural Entheseal Lesions With an Increased Risk of Progression From Psoriasis to Psoriatic Arthritis . Arthritis and Rheumatology . https://doi.org/10.1002/art.41239
Simon, D., Tascilar, K., Schmidt, K., Manger, B., Weckwerth, L., Sokolova, M.,... Schett, G. (2021). Humoral and Cellular Immune Responses to SARS–CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion . Arthritis and Rheumatology . https://doi.org/10.1002/art.41914
Sokolova, M., Rech, J., Hagen, M., Schett, G., & Steffen, U. (2021). ASSOCIATION OF ANTI-CITRULLINATED PROTEIN ANTIBODIES OF IgA SUBCLASSES WITH SUSTAINED REMISSION AND FLARE IN RHEUMATOID ARTHRITIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 461-461). LONDON: BMJ PUBLISHING GROUP.
Sokolova, M., Schett, G., & Steffen, U. (2021). Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings . Clinical Reviews in Allergy & Immunology . https://doi.org/10.1007/s12016-021-08890-1
Stehr, A., Wang, G., Demmler, R., Stemmler, M., Straube, J., Tripal, P.,... Stürzl, M. (2021). Neutrophil extracellular traps drive epithelial‐mesenchymal transition of human colon cancer . Journal of Pathology , 256 (4), 455-467. https://doi.org/10.1002/path.5860
Stock, M., & Schett, G. (2021). Vitamin k-dependent proteins in skeletal development and disease . International Journal of Molecular Sciences , 22 (17). https://doi.org/10.3390/ijms22179328
Szekanecz, Z., Mcinnes, I.B., Schett, G., Szamosi, S., Benko, S., & Szucs, G. (2021). Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases . Nature Reviews Rheumatology . https://doi.org/10.1038/s41584-021-00652-9
Söllner, S., Welsch, G.H., Gelse, K., Goldmann, A., Kleyer, A., Schett, G., & Pachowsky, M. (2021). gagCEST imaging at 3 T MRI in patients with articular cartilage lesions of the knee and intraoperative validation . Osteoarthritis and Cartilage . https://doi.org/10.1016/j.joca.2021.04.012
Tascilar, K., Hagen, M., Kleyer, A., Simon, D., Reiser, M., Hueber, A.,... Rech, J. (2021). Treatment tapering and stopping in patients with rheumatoid arthritis in stable remission (RETRO): a multicentre, randomised, controlled, open-label, phase 3 trial . The Lancet Rheumatology , 3 (11), e767-e777. https://doi.org/10.1016/S2665-9913(21)00220-4
Tascilar, K., Simon, D., Krönke, G., Kleyer, A., Ramming, A., Atreya, R.,... Schett, G. (2021). PATIENTS WITH IMMUNE MEDIATED INFLAMMATORY DISEASES ARE OVERREPRESENTED IN LOW-FREQUENCY VIRAL SYMPTOM CLUSTERS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 996-997). LONDON: BMJ PUBLISHING GROUP.
Tascilar, K., Simon, D., Liphardt, A.-M., Meinderink, T., Bayat, S., Rech, J.,... Kleyer, A. (2021). SPATIOTEMPORAL DYNAMICS OF BONE LOSS BEFORE AND AFTER THE ONSET OF RHEUMATOID ARTHRITIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 88-89). LONDON: BMJ PUBLISHING GROUP.
Valor-Mendez, L., Manger, B., Cavallaro, A.J., Achenbach, S., Schett, G., & Rech, J. (2021). Autoinflammation leading to autoimmunity in adult-onset Still’s disease: more than simple coincidence? European Journal of Medical Research , 26 (1). https://doi.org/10.1186/s40001-021-00581-z
Valor-Mendez, L., Manger, B., Schett, G., & Kleyer, A. (2021). Severe Hepatitis E virus infection in a patient with rheumatoid arthritis treated with baricitinib . Zeitschrift für Rheumatologie . https://doi.org/10.1007/s00393-021-01020-4
Valor-Mendez, L., Sticherling, M., Kleyer, A., & Schett, G. (2021). Successful treatment of refractory palmoplantar psoriasis in a psoriatic arthritis patient with the JAK inhibitor tofacitinib . Clinical and Experimental Rheumatology , 39 (1), 228-228. https://doi.org/10.55563/clinexprheumatol/xdcraa
Valor-Méndez, L., Kleyer, A., Rech, J., Manger, B., & Schett, G. (2021). Long-term B-lymphocyte depletion and remission of granulomatosis with polyangiitis after two courses of rituximab treatment . Rheumatology , 60 (5), e162-e164. https://doi.org/10.1093/rheumatology/keaa727
Valor-Méndez, L., Kleyer, A., Rech, J., Manger, B., & Schett, G. (2021). Sustained clinical remission under infliximab/rituximab combination therapy in a patient with granulomatosis with polyangiitis . Autoimmunity Highlights , 12 (1). https://doi.org/10.1186/s13317-020-00147-9
Valor-Méndez, L., Kleyer, A., Schett, G., Manger, B., & Sticherling, M. (2021). Contrary immediate effect of abatacept on skin and joint manifestations in psoriatic arthritis . Rheumatology , 60 (9), e312-e313. https://doi.org/10.1093/rheumatology/keab206
Valor-Méndez, L., Tascilar, K., Simon, D., Distler, J., Kleyer, A., Schett, G., & Rech, J. (2021). Correspondence on ‘Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort' . Annals of the Rheumatic Diseases . https://doi.org/10.1136/annrheumdis-2021-220898
Valor-Méndez, L., Voskens, C., Rech, J., Kleyer, A., & Schett, G. (2021). Herpes simplex infection in a patient with rheumatoid arthritis treated with baricitinib: a case report . Rheumatology , 60 (4), e122-e123. https://doi.org/10.1093/rheumatology/keaa521
Vielreicher, M., Bozec, A., Schett, G., & Friedrich, O. (2021). Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging . Frontiers in Bioengineering and Biotechnology , 9 . https://doi.org/10.3389/fbioe.2021.608383
Vitali, F., Simon, D., Neurath, M., Schett, G., & Zundler, S. (2021). Vedolizumab-associated enthesitis: correlation or causality? Rheumatology , 60 (12), 5491-5492. https://doi.org/10.1093/rheumatology/keab396
Vodencarevic, A., Tascilar, K., Reiser, M., Hueber, A., Haschka, J., Bayat, S.,... Hartmann, F. (2021). Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs . Arthritis Research & Therapy , 23 (1). https://doi.org/10.1186/s13075-021-02439-5
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Xu, X., Li, Y.N., Chen, C.-W., Trinh-Minh, T., Schett, G., & Distler, J. (2021). INACTIVATION OF ALDEHYDE DEHYDROGENASE 3A2 INHIBITS FIBROBLAST ACTIVATION AND TISSUE FIBROSIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 391-391). LONDON: BMJ PUBLISHING GROUP.
Yaykasli, K.O., Munoz, L.E., Mahajan, A., Knopf, J., Schett, G., Herrmann, M., & Schauer, C. (2021). Neutrophil extracellular trap‐driven occlusive diseases . Cells , 10 (9). https://doi.org/10.3390/cells10092208
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Zaiss, M., Joyce Wu, H.-J., Mauro, D., Schett, G., & Ciccia, F. (2021). The gut-joint axis in rheumatoid arthritis . Nature Reviews Rheumatology . https://doi.org/10.1038/s41584-021-00585-3
Zehender, A., Li, Y.-N., Lin, N.Y., Stefanica, A., Nüchel, J., Chen, C.-W.,... Distler, J. (2021). TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy . Nature Communications , 12 (1). https://doi.org/10.1038/s41467-021-24601-y
Zhang, Y., Shen, L., Dreißigacker, K., Zhu, H., Trinh, M.T., Meng, X.,... Distler, J. (2021). Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease . Blood , 137 (17), 2403-2416. https://doi.org/10.1182/blood.2020008720
2020
Adam, S., Simon, N., Steffen, U., Andes, F.T., Scholtysek, C., Müller, D.,... Hueber, A. (2020). JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function . Science Translational Medicine , 12 (530). https://doi.org/10.1126/scitranslmed.aay4447
Anchang, C.G., Lawaree, B.M., Weber, S., Rauber, S., Wohlfahrt, T., Luber, M.,... Ramming, A. (2020). HIGH DIMENSIONAL ANALYSIS REVEAL A NETWORK OF CERTAIN TRANSCRIPTION FACTORS THAT LINK VASCULOPATHY AND ORGAN FIBROSIS IN SYSTEMIC SCLEROSIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 90-91). ONLINE: LONDON: BMJ PUBLISHING GROUP.
Andes, F.T., Adam, S., Hahn, M., Aust, O., Frey, S., Grüneboom, A.,... Steffen, U. (2020). The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption . Bone . https://doi.org/10.1016/j.bone.2020.115665
Andreev, D., Liu, M., Kachler, K., Llerins Perez, M., Kirchner, P., Kölle, J.,... Bozec, A. (2020). Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis . Annals of the Rheumatic Diseases . https://doi.org/10.1136/annrheumdis-2020-218902
Andreev, D., Liu, M., Weidner, D., Kachler, K., Faas, M., Grüneboom, A.,... Bozec, A. (2020). Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin . Journal of Clinical Investigation , 130 (9), 4811-4830. https://doi.org/10.1172/JCI134214
Araujo, E.G., & Schett, G. (2020). Enthesitis in psoriatic arthritis (Part 1): pathophysiology . Rheumatology , 59 (1), i10-i14. https://doi.org/10.1093/rheumatology/keaa039
Ariza, Y., Weber, S., Neise, N., Kreuter, A., Schett, G., Distler, J., & Ramming, A. (2020). ADAPTOR PROTEINS ACTIVATE FIBROBLASTS IN SYSTEMIC SCLEROSIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1371-1372). ONLINE: LONDON: BMJ PUBLISHING GROUP.
Azizov, V., Dietel, K., Steffen, F., Dürholz, K., Meidenbauer, J., Lucas, S.,... Zaiss, M. (2020). Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis . Nature Communications , 11 (1). https://doi.org/10.1038/s41467-020-15855-z
Baraliakos, X., Gossec, L., Pournara, E., Jeka, S., Blanco, R., D'Angelo, S.,... Coates, L.C. (2020). SECUKINUMAB IMPROVES CLINICAL AND IMAGING OUTCOMES IN PATIENTS WITH PSORIATIC ARTHRITIS AND AXIAL MANIFESTATIONS WITH INADEQUATE RESPONSE TO NSAIDS: WEEK 52 RESULTS FROM THE MAXIMISE TRIAL . In ANNALS OF THE RHEUMATIC DISEASES (pp. 35-36). , ELECTR NETWORK: LONDON: BMJ PUBLISHING GROUP.
Baraliakos, X., Gossec, L., Pournara, E., Jeka, S., Blanco, R., D'Angelo, S.,... Coates, L. (2020). Secukinumab Provides Sustained Improvements in Clinical and Imaging Outcomes in Patients with Psoriatic Arthritis and Axial Manifestations: Results from the MAXIMISE Trial . In ARTHRITIS & RHEUMATOLOGY . HOBOKEN: WILEY.
Bayat, S., Simon, D., Pecherstorfer, C., Ellmann, H., Figueiredo, C., Englbrecht, M.,... Schett, G. (2020). FINE STRUCTURE ANALYSIS OF THE INTER-RELATION BETWEEN TOPHUS DEPOSITION AND BONE LESIONS IN GOUT USING A COMBINATION OF DUAL ENERGY AND HIGH-RESOLUTION CT . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1232-1232). Online: LONDON: BMJ PUBLISHING GROUP.
Bayat, S., Simon, D., Schuster, L., Schett, G., & Kleyer, A. (2020). Cinematic Rendering Enables Depiction of Bone Anabolic Effects in Patients Treated with Baricitinib . In ARTHRITIS & RHEUMATOLOGY . HOBOKEN: WILEY.
Bayat, S., Tascilar, K., Kaufmann, V., Kleyer, A., Simon, D., Knitza, J.,... Schett, G. (2020). HIGH REMISSION RATES IN RA - REAL LIFE DATA FROM BARITICINIB . In ANNALS OF THE RHEUMATIC DISEASES (pp. 1459-1460). , ELECTR NETWORK: LONDON: BMJ PUBLISHING GROUP.
Cao, S., Chen, X., Schett, G., & Bozec, A. (2020). L-ARGININE SUPPLEMENTATION AMELIORATES BONE EROSION IN RHEUMATOID ARTHRITIS THROUGH INHIBITION OF RANKL/RANK/TRAF6 PATHWAY AND REPROGRAMMING OSTEOCLAST METABOLISM . In ANNALS OF THE RHEUMATIC DISEASES (pp. 927-927). Online: LONDON: BMJ PUBLISHING GROUP.
Chakraborty, D., Zhu, H., Juengel, A., Summa, L., Li, Y.N., Bergmann, C.,... Distler, J. (2020). FIBROBLAST GROWTH FACTOR RECEPTOR 3 REGULATES THE ACTIVITY OF PROFIBROTIC CYTOKINE AND GROWTH FACTOR PATHWAYS TO DRIVE FIBROBLAST ACTIVATION AND TISSUE FIBROSIS IN SYSTEMIC SCLEROSIS . In ANNALS OF THE RHEUMATIC DISEASES (pp. 91-91). LONDON: BMJ PUBLISHING GROUP.
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One focus of our research is data acquisition (e.g. data from imaging MRI or CT, basic research, clinical trial data, digital applications Apps) and the distribution of data for analysis using AI methods to improve early diagnosis, differential diagnosis and prediction of the course of the disease of rheumatic diseases such as rheumatoid arthritis or psoriatic arthritis.
Research projects
Umfassende Charakterisierung von Patienten mit entzündlichen Knochenerkrankungen durch serologisches Profiling und Bildgebung (Z01)
(Third Party Funds Group – Sub project)
Term: 1. April 2024 - 31. December 2027
Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)
Die Rolle von Typ-I-Interferon bei entzündlichen Knochenerkrankungen (C06)
(Third Party Funds Group – Sub project)
Term: 1. April 2024 - 31. December 2027
Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)
Im Projekt C06 wird untersucht, wie ungebremstes Typ-I-IFN den entzündlichen Knochenverlust antreibt. Primäre Fibroblasten von Patienten mit IFIH1-Mutationen sezernieren große Mengen von VEGF, einem wichtigen Regulator des Knochens, was auf eine bisher nicht erkannte Verbindung zwischen Typ-I-IFN und VEGF in der Knochenhomöostase hindeutet. Ziel dieses Projekts ist es, einen Einblick in die Mechanismen der durch Typ-I-IFN vermittelten entzündlichen Knochenerkrankung zu gewinnen und neue Wege aufzuzeigen, die für therapeutische Eingriffe genutzt werden können.
Bewegungsmuster der Hand aus empathokinästhetischen Sensordaten als diagnostische Größe für Krankheitsaktivität bei Patienten mit rheumatischen Erkrankungen
(Third Party Funds Group – Sub project)
Term: 1. July 2021 - 30. June 2025
Funding source: DFG / Sonderforschungsbereich (SFB)
URL: https://www.empkins.de/
Unter standardisierten Bedingungen wird in D01 ein umfassender Datensatz zum aktuellen Erkrankungsstatus von Patienten (N = 150) mit RA und PsA in Kombination mit einer umfangreichen klinischen Testbatterie von Handfunktion sowie auch Vergleichsdaten einer gesunden Kohorte (N = 75) erhoben. Die parallele Erfassung von Handfunktion mittels „state-of-the-art“ Motion-Capture-Sensorik bietet eine kritische Grundlage für die experimentelle Evaluation und integrierte Dateninterpretation der neuartigen Sensordaten (TPe A01, A02 und A03), die bei der Erfassung von Handfunktion mittels EmpkinS in der 2. Hälfte der 1. Förderperiode erfasst werden.
2025
2024
2023
2022
2021
2020
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