Prof. Dr. Georg Schett

One focus of our research is data acquisition (e.g. data from imaging MRI or CT, basic research, clinical trial data, digital applications Apps) and the distribution of data for analysis using AI methods to improve early diagnosis, differential diagnosis and prediction of the course of the disease of rheumatic diseases such as rheumatoid arthritis or psoriatic arthritis.

Research projects

Emerging Fields Initiative: MIRACLE – MR-based Immune-metabolic Redefinition of Arthritis and MusCuloskletaL DisEase (2018)
BMBF Consortium: Mascara Molecular Assessment of Signatures ChAracterizing the Remission of Arthritis (2019)
planned SFB: EmpkinS Empathokinästethische Sensorik (2020)
Imaging and deep learning: implementation of AI methods on radiological images such as CT/MRT in patients with rheumatic diseases (RMD)
Digital Health: Evaluation of the use of digital applications (APPs) for recording disease activity and differential diagnosis of rheumatic diseases in patients with RMDs
Use of sensor technology in rheumatology. Development and evaluation of sensor technologies for the analysis of movement patterns and hand function in patients with RMDs

Umfassende Charakterisierung von Patienten mit entzündlichen Knochenerkrankungen durch serologisches Profiling und Bildgebung (Z01)

(Third Party Funds Group – Sub project)

Overall project: TRR 369: DIONE Entzündungsbedingte Knochendegeneration
Term: 1. April 2024 - 31. December 2027
Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)

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Die Rolle von Typ-I-Interferon bei entzündlichen Knochenerkrankungen (C06)

(Third Party Funds Group – Sub project)

Overall project: TRR 369: DIONE Entzündungsbedingte Knochendegeneration
Term: 1. April 2024 - 31. December 2027
Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)

Abstract

Im Projekt C06 wird untersucht, wie ungebremstes Typ-I-IFN den entzündlichen Knochenverlust antreibt. Primäre Fibroblasten von Patienten mit IFIH1-Mutationen sezernieren große Mengen von VEGF, einem wichtigen Regulator des Knochens, was auf eine bisher nicht erkannte Verbindung zwischen Typ-I-IFN und VEGF in der Knochenhomöostase hindeutet. Ziel dieses Projekts ist es, einen Einblick in die Mechanismen der durch Typ-I-IFN vermittelten entzündlichen Knochenerkrankung zu gewinnen und neue Wege aufzuzeigen, die für therapeutische Eingriffe genutzt werden können.

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2022

Andreev, D., Kachler, K., Bozec, A., & Schett, G. (2022). Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism. Bone, 162. https://doi.org/10.1016/j.bone.2022.116468
Bayat, S., Tascilar, K., Bohr, D., Krönke, G., Simon, D., Knitza, J.,... Kleyer, A. (2022). Efficacy and drug persistence of baricitinib monotherapy is similar to combination therapy in patients with active RA: a prospective observational study. RMD Open, 8(2). https://doi.org/10.1136/rmdopen-2022-002674
Bayat, S., Tascilar, K., Bohr, D., Simon, D., Kronke, G., Hartmann, F.,... Kleyer, A. (2022, June). SIMILAR EFFICACY AND DRUG SURVIVAL RATES OF BARICITINIB MONOTHERAPY AND BARICITINIB/METHOTREXATE COMBINATION THERAPY IN REAL-LIFE TREATMENT OF RHEUMATOID ARTHRITIS - RESULTS FROM A PROSPECTIVE COHORT OF BARICITINIB-TREATED PATIENTS. Poster presentation.
Birkner, B., Rech, J., Edelmann, E., Verheyen, F., Schett, G., & Stargardt, T. (2022). Patient-individual tapering of DMARDs in rheumatoid arthritis patients in a real-world setting. Rheumatology. https://doi.org/10.1093/rheumatology/keac472
Cao, S., Song, R., Meng, X., Kachler, K., Fuchs, M., Meng, X.,... Bozec, A. (2022). L-ARGININE REPROGRAMS OSTEOCLAST PURINE METABOLISM AMELIORATING BONE LOSS IN RHEUMATOID ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 52-52). LONDON: BMJ PUBLISHING GROUP.
Coppers, B., Heinrich, S., Phutane, U., Berisha, D., Tascilar, K., Kleyer, A.,... Liphardt, A.-M. (2022). Feasibility of using optoelectronic measurement of hand movement for characterizing hand function in rheumatoid arthritis. Poster presentation at 75th EULAR (European Alliance of Associations for Rheumatology), European Congress of Rheumatology 2022, Copenhagen, DK.
Coppers, B., Heinrich, S., Phutane, U., Berisha, D., Tascilar, K., Kleyer, A.,... Liphardt, A.-M. (2022). Evaluation of marker-based motion capturing to charactherize basic hand movements in rheumatic patients. Poster presentation at 27th Congress of the European Society of Biomechanics, Porto, PT.
Coppers, B., Phutane, U., Berisha, D., Tascilar, K., Kleyer, A., Simon, D.,... Liphardt, A.-M. (2022). Establishment and evaluation of a sensor-based method to assess hand function in patients with rheumatoid arthritis. In Proceedings of the conference, World Biomechanics Congress 2022. Taipei (online), TW.
D'Agostino, M.A., Boers, M., Gaillez, C., Gamez, C., Ventura, L., Padovano, J.R.I.,... Schett, G. (2022). RESPONSIVENESS OF A COMBINED POWER DOPPLER AND GREYSCALE ULTRASOUND SCORE FOR ASSESSING SYNOVITIS AT JOINT LEVEL IN PSORIATIC ARTHRITIS PATIENTS WITH INADEQUATE RESPONSE TO CSDMARDS: DATA FROM THE ULTIMATE TRIAL. In ANNALS OF THE RHEUMATIC DISEASES (pp. 171-172). LONDON: BMJ PUBLISHING GROUP.
D'Agostino, M.A., Boers, M., Schett, G., Conaghan, P.G., Naredo, E., Mandl, P.,... Bao, W. (2022). REDUCED JOINT SYNOVITIS ASSESSMENT VERSUS THE GLOBAL EULAR OMERACT SYNOVITIS SCORE (GLOESS) TO PREDICT THE RESPONSE TO SECUKINUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND INADEQUATE RESPONSE TO CONVENTIONAL DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS: EXPLORATORY RESULTS FROM THE ULTIMATE TRIAL. In ANNALS OF THE RHEUMATIC DISEASES (pp. 195-196). LONDON: BMJ PUBLISHING GROUP.
D'Agostino, M.-A., Conaghan, P.G., Gaillez, C., Naredo, E., Mandl, P., Carron, P.,... Boers, M. (2022). How Well Does Ultrasound-assessed Synovitis in Reduced Joint Sets Predict the Response to Secukinumab in Patients with Active Psoriatic Arthritis and Inadequate Response to Conventional DMARDs? - Exploratory Results from a Phase 3b Study. In ARTHRITIS & RHEUMATOLOGY (pp. 4246-4248). HOBOKEN: WILEY.
Degboe, Y., Sunzini, F., Sood, S., Bozec, A., Sokolova, M., Zekovic, A.,... Goodyear, C.S. (2022). Apremilast inhibits inflammatory osteoclastogenesis. Rheumatology, 61(1), 452-461. https://doi.org/10.1093/rheumatology/keab315
Dölling, M., Eckstein, M., Singh, J., Schoen, J., Shan, X., Bozec, A.,... Schauer, C. (2022). Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.726153
Dürholz, K., Lucas, S., Schmid, E., Schaelter, F., Frech, M., Azizov, V.,... Zaiss, M. (2022). Propionate induced bacterial-derived histamine promotes resolution of synovial inflammation. In EUROPEAN JOURNAL OF IMMUNOLOGY (pp. 29-30). HOBOKEN: WILEY.
Dürholz, K., Schmid, E., Frech, M., Azizov, V., Otterbein, N., Lucas, S.,... Zaiss, M. (2022). Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.908174
Fagni, F., Schmidt, K., Bohr, D., Valor, L., Hartmann, F., Tascilar, K.,... Harrer, T. (2022). PRE-EXPOSURE PROPHYLAXIS FOR SARS-COV-2 INFECTION WITH SUBCUTANEOUS CASIRIVIMAB/IMDEVIMAB IN PATIENTS WITH IMMUNE MEDIATED INFLAMMATORY DISEASES. In ANNALS OF THE RHEUMATIC DISEASES (pp. 968-969). LONDON: BMJ PUBLISHING GROUP.
Fagni, F., Schmidt, K., Bohr, D., Valor-Mendez, L., Tascilar, K., Manger, K.,... Hartmann, F. (2022). Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccination. RMD Open, 8(1). https://doi.org/10.1136/rmdopen-2022-002323
Fagni, F., Simon, D., Kleyer, A., Tascilar, K., Taubmann, J., Bayat, S.,... Schmidkonz, C. (2022). Fibroblast Activation in Psoriasis Patients Assessed by Ga-68-FAPI-04 PET-CT Is Associated with Progression to Psoriatic Arthritis. In ARTHRITIS & RHEUMATOLOGY (pp. 2425-2427). HOBOKEN: WILEY.
Feurstein, J., Behanova, M., Haschka, J., Roetzer, K., Uyanik, G., Hadzimuratovic, B.,... Kocijan, R. (2022). Identifying adult hypophosphatasia in the rheumatology unit. Orphanet Journal of Rare Diseases, 17(1). https://doi.org/10.1186/s13023-022-02572-7
Folle, L., Bayat, S., Kleyer, A., Fagni, F., Kapsner, L., Schlereth, M.,... Schett, G. (2022, June). CLASSIFICATION OF PSORIATIC ARTHRITIS, SERONEGATIVE RHEUMATOID ARTHRITIS, AND SEROPOSITIVE RHEUMATOID ARTHRITIS USING DEEP LEARNING ON MAGNETIC RESONANCE IMAGING. Paper presentation at EULAR Congress, Kopenhagen, DK.
Folle, L., Bayat, S., Kleyer, A., Fagni, F., Kapsner, L., Schlereth, M.,... Simon, D. (2022). Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis. Rheumatology. https://doi.org/10.1093/rheumatology/keac197
Folle, L., Bayat, S., Kleyer, A., Fagni, F., Kapsner, L., Schlereth, M.,... Simon, D. (2022, November). Neural Networks for Distinguishing Rheumatoid Arthritis from Psoriatic Arthritis by Using Magnetic Resonance Imaging. Poster presentation at ACR Convergence 2022, Philadelphia, PA, US.
Folle, L., Meinderink, T., Simon, D., Liphardt, A.-M., Thies, M., Krönke, G.,... Maier, A. (2022, June). Automated Bone Density Measurements using Deep Learning. Poster presentation at QMSKI, Nordwijk, NL.
Folle, L., Simon, D., Tascilar, K., Krönke, G., Liphardt, A.-M., Maier, A.,... Kleyer, A. (2022). Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns—How Neural Networks Can Tell Us Where to “Deep Dive” Clinically. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.850552
Frech, M., Omata, Y., Schmalzl, A., Wirtz, S., Taher, L., Schett, G.,... Sarter, K. (2022). Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.757436
Fuchs, F., Morf, H., Mohn, J., Muehlensiepen, F., Ignatyev, Y., Bohr, D.,... Knitza, J. (2022). Diagnostic delay stages and pre-diagnostic treatment in patients with suspected rheumatic diseases before special care consultation: results of a multicenter-based study. Rheumatology International. https://doi.org/10.1007/s00296-022-05223-z
Gasperi, N., Schreiber, N., Bosch, P., Adinolfi, A., Kleyer, A., Hagen, M.,... Dejaco, C. (2022). Ultrasound-detected inflammation is more common in clinically manifest hand osteoarthritis than in painless bony enlarged finger joints: subanalysis of the population-based Bruneck study. Therapeutic Advances in Musculoskeletal Disease, 14. https://doi.org/10.1177/1759720X221096382
Gerner, M., Vuillerme, N., Aubourg, T., Messner, E.M., Terhorst, Y., Hörmann, V.,... Orlemann, T. (2022). Review and Analysis of German Mobile Apps for Inflammatory Bowel Disease Management Using the Mobile Application Rating Scale: Systematic Search in App Stores and Content Analysis. JMIR mHealth and uHealth, 10(5). https://doi.org/10.2196/31102
Gimpel, A., Maccataio, A., Unterweger, H., Sokolova, M., Schett, G., & Steffen, U. (2022). IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.761816
Gouze, H., Aegerter, P., Said-Nahal, R., Zins, M., Goldberg, M., Morelle, G.,... D'Agostino, M.A. (2022). Rheumatoid arthritis, as a clinical disease, but not rheumatoid arthritis-associated autoimmunity, is linked to cardiovascular events. Arthritis Research & Therapy, 24(1). https://doi.org/10.1186/s13075-022-02722-z
Gregoric, G., Gaculenko, A., Nagel, L., Popp, V., Maschauer, S., Prante, O.,... Bäuerle, T. (2022). Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT. Cancers, 14(10). https://doi.org/10.3390/cancers14102482
Groetsch, J., Tascilar, K., Schett, G., Foell, D., & Rech, J. (2022). BASELINE CLINICAL DISEASE ACTIVITY IS NOT CRITICAL FOR PREDICTING REMISSION OF ADULTS ONSET STILL'S DISEASE. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1008-1008). LONDON: BMJ PUBLISHING GROUP.
Gräf, M., Knitza, J., Leipe, J., Krusche, M., Welcker, M., Kuhn, S.,... Callhoff, J. (2022). A Symptom Checker App Is Better at Classifying Inflammatory Disease Than Physicians Who Are Presented Identical Information. In ARTHRITIS & RHEUMATOLOGY (pp. 3511-3513). HOBOKEN: WILEY.
Gräf, M., Knitza, J., Leipe, J., Krusche, M., Welcker, M., Kuhn, S.,... Callhoff, J. (2022). Comparison of physician and artificial intelligence-based symptom checker diagnostic accuracy. Rheumatology International. https://doi.org/10.1007/s00296-022-05202-4
Grötsch, B., Schachtschabel, E., Tripal, P., Schmid, B., Smith, A.-S., Schett, G., & Bozec, A. (2022). Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.958974
Györfi, A.-H., Schett, G., & Distler, J. (2022). Response to: 'Correspondence on 'Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis'' by Jeny et al. Annals of the Rheumatic Diseases, 81(12). https://doi.org/10.1136/annrheumdis-2020-218983
Haschka, J., Simon, D., Bayat, S., Messner, Z., Kampylafka, E., Fagni, F.,... Rech, J. (2022, June). IDENTIFICATION OF CIRCULATING MICRORNA SIGNATURES IN PATIENTS WITH PSORIASIS WITH SUBCLINICAL JOINT DISEASE AND PATIENTS WITH PSORIATIC ARTHRITIS. Poster presentation.
Kemenes, S., Bayat, S., Simon, D., Krönke, G., Bohr, D., Valor, L.,... Kleyer, A. (2022). BARICITINIB LEADS TO RAPID AND PERSISTENT RESOLUTION OF SYNOVITIS AS MEASURED BY HAND MRI IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS (RA) FAILING CS/BDMARD THERAPY. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1320-1321). LONDON: BMJ PUBLISHING GROUP.
Kemenes, S., Hartmann, F., Tascilar, K., Simon, D., Bayat, S., Krönke, G.,... Kleyer, A. (2022). Baricitinib Improves Bone Biomechanical Properties in Rheumatoid Arthritis (RA) - Results of a Prospective Interventional Study. In ARTHRITIS & RHEUMATOLOGY (pp. 3931-3933). HOBOKEN: WILEY.
Kerker, I., Löhr, S., Uebe, S., Popp, B., Vasileiou, G., Bowes, J.,... Hüffmeier, U. (2022). Common RUNX3 missense variant contributes to psoriatic arthritis by modifying differentiation of CD8(+) T-cells. In EUROPEAN JOURNAL OF HUMAN GENETICS (pp. 554-555). LONDON: SPRINGERNATURE.
Knevel, R., Knitza, J., Hensvold, A., Circiumaru, A., Bruce, T., Evans, S.,... Catrina, A. (2022). Rheumatic?—A Digital Diagnostic Decision Support Tool for Individuals Suspecting Rheumatic Diseases: A Multicenter Pilot Validation Study. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.774945
Knitza, J., Grahammer, M., Böltz, S., Lang, J., Detert, M., Bader, M.,... Detert, J. (2022). DIGITALLY ENHANCED TREAT-TO-TARGET AND SHARED DECISION-MAKING APPROACH WITH A DIGITAL HEALTH APPLICATION: INTERIM RESULTS FROM A RANDOMIZED CONTROLLED TRIAL. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1088-1089). LONDON: BMJ PUBLISHING GROUP.
Knitza, J., Janousek, L., Kluge, F., Von Der Decken, C.B., Kleinert, S., Vorbrueggen, W.,... Bartz-Bazzanella, P. (2022). Machine learning-based improvement of an online rheumatology referral and triage system. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.954056
Knitza, J., Muehlensiepen, F., Ignatyev, Y., Fuchs, F., Mohn, J., Simon, D.,... Hueber, A. (2022). Patient's Perception of Digital Symptom Assessment Technologies in Rheumatology: Results From a Multicentre Study. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.844669
Knitza, J., Tascilar, K., Vuillerme, N., Eimer, E., Matusewicz, P., Corte, G.,... Simon, D. (2022). Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients-results from a randomized controlled trial. Arthritis Research & Therapy, 24(1). https://doi.org/10.1186/s13075-022-02809-7
Knitza, J., Tascilar, K., Vuillerme, N., Vogt, E., Matusewicz, P., Corte, G.,... Simon, D. (2022). PATIENT SELF-SAMPLING IN RHEUMATOID ARTHRITIS: RESULTS FROM A RANDOMIZED CONTROLLED TRIAL. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1117-1117). LONDON: BMJ PUBLISHING GROUP.
Kretschmann, S., Völkl, S., Reimann, H., Krönke, G., Schett, G., Achenbach, S.,... Aigner, M. (2022). Successful Generation of CD19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus. Transplantation and Cellular Therapy. https://doi.org/10.1016/j.jtct.2022.10.004
Kuwert, T., Schmidkonz, C., Prante, O., Schett, G., & Ramming, A. (2022). FAPI PET Opens a New Window to Understanding Immune-Mediated Inflammatory Diseases. Journal of Nuclear Medicine, 63(8), 1136-1137. https://doi.org/10.2967/jnumed.122.263922
Labinsky, H., Von Rohr, S., Raimondo, M.G., Vogt, E., Horstmann, B., Gehring, I.,... Knitza, J. (2022). Accelerating AxSpA Diagnosis: Exploring At-home Self-sampling, Symptom Checkers, Medical Student-visits and Asynchronous Reportbased Assessment. In ARTHRITIS & RHEUMATOLOGY (pp. 94-95). HOBOKEN: WILEY.
Lai, C., Heinemann, J., Schleicher, U., Schett, G., Bogdan, C., Bozec, A., & Soulat, D. (2022). Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.4733
Leppkes, M., Lindemann, A., Goesswein, S., Paulus, S., Roth, D., Hartung, A.,... Neurath, M. (2022). Neutrophils prevent rectal bleeding in Ulcerative Colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis. In JOURNAL OF CROHNS & COLITIS (pp. I178-I179). OXFORD: OXFORD UNIV PRESS.
Li, Y., Chen, C.-W., Trinh, M.T., Honglin, Z., Hubel, P., Pfannstiel, J.,... Distler, J. (2022). O-GLCNACYLATION ON NUP153 REGULATES THE EARLY STAGES OF OSTEOCLASTOGENESIS THROUGH MYC NUCLEAR TRANSLOCATION. In ANNALS OF THE RHEUMATIC DISEASES (pp. 426-426). LONDON: BMJ PUBLISHING GROUP.
Li, Y.-N., Chen, C.-W., Trinh, M.T., Zhu, H., Matei, A.-E., Györfi, A.-H.,... Distler, J. (2022). Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153. Bone Research, 10(1). https://doi.org/10.1038/s41413-022-00218-9
Liphardt, A.-M., Tascilar, K., Coppers, B., Manger, E., Liehr, S., Bieniek, L.M.,... Kleyer, A. (2022). SUBJECTIVE ASSESSMENT OF PHYSICAL FUNCTION DOES NOT SUFFICIENTLY EXPLAIN VARIANCE OF MEASURED HAND FUNCTION AND GRIP STRENGTH IN ARTHRITIS PATIENTS AND NON-ARTHRITIS CONTROLS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 218-218). LONDON: BMJ PUBLISHING GROUP.
Lyu, P., Wen, J., Stolzer, I., Gießl, A., Song, R., Meng, X.,... Bozec, A. (2022). INTESTINAL HIF1 alpha EXPRESSION PROTECTS AGAINST EPITHELIAL CELL DEATH IN ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 460-460). LONDON: BMJ PUBLISHING GROUP.
Mackensen, A., Müller, F., Mougiakakos, D., Böltz, S., Wilhelm, A., Aigner, M.,... Schett, G. (2022). Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nature Medicine. https://doi.org/10.1038/s41591-022-02017-5
Marzo-Ortega, H., Theander, E., Neuhold, M., Bergmans, P., Shawi, M., Perate, M.,... Schett, G. (2022). GUSELKUMAB IMPROVES DACTYLITIS IN PSA PATIENTS WITH INADEQUATE RESPONSE TO TNFI: DATA FROM THE PHASE 3B COSMOS TRIAL. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1577-1578). LONDON: BMJ PUBLISHING GROUP.
Matei, A.-E., Marketa, K., Xu, L., Györfi, A.-H., Boxberger, E., Soteriou, D.,... Distler, J. (2022, June). BIOPHYSICAL PROPERTIES OF MONOCYTES INDICATE DISEASE ACTIVITY, SEVERITY OF FIBROTIC OR MICROVASCULAR MANIFESTATIONS AND THE RISK FOR PROGRESSION IN SYSTEMIC SCLEROSIS. Poster presentation.
Mease, P., Van Der Heijde, D., Kirkham, B., Schett, G., Orbai, A.-M., Ritchlin, C.,... Ligozio, G. (2022). Quantification of pre-existing radiographic damage and its relationship with joint activity and long-term clinical outcomes with secukinumab therapy in patients with psoriatic arthritis. Arthritis Research & Therapy, 24(1). https://doi.org/10.1186/s13075-022-02944-1
Mease, P.J., Gladman, D., Schett, G., Paris, M., Cheng, S., Richter, S.,... Kavanaugh, A. (2022). Exposure-Adjusted Incidence Rate for Adverse Events of Special Interest in Patients with Psoriatic Arthritis Treated with Apremilast. In ARTHRITIS & RHEUMATOLOGY (pp. 4244-4246). HOBOKEN: WILEY.
Mellor, L.F., Gago-Lopez, N., Bakiri, L., Schmidt, F.N., Busse, B., Rauber, S.,... Wagner, E.F. (2022). Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2022-222229
Meng, X., Lin, Z., Cao, S., Janowska, I., Sonomoto, K., Andreev, D.,... Wiesener, M. (2022). Estrogen-mediated downregulation of HIF-1 alpha signaling in B lymphocytes influences postmenopausal bone loss. Bone Research, 10(1). https://doi.org/10.1038/s41413-022-00189-x
Morf, H., Roemer, F., Agaimy, A., Schett, G., & Manger, B. (2022). IgG4-related fasciitis. Rheumatology, 61(1), E11-E12. https://doi.org/10.1093/rheumatology/keab669
Muehlensiepen, F., May, S., Hadaschik, K., Vuillerme, N., Heinze, M., Grahammer, M.,... Knitza, J. (2022). Digitally supported shared decision-making and treat-to-target in rheumatology: a qualitative study embedded in a multicenter randomized controlled trial. Rheumatology International. https://doi.org/10.1007/s00296-022-05224-y
Muehlensiepen, F., May, S., Zarbl, J., Vogt, E., Boy, K., Heinze, M.,... Knitza, J. (2022). At-home blood self-sampling in rheumatology: a qualitative study with patients and health care professionals. BMC Health Services Research, 22(1). https://doi.org/10.1186/s12913-022-08787-5
Müller, F., Völkl, S., Mougiakakos, D., Böltz, S., Aigner, M., Gary, R.,... Mackensen, A. (2022). CD19-Targeted CAR-T Cells in Refractory Systemic Lupus Erythematosus: Safety, Efficacy, and Mechanistic Insights from the First Five Patients. In BLOOD (pp. 4562-4563). New Orleans, LA, US: WASHINGTON: AMER SOC HEMATOLOGY.
Omata, Y., Frech, M., Saito, T., Schett, G., Zaiss, M., & Tanaka, S. (2022). Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity. International Journal of Molecular Sciences, 23(3). https://doi.org/10.3390/ijms23031104
Omata, Y., Okada, H., Uebe, S., Izawa, N., Ekici, A.B., Sarter-Zaiss, K.,... Zaiss, M. (2022). Interspecies Single-Cell RNA-Seq Analysis Reveals the Novel Trajectory of Osteoclast Differentiation and Therapeutic Targets. JBMR Plus. https://doi.org/10.1002/jbm4.10631
Ovseiko, P., Gossec, L., Andreoli, L., Kiltz, U., Van Mens, L., Hassan, N.,... Coates, L.C. (2022). Gender equity in academic rheumatology, current status and potential for improvement: a cross-sectional study to inform an EULAR task force. RMD Open, 8(2). https://doi.org/10.1136/rmdopen-2022-002518
Pachowsky, M., Morf, H., Simon, D., Schönau, V., Valor, L., Knitza, J.,... Kleyer, A. (2022). PHOTOREALISTIC DEPICTION OF RHEUMATIC PATHOLOGIES BY CINEMATIC RENDERING FACILITATES DISEASE UNDERSTANDING OF PATIENTS WITH RHEUMATIC DISEASES. In ANNALS OF THE RHEUMATIC DISEASES (pp. 194-195). LONDON: BMJ PUBLISHING GROUP.
Pachowsky, M., Morf, H., Simon, D., Schönau, V., Valor-Mendez, L., Knitza, J.,... Kleyer, A. (2022). Cinematic rendering in rheumatic diseases-Photorealistic depiction of pathologies improves disease understanding for patients. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.946106
Pachowsky, M., Raimondo, M.G., Xu, C., Rauber, S., Tascilar, K., Labinsky, H.,... Ramming, A. (2022). Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-222061
Pinto, A.C.M.D., Nunes, R.D.M., Nogueira, I.A., Fischer, B., Lucas, R., Girao-Carmona, V.C.C.,... Rocha, F.A.C. (2022). Potent anti-inflammatory activity of the lectin-like domain of TNF in joints. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1049368
Rahman, P., Mcinnes, I., Deodhar, A., Schett, G., Mease, P.J., Shawi, M.,... Mcgonagle, D. (2022). GUSELKUMAB MAINTAINS RESOLUTION OF DACTYLITIS AND ENTHESITIS IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS: RESULTS THROUGH 2 YEARS FROM A PHASE 3 STUDY. In ANNALS OF THE RHEUMATIC DISEASES (pp. 826-827). LONDON: BMJ PUBLISHING GROUP.
Raimondo, M.G., Anchang, C.G., Labinsky, H., Saad, M.s.a., Rauber, S., Vogg, M.,... Ramming, A. (2022). JAK Inhibition Re-balances Gene Expression Profile of Circulating Immune Cells in Patients with Psoriatic Arthritis. In ARTHRITIS & RHEUMATOLOGY (pp. 4254-4255). HOBOKEN: WILEY.
Raimondo, M.G., Pachowsky, M., Xu, C., Rauber, S., Tascilar, K., Labinsky, H.,... Ramming, A. (2022). A MINIMAL-INVASIVE METHOD TO RETRIEVE AND IDENTIFY ENTHESEAL TISSUE FROM PSORIATIC ARTHRITIS PATIENTS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1187-1187). LONDON: BMJ PUBLISHING GROUP.
Raimondo, M.G., Pachowsky, M., Xu, C., Rauber, S., Tascilar, K., Labinsky, H.,... Ramming, A. (2022). Entheseal Biopsy Approach: An Ultrasound-guided Method for Retrieval of Entheseal Tissue from Psoriatic Arthritis Patients. In ARTHRITIS & RHEUMATOLOGY (pp. 2033-2034). HOBOKEN: WILEY.
Raimondo, M.G., Rauber, S., Xu, C., Mohammadian, H., Vogg, M., Anchang, C.G.,... Ramming, A. (2022). TEMPORAL MIGRATION OF IMMUNE CELLS FROM PSORIATIC SKIN TO JOINTS INITIATING SYNOVIAL INFLAMMATION IN PSORIATIC ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 479-479). LONDON: BMJ PUBLISHING GROUP.
Rauber, S., Mohammadian, H., Schmidkonz, C., Atzinger, A., Raimondo, M.G., Labinsky, H.,... Ramming, A. (2022). Fibroblast Activation Protein (FAP) PET-CT for Depicting Inflammatory Joint Damage in Patients with Psoriatic Arthritis. In ARTHRITIS & RHEUMATOLOGY (pp. 3176-3177). HOBOKEN: WILEY.
Rech, J., Kleyer, A., Ostergaard, M., Hagen, M., Mendez, L.V., Tascilar, K.,... Schett, G. (2022). Abatacept Significantly Reduces Subclinical Inflammation During Treatment (6 Months), This Persists After Discontinuation (12 Months), Resulting in a Delay in the Clinical Development of RA in Patients at Risk of RA (The ARIAA Study). In ARTHRITIS & RHEUMATOLOGY (pp. 1067-1069). HOBOKEN: WILEY.
Rech, J., Kleyer, A., Ostergaard, M., Hagen, M., Valor, L., Tascilar, K.,... Schett, G. (2022). ABATACEPT DELAYS THE DEVELOPMENT OF RA-CLINICAL RESULTS AFTER 18 MONTHS FROM THE RANDOMIZED, PLACEBO-CONTROLLED ARIAA STUDY IN RA-AT RISK PATIENTS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 526-527). LONDON: BMJ PUBLISHING GROUP.
Rech, J., & Schett, G. (2022). Towards preventive treatment of rheumatoid arthritis. The Lancet, 400(10348), 253-255. https://doi.org/10.1016/S0140-6736(22)01327-7
Regierer, A., Weiss, A., Baraliakos, X., Behrens, F., Poddubnyy, D., Schett, G.,... Strangfeld, A. (2022). COMPARISON OF PATIENTS WITH AXIAL PSA AND PATIENTS WITH AXSPA AND CONCOMITANT PSORIASIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 864-865). LONDON: BMJ PUBLISHING GROUP.
Reimann, H., Kremer, A., Blumenberg, V., Schmidt, K., Aigner, M., Kremer, A.,... Völkl, S. (2022). Sars-Cov-2 Vaccine-Induced Cellular and Humoral Immunity in Patients after CD19.CAR-T Cell Therapy. In BLOOD (pp. 10279-10280). WASHINGTON: AMER SOC HEMATOLOGY.
Royzman, D., Andreev, D., Stich, L., Peckert, K., Wild, A., Zinser, E.,... Steinkasserer, A. (2022). The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.936995
Schett, G., Böltz, S., Müller, F., Kleyer, A., Völkl, S., Aigner, M.,... Andreas, M. (2022). CAR-T CELL TREATMENT OF REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS- SAFETY AND PRELIMINARY EFFICACY DATA FROM THE FIRST FOUR PATIENTS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 185-185). LONDON: BMJ PUBLISHING GROUP.
Schett, G., Böltz, S., Müller, F., Kleyer, A., Völkl, S., Aigner, M.,... Mackensen, A. (2022). CAR T Cell Treatment of Refractory Systemic Lupus Erythematosus. In ARTHRITIS & RHEUMATOLOGY (pp. 3284-3285). HOBOKEN: WILEY.
Schett, G., Loza, M.J., Palanichamy, A., Fitzgerald, O., Ritchlin, C., Bay-Jensen, A.-C.,... Sweet, K. (2022). Collagen Turnover Biomarkers Associate with Active Psoriatic Arthritis and Decrease with Guselkumab Treatment in a Phase 3 Clinical Trial (DISCOVER-2). Rheumatology and Therapy. https://doi.org/10.1007/s40744-022-00444-x
Schett, G., Loza, M.J., Palanichamy, A., Fitzgerald, O., Ritchlin, C., Bay-Jensen, A.-C.,... Sweet, K. (2022). Publisher Correction to: Collagen Turnover Biomarkers Associate with Active Psoriatic Arthritis and Decrease with Guselkumab Treatment in a Phase 3 Clinical Trial (DISCOVER-2) (Rheumatology and Therapy, (2022), 10.1007/s40744-022-00444-x). Rheumatology and Therapy. https://doi.org/10.1007/s40744-022-00470-9
Schett, G., Rahman, P., Ritchlin, C., Mcinnes, I.B., Elewaut, D., & Scher, J.U. (2022). Psoriatic arthritis from a mechanistic perspective. Nature Reviews Rheumatology. https://doi.org/10.1038/s41584-022-00776-6
Schett, G., & Takayanagi, H. (2022). Editorial overview: Osteoimmunology. Bone, 162. https://doi.org/10.1016/j.bone.2022.116466
Schmetzer, C., Vogt, E., Stellar, L., Godonou, E.-T., Liphardt, A.-M., Muehlensiepen, F.,... Knitza, J. (2022). Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.994770
Schmid, E., Dürholz, K., Frech, M., Otterbein, N., Lucas, S., Rauh, M.,... Zaiss, M. (2022). Microbiota-derived propionate modulates megakaryopoiesis and platelet function. In EUROPEAN JOURNAL OF IMMUNOLOGY (pp. 304-305). HOBOKEN: WILEY.
Schmidkonz, C., Kuwert, T., Atzinger, A., Cordes, M., Schett, G., Ramming, A., & Götz, T. (2022). Fibroblast Activation Protein Inhibitor Imaging in Nonmalignant Diseases: A New Perspective for Molecular Imaging. Journal of Nuclear Medicine, 63(12), 1786-1792. https://doi.org/10.2967/jnumed.122.264205
Schmidkonz, C., Rauber, S., Raimondo, M.G., Labinsky, H., Atzinger, A., Treutlein, C.,... Ramming, A. (2022). FIBROBLAST ACTIVATION PROTEIN (FAP) PET-CT IMAGING ALLOWS TO DEPICT INFLAMMATORY JOINT REMODELING IN PATIENTS WITH PSORIATIC ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 169-169). LONDON: BMJ PUBLISHING GROUP.
Schmidt, K.G., Harrer, E., Tascilar, K., Kuebel, S., El Kenz, B., Simon, D.,... Hartmann, F. (2022). Characterization of Serum and Mucosal SARS-CoV-2-Antibodies in HIV-1-Infected Subjects after BNT162b2 mRNA Vaccination or SARS-CoV-2 Infection. Viruses, 14(3). https://doi.org/10.3390/v14030651
Schoen, J., Euler, M., Schauer, C., Schett, G., Herrmann, M., Knopf, J., & Yaykasli, K.O. (2022). Neutrophils’ Extracellular Trap Mechanisms: From Physiology to Pathology. International Journal of Molecular Sciences, 23(21). https://doi.org/10.3390/ijms232112855
Schälter, F., Azizov, V., Frech, M., Dürholz, K., Sokolova, M., Hendel, A.,... Zaiss, M. (2022). The role of joint-draining lymph node stromal cells in inflammatory arthritis. In EUROPEAN JOURNAL OF IMMUNOLOGY (pp. 246-247). HOBOKEN: WILEY.
Schälter, F., Frech, M., Dürholz, K., Lucas, S., Sarter-Zaiss, K., Lebon, L.,... Zaiss, M. (2022). Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner. International Journal For Parasitology. https://doi.org/10.1016/j.ijpara.2022.04.004
Schönau, V., Corte, G., Ott, S., Tascilar, K., Hartmann, F., Manger, B.,... Schett, G. (2022). CHARACTERIZATION OF RELAPSES IN PATIENTS WITH GIANT CELL ARTERITIS (GCA) PATIENTS- DATA FROM THE REAL-LIFE TREATMENT AND SAFETY (REATS)-GCA COHORT. In ANNALS OF THE RHEUMATIC DISEASES (pp. 694-694). LONDON: BMJ PUBLISHING GROUP.
Sehnert, B., Valero-Esquitino, V., Schett, G., Unger, T., Steckelings, U.M., & Voll, R.E. (2022). Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.921488
Shan, X., Reichardt, C., Singh, J., Zeitler, A., Schauer, C., Knopf, J.,... Munoz, L.E. (2022). Early Histopathological Changes of the Salivary Glands Associated with the Development of Primary Sjogren's Syndrome. In ARTHRITIS & RHEUMATOLOGY (pp. 3984-3984). HOBOKEN: WILEY.
Siebert, S., Coates, L., Schett, G., Raychaudhuri, S.P., Chen, W., Gao, S.,... Deodhar, A. (2022). IMMUNOLOGICAL DIFFERENCES BETWEEN PSA PATIENTS WHO ARE TUMOR NECROSIS FACTOR INHIBITOR-NAIVE AND WHO HAVE INADEQUATE RESPONSE TO TUMOR NECROSIS FACTOR INHIBITORS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 254-255). LONDON: BMJ PUBLISHING GROUP.
Siebert, S., Schett, G., Raychaudhuri, S.P., Guma, M., Chen, W., Gao, S.,... Rahman, P. (2022). Changes in Serum Cytokines by Week 24 Correlate with Long-Term Efficacy of Guselkumab Through Two Years in Bio-Naive Adults with PsA. In ARTHRITIS & RHEUMATOLOGY (pp. 4168-4170). HOBOKEN: WILEY.
Simon, D., Fagni, F., & Schett, G. (2022). Sequential interleukin-17/interleukin-23 inhibition in treatment-refractory psoriatic arthritis. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2022-222415
Simon, D., Fagni, F., Tascilar, K., & Schett, G. (2022). Reply. Arthritis and Rheumatology, 74(12). https://doi.org/10.1002/art.42305
Simon, D., Kleyer, A., Bui, C.D., Hueber, A., Bang, H., Ramming, A.,... Schett, G. (2022). Microstructural Bone Changes Are Associated With Broad-Spectrum Autoimmunity and Predict the Onset of Rheumatoid Arthritis. Arthritis and Rheumatology. https://doi.org/10.1002/art.41229
Simon, D., Tascilar, K., Fagni, F., Kleyer, A., Krönke, G., Meder, C.,... Hartmann, F. (2022). Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study. The Lancet Rheumatology, 4(9), e614-e625. https://doi.org/10.1016/S2665-9913(22)00191-6
Simon, D., Tascilar, K., Kleyer, A., Fagni, F., Krönke, G., Meder, C.,... Schett, G. (2022). Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort. Arthritis and Rheumatology. https://doi.org/10.1002/art.42035
Singh, J., Herrmann, I., Mahajan, A., Schauer, C., Shan, X., Hartmann, A.,... Knopf, J. (2022). A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19. International Journal of Molecular Sciences, 23(23). https://doi.org/10.3390/ijms232315126
Sokolova, M., Hagen, M., Bang, H., Schett, G., Rech, J., & Steffen, U. (2022). IgA anti-citrullinated protein antibodies are associated with flares during DMARD tapering in rheumatoid arthritis. Rheumatology, 61(5), 2124-2131. https://doi.org/10.1093/rheumatology/keab585
Sokolova, M., Hartmann, F., Sieghart, D., Steiner, G., Kleyer, A., Schett, G., & Steffen, U. (2022). IGA ACPA ARE ASSOCIATED WITH PROGRESSION TO RHEUMATOID ARTHRITIS IN INDIVIDUALS AT-RISK AND DECLINE IN LEVELS AROUND THE DISEASE ONSET. In ANNALS OF THE RHEUMATIC DISEASES (pp. 515-516). LONDON: BMJ PUBLISHING GROUP.
Süß, P., Masanetz, R.K., Baum, W., Schett, G., Schlachetzki, J., & Winkler, J. (2022). The transcriptional regulator DREAM modulates glial cell proliferation dependent on the regional inflammatory microenvironment. In JOURNAL OF NEUROCHEMISTRY (pp. 143-143). HOBOKEN: WILEY.
Tascilar, K., Fagni, F., Kleyer, A., Bayat, S., Heidemann, R., Steiger, F.,... Simon, D. (2022). NON-INVASIVE IN VIVO METABOLIC PROFILING OF INFLAMMATION IN JOINTS AND ENTHESES BY OPTOACOUSTIC IMAGING. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1032-1032). LONDON: BMJ PUBLISHING GROUP.
Tascilar, K., Fagni, F., Kleyer, A., Bayat, S., Heidemann, R., Steiger, F.,... Simon, D. (2022). Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography. Rheumatology. https://doi.org/10.1093/rheumatology/keac346
Tascilar, K., Simon, D., Kleyer, A., Fagni, F., Krönke, G., Meder, C.,... Schett, G. (2022). LONG-TERM HUMORAL RESPONSE TO SARS-COV-2 VACCINATION IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASE. In ANNALS OF THE RHEUMATIC DISEASES (pp. 371-372). LONDON: BMJ PUBLISHING GROUP.
Thies, M., Wagner, F., Huang, Y., Gu, M., Kling, L., Pechmann, S.,... Maier, A. (2022). Calibration by differentiation – Self-supervised calibration for X-ray microscopy using a differentiable cone-beam reconstruction operator. Journal of Microscopy. https://doi.org/10.1111/jmi.13125
Treutlein, C., Distler, J., Tascilar, K., Chenguiti Fakhouri, S., Györfi, A.-H., Atzinger, A.,... Bergmann, C. (2022). Assessment of myocardial fibrosis in patients with systemic sclerosis using [Ga-68]Ga-FAPI-04-PET-CT. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-022-06081-4
Treutlein, C., Schmidkonz, C., Tascilar, K., Chenguiti Fakhouri, S., Dees, C., Györfi, A.-H.,... Bergmann, C. (2022, June). ASSESSMENT OF SYSTEMIC SCLEROSIS RELATED MYOCARDIAL FIBROSIS BY 68GA-FAPI-04 PET/CT. Poster presentation.
Truong, M.T., Nwosu, O.B., Gaytan Torres, M.E., Segura Vargas, M.P., Seifer, A.-K., Nitschke, M.,... Morf, H. (2022). A Yoga Exercise App Designed for Patients With Axial Spondylarthritis: Development and User Experience Study. JMIR Formative Research, 6(6), e34566. https://doi.org/10.2196/34566
Valor-Mendez, L., Dorn, C., Manger, B., Schett, G., & Kleyer, A. (2022). Re-exposure with a TNF inhibitor bio-similar was well tolerated and led to sustained control of psoriatic arthritis after allergic reaction to the TNF inhibitor bio-originator. Rheumatology Advances in Practice, 6(3). https://doi.org/10.1093/rap/rkac079
Valor-Mendez, L., Manger, B., Knitza, J., Schmidkonz, C., Kleyer, A., & Schett, G. (2022). Clinical Images: Tissue remodeling in autoimmune statin-induced necrotizing autoimmune myopathy. ACR Open Rheumatology. https://doi.org/10.1002/acr2.11475
Valor-Mendez, L., Manger, B., Wacker, J., Kleyer, A., & Schett, G. (2022). Lymph node and pulmonary tuberculosis during upadacitinib treatment in a psoriatic arthritis patient. Rheumatology Advances in Practice, 6(2). https://doi.org/10.1093/rap/rkac032
Valor-Mendez, L., Manger, B., Winterholler, M., Schett, G., Tuerk, M., & Knitza, J. (2022). Rare meets rarer: anti-synthetase syndrome in a patient with facio-scapulo-humeral muscular dystrophy. Rheumatology. https://doi.org/10.1093/rheumatology/keac328
Valor-Méndez, L., Schett, G., & Manger, B. (2022). Treatment of refractory hypocomplementaemic urticarial vasculitis syndrome progressing to systemic lupus erythematosus with belimumab. Clinical and Experimental Rheumatology, 40(4), 854-855. https://doi.org/10.55563/clinexprheumatol/m9dexe
Valor-Méndez, L., Wacker, J., Schett, G., Manger, B., Fürst, J., Strauss, R., & Kleyer, A. (2022). Clinical Images: Voriconazole-induced synovitis, enthesitis, and periostitis. Arthritis and Rheumatology, 74(7), 1183-. https://doi.org/10.1002/art.42085
Wagner, F., Thies, M., Gu, M., Huang, Y., Pechmann, S., Patwari, M.,... Maier, A. (2022). Ultra low‐parameter denoising: Trainable bilateral filter layers in computed tomography. Medical Physics, 49(8), 5107-5120. https://doi.org/10.1002/mp.15718
Wagner, F., Thies, M., Karolczak, M., Pechmann, S., Huang, Y., Gu, M.,... Maier, A. (2022). Monte Carlo Dose Simulation for In-Vivo X-Ray Nanoscopy. In Klaus Maier-Hein, Thomas M. Deserno, Heinz Handels, Andreas Maier, Christoph Palm, Thomas Tolxdorff (Eds.), Informatik aktuell (pp. 107-112). Heidelberg, DEU: Springer Science and Business Media Deutschland GmbH.
Weber, N., Lennartz, R., Knitza, J., Bayat, S., Sadeghi, M., Ibrahim, A.,... Kleyer, A. (2022). AB1528-HPR FULL BODY HAPTIC BODYSUIT - AN INSTRUMENT TO MEASURE THE RANGE AND SPEED OF MOTION IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS (axSpA) - PRELIMINARY RESULTS. Annals of the Rheumatic Diseases, 81, 1866.2-1867. https://doi.org/10.1136/annrheumdis-2022-eular.3069
Wen, J., Lyu, P., Stolzer, I., Xu, J., Gießl, A., Lin, Z.,... Bozec, A. (2022). Epithelial HIF2 alpha expression induces intestinal barrier dysfunction and exacerbation of arthritis. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-222035
Yalcin Mutlu, M., Taubmann, J., Wacker, J., Tascilar, K., Fagni, F., Gerner, M.,... Simon, D. (2022). Neutralizing monoclonal antibodies against SARS-CoV-2 for COVID-19 pneumonia in a rituximab treated patient with systemic sclerosis-A case report and literature review. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.934169
Yalcin Mutlu, M., Wacker, J., Tascilar, K., Taubmann, J., Manger, B., Krönke, G.,... Simon, D. (2022). Effective and safe treatment of anti-CD38 therapy in systemic lupus erythematosus-associated refractory cerebral vasculitis induces immune tolerance. Rheumatology. https://doi.org/10.1093/rheumatology/keac393
Zarbl, J., Eimer, E., Gigg, C., Bendzuck, G., Korinth, M., Elling-Audersch, C.,... Knitza, J. (2022). Remote self-collection of capillary blood using upper arm devices for autoantibody analysis in patients with immune-mediated inflammatory rheumatic diseases. RMD Open, 8(2). https://doi.org/10.1136/rmdopen-2022-002641
Zhou, X., Trinh, M.T., Tran Manh, C., Giessl, A., Bergmann, C., Györfi, A.-H.,... Distler, J. (2022). DEREGULATION OF TFAM EXPRESSION PROMOTES MITOCHONDRIAL DAMAGE AND FIBROBLAST ACTIVATION IN SYSTEMIC SCLEROSIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1195-1195). LONDON: BMJ PUBLISHING GROUP.
Zhou, X., Trinh, M.T., Tran Manh, C., Gießl, A., Bergmann, C., Györfi, A.-H.,... Distler, J. (2022). Impaired Mitochondrial Transcription Factor A Expression Promotes Mitochondrial Damage to Drive Fibroblast Activation and Fibrosis in Systemic Sclerosis. Arthritis and Rheumatology. https://doi.org/10.1002/art.42033

2021

Ackermann, M., Anders, H.-J., Bilyy, R., Bowlin, G.L., Daniel, C., De Lorenzo, R.,... Schauer, C. (2021). Patients with COVID-19: in the dark-NETs of neutrophils. Cell Death and Differentiation. https://doi.org/10.1038/s41418-021-00805-z
Anchang, C.G., Xu, C., Raimondo, M.G., Atreya, R., Maier, A., Schett, G.,... Ramming, A. (2021). The potential of omics technologies for the treatment of immune‐mediated inflammatory diseases. International Journal of Molecular Sciences, 22(14). https://doi.org/10.3390/ijms22147506
Behrens, F., Leage, S.L., Sapin, C., El Baou, C., De La Torre, I., Meszaros, G.,... Gossec, L. (2021). Correction to: Measuring treatment effect on psoriatic arthritis-related domains: insights from the SPIRIT-H2H study at weeks 24 and 52 (Clinical Rheumatology, (2021), 40, 12, (4943-4954), 10.1007/s10067-021-05891-5). Clinical Rheumatology, 40(12), 4955-4956. https://doi.org/10.1007/s10067-021-05966-3
Behrens, F., Leage, S.L., Sapin, C., El Baou, C., De La Torre, I., Meszaros, G.,... Gossec, L. (2021). Measuring treatment effect on psoriatic arthritis-related domains: insights from the SPIRIT-H2H study at weeks 24 and 52. Clinical Rheumatology. https://doi.org/10.1007/s10067-021-05891-5
Bergmann, C., Distler, J., Treutlein, C., Tascilar, K., Müller, A., Atzinger, A.,... Schmidkonz, C. (2021). 68GA-FAPI-04 PET/CT STUDY EXTENSION FOR THE ASSESSMENT OF FIBROBLAST ACTIVATION AND RISK EVALUATION IN SYSTEMIC SCLEROSIS-RELATED INTERSTITIAL LUNG DISEASE. In ANNALS OF THE RHEUMATIC DISEASES (pp. 165-166). LONDON: BMJ PUBLISHING GROUP.
Bergmann, C., Distler, J., Treutlein, C., Tascilar, K., Müller, A., Atzinger, A.,... Schmidkonz, C. (2021). 68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre, pilot study. The Lancet Rheumatology. https://doi.org/10.1016/S2665-9913(20)30421-5
Bergmann, C., Hallenberger, L., Chenguiti Fakhouri, S., Chenguiti Fakhouri, S., Merlevede, B., Brandt, A.,... Distler, J. (2021). X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc). Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2020-219822
Bleckwedel-Rolack, L.L.K., Tascilar, K., Nees, V., Hühne, J., Hueber, A., Rech, J.,... Liphardt, A.-M. (2021). PATIENTS AT RISK FOR RA SHOW THE SAME AMOUNT OF ACUTE SOLUBLE CARTILAGE DEGRADATION MARKERS AFTER PHYSICAL ACTIVITY COMPARED TO PATIENTS WITH ESTABLISHED RA. In ANNALS OF THE RHEUMATIC DISEASES (pp. 420-421). LONDON: BMJ PUBLISHING GROUP.
Boers, M., Conaghan, P.G., Schett, G., Mandl, P., Naredo, E., Van Den Bosch, F.,... D'Agostino, M.A. (2021). RESPONSIVENESS OF ULTRASOUND SYNOVITIS AND CLINICAL OUTCOMES IN PSORIATIC ARTHRITIS TREATED WITH SECUKINUMAB: DATA FROM THE ULTIMATE TRIAL. In ANNALS OF THE RHEUMATIC DISEASES (pp. 314-314). LONDON: BMJ PUBLISHING GROUP.
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Brandl, C., Bucci, L., Schett, G., & Zaiss, M. (2021). Crossing the barriers: Revisiting the gut feeling in rheumatoid arthritis. European Journal of Immunology. https://doi.org/10.1002/eji.202048876
Burmester, G.R., Manger, B., Schett, G., & Schulze-Koops, H. (2021). Joachim Robert Kalden: One of the founders of autoimmunity research and immunotherapy. Annals of the Rheumatic Diseases, 80(6), 682-684. https://doi.org/10.1136/annrheumdis-2021-220529
Burmester, G.R., & Schett, G. (2021). Eighty years of rheumatology—Milestones in diagnosis, treatment and research Achtzig Jahre Rheumatologie – Meilensteine in Diagnose, Therapie und Forschung. Zeitschrift für Rheumatologie. https://doi.org/10.1007/s00393-021-01039-7
Bénard, A., Jacobsen, A., Brunner, M., Krautz, C., Klösch, B., Swierzy, I.,... Weber, G. (2021). Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-21310-4
Cao, S., Schnelzer, A., Hannemann, N., Schett, G., Soulat, D., & Bozec, A. (2021). The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.701675
Chen, C.-W., Li, Y.N., Trinh, M.T., Honglin, Z., Matei, A.-E., Ding, X.,... Ramming, A. (2021). DYNAMIC CHANGES IN O-GLCNACYLATION REGULATE OSTEOCLAST DIFFERENTIATION AND BONE LOSS IN ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 121-122). LONDON: BMJ PUBLISHING GROUP.
Coates, L.C., Gossec, L., Theander, E., Bergmans, P., Neuhold, M., Karyekar, C.,... Mcinnes, I. (2021). EFFICACY AND SAFETY OF GUSELKUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS WHO DEMONSTRATED INADEQUATE RESPONSE TO TUMOR NECROSIS FACTOR INHIBITION: WEEK 24 RESULTS OF A PHASE 3B, RANDOMIZED, CONTROLLED STUDY. In ANNALS OF THE RHEUMATIC DISEASES (pp. 140-141). LONDON: BMJ PUBLISHING GROUP.
Coates, L.C., Gossec, L., Theander, E., Bergmans, P., Neuhold, M., Karyekar, C.S.,... Mcinnes, I.B. (2021). Efficacy and safety of guselkumab in patients with active psoriatic arthritis who are inadequate responders to tumour necrosis factor inhibitors: results through one year of a phase IIIb, randomised, controlled study (COSMOS). Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-220991
Corte, G., Bayat, S., Tascilar, K., Valor, L., Schuster, L., Knitza, J.,... Simon, D. (2021). ACCURACY AND PERFORMANCE OF A HANDHELD ULTRASOUND DEVICE TO ASSESS ARTICULAR AND PERIARTICULAR PATHOLOGIES IN PATIENTS WITH INFLAMMATORY ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 979-980). LONDON: BMJ PUBLISHING GROUP.
Corte, G., Bayat, S., Tascilar, K., Valor-Mendez, L., Schuster, L., Knitza, J.,... Simon, D. (2021). Performance of a handheld ultrasound device to assess articular and periarticular pathologies in patients with inflammatory arthritis. Diagnostics, 11(7). https://doi.org/10.3390/diagnostics11071139
Costantino, F., Aegerter, P., Schett, G., De Craemer, A.-S., Molto, A., Van Den Bosch, F.,... D'Agostino, M.-A. (2021). Cluster analysis in early axial spondyloarthritis predicts poor outcome in the presence of peripheral articular manifestations. Rheumatology. https://doi.org/10.1093/rheumatology/keab873
D'Agostino, M.A., Conaghan, P.G., Gaillez, C., Boers, M., Naredo, E., Carron, P.,... Schett, G. (2021). TOWARDS DEVELOPMENT OF AN ULTRASOUND ENTHESITIS SCORE IN PSORIATIC ARTHRITIS: 24-WEEK RESULTS FROM THE PHASE III RANDOMISED ULTIMATE STUDY. In ANNALS OF THE RHEUMATIC DISEASES (pp. 136-137). LONDON: BMJ PUBLISHING GROUP.
D'Agostino, M.A., Schett, G., Gaillez, C., Conaghan, P., Naredo, E., Carron, P.,... Demanse, D. (2021). Clusters of Psoriatic Arthritis Patients at Baseline Based on Different Ultrasound Detected Synovitis: Exploratory Analysis from a Phase III Study. In ARTHRITIS & RHEUMATOLOGY (pp. 2834-2837). HOBOKEN: WILEY.
D'Agostino, M.A., Schett, G., Gaillez, C., Guerrero, C., Hanova, P., Cazenave, T.,... Conaghan, P. (2021). Ultrasound Demonstrates Continued Improvement in Psoriatic Arthritis Synovitis and Enthesitis with Secukinumab: 52-week Results from a Phase III Study. In ARTHRITIS & RHEUMATOLOGY (pp. 2839-2842). HOBOKEN: WILEY.
D'Agostino, M.A., Schett, G., Lopez-Rdz, A., Senolt, L., Fazekas, K., Burgos-Vargas, R.,... Gaillez, C. (2021). Response to secukinumab on synovitis using Power Doppler ultrasound in psoriatic arthritis: 12-week results from a phase III study, ULTIMATE. Rheumatology. https://doi.org/10.1093/rheumatology/keab628
Dees, C., Pötter, S., Fuchs, M., Bergmann, C., Matei, A.-E., Györfi, A.-H.,... Distler, H.W. (2021). NCOA3 AMPLIFIES PROFIBROTIC TRANSCRIPTIONAL PROGRAMS IN SYSTEMIC SCLEROSIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 440-441). LONDON: BMJ PUBLISHING GROUP.
Doerner, T., & Schett, G. (2021). 80 Meilensteine der Rheumatologie aus 80 Jahren – IV: 2000–2020. Zeitschrift für Rheumatologie, 80(6), 528-538. https://doi.org/10.1007/s00393-021-01038-8
Dorst, D.N., Rijpkema, M., Buitinga, M., Walgreen, B., Helsen, M.M.A., Brennan, E.,... Koenders, M. (2021). Targeting of fibroblast activation protein in rheumatoid arthritis patients: imaging and ex vivo photodynamic therapy. Rheumatology. https://doi.org/10.1093/rheumatology/keab664
Faas, M., Ipseiz, N., Ackermann, J., Culemann, S., Grüneboom, A., Schröder, F.,... Krönke, G. (2021). IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity, 54(11), 2531-2546.e5. https://doi.org/10.1016/j.immuni.2021.09.010
Fagni, F., Simon, D., Tascilar, K., Schoenau, V., Sticherling, M., Neurath, M., & Schett, G. (2021). COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses. The Lancet Rheumatology, 3(10), e724-e736. https://doi.org/10.1016/S2665-9913(21)00247-2
Feurstein, J., Behanova, M., Haschka, J., Roetzer, K., Uyanik, G., Witsch-Baumgartner, M.,... Kocijan, R. (2021). IDENTIFYING ADULT HYPOPHOSPHATASIA IN THE RHEUMATOLOGY UNIT. In ANNALS OF THE RHEUMATIC DISEASES (pp. 848-848). LONDON: BMJ PUBLISHING GROUP.
Folle, L., Liu, C., Simon, D., Meinderink, T., Liphardt, A.-M., Krönke, G.,... Kleyer, A. (2021, May). Differential diagnosis of RA and PsA using neural networks on 3D bone shape of finger joints. Paper presentation at EULAR 2021 Congress, Paris, FR.
Folle, L., Meinderink, T., Simon, D., Liphardt, A.-M., Krönke, G., Schett, G.,... Maier, A. (2021). Deep learning methods allow fully automated segmentation of metacarpal bones to quantify volumetric bone mineral density. Scientific Reports, 11(1), 9697. https://doi.org/10.1038/s41598-021-89111-9
Frech, M., Schuster, G., Andes, F.T., Schett, G., Zaiss, M., & Sarter, K. (2021). RANKL-Induced Btn2a2 – A T Cell Immunomodulatory Molecule – During Osteoclast Differentiation Fine-Tunes Bone Resorption. Frontiers in Endocrinology, 12. https://doi.org/10.3389/fendo.2021.685060
Friščić, J., Böttcher, M., Reinwald, C., Bruns, H., Wirth, B., Popp, S.,... Hoffmann, M. (2021). The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity. https://doi.org/10.1016/j.immuni.2021.03.003
Friščić, J., Dürholz, K., Chen, X., Engdahl, C., Möller, L., Schett, G.,... Hoffmann, M. (2021). Dietary derived propionate regulates pathogenic fibroblast function and ameliorates experimental arthritis and inflammatory tissue priming. Nutrients, 13(5). https://doi.org/10.3390/nu13051643
Gaculenko, A., Gregoric, G., Popp, V., Seyler, L., Ringer, M., Kachler, K.,... Bozec, A. (2021). Systemic PPAR gamma Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.4422
Genovese, M.C., Buckley, C.D., Saurigny, D., Schett, G., Davy, K., Gupta, A.,... Tak, P.P. (2021). Targeting GM-CSF in rheumatological conditions: risk of PAP – Authors' reply. The Lancet Rheumatology, 3(7), e473-e474. https://doi.org/10.1016/S2665-9913(21)00146-6
Genovese, M.C., Buckley, C.D., Saurigny, D., Schett, G., Davy, K., Gupta, A.,... Tak, P.P. (2021). Targeting GM-CSF in rheumatological conditions: risk of PAP Reply. The Lancet Rheumatology, 3(7), E473-E474. https://doi.org/10.1016/s2665-9913(21)00145-4
Groen, S.S., Sinkeviciute, D., Bay-Jensen, A.C., Thudium, C.S., Karsdal, M.A., Thomsen, S.F.,... Nielsen, S.H. (2021). Exploring IL-17 in spondyloarthritis for development of novel treatments and biomarkers. Autoimmunity Reviews, 20(3). https://doi.org/10.1016/j.autrev.2021.102760
Györfi, A.-H., Matei, A.-E., Fuchs, M., Liang, C., Rigau, A., Hong, X.,... Distler, J. (2021). Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation. Journal of Experimental Medicine, 218(9). https://doi.org/10.1084/jem.20201916
Györfi, A.-H., Matei, A.-E., Fuchs, M., Rigau, A., Hong, X., Honglin, Z.,... Distler, J. (2021). ENGRAILED 1 COORDINATES CYTOSKELETAL ORGANIZATION TO PROMOTE MYOFIBROBLAST DIFFERENTIATION AND FIBROTIC TISSUE REMODELING. In ANNALS OF THE RHEUMATIC DISEASES (pp. 391-391). LONDON: BMJ PUBLISHING GROUP.
Haberman, R., Herati, R., Simon, D., Samanovic, M., Tuen, M., Blank, R.,... Scher, J. (2021). Methotrexate Hampers Immunogenicity to BNT162b2 mRNA COVID-19 Vaccine in Immune-Mediated Inflammatory Disease. In ARTHRITIS & RHEUMATOLOGY (pp. 3205-3208). HOBOKEN: WILEY.
Haberman, R.H., Herati, R.S., Simon, D., Samanovic, M., Blank, R.B., Tuen, M.,... Scher, J.U. (2021). Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease. Annals of the Rheumatic Diseases, 80(10), 1339-1344. https://doi.org/10.1136/annrheumdis-2021-220597
Hagen, M., Tascilar, K., Reiser, M., Valor, L., Haschka, J., Kleyer, A.,... Schett, G. (2021). TREATMENT TAPERING AND WITHDRAWAL IN RHEUMATOID ARTHRITIS WITH STABLE REMISSION - FINAL ANALYSIS OF THE RETRO STUDY. In ANNALS OF THE RHEUMATIC DISEASES (pp. 194-195). LONDON: BMJ PUBLISHING GROUP.
Haskamp, S., Horowitz, J., Oji, V., Philipp, S., Sticherling, M., Schäkel, K.,... Hüffmeier, U. (2021). Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2021.01.017
Huang, Y., Mill, L., Stoll, R., Kling, L., Aust, O., Wagner, F.,... Maier, A. (2021). Semi-Permeable Filters for Interior Region of Interest Dose Reduction in X-Ray Microscopy. In Bildverarbeitung für die Medizin. Regensburg, DE: Springer.
Hülser, M.L., Luo, Y., Frommer, K., Hasseli, R., Köhler, K., Diller, M.,... Neumann, E. (2021). Systemic versus local adipokine expression differs in a combined obesity and osteoarthritis mouse model. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-96545-8
Kaaij, M.H., Rip, J., Jeucken, K.C., Kan, Y.Y., van Rooijen, C.C., Saris, J.,... Tas, S.W. (2021). Overexpression of transmembrane TNF drives development of ectopic lymphoid structures in the bone marrow and B cell lineage alterations in experimental spondyloarthritis. Journal of Immunology, 207(9), 2337-2346. https://doi.org/10.4049/jimmunol.2100512
Kaeley, G., Schett, G., Conaghan, P., Mcgonagle, D., Behrens, F., Goupille, P.,... Bakewell, C. (2021). Secukinumab Treatment Provides Sustained Resolution of Enthesitis at Individual Joints Through 52 Weeks in a Phase 3b, Double-Blind, Randomized, Active-Controlled Study. In ARTHRITIS & RHEUMATOLOGY (pp. 3808-3811). HOBOKEN: WILEY.
Kaeley, G.S., Schett, G., Conaghan, P.G., Mcgonagle, D., Behrens, F., Goupille, P.,... Bakewell, C. (2021). ENTHESITIS IN PATIENTS WITH PSORIATIC ARTHRITIS TREATED WITH SECUKINUMAB OR ADALIMUMAB: A POST HOC ANALYSIS OF EXCEED. In ANNALS OF THE RHEUMATIC DISEASES (pp. 311-312). LONDON: BMJ PUBLISHING GROUP.
Klemm, P., Kleyer, A., Tascilar, K., Schuster, L., Meinderink, T., Steiger, F.,... Hartmann, F. (2021). A virtual reality based app to educate health care professionals and medical students about inflammatory arthritis: Feasibility study. JMIR Serious Games, 9(2). https://doi.org/10.2196/23835
Klemm, P., Kleyer, A., Tascilar, K., Schuster, L., Meinderink, T., Steiger, F.,... Simon, D. (2021, June). EVALUATION OF A VIRTUAL REALITY-BASED APPLICATION TO EDUCATE HEALTHCARE PROFESSIONALS AND MEDICAL STUDENTS ABOUT INFLAMMATORY ARTHRITIS. Poster presentation.
Kleyer, A., Roemer, F., Schett, G., & Manger, B. (2021). Differenzialdiagnose Rückenschmerzen mit Entzündungsparametern: Fallvorstellung: Manifestation einer CPPD als Crowned Dens Syndrom mit Befall peripherer Gelenke. Aktuelle Rheumatologie, 46(1), 76-79. https://doi.org/10.1055/a-1327-1424
Knevel, R., Knitza, J., Hensvold, A., Circiumaru, A., Bruce, T., Evans, S.,... Catrina, A. (2021). RHEUMATIC? - A DIGITAL DIAGNOSTIC DECISION SUPPORT TOOL FOR INDIVIDUALS SUSPECTING RHEUMATIC DISEASES: A MULTICENTER VALIDATION STUDY. Annals of the Rheumatic Diseases, 87-88. https://doi.org/10.1136/annrheumdis-2021-eular.1118
Knitza, J., Mohn, J., Bergmann, C., Kampylafka, E., Hagen, M., Bohr, D.,... Welcker, M. (2021). Accuracy, patient-perceived usability, and acceptance of two symptom checkers (Ada and Rheport) in rheumatology: interim results from a randomized controlled crossover trial. Arthritis Research & Therapy, 23(1). https://doi.org/10.1186/s13075-021-02498-8
Knitza, J., Tascilar, K., Gruber, E., Kaletta, H., Hagen, M., Liphardt, A.-M.,... Hueber, A. (2021). Accuracy and usability of a diagnostic decision support system in the diagnosis of three representative rheumatic diseases: a randomized controlled trial among medical students. Arthritis Research & Therapy, 23(1). https://doi.org/10.1186/s13075-021-02616-6
Kolbinger, F., Di Padova, F., Deodhar, A., Hawkes, J.E., Huppertz, C., Kuiper, T.,... Bruin, G. (2021). Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and safety. Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2021.107925
Lambrecht, A., Vuillerme, N., Raab, C., Simon, D., Messner, E.-M., Hagen, M.,... Knitza, J. (2021). Quality of a Supporting Mobile App for Rheumatic Patients: Patient-Based Assessment Using the User Version of the Mobile Application Scale (uMARS). Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.715345
Leppkes, M., Lindemann, A., Goesswein, S., Paulus, S., Roth, D., Hartung, A.,... Neurath, M. (2021). Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis. Gut. https://doi.org/10.1136/gutjnl-2021-324725
Lindner, L., Weiss, A., Reich, A., Kindler, S., Behrens, F., Braun, J.,... Regierer, A.C. (2021). Implementing an automated monitoring process in a digital, longitudinal observational cohort study. Arthritis Research & Therapy, 23(1). https://doi.org/10.1186/s13075-021-02563-2
Mahajan, A., Hasíková, L., Hampel, U., Grüneboom, A., Shan, X., Herrmann, I.,... Schauer, C. (2021). Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation. Ocular Surface, 20, 1-12. https://doi.org/10.1016/j.jtos.2020.12.005
Manger, B., & Schett, G. (2021). 80 Meilensteine der Rheumatologie aus 80 Jahren – I: 1940–1960. Zeitschrift für Rheumatologie. https://doi.org/10.1007/s00393-021-01031-1
Martinsson, K., Dürholz, K., Schett, G., Zaiss, M., & Kastbom, A. (2021). Higher serum levels of short-chain fatty acids are associated with non-progression to arthritis in individuals at increased risk of RA. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-221386
Matei, A.-E., Kubankova, M., Györfi, A., Boxberger, E., Soteriou, D., Papava, M.,... Guck, J. (2021). CIRCULATING MONOCYTES HAVE DISTINCT PHYSICAL PROPERTIES THAT CORRELATE WITH DISEASE ACTIVITY AND SEVERITY AND PREDICT PROGRESSION IN SYSTEMIC SCLEROSIS. Annals of the Rheumatic Diseases, 1238-1238. https://doi.org/10.1136/annrheumdis-2021-eular.1274
Mcgonagle, D., Mcinnes, I.B., Deodhar, A., Schett, G., Shawi, M., Kafka, S.,... Mease, P.J. (2021). Resolution of enthesitis by guselkumab and relationships to disease burden: 1-year results of two phase 3 psoriatic arthritis studies. Rheumatology, 60(11), 5337-5350. https://doi.org/10.1093/rheumatology/keab285
Mease, P., Deodhar, A., Merola, J., Mcinnes, I., Assudani, D., Bajracharya, R.,... Schett, G. (2021). Bimekizumab in Patients with Psoriatic Arthritis: 3-Year Results for Overall and Tumor Necrosis Factor Inhibitor (TNFi)-Naive Populations from a Phase 2b Open-Label Extension Study. In ARTHRITIS & RHEUMATOLOGY (pp. 2782-2785). HOBOKEN: WILEY.
Michaelis, J., Reiher, I., Heinrich, S., Coppers, B., Schett, G., Kleyer, A.,... Liphardt, A.-M. (2021). CyberGlove for clinical use? Poster presentation at FAU-Networking Night Medizintechnik, Erlangen, DE.
Millar, N.L., Mcinnes, I., Mindeholm, L., Seroutou, A., Praestgaard, J., Schramm, U.,... Schieker, M. (2021). EFFICACY AND SAFETY OF SECUKINUMAB IN PATIENTS WITH ROTATOR CUFF TENDINOPATHY: A 24-WEEK, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE II PROOF-OF-CONCEPT TRIAL. In ANNALS OF THE RHEUMATIC DISEASES (pp. 211-212). LONDON: BMJ PUBLISHING GROUP.
Mougiakakos, D., Krönke, G., & Schett, G. (2021). More on CD19-CAR T Cells in Systemic Lupus Erythematosus. New England Journal of Medicine, 385(19). https://doi.org/10.1056/nejmc2114593
Mougiakakos, D., Krönke, G., Völkl, S., Kretschmann, S., Aigner, M., Kharboutli, S.,... Schett, G. (2021). CD19-targeted CAR T cells in refractory systemic lupus erythematosus. New England Journal of Medicine, 385(6), 567-569. https://doi.org/10.1056/NEJMc2107725
Mucke, J., Knitza, J., Muehlensiepen, F., Grahammer, M., Stenzel, R., Simon, D.,... Krusche, M. (2021). TELERA-Asynchronous TELEmedicine for Patients With Rheumatoid Arthritis: Study Protocol for a Prospective, Multi-Center, Randomized Controlled Trial. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.791715
Müehlensiepen, F., Kurkowski, S., Krusche, M., Mucke, J., Prill, R., Heinze, M.,... Knitza, J. (2021). Digital health transition in rheumatology: A qualitative study. International Journal of Environmental Research and Public Health, 18(5), 1-11. https://doi.org/10.3390/ijerph18052636
Nagy, G., Roodenrijs, N.M., Welsing, P.M., Kedves, M., Hamar, A., Van Der Goes, M.C.,... Van Laar, J.M. (2021). EULAR definition of difficult-To-Treat rheumatoid arthritis. Annals of the Rheumatic Diseases, 80(1), 31-35. https://doi.org/10.1136/annrheumdis-2020-217344
Nagy, G., Roodenrijs, N.M.T., Welsing, P.M.J., Kedves, M., Hamar, A., Van Der Goes, M.C.,... Van Laar, J.M. (2021). EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-220973
O'Neil, L.J., Hu, P., Liu, Q., Islam, M.M., Spicer, V., Rech, J.,... Wilkins, J.A. (2021). Proteomic Approaches to Defining Remission and the Risk of Relapse in Rheumatoid Arthritis. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.729681
Ovseiko, P.V., Gossec, L., Andreoli, L., Kiltz, U., Van Mens, L., Hassan, N.,... Coates, L.C. (2021). A FRAMEWORK OF POTENTIAL INTERVENTIONS TO ACCELERATE GENDER-EQUITABLE CAREER ADVANCEMENT IN ACADEMIC RHEUMATOLOGY. In ANNALS OF THE RHEUMATIC DISEASES (pp. 39-40). LONDON: BMJ PUBLISHING GROUP.
Pachowsky, M., Söllner, S., Kleyer, A., Welsch, G., & Schett, G. (2021). CARTILAGE LESIONS OF THE KNEE: GAGCEST IMAGING AT 3 T MRI AND INTRAOPERATIVE VALIDATION. In ANNALS OF THE RHEUMATIC DISEASES (pp. 60-61). LONDON: BMJ PUBLISHING GROUP.
Pfeifle, R., Kittler, J., Wuhrer, M., Schett, G., & Krönke, G. (2021). THE IMPACT OF IL-17A THERAPY ON IGG SIALYLATION IN HUMANS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1042-1043). LONDON: BMJ PUBLISHING GROUP.
Pfeil, A., Franz, M., Hoffmann, T., Klemm, P., Oelzner, P., Muller-Ladner, U.,... Hueber, A. (2021). Virtual teaching for medical students during SARS-CoV-2 pandemic. Clinical and Experimental Rheumatology, 39(6), 1447-1448. https://doi.org/10.55563/clinexprheumatol/0dbnx5
Pfeil, A., Franz, M., Hoffmann, T., Klemm, P., Oelzner, P., Müller-Ladner, U.,... Kleyer, A. (2021). Virtual teaching for medical students during SARS-CoV-2 pandemic. Clinical and Experimental Rheumatology, 39(6), 1447-1448. https://doi.org/10.55563/clinexprheumatol/0dbnx5
Pfeil, A., Marcus, F., Hoffmann, T., Klemm, P., Oelzner, P., Muller-Ladner, U.,... Kleyer, A. (2021). EVALUATION OF A VIRTUAL REALITY TEACHING CONCEPT FOR MEDICAL STUDENTS DURING THE SARS-COV-2 PANDEMIC. In ANNALS OF THE RHEUMATIC DISEASES (pp. 40-40). LONDON: BMJ PUBLISHING GROUP.
Phutane, U., Liphardt, A.-M., Bräunig, J., Penner, J., Klebl, M., Vossiek, M.,... Leyendecker, S. (2021). Evaluation of Optical and Radar Based Motion Capturing Technologies for Characterizing Hand Movement in Rheumatoid Arthritis — A Pilot Study. Sensors, 21(4). https://doi.org/10.3390/s21041208
Pournara, E., Kormaksson, M., Nash, P., Ritchlin, C.T., Kirkham, B.W., Ligozio, G.,... Mcinnes, I.B. (2021). Clinically relevant patient clusters identified by machine learning from the clinical development programme of secukinumab in psoriatic arthritis. RMD Open, 7(3). https://doi.org/10.1136/rmdopen-2021-001845
Rahman, P., Mcinnes, I., Deodhar, A., Schett, G., Mease, P., Shawi, M.,... Mcgonagle, D. (2021). Guselkumab (TREMFYA (R)) Maintains Resolution of Dactylitis and Enthesitis in Patients with Active Psoriatic Arthritis: Results Through 2 Years from a Phase 3 Study. In ARTHRITIS & RHEUMATOLOGY (pp. 2757-2760). HOBOKEN: WILEY.
Rech, J., Hueber, A., Ostergaard, M., Tascilar, K., Hagen, M., Mendez, L.V.,... Schett, G. (2021). Abatacept Reverses Subclinical Arthritis in Patients with High-risk to Develop Rheumatoid Arthritis -results from the Randomized, Placebo-controlled ARIAA Study in RA-at Risk Patients. In ARTHRITIS & RHEUMATOLOGY (pp. 939-941). HOBOKEN: WILEY.
Regierer, A., Weiss, A., Bohl-Buehler, M., Baraliakos, X., Behrens, F., Schett, G., & Strangfeld, A. (2021). DEPRESSIVE SYMPTOMS IN PSA: A CROSS-SECTIONAL ANALYSIS FROM THE NATIONAL GERMAN RABBIT-SPA REGISTRY. Annals of the Rheumatic Diseases, 135-136. https://doi.org/10.1136/annrheumdis-2021-eular.2130
Regierer, A.C., Weiss, A., Poddubnyy, D., Kellner, H., Behrens, F., Schett, G.,... Strangfeld, A. (2021). DOSING OF BDMARDS IN AXSPA AND PSA IN A REAL WORLD SETTING. In ANNALS OF THE RHEUMATIC DISEASES (pp. 373-373). LONDON: BMJ PUBLISHING GROUP.
Schaelter, F., Dürholz, K., Bucci, L., Burmester, G., Caporali, R., Figuereido, C.,... Schett, G. (2021). Does methotrexate influence COVID-19 infection? Case series and mechanistic data. Arthritis Research & Therapy, 23(1). https://doi.org/10.1186/s13075-021-02464-4
Schenker, H., Hagen, M., Simon, D., Schett, G., & Manger, B. (2021). Reactive arthritis and cutaneous vasculitis after SARS-CoV-2 infection. Rheumatology, 60(1), 479-480. https://doi.org/10.1093/rheumatology/keaa689
Schenker, H., Tascilar, K., Konerth, L., Sergeeva, M., Prade, J., Strobelt, S.,... Rech, J. (2021). Prediction of response to Certolizumab-Pegol in rheumatoid arthritis (PreCePRA) by functional MRI of the brain – Study protocol for a randomized double-blind controlled study. Contemporary Clinical Trials Communications, 22. https://doi.org/10.1016/j.conctc.2021.100770
Schett, G. (2021). GUT MICROBIOME, BONE AND JOINT. In OSTEOPOROSIS INTERNATIONAL (pp. S39-S39). LONDON: SPRINGER LONDON LTD.
Schett, G. (2021). The role of IL-23 in joint disease. Rheumatology, 60(11), 5486-5487. https://doi.org/10.1093/rheumatology/keab073
Schett, G., Baraliakos, X., Van Den Bosch, F., Deodhar, A., Ostergaard, M., Das Gupta, A.,... Gensler, L.S. (2021). Secukinumab Efficacy on Enthesitis in Patients With Ankylosing Spondylitis: Pooled Analysis of Four Pivotal Phase III Studies. Journal of Rheumatology, 48(8), 1251-1258. https://doi.org/10.3899/jrheum.201111
Schett, G., Kalden, J., & Manger, B. (2021). 80 Meilensteine der Rheumatologie aus 80 Jahren – II: 1961–1980. Zeitschrift für Rheumatologie. https://doi.org/10.1007/s00393-021-01032-0
Schett, G., Loza, M.J., Palanichamy, A., Fitzgerald, O., Ritchlin, C., Baribaud, F., & Sweet, K. (2021). COLLAGEN TURNOVER MARKERS ASSOCIATE WITH ACTIVE PSORIATIC ARTHRITIS AND DECREASE WITH GUSELKUMAB TREATMENT. Clinical and Experimental Rheumatology, 1217-1218.
Schett, G., Mcinnes, I.B., & Neurath, M. (2021). Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs. New England Journal of Medicine, 385(7), 628-639. https://doi.org/10.1056/NEJMra1909094
Schmidkonz, C., Distler, J., Treutlein, C., Atzinger, A., Prante, O., Ritt, P.,... Bergmann, C. (2021). Ga-68-FAPI-04 PET/CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-related interstitial lung disease. European Journal of Nuclear Medicine and Molecular Imaging, S158-S159. https://doi.org/10.1055/s-0041-1726695
Schmidkonz, C., Rauber, S., Atzinger, A., Götz, T.I., Soare, A., Cordes, M.,... Ramming, A. (2021). Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging. European Journal of Nuclear Medicine and Molecular Imaging, S125-S126. https://doi.org/10.1055/s-0041-1726701
Schälter, F., Dürholz, K., Bucci, L., Burmester, G.R., Caporali, R., Figuereido, C.,... Schett, G. (2021). Does methotrexate influence COVID-19 infection? Case series and mechanistic data. Arthritis Research & Therapy. https://doi.org/10.1186/s13075-021-02464-4
Schönau, V., Roth, J., Tascilar, K., Corte, G., Manger, B., Rech, J.,... Muratore, F. (2021). Resolution of vascular inflammation in patients with new-onset giant cell arteritis: data from the RIGA study. Rheumatology, 60(8), 3851-3861. https://doi.org/10.1093/rheumatology/keab332
Simon, D., Kleyer, A., Bayat, S., Knitza, J., Valor, L., Schweiger, M.,... Hueber, A. (2021). BIOMECHANICAL STRESS IN THE CONTEXT OF COMPETITIVE SPORTS TRAINING TRIGGERS ENTHESITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1275-1275). LONDON: BMJ PUBLISHING GROUP.
Simon, D., Kleyer, A., Bayat, S., Knitza, J., Valor-Mendez, L., Schweiger, M.,... Hueber, A. (2021). Biomechanical stress in the context of competitive sports training triggers enthesitis. Arthritis Research & Therapy, 23(1). https://doi.org/10.1186/s13075-021-02530-x
Simon, D., Tascilar, K., Fagni, F., Krönke, G., Kleyer, A., Meder, C.,... Ramming, A. (2021). SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-220461
Simon, D., Tascilar, K., Fagni, F., Schmidt, K., Krönke, G., Kleyer, A.,... Schett, G. (2021). Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-221554
Simon, D., Tascilar, K., Kleyer, A., Bayat, S., Kampylafka, E., Sokolova, M.,... Schett, G. (2021). Association of Structural Entheseal Lesions With an Increased Risk of Progression From Psoriasis to Psoriatic Arthritis. Arthritis and Rheumatology. https://doi.org/10.1002/art.41239
Simon, D., Tascilar, K., Schmidt, K., Manger, B., Weckwerth, L., Sokolova, M.,... Schett, G. (2021). Humoral and Cellular Immune Responses to SARS–CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion. Arthritis and Rheumatology. https://doi.org/10.1002/art.41914
Sokolova, M., Rech, J., Hagen, M., Schett, G., & Steffen, U. (2021). ASSOCIATION OF ANTI-CITRULLINATED PROTEIN ANTIBODIES OF IgA SUBCLASSES WITH SUSTAINED REMISSION AND FLARE IN RHEUMATOID ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 461-461). LONDON: BMJ PUBLISHING GROUP.
Sokolova, M., Schett, G., & Steffen, U. (2021). Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings. Clinical Reviews in Allergy & Immunology. https://doi.org/10.1007/s12016-021-08890-1
Stehr, A., Wang, G., Demmler, R., Stemmler, M., Straube, J., Tripal, P.,... Stürzl, M. (2021). Neutrophil extracellular traps drive epithelial‐mesenchymal transition of human colon cancer. Journal of Pathology, 256(4), 455-467. https://doi.org/10.1002/path.5860
Stock, M., & Schett, G. (2021). Vitamin k-dependent proteins in skeletal development and disease. International Journal of Molecular Sciences, 22(17). https://doi.org/10.3390/ijms22179328
Szekanecz, Z., Mcinnes, I.B., Schett, G., Szamosi, S., Benko, S., & Szucs, G. (2021). Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases. Nature Reviews Rheumatology. https://doi.org/10.1038/s41584-021-00652-9
Söllner, S., Welsch, G.H., Gelse, K., Goldmann, A., Kleyer, A., Schett, G., & Pachowsky, M. (2021). gagCEST imaging at 3 T MRI in patients with articular cartilage lesions of the knee and intraoperative validation. Osteoarthritis and Cartilage. https://doi.org/10.1016/j.joca.2021.04.012
Tascilar, K., Hagen, M., Kleyer, A., Simon, D., Reiser, M., Hueber, A.,... Rech, J. (2021). Treatment tapering and stopping in patients with rheumatoid arthritis in stable remission (RETRO): a multicentre, randomised, controlled, open-label, phase 3 trial. The Lancet Rheumatology, 3(11), e767-e777. https://doi.org/10.1016/S2665-9913(21)00220-4
Tascilar, K., Simon, D., Krönke, G., Kleyer, A., Ramming, A., Atreya, R.,... Schett, G. (2021). PATIENTS WITH IMMUNE MEDIATED INFLAMMATORY DISEASES ARE OVERREPRESENTED IN LOW-FREQUENCY VIRAL SYMPTOM CLUSTERS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 996-997). LONDON: BMJ PUBLISHING GROUP.
Tascilar, K., Simon, D., Liphardt, A.-M., Meinderink, T., Bayat, S., Rech, J.,... Kleyer, A. (2021). SPATIOTEMPORAL DYNAMICS OF BONE LOSS BEFORE AND AFTER THE ONSET OF RHEUMATOID ARTHRITIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 88-89). LONDON: BMJ PUBLISHING GROUP.
Valor-Mendez, L., Manger, B., Cavallaro, A.J., Achenbach, S., Schett, G., & Rech, J. (2021). Autoinflammation leading to autoimmunity in adult-onset Still’s disease: more than simple coincidence? European Journal of Medical Research, 26(1). https://doi.org/10.1186/s40001-021-00581-z
Valor-Mendez, L., Manger, B., Schett, G., & Kleyer, A. (2021). Severe Hepatitis E virus infection in a patient with rheumatoid arthritis treated with baricitinib. Zeitschrift für Rheumatologie. https://doi.org/10.1007/s00393-021-01020-4
Valor-Mendez, L., Sticherling, M., Kleyer, A., & Schett, G. (2021). Successful treatment of refractory palmoplantar psoriasis in a psoriatic arthritis patient with the JAK inhibitor tofacitinib. Clinical and Experimental Rheumatology, 39(1), 228-228. https://doi.org/10.55563/clinexprheumatol/xdcraa
Valor-Méndez, L., Kleyer, A., Rech, J., Manger, B., & Schett, G. (2021). Long-term B-lymphocyte depletion and remission of granulomatosis with polyangiitis after two courses of rituximab treatment. Rheumatology, 60(5), e162-e164. https://doi.org/10.1093/rheumatology/keaa727
Valor-Méndez, L., Kleyer, A., Rech, J., Manger, B., & Schett, G. (2021). Sustained clinical remission under infliximab/rituximab combination therapy in a patient with granulomatosis with polyangiitis. Autoimmunity Highlights, 12(1). https://doi.org/10.1186/s13317-020-00147-9
Valor-Méndez, L., Kleyer, A., Schett, G., Manger, B., & Sticherling, M. (2021). Contrary immediate effect of abatacept on skin and joint manifestations in psoriatic arthritis. Rheumatology, 60(9), e312-e313. https://doi.org/10.1093/rheumatology/keab206
Valor-Méndez, L., Tascilar, K., Simon, D., Distler, J., Kleyer, A., Schett, G., & Rech, J. (2021). Correspondence on ‘Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort'. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-220898
Valor-Méndez, L., Voskens, C., Rech, J., Kleyer, A., & Schett, G. (2021). Herpes simplex infection in a patient with rheumatoid arthritis treated with baricitinib: a case report. Rheumatology, 60(4), e122-e123. https://doi.org/10.1093/rheumatology/keaa521
Vielreicher, M., Bozec, A., Schett, G., & Friedrich, O. (2021). Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging. Frontiers in Bioengineering and Biotechnology, 9. https://doi.org/10.3389/fbioe.2021.608383
Vitali, F., Simon, D., Neurath, M., Schett, G., & Zundler, S. (2021). Vedolizumab-associated enthesitis: correlation or causality? Rheumatology, 60(12), 5491-5492. https://doi.org/10.1093/rheumatology/keab396
Vodencarevic, A., Tascilar, K., Reiser, M., Hueber, A., Haschka, J., Bayat, S.,... Hartmann, F. (2021). Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs. Arthritis Research & Therapy, 23(1). https://doi.org/10.1186/s13075-021-02439-5
Wagner, A., Danko, V., Federle, A., Klett, D., Simon, D., Heiß, R.,... Knieling, F. (2021). Precision of handheld multispectral optoacoustic tomography for muscle imaging. Photoacoustics, 21. https://doi.org/10.1016/j.pacs.2020.100220
Xu, X., Li, Y.N., Chen, C.-W., Trinh-Minh, T., Schett, G., & Distler, J. (2021). INACTIVATION OF ALDEHYDE DEHYDROGENASE 3A2 INHIBITS FIBROBLAST ACTIVATION AND TISSUE FIBROSIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 391-391). LONDON: BMJ PUBLISHING GROUP.
Yaykasli, K.O., Munoz, L.E., Mahajan, A., Knopf, J., Schett, G., Herrmann, M., & Schauer, C. (2021). Neutrophil extracellular trap‐driven occlusive diseases. Cells, 10(9). https://doi.org/10.3390/cells10092208
Zaharia, O.P., Pesta, D.H., Bobrov, P., Kupriyanova, Y., Herder, C., Karusheva, Y.,... Szendroedi, J. (2021). Reduced Muscle Strength Is Associated With Insulin Resistance in Type 2 Diabetes Patients With Osteoarthritis. Journal of Clinical Endocrinology and Metabolism, 106(4), 1062-1073. https://doi.org/10.1210/clinem/dgaa912
Zaiss, M., Joyce Wu, H.-J., Mauro, D., Schett, G., & Ciccia, F. (2021). The gut-joint axis in rheumatoid arthritis. Nature Reviews Rheumatology. https://doi.org/10.1038/s41584-021-00585-3
Zehender, A., Li, Y.-N., Lin, N.Y., Stefanica, A., Nüchel, J., Chen, C.-W.,... Distler, J. (2021). TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-24601-y
Zhang, Y., Shen, L., Dreißigacker, K., Zhu, H., Trinh, M.T., Meng, X.,... Distler, J. (2021). Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease. Blood, 137(17), 2403-2416. https://doi.org/10.1182/blood.2020008720

2020

Adam, S., Simon, N., Steffen, U., Andes, F.T., Scholtysek, C., Müller, D.,... Hueber, A. (2020). JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function. Science Translational Medicine, 12(530). https://doi.org/10.1126/scitranslmed.aay4447
Anchang, C.G., Lawaree, B.M., Weber, S., Rauber, S., Wohlfahrt, T., Luber, M.,... Ramming, A. (2020). HIGH DIMENSIONAL ANALYSIS REVEAL A NETWORK OF CERTAIN TRANSCRIPTION FACTORS THAT LINK VASCULOPATHY AND ORGAN FIBROSIS IN SYSTEMIC SCLEROSIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 90-91). ONLINE: LONDON: BMJ PUBLISHING GROUP.
Andes, F.T., Adam, S., Hahn, M., Aust, O., Frey, S., Grüneboom, A.,... Steffen, U. (2020). The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption. Bone. https://doi.org/10.1016/j.bone.2020.115665
Andreev, D., Liu, M., Kachler, K., Llerins Perez, M., Kirchner, P., Kölle, J.,... Bozec, A. (2020). Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2020-218902
Andreev, D., Liu, M., Weidner, D., Kachler, K., Faas, M., Grüneboom, A.,... Bozec, A. (2020). Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin. Journal of Clinical Investigation, 130(9), 4811-4830. https://doi.org/10.1172/JCI134214
Araujo, E.G., & Schett, G. (2020). Enthesitis in psoriatic arthritis (Part 1): pathophysiology. Rheumatology, 59(1), i10-i14. https://doi.org/10.1093/rheumatology/keaa039
Ariza, Y., Weber, S., Neise, N., Kreuter, A., Schett, G., Distler, J., & Ramming, A. (2020). ADAPTOR PROTEINS ACTIVATE FIBROBLASTS IN SYSTEMIC SCLEROSIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1371-1372). ONLINE: LONDON: BMJ PUBLISHING GROUP.
Azizov, V., Dietel, K., Steffen, F., Dürholz, K., Meidenbauer, J., Lucas, S.,... Zaiss, M. (2020). Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-15855-z
Baraliakos, X., Gossec, L., Pournara, E., Jeka, S., Blanco, R., D'Angelo, S.,... Coates, L.C. (2020). SECUKINUMAB IMPROVES CLINICAL AND IMAGING OUTCOMES IN PATIENTS WITH PSORIATIC ARTHRITIS AND AXIAL MANIFESTATIONS WITH INADEQUATE RESPONSE TO NSAIDS: WEEK 52 RESULTS FROM THE MAXIMISE TRIAL. In ANNALS OF THE RHEUMATIC DISEASES (pp. 35-36). , ELECTR NETWORK: LONDON: BMJ PUBLISHING GROUP.
Baraliakos, X., Gossec, L., Pournara, E., Jeka, S., Blanco, R., D'Angelo, S.,... Coates, L. (2020). Secukinumab Provides Sustained Improvements in Clinical and Imaging Outcomes in Patients with Psoriatic Arthritis and Axial Manifestations: Results from the MAXIMISE Trial. In ARTHRITIS & RHEUMATOLOGY. HOBOKEN: WILEY.
Bayat, S., Simon, D., Pecherstorfer, C., Ellmann, H., Figueiredo, C., Englbrecht, M.,... Schett, G. (2020). FINE STRUCTURE ANALYSIS OF THE INTER-RELATION BETWEEN TOPHUS DEPOSITION AND BONE LESIONS IN GOUT USING A COMBINATION OF DUAL ENERGY AND HIGH-RESOLUTION CT. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1232-1232). Online: LONDON: BMJ PUBLISHING GROUP.
Bayat, S., Simon, D., Schuster, L., Schett, G., & Kleyer, A. (2020). Cinematic Rendering Enables Depiction of Bone Anabolic Effects in Patients Treated with Baricitinib. In ARTHRITIS & RHEUMATOLOGY. HOBOKEN: WILEY.
Bayat, S., Tascilar, K., Kaufmann, V., Kleyer, A., Simon, D., Knitza, J.,... Schett, G. (2020). HIGH REMISSION RATES IN RA - REAL LIFE DATA FROM BARITICINIB. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1459-1460). , ELECTR NETWORK: LONDON: BMJ PUBLISHING GROUP.
Cao, S., Chen, X., Schett, G., & Bozec, A. (2020). L-ARGININE SUPPLEMENTATION AMELIORATES BONE EROSION IN RHEUMATOID ARTHRITIS THROUGH INHIBITION OF RANKL/RANK/TRAF6 PATHWAY AND REPROGRAMMING OSTEOCLAST METABOLISM. In ANNALS OF THE RHEUMATIC DISEASES (pp. 927-927). Online: LONDON: BMJ PUBLISHING GROUP.
Chakraborty, D., Zhu, H., Juengel, A., Summa, L., Li, Y.N., Bergmann, C.,... Distler, J. (2020). FIBROBLAST GROWTH FACTOR RECEPTOR 3 REGULATES THE ACTIVITY OF PROFIBROTIC CYTOKINE AND GROWTH FACTOR PATHWAYS TO DRIVE FIBROBLAST ACTIVATION AND TISSUE FIBROSIS IN SYSTEMIC SCLEROSIS. In ANNALS OF THE RHEUMATIC DISEASES (pp. 91-91). LONDON: BMJ PUBLISHING GROUP.
Chakraborty, D., Zhu, H., Juengel, A., Summa, L., Li, Y.-N., Matei, A.-E.,... Distler, J. (2020). Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis. Science Translational Medicine, 12(563). https://doi.org/10.1126/scitranslmed.aaz5506
Chen, G.L., Li, R., Chen, X.X., Wang, J., Cao, S., Song, R.,... Bozec, A. (2020). Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b. Cell Death and Differentiation. https://doi.org/10.1038/s41418-020-00660-4
D'Agostino, M., Schett, G., Lopez-Rdz, A., Senolt, L., Maldonado-Cocco, J., Burgos-Vargas, R.,... Gaillez, C. (2020). Secukinumab Significantly Decreased Joint Synovitis Measured by Power Doppler Ultrasonography in Biologic-naive Patients with Active Psoriatic Arthritis: Primary (12-Week) Results from a Randomized, Placebo-Controlled Phase III Study. In ARTHRITIS & RHEUMATOLOGY. HOBOKEN: WILEY.
Dees, C., Poetter, S., Zhang, Y., Bergmann, C., Zhou, X., Luber, M.,... Distler, J. (2020). AMPLIFICATION OF THE PRO-FIBROTIC JAK2-STAT3 SIGNALING AXIS BY TGFB-INDUCED EPIGENETIC SILENCING OF SOCS3. In ANNALS OF THE RHEUMATIC DISEASES (pp. 1084-1084). , ELECTR NETWORK: LONDON: BMJ PUBLISHING GROUP.
Dees, C., Pötter, S., Zhang, Y., Bergmann, C., Zhou, X., Luber, M.,... Distler, J. (2020). TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis. Journal of Clinical Investigation, 130(5), 2347-2363. https://doi.org/10.1172/JCI122462
Dürholz, K., Hofmann, J., Iljazovic, A., Häger, J., Lucas, S., Sarter, K.,... Zaiss, M. (2020). Dietary short-term fiber interventions in arthritis patients increase systemic scfa levels and regulate inflammation. Nutrients, 12(10), 1-11. https://doi.org/10.3390/nu12103207
Figueiredo, C.P., Perez, M.O., Sales, L.P., Schett, G., & Pereira, R.M.R. (2020). HR-pQCT in vivo imaging of periarticular bone changes in chronic inflammatory diseases: Data from acquisition to impact on treatment indications. Modern Rheumatology. https://doi.org/10.1080/14397595.2020.1804669
Finzel, S., Aegerter, P., Schett, G., & D'Agostino, M.-A. (2020). Identification, localization and differentiation of erosions and physiological bone channels by ultrasound in rheumatoid arthritis patients. Rheumatology, 59(12), 3784-3792. https://doi.org/10.1093/rheumatology/keaa183
Frey, S., Sticht, H., Wilsmann-Theis, D., Gerschütz, A., Wolf, K., Löhr, S.,... Hüffmeier, U. (2020). Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2019.11.024
Friedberger, A., Figueiredo, C., Bäuerle, T., Schett, G., & Engelke, K. (2020). A new method for quantitative assessment of hand muscle volume and fat in magnetic resonance images. BMC Rheumatology, 4(1). https://doi.org/10.1186/s41927-020-00170-3
Friedberger, A., Figueiredo, C., Grimm, A., Oliveira, I., Bäuerle, T., Rech, J.,... Engelke, K. (2020). Quantification of hand muscle volume and composition in patients with rheumatoid arthritis, psoriatic arthritis and psoriasis. BMC Musculoskeletal Disorders, 21(1). https://doi.org/10.1186/s12891-020-03194-5
Gossec, L., Baraliakos, X., Kerschbaumer, A., de Wit, M., McInnes, I., Dougados, M.,... Smolen, J.S. (2020). EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update. Annals of the Rheumatic Diseases, 79(6), 700-712. https://doi.org/10.1136/annrheumdis-2020-217159
Gracey, E., Burssens, A., Cambre, I., Schett, G., Lories, R., Mcinnes, I.B.,... Elewaut, D. (2020). Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis. Nature Reviews Rheumatology. https://doi.org/10.1038/s41584-019-0364-x
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Prof. Dr. Georg Schett

Research projects

Umfassende Charakterisierung von Patienten mit entzündlichen Knochenerkrankungen durch serologisches Profiling und Bildgebung (Z01)

Die Rolle von Typ-I-Interferon bei entzündlichen Knochenerkrankungen (C06)

2025

2024

2023

2022

2021

2020

Related Research Fields

Contact:

Research projects

Current Projects

Umfassende Charakterisierung von Patienten mit entzündlichen Knochenerkrankungen durch serologisches Profiling und Bildgebung (Z01)

Die Rolle von Typ-I-Interferon bei entzündlichen Knochenerkrankungen (C06)

Recent publications

2025

2024

2023

2022

2021

2020

Related Research Fields

Contact: