The research group concentrates on cellular responses to exposure to hazardous substances/xenobiotics. To achieve this objective, the fate of xenobiotics is monitored from the uptake/metabolization to the occurrence of adverse responses. The group uses cell models (2D and 3D models) that are exposed to xenobiotics time- and dose-dependently.
Research projects
Toxicology
Metabolomics
High throughput screening
Modeling – 2D and 3D cell modells
Dose- and time-dependent response
Current projects Current projects
Recent publications Recent publications
2024
Masutin, V., Kersch, C., Alsaleh, R., & Schmitz-Spanke, S. (2024). Differential effects of benzo[a]pyrene exposure on glutathione and purine metabolism in keratinocytes: Dose-dependent and UV co-exposure effects . Experimental Dermatology , 33 (3). https://doi.org/10.1111/exd.15044
Wohlfahrt, J., Verma, N., Alsaleh, R., Kersch, C., & Schmitz-Spanke, S. (2024). A pilot study exploring time- and dose-dependent DNA damage and chromosomal instability caused by benzo[a]pyrene in two urothelial cell types . Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis , 828 . https://doi.org/10.1016/j.mrfmmm.2024.111855
2022
Masutin, V., Kersch, C., & Schmitz-Spanke, S. (2022). A systematic review: metabolomics-based identification of altered metabolites and pathways in the skin caused by internal and external factors . Experimental Dermatology . https://doi.org/10.1111/exd.14529
Weistenhöfer, W., Golka, K., Bolm-Audorff, U., Bolt, H.M., Bruning, T., Hallier, E.,... Drexler, H. (2022). Work-related bladder cancer -The BK 1301 matrix as an algorithm and decision aid in the context of an assessment of an occupational disease Das beruflich bedingte Harnblasenkarzinom-Die BK 1301-Matrix als Algorithmus und Entscheidungshilfe fur eine Zusammenhangsbegutachtung . Arbeitsmedizin, Sozialmedizin, Umweltmedizin , 2022 (3), 177-189. https://doi.org/10.17147/asu-1-174375
Weistenhöfer, W., Lutz, R., Hiller, J., Schmitz-Spanke, S., & Drexler, H. (2022). Syncarcinogenesis of natural UV radiation and polycyclic aromatic hydrocarbons in the development of squamous cell carcinomas of the skin? Journal der Deutschen Dermatologischen Gesellschaft . https://doi.org/10.1111/ddg.14818
2021
Letzel, S., Schmitz-Spanke, S., Lang, J., & Nowak, D. (Hrg.) (2021). Krebs und Arbeit - Arbeits- und sozialmedizinische Aspekte . Landsberg am Elsch: ecomed-storck GmbH.
Verma, N., Pink, M., & Schmitz-Spanke, S. (2021). A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure . Archives of Toxicology . https://doi.org/10.1007/s00204-021-03032-0
Weistenhöfer, W., Drexler, H., & Schmitz-Spanke, S. (2021). Hemmung der Neurotoxischen Esterase: Bewertung von Studienergebnissen . In Tagungsband 61. Jahrestagung der DGAUM . Jena, DE.
2020
De Rentis, A., Pink, M., Verma, N., & Schmitz-Spanke, S. (2020). Assessment of the different skin sensitization potentials of irritants and allergens as single substances and in combination using the KeratinoSens assay. Contact Dermatitis . https://doi.org/10.1111/cod.13762
Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A.,... Eisenbrand, G. (2020). Correction to: Mode of action-based risk assessment of genotoxic carcinogens (Archives of Toxicology, (2020), 94, 6, (1787-1877), 10.1007/s00204-020-02733-2) . Archives of Toxicology . https://doi.org/10.1007/s00204-020-02862-8
Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A.,... Eisenbrand, G. (2020). Mode of action-based risk assessment of genotoxic carcinogens . Archives of Toxicology , 94 (6), 1787-1877. https://doi.org/10.1007/s00204-020-02733-2
Letzel, S., Schmitz-Spanke, S., Lang, J., & Nowak, D. (Hrg.) (2020). Telemedizin - E-Health in der Arbeitsmedizin . Landsberg am Lech: ecomed MEDIZIN.
Pink, M., Verma, N., & Schmitz-Spanke, S. (2020). Benchmark dose analyses of toxic endpoints in lung cells provide sensitivity and toxicity ranking across metal oxide nanoparticles and give insights into the mode of action . Toxicology Letters . https://doi.org/10.1016/j.toxlet.2020.06.012
Weistenhöfer, W., Drexler, H., Hartwig, A., & Schmitz-Spanke, S. (2020). Assessment values in biological material for carcinogenic substances by the example of 1,4-dichlorobenzene . In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (pp. 54-54). Leipzig, DE: NEW YORK: SPRINGER.
Weistenhöfer, W., Hiller, J., Lösch, R., Schmitz-Spanke, S., & Drexler, H. (2020). PAK und UV-Strahlung: Synkanzerogenese? In Proceedings of the 60. Wissenschaftliche Jahrestagung der DGAUM . München, DE.
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The research group concentrates on cellular responses to exposure to hazardous substances/xenobiotics. To achieve this objective, the fate of xenobiotics is monitored from the uptake/metabolization to the occurrence of adverse responses. The group uses cell models (2D and 3D models) that are exposed to xenobiotics time- and dose-dependently.
Research projects
Current projects
No projects found.
Recent publications
2024
2022
2021
2020
Related Research Fields
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