Prof. Dr. Oliver Friedrich

Institute of Medical Biotechnology

The Institute of Medical Biotechnology designs and engineers new systems technologies that allow to investigate and manipulate optical and mechanical properties of biological tissues in health, disease and tissue engineering.

Research projects

  • Optical technologies
  • Opto-Biomechatronics
  • Bioreactor technologies
  • Multiphoton endoscopy technologies
  • Image processing, pattern recognition & AI
  • Label-free optical metrologies for tissue diagnostics
  • Multidimensional cell and tissue stretch systems technologies for mechanobiology
  • Bioprocess engineering for optical tissue clearing
  • High pressure biotechnology
  • Robophotonics

  • Application of an IsoStretcher biomechatronics platform and engineering of a novel parallelized MultiStretcher technology for studies of cardiac mechano-signaling in HL-1 atrial cardiomyocytes

    (Non-FAU Project)

    Term: 1. July 2019 - 30. June 2022

    The heart transforms electrical signals into mechanical action tocontinuously pump blood through our circulation. In reverse, mechanical stimuliduring active contraction or passive filling distention are sensed and modulateelectrical signals through so called cardiac mechano-electric feedback(MEF)[1]. The MEF involves complex activation of mechanical biosensorsinitiating short-term and long-term effects through Ca2+ signals incardiomyocytes in acute and chronic pressure overload scenarios (e.g. heartfailure). How mechanical forces alter cardiac function at the molecular levelremains unknown. In this innovative project, we aim to study how definedmechanical stimuli (stress) deform the cell membrane (strain) leading toactivation of mechanosensitive channels (MSC), including the recentlydiscovered family of Piezo channels[3] suspected to play a major role indevelopment of cardiac hypertrophy and heart failure[2]. We will first focus onthe murine immortalised atrial cardiomyocytes HL-1 cell line to investigate Ca2+signalling through aberrantly activated MSC and subsequent MEF before studyingmammalian adult ventricular cardiomyocytes. One part of this internationalcollaborative project consists in redesigning an existing IsoStretcher biomechatronics system[4] into a next generation MultiStretcher system for scaling uphigh-content screening of cellular signalling pathways and control ofbiological batch-to-batch variation. While the engineering of this parallelizedMultiStretcher will be carried out at the institution (Medical BiotechnologyInstitute at Friedrich Alexander University, FAU, Erlangen-Nürnberg) by theteam of Prof Oliver Friedrich, our long-standing collaborator and internationalco-investigator on this project, the application of the Iso- and MultiStretcherfor investigations of MEF-related cell biology and pharmacology will be carriedout at the Victor Chang Cardiac Research Institute (VCCRI). The systemtechnology will be transferred to VCCRI for the ongoing support of cardiacmechanotransduction research.

  • Application of an IsoStretcher biomechatronics platform and engineering of a novel palallelised MultiStretcher technology for studies of cardiac mechano-signalling in HL-1 atrial cardiomyocytes

    (Third Party Funds Single)

    Term: 1. July 2019 - 30. June 2022
    Funding source: andere Förderorganisation

2022

2021

2020

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