Prof. Dr. Tomohisa Toda
Institute for Medical Physics / Institute for Biochemistry
E42: Elucidating the roles of long-lived RNAs in motor neuron diseases
(FAU Funds)Project leader: ,
Term: 1. June 2026 - 30. November 2028The molecular basis of motor neuron vulnerability in motor neuron diseases (MNDs) remains poorly understood. RNA dysregulation has been linked to MNDs, and LL-RNAs have recently been identified as a potentially critical component of neural longevity. We found an enrichment of long-lived RNAs (LL-RNAs) in human motor neurons. Thus, this project will investigate the mechanistic role of LL-RNAs in MNDs using brain organoids, aiming to identify novel biomarkers and therapeutic targets.
2025
- Hetzer, M.W., & Toda, T. (2025). Long-lived cellular molecules in the brain. Trends in Neurosciences. https://doi.org/10.1016/j.tins.2025.07.004
2023
- Toda, T. (2023). Nuclear structural proteins underlying the long-term maintenance and aging of neural stem cells 核内構造タンパク質を介した神経幹細胞維持機構とその老化. SEIKAGAKU , 95(1), 83-86. https://doi.org/10.14952/SEIKAGAKU.2023.950083
2022
- Mestres, I., Houtman, J., Calegari, F., & Toda, T. (2022). A Nuclear Belt Fastens on Neural Cell Fate. Cells, 11(11). https://dx.doi.org/10.3390/cells11111761
2021
- Bedrosian, T.A., Houtman, J., Eguiguren, J.S., Ghassemzadeh, S., Rund, N., Novaresi, N.M.,... Toda, T. (2021). Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. The EMBO Journal, 40(3). https://doi.org/10.15252/embj.2020105819
- Soni, A., Kluetsch, D., Hu, X., Houtman, J., Rund, N., Mccloskey, A.,... Toda, T. (2021). Improved method for efficient generation of functional neurons from murine neural progenitor cells. Cells, 10(8). https://doi.org/10.3390/cells10081894