We investigate how cellular forces, local cell, and tissue viscoelasticity, and cellular mechanosensitivity contribute to CNS development and disease. Methods we are exploiting include atomic force microscopy, traction force microscopy, custom-built simple and complex compliant cell culture substrates, optical microscopy including confocal laser scanning microscopy, and cell biological techniques.
Research projects
Role of tissue mechanics in regulating neuronal development
Quantification of CNS tissue mechanics in health and disease
Role of tissue mechanics in pathological processes such as foreign body reactions and spinal cord injuries
Symmetry breaking of microtubule networks in neurons
Development of atomic force microscopy-based methods to measure and manipulate tissue mechanics
Development of AI-based software for automated data/image analysis
Current projects Current projects
Recent publications Recent publications
2022
Barone, D.G., Carnicer-Lombarte, A., Tourlomousis, P., Hamilton, R.S., Prater, M., Rutz, A.L.,... Bryant, C.E. (2022). Prevention of the foreign body response to implantable medical devices by inflammasome inhibition . Proceedings of the National Academy of Sciences of the United States of America , 119 (12), e2115857119. https://dx.doi.org/10.1073/pnas.2115857119
Jakobs, M.A., Zemel, A., & Franze, K. (2022). Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation . eLife , 11 . https://dx.doi.org/10.7554/eLife.77608
Kaplan, L., Drexler, C., Pfaller, A.M., Brenna, S., Wunderlich, K.A., Dimitracopoulos, A.,... Grosche, A. (2022). Retinal regions shape human and murine Muller cell proteome profile and functionality . Glia . https://dx.doi.org/10.1002/glia.24283
Schaeffer, J., Weber, I.P., Thompson, A.J., Keynes, R.J., & Franze, K. (2022). Axons in the Chick Embryo Follow Soft Pathways Through Developing Somite Segments . Frontiers in Cell and Developmental Biology , 10 . https://dx.doi.org/10.3389/fcell.2022.917589
Yanagida, A., Corujo-Simon, E., Revell, C.K., Sahu, P., Stirparo, G.G., Aspalter, I.M.,... Chalut, K.J. (2022). Cell surface fluctuations regulate early embryonic lineage sorting . Cell , 185 (5), 777-793.e20. https://dx.doi.org/10.1016/j.cell.2022.01.022
2021
Labouesse, C., Tan, B.X., Agley, C.C., Hofer, M., Winkel, A.K., Stirparo, G.G.,... Chalut, K.J. (2021). StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells . Nature Communications , 12 (1). https://dx.doi.org/10.1038/s41467-021-26236-5
Lippert, A.H., Dimov, I.B., Winkel, A.K., Humphrey, J., Mccoll, J., Chen, K.Y.,... Klenerman, D. (2021). Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions. Biophysical Journal , 120 (1), 35-45. https://dx.doi.org/10.1016/j.bpj.2020.11.021
Oliveri, H., Franze, K., & Goriely, A. (2021). Theory for Durotactic Axon Guidance . Physical Review Letters , 126 (11). https://dx.doi.org/10.1103/PhysRevLett.126.118101
Wang, D.-Y., Melero, C., Albaraky, A., Atherton, P., Jansen, K.A., Dimitracopoulos, A.,... Ballestrem, C. (2021). Vinculin is required for neuronal mechanosensing but not for axon outgrowth . Experimental Cell Research , 407 (2). https://dx.doi.org/10.1016/j.yexcr.2021.112805
2020
Axpe, E., Orive, G., Franze, K., & Appel, E.A. (2020). Towards brain-tissue-like biomaterials . Nature Communications , 11 (1). https://dx.doi.org/10.1038/s41467-020-17245-x
Dimitracopoulos, A., Srivastava, P., Chaigne, A., Win, Z., Shlomovitz, R., Lancaster, O.M.,... Baum, B. (2020). Mechanochemical Crosstalk Produces Cell-Intrinsic Patterning of the Cortex to Orient the Mitotic Spindle. Current Biology , 30 (18), 3687-3696.e4. https://dx.doi.org/10.1016/j.cub.2020.06.098
Franze, K. (2020). Integrating Chemistry and Mechanics: The Forces Driving Axon Growth . In (pp. 61-83). Annual Reviews Inc..
Jakobs, M.A.H., Franze, K., & Zemel, A. (2020). Mechanical Regulation of Neurite Polarization and Growth: A Computational Study . Biophysical Journal , 118 (8), 1914-1920. https://dx.doi.org/10.1016/j.bpj.2020.02.031
Kjell, J., Fischer-Sternjak, J., Thompson, A.J., Friess, C., Sticco, M.J., Salinas, F.,... Goetz, M. (2020). Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis . Cell Stem Cell , 26 (2), 277-293.e8. https://dx.doi.org/10.1016/j.stem.2020.01.002
Kulenkampff, K., Lippert, A.H., Mccoll, J., Santos, A.M., Ponjavic, A., Jenkins, E.,... Klenerman, D. (2020). The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale . Biophysical Journal , 118 (6), 1261-1269. https://dx.doi.org/10.1016/j.bpj.2020.01.019
Rheinlaender, J., Dimitracopoulos, A., Wallmeyer, B., Kronenberg, N.M., Chalut, K.J., Gather, M.C.,... Franze, K. (2020). Cortical cell stiffness is independent of substrate mechanics . Nature Materials . https://dx.doi.org/10.1038/s41563-020-0684-x
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We investigate how cellular forces, local cell, and tissue viscoelasticity, and cellular mechanosensitivity contribute to CNS development and disease. Methods we are exploiting include atomic force microscopy, traction force microscopy, custom-built simple and complex compliant cell culture substrates, optical microscopy including confocal laser scanning microscopy, and cell biological techniques.
Research projects
Current projects
No projects found.
Recent publications
2022
2021
2020
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