Prof. Dr. Simone Schmitz-Spanke

Institute and Polyclinic for Occupational, Social and Environmental Medicine

The research group concentrates on cellular responses to exposure to hazardous substances/xenobiotics. To achieve this objective, the fate of xenobiotics is monitored from the uptake/metabolization to the occurrence of adverse responses. The group uses cell models (2D and 3D models) that are exposed to xenobiotics time- and dose-dependently.

Research projects

Toxicology
Metabolomics
High throughput screening
Modeling – 2D and 3D cell modells
Dose- and time-dependent response

Current projects

Bayerischer Projektverbund "Messung, Charakterisierung und Bewertung ultrafeiner Partikel" BayUFP

(Third Party Funds Group – Overall project)

Term: 1. November 2020 - 31. October 2023
Funding source: Bayerisches Staatsministerium für Umwelt und Verbraucherschutz (StMUV) (ab 10/2013)
URL: https://www.ultrafeinepartikel.de

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Biologische Antwort auf Partikel in einem Lungenmodell

(Third Party Funds Single)

Term: 1. November 2020 - 31. October 2023
Funding source: Bayerisches Staatsministerium für Umwelt und Verbraucherschutz (StMUV) (ab 10/2013)
URL: https://www.ultrafeinepartikel.de/

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Recent publications

2022

Masutin, V., Kersch, C., & Schmitz-Spanke, S. (2022). A systematic review: metabolomics-based identification of altered metabolites and pathways in the skin caused by internal and external factors. Experimental Dermatology. https://dx.doi.org/10.1111/exd.14529
Weistenhöfer, W., Golka, K., Bolm-Audorff, U., Bolt, H.M., Bruning, T., Hallier, E.,... Drexler, H. (2022). Work-related bladder cancer -The BK 1301 matrix as an algorithm and decision aid in the context of an assessment of an occupational disease Das beruflich bedingte Harnblasenkarzinom-Die BK 1301-Matrix als Algorithmus und Entscheidungshilfe fur eine Zusammenhangsbegutachtung. Arbeitsmedizin, Sozialmedizin, Umweltmedizin, 2022(3), 177-189. https://dx.doi.org/10.17147/asu-1-174375
Weistenhöfer, W., Lutz, R., Hiller, J., Schmitz-Spanke, S., & Drexler, H. (2022). Syncarcinogenesis of natural UV radiation and polycyclic aromatic hydrocarbons in the development of squamous cell carcinomas of the skin? Journal der Deutschen Dermatologischen Gesellschaft. https://dx.doi.org/10.1111/ddg.14818

2021

Letzel, S., Schmitz-Spanke, S., Lang, J., & Nowak, D. (Hrg.) (2021). Krebs und Arbeit - Arbeits- und sozialmedizinische Aspekte. Landsberg am Elsch: ecomed-storck GmbH.
Verma, N., Pink, M., & Schmitz-Spanke, S. (2021). A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure. Archives of Toxicology. https://dx.doi.org/10.1007/s00204-021-03032-0

2020

De Rentis, A., Pink, M., Verma, N., & Schmitz-Spanke, S. (2020). Assessment of the different skin sensitization potentials of irritants and allergens as single substances and in combination using the KeratinoSens assay. Contact Dermatitis. https://dx.doi.org/10.1111/cod.13762
Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A.,... Eisenbrand, G. (2020). Correction to: Mode of action-based risk assessment of genotoxic carcinogens (Archives of Toxicology, (2020), 94, 6, (1787-1877), 10.1007/s00204-020-02733-2). Archives of Toxicology. https://dx.doi.org/10.1007/s00204-020-02862-8
Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A.,... Eisenbrand, G. (2020). Mode of action-based risk assessment of genotoxic carcinogens. Archives of Toxicology, 94(6), 1787-1877. https://dx.doi.org/10.1007/s00204-020-02733-2
Letzel, S., Schmitz-Spanke, S., Lang, J., & Nowak, D. (Hrg.) (2020). Telemedizin - E-Health in der Arbeitsmedizin. Landsberg am Lech: ecomed MEDIZIN.
Pink, M., Verma, N., & Schmitz-Spanke, S. (2020). Benchmark dose analyses of toxic endpoints in lung cells provide sensitivity and toxicity ranking across metal oxide nanoparticles and give insights into the mode of action. Toxicology Letters. https://dx.doi.org/10.1016/j.toxlet.2020.06.012
Weistenhöfer, W., Drexler, H., Hartwig, A., & Schmitz-Spanke, S. (2020). Assessment values in biological material for carcinogenic substances by the example of 1,4-dichlorobenzene. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (pp. 54-54). Leipzig, DE: NEW YORK: SPRINGER.
Weistenhöfer, W., Hiller, J., Lösch, R., Schmitz-Spanke, S., & Drexler, H. (2020). PAK und UV-Strahlung: Synkanzerogenese? In Proceedings of the 60. Wissenschaftliche Jahrestagung der DGAUM. München, DE.

Related Research Fields

Biomaterials

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