Prof. Dr. med. Stefan Nikolaus Linsler
Full Professor for Neurosurgery and Chairman, Medizincampus Oberfranken, Bayreuth

Prof. Dr. med. Stefan Nikolaus Linsler
Full Professor for Neurosurgery and Chairman, Medizincampus Oberfranken, Bayreuth

Prof. Dr. med. Stefan Nikolaus Linsler

Full Professor for Neurosurgery and Chairman, Medizincampus Oberfranken, Bayreuth

In general, my team is interested in developement and implementation of novel technologies such as robotics, augmented reality and virtual reality in surgical daily routine in cranial and spinal neurosurgery. Additionally, my team focus in intraoperative RAMAN-spectroscopy and genetic and epigenetic findings in brain tumors. Furthermore, the motor and language mapping with transcranial magnetic stimulation for surgical planning as well as for rehabiliation are of interest for us neurosurgeons. Finally, the development and evaluation of new minimally invasive surgical techniques approaching difficult skull base pathologies und pituitary tumors is in my focus.

Robotic-assisted Cranial and Spinal Neurosurgery and Stereotaxy
Augmented reality in cranial and spinal Neurosurgery
Virtual Reality in surgical planning and education
Epigenetics and molecular findings in intraoperative specimen with RAMAN-spectroscopy
Language and motor mapping with transcranial magnetic stimulation
Minimally invasive skull base surgery and pituitary surgery

ACDF mit oder ohne Platte: Biomechanik und Outcome in einer Pateintenkohorte

(Own Funds)

Project leader: Stefan Nikolaus Linsler
Term: since 1. August 2024

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Vergleich des VEPs zur Flowanalyse es N. optikus in der intraoperativen ICG-Angiographie

(Own Funds)

Project leader: Stefan Nikolaus Linsler
Term: since 1. March 2024

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Neuropsychologische Testung nach Hirntumoreingriffen

(Own Funds)

Project leader: Stefan Nikolaus Linsler
Term: since 1. March 2024

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2026

Khafaji, F., Reyes Medina, B., Sippl, C., & Linsler, S.N. (2026). Accuracy of indocyanine green videoangiography in predicting visual outcomes for anterior skull base surgeries, compared to intraoperative visual evoked potential: a pilot explorative study. Frontiers in Neurology. https://doi.org/DOI 10.3389/fneur.2026.1762604
Linsler, S., Moroldo, A.L., Schulz-Schaeffer, W., Ketter, R., Oertel, J., & Urbschat, S. (2026). Growth pattern and molecular biological analysis of primary meningioma cell cultures under different conditions. Molecular Medicine Reports, 34(2). https://doi.org/10.3892/mmr.2026.13938
Reyes Medina, B., Khafaji, F., Saffour, S., Sippl, C., & Linsler, S.N. (2026). Accuracy and effectiveness of thoracolumbar pedicle screw placement with a mixed reality head mounted device: first clinical experience and results. Brain and Spine, 6. https://doi.org/10.1016/j.bas.2026.106022
Sippl, C., Stark, F., Schneider, I., Reyes Medina, B., Schulz-Schaeffer, W., Brinkmann, M.,... Linsler, S.N. (2026). Stimulated Raman Spectroscopy for Intraoperative Glioblastoma Diagnosis—A Complementary Tool to Frozen Section? Cancers, 18(7). https://doi.org/10.3390/cancers18071053

2025

Khafaji, F., Sippl, C., Prell, J., & Linsler, S.N. (2025). Use of technologies in neurosurgery - a national survey of the section "techniques and innovations". Neurosurgical Review. https://doi.org/10.1007/s10143-025-03955-7
Reyes Medina, B., Linsler, S., Saffour, S., Sitoci-Ficici, K.H., & Oertel, J. (2025). Dural repair after intraoperative CSF leakage in endoscopic endonasal skull base surgery without pedicled nasoseptal flap: is it a safe surgical technique? Neurosurgical Review, 48(1). https://doi.org/10.1007/s10143-025-03831-4

2024

Linsler, S.N. (2024). Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase. Cancers.
Linsler, S.N. (2024). Endonasal endoscopic or endoscopic-assisted transcranial surgery of Rathke's cleft cysts: does the approach and surgical technique influence the radicality and recurrence rate? Neurosurgical Review.
Quiring, A., Spielmann, H., Teping, F., Saffour, S., Khafaji, F., Schulz-Schaeffer, W.,... Sippl, C. (2024). Epigenetic Characteristics in Primary and Recurrent Glioblastoma—Influence on the Clinical Course. Biomedicines, 12(9). https://doi.org/10.3390/biomedicines12092078

2023

Agresta, G., Campione, A., Veiceschi, P., Gallo, D., Agosti, E., Massimi, L.,... Locatelli, D. (2023). Clinical and oncological outcomes in single-stage versus staged surgery for pediatric craniopharyngiomas: a multicenter retrospective study. Journal of Endocrinological Investigation, 46(6), 1219-1232. https://doi.org/10.1007/s40618-022-01993-2
Breuskin, D., Fischer, G., Oertel, J., & Linsler, S. (2023). Single-step resection and reconstruction of orbito-fronto-temporal pathologies using a PMMA CAD-implant. Journal of Neurosurgical Sciences, 67(6), 679-687. https://doi.org/10.23736/S0390-5616.22.05758-7

2022

Kühn, J.P., Linsler, S., Nourkami-Tutdibi, N., Meyer, S., Becker, S.L., Yilmaz, U.,... Kulas, P. (2022). Pott’s Puffy Tumor: a need for interdisciplinary diagnosis and treatment. German Version Pott-Puffy-Tumor: die Notwendigkeit einer interdisziplinären Diagnostik und Behandlung. HNO, 70(7), 550-556. https://doi.org/10.1007/s00106-021-01133-x
Kühn, J.P., Linsler, S., Nourkami-Tutdibi, N., Meyer, S., Becker, S.L., Yilmaz, U.,... Kulas, P. (2022). Pott’s puffy tumor: a need for interdisciplinary diagnosis and treatment Pott’s-Puffy-Tumor: die Notwendigkeit einer interdisziplinären Diagnostik und Behandlung. HNO, 70, 8-13. https://doi.org/10.1007/s00106-021-01134-w
Meyer, S., Nemat, S., Linsler, S., Bay, J., Zemlin, M., & Poryo, M. (2022). Distended abdomen due to a pseudocyst around a ventriculoperitoneal shunt Distendiertes Abdomen auf Grund einer Pseudozyste bei ventrikulo-peritonealem Shunt. Wiener Medizinische Wochenschrift, 172(13-14), 292-293. https://doi.org/10.1007/s10354-021-00870-6
Oertel, J., Fischer, G., Linsler, S., Huelser, M., Sippl, C., & Teping, F. (2022). Endoscope-assisted resection of brainstem cavernous malformations. Neurosurgical Review, 45(4), 2823-2836. https://doi.org/10.1007/s10143-022-01793-5
Oertel, J., Linsler, S., Strohm, L., & Senger, S. (2022). Management of severe intraoperative hemorrhage during intraventricular neuroendoscopic procedures: the dry field technique. Acta Neurochirurgica, 164(10), 2551-2557. https://doi.org/10.1007/s00701-022-05207-9

2021

Linsler, S., & Medina, B.R. (2021). Neurosurgical treatment of cervical spine injuries Neurochirurgische Eingriffe bei Traumata der Halswirbelsäule. Radiologe, 61(8), 720-728. https://doi.org/10.1007/s00117-021-00881-9
Linsler, S., Müller, S.J., Müller, A., Senger, S., & Oertel, J.M. (2021). Fluorescence image-guided resection of intracranial meningioma: an experimental in vivo study on nude mice. Annals of Anatomy-Anatomischer Anzeiger, 237. https://doi.org/10.1016/j.aanat.2021.151752
Linsler, S., Senger, S., Hero-Gross, R., Steudel, W.I., & Oertel, J. (2021). The endoscopic surgical resection of intrasellar lesions conserves the hormonal function: A negative correlation to the microsurgical technique. Journal of Neurosurgical Sciences, 64(6), 515-524. https://doi.org/10.23736/S0390-5616.18.04242-X
Oertel, J., Linsler, S., Wagner, W., Gaab, M., Schroeder, H., & Rediker, J. (2021). Endoscopic treatment of intracranial arachnoid cysts: A retrospective analysis of a 25-year experience. Operative Neurosurgery, 20(1), 32-44. https://doi.org/10.1093/ons/opaa292
Senger, S., Linsler, S., Sippl, C., & Oertel, J. (2021). Evaluation of a fluorescence endoscope in murine in-vivo auto-fluorescence glioma models. Annals of Anatomy-Anatomischer Anzeiger, 237. https://doi.org/10.1016/j.aanat.2021.151746
Teping, F., Linsler, S., Zemlin, M., & Oertel, J. (2021). The semisitting position in pediatric neurosurgery: pearls and pitfalls of a 10-year experience. Journal of Neurosurgery-Pediatrics, 28(6), 724-733. https://doi.org/10.3171/2021.6.PEDS21161
Thomale, U.W., Auer, C., Spennato, P., Schaumann, A., Behrens, P., Gorelyshev, S.,... Bock, H.C. (2021). TROPHY registry — status report. Childs Nervous System, 37(11), 3549-3554. https://doi.org/10.1007/s00381-021-05258-w

2020

Flotats-Bastardas, M., Hahn, A., Schwartz, O., Linsler, S., Meyer, S., Kolodziej, M., & Koehler, C. (2020). Multicenter Experience with Nusinersen Application via an Intrathecal Port and Catheter System in Spinal Muscular Atrophy. Neuropediatrics, 51(6), 401-406. https://doi.org/10.1055/s-0040-1715481
Flotats-Bastardas, M., Linsler, S., Zemlin, M., & Meyer, S. (2020). Nusinersen Administration Via an Intrathecal Port in a 16-Year-Old Spinal Muscular Atrophy Patient with Profound Scoliosis. Pediatric Neurosurgery, 55(1), 54-57. https://doi.org/10.1159/000504058
Nourkami-Tutdibi, N., Linsler, S., Yilmaz, U., Pfeifer, J., Derouet, C., Becker, S.L.,... Kulas, P. (2020). A 6-Year-Old Boy with a Frontal Mass: Pott Puffy Tumor. Journal of Pediatrics, 217, 211-. https://doi.org/10.1016/j.jpeds.2019.09.047
Oertel, J., Senger, S., & Linsler, S. (2020). The extended endoscopic approach to perisellar and skull base lesions: is one nostril enough? Neurosurgical Review, 43(6), 1519-1529. https://doi.org/10.1007/s10143-019-01171-8

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