Prof. Dr. Tobias Bäuerle

Institute of Radiology

Carcinogenesis and inflammation induce processes of tumor and immune cells that interact with the local microenvironment and may have systemic impact resulting in distant metastasis or a systemic response on inflammation, respectively. The primary area of research is to assess these processes by multimodal imaging on the translational and clinical level including MRI, CT, PET, ultrasound, and optical imaging.

Research projects

  • The aim of our group is to develop novel imaging techniques for the assessment of tumor growth, metastasis, and inflammatory processes for translational purposes in preclinical models and patients
  • To assess quantitative parameters in local and systemic disease
  • To implement machine learning algorithms for integration of large amounts of imaging data to detect, diagnose or predict oncologic or inflammatory disease.

Current projects

  • J107: Deciphering the PU.1 transcriptional network in osteoblasts and its role in osteoproliferative arthritis

    (FAU Funds)

    Term: 1. January 2024 - 31. August 2026
    PU.1 controls the transcriptional network of matrix production in fibrotic fibroblasts. We have now found that PU.1 is also expressed in matrix-producing osteoblasts. In this proposal, we aim to study the PU.1 network in biopsies from patients with osteoproliferative arthritis by imaging mass cytometry, to dissect PU.1-driven transcription in human osteoblastogenic cultures by ATTAC/CHIP/RNA-seq, and to use a novel osteoblast-targeting PU.1 inhibitor in experimental osteoproliferative arthritis.
  • J106: Tissue imprinting of skin-derived immune cells in psoriatic arthritis

    (FAU Funds)

    Term: 1. September 2023 - 28. February 2026
    To date, it is still obscure why in some patients with psoriasis the autoimmune process is restrained to the skin, whereas in other it extends to the joints. We will adopt models resembling psoriasis and psoriatic arthritis, with the aim of studying the joint involvement secondary to skin inflammation. The comprehension and characterization of the underlying mechanisms involved in the “skin-joint axis” is pivotal for a better understanding of the link between physical barriers and autoimmunity.
  • Datenmanagement, Bioinformatik und Imaging-Plattform (Z01)

    (Third Party Funds Group – Sub project)

    Overall project: TRR 305: Über die Analyse der metastatischen Koloniebildung zu neuen systemischen Krebstherapien
    Term: 1. January 2021 - 31. December 2024
    Funding source: DFG / Sonderforschungsbereich / Transregio (SFB / TRR)

Recent publications






Related Research Fields