Abscopal effects are rare events of local radiotherapy (RT) inducing systemic anti-tumor immune responses leading to the reduction of tumor masses outside of the irradiation field. We hypothesize that the addition of adjuvants to high hydrostatic pressure generated whole tumor cell vaccines in combination with RT and immune checkpoint inhibition induce abscopal effects in an orthotopic breast cancer model. Further, we hypothesize that cDC1s play a central role in this immune response.
The role of cDC1s in abscopal effects of a multimodal radioimmunotherapy including whole tumor cell vaccines
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