Prof. Dr. Simone Schmitz-Spanke
Institute and Polyclinic for Occupational, Social and Environmental Medicine
Prof. Dr. Simone Schmitz-Spanke
Institute and Polyclinic for Occupational, Social and Environmental Medicine
The research group concentrates on cellular responses to exposure to hazardous substances/xenobiotics. To achieve this objective, the fate of xenobiotics is monitored from the uptake/metabolization to the occurrence of adverse responses. The group uses cell models (2D and 3D models) that are exposed to xenobiotics time- and dose-dependently.
Research projects
- Toxicology
- Metabolomics
- High throughput screening
- Modeling – 2D and 3D cell modells
- Dose- and time-dependent response
No projects found.
2026
- Boehler, M.P., Kersch, C., Rossbach, B., Kaifie-Pechmann, A., & Schmitz-Spanke, S. (2026). Effect biomonitoring in a controlled firefighting setting: an untargeted metabolomic pilot study. Archives of Toxicology. https://doi.org/10.1007/s00204-026-04397-w
2025
- Kersch, C., Masutin, V., Alsaleh, R., & Schmitz-Spanke, S. (2025). Benzo[a]pyrene and UV light co-exposure: differential effects on oxidative stress and genotoxicity in human keratinocytes and ex vivo skin. Archives of Toxicology. https://doi.org/10.1007/s00204-025-04098-w
- Kersch, C., Masutin, V., Kuhlmann, L., Alsaleh, R., Kaifie-Pechmann, A., & Schmitz-Spanke, S. (2025). Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene. Archives of Toxicology, 99, 4481-4492. https://doi.org/10.1007/s00204-025-04155-4
- Lauenstein, J., van de Weyer, S., Alsaleh, R., Wiedmer, C., Büttner, A., Kersch, C., & Schmitz-Spanke, S. (2025). Exploring the Activation of the Keap1-Nrf2-ARE Pathway by PAHs in Children's Toys. Contact Dermatitis. https://doi.org/10.1111/cod.14792
2024
- Masutin, V., Kersch, C., Alsaleh, R., & Schmitz-Spanke, S. (2024). Differential effects of benzo[a]pyrene exposure on glutathione and purine metabolism in keratinocytes: Dose-dependent and UV co-exposure effects. Experimental Dermatology, 33(3). https://doi.org/10.1111/exd.15044
- Offer, S., Di Bucchianico, S., Czech, H., Pardo, M., Pantzke, J., Bisig, C.,... Zimmermann, R. (2024). The chemical composition of secondary organic aerosols regulates transcriptomic and metabolomic signaling in an epithelial-endothelial in vitro coculture. Particle and Fibre Toxicology, 21(1). https://doi.org/10.1186/s12989-024-00600-x
- Wohlfahrt, J., Verma, N., Alsaleh, R., Kersch, C., & Schmitz-Spanke, S. (2024). A pilot study exploring time- and dose-dependent DNA damage and chromosomal instability caused by benzo[a]pyrene in two urothelial cell types. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 828. https://doi.org/10.1016/j.mrfmmm.2024.111855
2022
- Masutin, V., Kersch, C., & Schmitz-Spanke, S. (2022). A systematic review: metabolomics-based identification of altered metabolites and pathways in the skin caused by internal and external factors. Experimental Dermatology. https://doi.org/10.1111/exd.14529
- Weistenhöfer, W., Golka, K., Bolm-Audorff, U., Bolt, H.M., Bruning, T., Hallier, E.,... Drexler, H. (2022). Work-related bladder cancer -The BK 1301 matrix as an algorithm and decision aid in the context of an assessment of an occupational disease Das beruflich bedingte Harnblasenkarzinom-Die BK 1301-Matrix als Algorithmus und Entscheidungshilfe fur eine Zusammenhangsbegutachtung. Arbeitsmedizin, Sozialmedizin, Umweltmedizin, 2022(3), 177-189. https://doi.org/10.17147/asu-1-174375
- Weistenhöfer, W., Lutz, R., Hiller, J., Schmitz-Spanke, S., & Drexler, H. (2022). Syncarcinogenesis of natural UV radiation and polycyclic aromatic hydrocarbons in the development of squamous cell carcinomas of the skin? Journal der Deutschen Dermatologischen Gesellschaft. https://doi.org/10.1111/ddg.14818
2021
- Letzel, S., Schmitz-Spanke, S., Lang, J., & Nowak, D. (Hrg.) (2021). Krebs und Arbeit - Arbeits- und sozialmedizinische Aspekte. Landsberg am Elsch: ecomed-storck GmbH.
- Verma, N., Pink, M., & Schmitz-Spanke, S. (2021). A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure. Archives of Toxicology. https://doi.org/10.1007/s00204-021-03032-0
- Weistenhöfer, W., Drexler, H., & Schmitz-Spanke, S. (2021). Hemmung der Neurotoxischen Esterase: Bewertung von Studienergebnissen. In Tagungsband 61. Jahrestagung der DGAUM. Jena, DE.
2020
- De Rentis, A., Pink, M., Verma, N., & Schmitz-Spanke, S. (2020). Assessment of the different skin sensitization potentials of irritants and allergens as single substances and in combination using the KeratinoSens assay. Contact Dermatitis. https://doi.org/10.1111/cod.13762
- Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A.,... Eisenbrand, G. (2020). Correction to: Mode of action-based risk assessment of genotoxic carcinogens (Archives of Toxicology, (2020), 94, 6, (1787-1877), 10.1007/s00204-020-02733-2). Archives of Toxicology. https://doi.org/10.1007/s00204-020-02862-8
- Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A.,... Eisenbrand, G. (2020). Mode of action-based risk assessment of genotoxic carcinogens. Archives of Toxicology, 94(6), 1787-1877. https://doi.org/10.1007/s00204-020-02733-2
- Letzel, S., Schmitz-Spanke, S., Lang, J., & Nowak, D. (Hrg.) (2020). Telemedizin - E-Health in der Arbeitsmedizin. Landsberg am Lech: ecomed MEDIZIN.
- Pink, M., Verma, N., & Schmitz-Spanke, S. (2020). Benchmark dose analyses of toxic endpoints in lung cells provide sensitivity and toxicity ranking across metal oxide nanoparticles and give insights into the mode of action. Toxicology Letters. https://doi.org/10.1016/j.toxlet.2020.06.012
- Weistenhöfer, W., Drexler, H., Hartwig, A., & Schmitz-Spanke, S. (2020). Assessment values in biological material for carcinogenic substances by the example of 1,4-dichlorobenzene. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (pp. 54-54). Leipzig, DE: NEW YORK: SPRINGER.
- Weistenhöfer, W., Hiller, J., Lösch, R., Schmitz-Spanke, S., & Drexler, H. (2020). PAK und UV-Strahlung: Synkanzerogenese? In Proceedings of the 60. Wissenschaftliche Jahrestagung der DGAUM. München, DE.