Prof. Dr. Christoph Alexiou
Department of Otho-Rhino-Laryngology, Head&Neck Surgery, Section for Experimental Oncology and Nanomedicine (SEON)

The Section of Experimental Oncology and Nanomedicine develops and applies iron oxide nanoparticles in Oncology, Cardiovascular diseases, Regenerative Medicine and infectious diseases. Furthermore artificial intelligence based procedures including robotics are performed in vitro and in vivo.
Research projects
- Nanomedicine
- Oncology
- Cardiovascular diseases
- Infectious diseases
- Artifical Intelligence
- Robotics
-
GRK 2950 P6: Development of Tumor Models for MC based on Additive Manufacturing Approaches
(Third Party Funds Group – Sub project)
Overall project: GRK 2950: Synthetic Molecular Communication Across Different Scales: From Theory to Experiments
Project leader:
Term: 1. June 2024 - 31. May 2029
Acronym: GRK 2950 P6
Funding source: DFG / Graduiertenkolleg (GRK) -
GRK 2950 P5: Lumped-Parameter Models for and Optimization of SPION Steering in Highly Branched Vascular and Tissue Structures
(Third Party Funds Group – Sub project)
Overall project: GRK 2950: Synthetic Molecular Communication Across Different Scales: From Theory to Experiments
Project leader:
Term: 1. June 2024 - 31. May 2029
Acronym: GRK 2950 P5
Funding source: DFG / Graduiertenkolleg (GRK)
URL: https://www.symocads.research.fau.eu/The goal of this project is to establish MC-based models and algorithms for optimization of SPION steering systems in highly branched vascular and tissue structures. To this end, a comprehensive numerical model for the MC channel relevant for SPION steering will be derived. Furthermore, in order to enable efficient optimization of the SPION steering system at affordable computational cost, a lumped-parameter approach will be used to develop approximate models. Based on these approximate models, given a certain vessel topology and tissue structure, algorithms for maximization of the number of particles delivered to a target area (representing the MC receiver) will be investigated, where both static and dynamic (time-varying) steering systems will be considered. The findings of P4 regarding the forces relevant for SPION steering will be integrated for development of the proposed comprehensive and approximate MC channel models as they become available. Furthermore, besides conventional electromagnets, the linear array structures investigated in P4 will be considered for steering algorithm design. Moreover, the developed MC channel models and steering algorithms will be experimentally validated and refined exploiting the physical tumor models provided by P6.
-
GRK 2950 P4: Forces, Limitations, and Concepts for SPION Steering
(Third Party Funds Group – Sub project)
Overall project: GRK 2950: Synthetic Molecular Communication Across Different Scales: From Theory to Experiments
Project leader:
Term: 1. June 2024 - 31. May 2029
Acronym: GRK 2950 P4
Funding source: DFG / Graduiertenkolleg (GRK)In our suproject we are studying new techniques for steering SPIONs (Super Paramagnetic Ion Oxides Nanoparticles) towards a target region by using specially shaped magnetic gradient fields.
-
SyMoCADS: Synthetic Molecular Communications Across Different Scales: From Theory to Experiments
(Third Party Funds Group – Overall project)
Project leader: , , , , , , , , ,
Term: 1. June 2024 - 31. May 2029
Acronym: SyMoCADS
Funding source: DFG / Graduiertenkolleg (GRK)
URL: https://www.symocads.research.fau.eu/https://www.idc.tf.fau.de/neues-graduiertenkolleg-symocads/
2026
- Alexiou, C., & Fadeel, B. (2026). Editorial: Nanomedicine – From bench to bedside. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2026.153417
- Genc, H., Stein, R., Ettner-Sitter, A., Siegert, T., Civelek, M., Alexiou, C.,... Cicha, I. (2026). Gold-modified superparamagnetic iron oxide nanoparticles: Magnetic accumulation under flow conditions and toxicity evaluation in vitro and in vivo. Nanotoxicology. https://doi.org/10.1080/17435390.2026.2652859
- Heger, L., Kaszubowski, T., Amon, L., Lehmann, C., Wingert, S., Medina-Echeverz, J.,... Dudziak, D. (2026). NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells. OncoImmunology, 15(1), 2613561-. https://doi.org/10.1080/2162402X.2026.2613561
- Heinen, L., Blersch, P.-R., Schnell, C., Meyer, K., Nagy, R., Halik, M.,... Tietze, R. (2026). Ultrasound-assisted size tuning of polyacrylic acid coated magnetic nanoparticle clusters for biomedical applications. Ultrasonics Sonochemistry, 130. https://doi.org/10.1016/j.ultsonch.2026.107876
- Heinen, L., Blersch, P.-R., Schnell, C., Meyer, K., Nagy, R., Halik, M.,... Tietze, R. (2026). Ultrasound-assisted size tuning of polyacrylic acid coated magnetic nanoparticle clusters for biomedical applications. Ultrasonics Sonochemistry, 130. https://doi.org/10.1016/j.ultsonch.2026.107876
- Heinen, L., Simonis, A., Rybniker, J., Günther, J., Vogel, P., Janko, C.,... Tietze, R. (2026). Detection of Pseudomonas aeruginosa in Whole Blood using a portable Magnetic Particle Spectrometer-a feasibility study. International Journal of Magnetic Particle Imaging, 12(1). https://doi.org/10.18416/ijmpi.2026.2603014
- Körber, M., Halter, F., Attia, D., Körber, E., Tietze, R., Alexiou, C.,... Mokhir, A. (2026). Copper(II)-Mediated Mitochondria-Targeting in Cancer Cells. Journal of Medicinal Chemistry, 69(14), 16896-16910. https://doi.org/10.1021/acs.jmedchem.6c00588
- Pointner, A., Thalheim, D., Belasi, S., Heinen, L., Carnell, L., Janko, C.,... Nagy, R. (2026). A Compact Incubation Platform for Long-Term Cultivation of Biological Samples for Nitrogen-Vacancy Center Widefield Microscopy. Advanced Materials. https://doi.org/10.1002/admt.70949
- Spielvogel, H., Schreiber, E., Siegert, T., & Alexiou, C. (2026). Corrigendum to “GMP-Compliant batch manufacturing of dextran-coated iron oxide nanoparticles: A process development case study” [Biochem. Biophys. Res. Communications 805 (2026) 153336] (Biochemical and Biophysical Research Communications (2026) 805, (S0006291X26001002), (10.1016/j.bbrc.2026.153336)). Biochemical and Biophysical Research Communications, 828. https://doi.org/10.1016/j.bbrc.2026.154070
- Spielvogel, H., Schreiber, E., Siegert, T., & Alexiou, C. (2026). GMP-compliant batch manufacturing of dextran-coated iron oxide nanoparticles: A process development case study. Biochemical and Biophysical Research Communications, 805. https://doi.org/10.1016/j.bbrc.2026.153336
- Tietze, R., Heinen, L., Lyer, S., & Alexiou, C. (2026). Design considerations and approaches for clinically approvable MPS/MPI SPIONs-the SEON concept-. International Journal of Magnetic Particle Imaging, 12(1). https://doi.org/10.18416/ijmpi.2026.2603035
- Voß, J., Rockmann, L., Meyer, V., Unterweger, H., Bröse, D., Heinen, L.,... Halik, M. (2026). The magnetic removal of PFAS from water − from molecules to microplastics. Materials Today, 99. https://doi.org/10.1016/j.mattod.2026.103471
2025
- Blersch, P.-R., Hoyer, T., Alexiou, C., Heindl, L.M., Gostian, A.-O., & Lyer, S. (2025). Exploring the Interplay Between Hyperthermia and Cytotoxic Drugs in Ocular Melanoma Cell Lines: Implications and Variability in Treatment Efficiency. Investigative Ophthalmology & Visual Science, 66(12). https://doi.org/10.1167/iovs.66.12.71
- Carnell, L., Alexiou, C., & Janko, C. (2025). SPION-functionalized CAR-T cells: Overcoming key barriers in solid tumor therapy. Biochemical and Biophysical Research Communications, 788. https://doi.org/10.1016/j.bbrc.2025.152770
- Cicha, I., Spielvogel, H., Tietze, R., Lyer, S., Janko, C., Civelek, M., & Alexiou, C. (2025). Nanoparticle-based delivery of RNA therapeutics. Nanomedicine, 20(12), 1385-1389. https://doi.org/10.1080/17435889.2025.2502314
- Günther, J., Kampf, T., Rückert, M.A., Friedrich, B., Reichl, T., Tietze, R.,... Vogel, P. (2025). Magnetic particle fingerprinting using COMPASS. International Journal of Magnetic Particle Imaging, 11. https://doi.org/10.18416/ijmpi.2025.2503004
- Pfister, F., Carnell, L., Löffler, L., Boosz, P., Schaft, N., Dörrie, J.,... Janko, C. (2025). Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism. MedComm, 6. https://doi.org/10.1002/mco2.70039
- Pointner, A., Thalheim, D., Belasi, S., Heinen, L., Bonato, C., Luehmann, T.,... Nagy, R. (2025). Optimizing SPION Labeling for Single-Cell Magnetic Microscopy. Journal of Physical Chemistry Letters. https://doi.org/10.1021/acs.jpclett.5c01446
- Pourshahrestani, S., Ünalan, I., Zeimaran, E., Xu, Z., Roether, J., Kerpes, A.,... Boccaccini, A.R. (2025). Tannic acid-loaded zinc- and copper-doped mesoporous bioactive glass nanoparticles: Potential antioxidant nanocarriers for wound healing. Bioactive Materials, 54, 71-85. https://doi.org/10.1016/j.bioactmat.2025.07.046
- Tietze, R., Hausen, E., Heinen, L., Schulte, N., Lyer, S., & Alexiou, C. (2025). Search and detect pathogens using magnetic iron oxide nanoparticles. Biochemical and Biophysical Research Communications, 781. https://doi.org/10.1016/j.bbrc.2025.152462
2024
- Adler, M.-Y., Issoual, I., Rückert, M., Deloch, L., Meier, C., Tschernig, T.,... Paulsen, F. (2024). Effect of micro- and nanoplastic particles on human macrophages. Journal of Hazardous Materials, 471. https://doi.org/10.1016/j.jhazmat.2024.134253
- Civelek, M., Cicha, I., Spielvogel, H., Tietze, R., Lyer, S., Janko, C., & Alexiou, C. (2024). Nanocarriers for therapeutic phytochemicals. Nanomedicine, 19(21-22), 1711-1716. https://doi.org/10.1080/17435889.2024.2380242
- Huber, C., Pavan, T.Z., Ullmann, I., Heim, C., Rupitsch, S.J., Vossiek, M.,... Lyer, S. (2024). A Review on Ultrasound-based Methods to Image the Distribution of Magnetic Nanoparticles in Biomedical Applications. Ultrasound in Medicine and Biology. https://doi.org/10.1016/j.ultrasmedbio.2024.10.007
- Janko, C., Civelek, M., Cicha, I., Spielvogel, H., Unterweger, H., & Alexiou, C. (2024). Nanoparticles for the treatment of inflammatory conditions. Nanomedicine, 19(2), 103-107. https://doi.org/10.2217/nnm-2023-0324
- Kurtuldu, F., Mutlu, N., Friedrich, R.P., Beltrán, A.M., Liverani, L., Detsch, R.,... Boccaccini, A.R. (2024). Gallium-containing mesoporous nanoparticles influence in-vitro osteogenic and osteoclastic activity. Biomaterials Advances, 162. https://doi.org/10.1016/j.bioadv.2024.213922
- Liang, C., Spörl, S., Xiao, Y., Habenicht, K.M., Haeusl, S.S., Sandner, I.,... Berberich-Siebelt, F. (2024). Oligoclonal CD4+CXCR5+ T cells with a cytotoxic phenotype appear in tonsils and blood. Communications Biology, 7(1). https://doi.org/10.1038/s42003-024-06563-1
- Mickoleit, F., Pfister, F., Friedrich, B., Markert, S., Kerpes, A., Janko, C.,... Tietze, R. (2024). Assessing Cytotoxicity, Endotoxicity, and Blood Compatibility of Nanoscale Iron Oxide Magnetosomes for Biomedical Applications. ACS Applied Nano Materials, 7(1), 1278-1288. https://doi.org/10.1021/acsanm.3c05248
- Mödl, L., Carnell, L., Stein, R., Kerpes, A., Pfister, F., Wirthl, B.,... Janko, C. (2024). Loading monocytes with magnetic nanoparticles enables their magnetic control without toxicity. Frontiers in Bioengineering and Biotechnology, 12. https://doi.org/10.3389/fbioe.2024.1498120
- Pourshahrestani, S., Zeimaran, E., Janko, C., Alexiou, C., Kerpes, A., Würz, A.,... Boccaccini, A.R. (2024). The effect of mesoporous bioactive glass nanoparticles incorporating various metallic ions (Cu, Zn, Mn, Te) on wound healing. Materials Advances, 5(16), 6630-6647. https://doi.org/10.1039/d4ma00392f
- Promny, D., Gill, D., Lyer, S., Alexiou, C., Buder, T., Neuhuber, W.,... Arkudas, A. (2024). Mapping wrist motion: 3D CT analysis after scapholunate ligament transection. Journal of Anatomy. https://doi.org/10.1111/joa.14119
- Sekita, A., Unterweger, H., Berg, S., Ohlmeyer, S., Bäuerle, T., Zheng, K.H.,... Cicha, I. (2024). Accumulation of Iron Oxide-Based Contrast Agents in Rabbit Atherosclerotic Plaques in Relation to Plaque Age and Vulnerability Features. International Journal of Nanomedicine, 19, 1645-1666. https://doi.org/10.2147/IJN.S430693
- Zheng, K., Bider, F., Monavari, M., Xu, Z., Janko, C., Alexiou, C.,... Boccaccini, A.R. (2024). Sol-gel derived B2O3-CaO borate bioactive glasses with hemostatic, antibacterial and pro-angiogenic activities. Regenerative Biomaterials, 11. https://doi.org/10.1093/rb/rbad105
2023
- Dinter, J., Friedrich, R.P., Yang, H., Pilarsky, C., Mangge, H., Pöttler, M.,... Lyer, S. (2023). Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids. Materials, 16(7). https://doi.org/10.3390/ma16072906
- Friedrich, B., Tietze, R., Dümig, M., Sover, A., Boca, M.A., Schreiber, E.,... Lyer, S. (2023). Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs. International Journal of Nanomedicine, 18, 3231-3246. https://doi.org/10.2147/IJN.S409559
- Friedrich, B., Tietze, R., Rückert, M.A., Kampf, T., Hennig, T., Dölken, L.,... Lyer, S. (2023). Fast detection of SARS-CoV2 Antibodies by the use of critical off-set magnetic particle spectroscopy (COMPASS). International Journal of Magnetic Particle Imaging, 9. https://doi.org/10.18416/IJMPI.2023.2303063
- Friedrich, B., Vogel, P., Rückert, M.A., Lyer, S., Günther, J., Wernery, U.,... Tietze, R. (2023). Detection of viral antibodies in camel sera using magnetic particle spectroscopy. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-023-12513-4
- Genc, H., Cianciosi, A., Lohse, R., Stahlhut, P., Groll, J., Alexiou, C.,... Juengst, T. (2023). Adjusting Degree of Modification and Composition of gelAGE-Based Hydrogels Improves Long-Term Survival and Function of Primary Human Fibroblasts and Endothelial Cells in 3D Cultures. Biomacromolecules. https://doi.org/10.1021/acs.biomac.2c01536
- Genc, H., Friedrich, B., Alexiou, C., Pietryga, K., Cicha, I., & Douglas, T.E. (2023). Endothelialization of Whey Protein Isolate-Based Scaffolds for Tissue Regeneration. Molecules, 28(20). https://doi.org/10.3390/molecules28207052
- Günther, J., Kampf, T., Rückert, M.A., Friedrich, B., Tietze, R., Lyer, S.,... Vogel, P. (2023). Insight COMPASS – the physics behind. International Journal of Magnetic Particle Imaging, 9(1). https://doi.org/10.18416/IJMPI.2023.2303089
- Heger, L., Hatscher, L., Liang, C., Lehmann, C., Amon, L., Lühr, J.J.,... Dudziak, D. (2023). XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors. Proceedings of the National Academy of Sciences of the United States of America, 120(33), e2300343120. https://doi.org/10.1073/pnas.2300343120
- Klemt, I., Varzatskii, O., Selin, R., Vakarov, S., Kovalska, V.B., Bila, G.,... Mokhir, A. (2023). 3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo. Journal of the American Chemical Society, 22252–22264. https://doi.org/10.1021/jacs.3c08827
- Lotter, S., Brand, L., Jamali, V., Schäfer, M., Loos, H., Unterweger, H.,... Schober, R. (2023). Experimental Research in Synthetic Molecular Communications - Part I. IEEE Nanotechnology Magazine, 1-12. https://doi.org/10.1109/MNANO.2023.3262100
- Lotter, S., Brand, L., Jamali, V., Schäfer, M., Loos, H.M., Unterweger, H.,... Schober, R. (2023). Experimental Research in Synthetic Molecular Communications - Part II. IEEE Nanotechnology Magazine, 1-12. https://doi.org/10.1109/MNANO.2023.3262377
- Lyer, S., Blersch, P.-R., Huber, C., Tietze, R., & Alexiou, C. (2023). Digitalization and (Nano)robotics in nanomedicine. In Ralf Huss (Eds.), Digital Medicine: Bringing Digital Solutions to Medical Practice. New York: Jenny Stanford Publishing.
- Pfister, F., Alexiou, C., & Janko, C. (2023). Cell Viability and Immunogenic Function of T Cells Loaded with Nanoparticles for Spatial Guidance in Magnetic Fields. In (pp. 331-346). Humana Press Inc..
- Pfister, F., Dörrie, J., Schaft, N., Buchele, V., Unterweger, H., Carnell, L.R.,... Janko, C. (2023). Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1223695
- Reinelt, M., Ahlfs, J., Stein, R., Alexiou, C., Bänsch, E., Friedrich, R.P.,... Neuß, N. (2023). Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system. Journal of Magnetism and Magnetic Materials, 582. https://doi.org/10.1016/j.jmmm.2023.170984
- Sebastian, S., Hoffmann, M.K., Howard, D., Young, C., Washington, J., Unterweger, H.,... Kempson, I. (2023). Kinetic Effects of Transferrin-Conjugated Gold Nanoparticles on the Antioxidant Glutathione-Thioredoxin Pathway. Antioxidants, 12(8). https://doi.org/10.3390/antiox12081617
- Tietze, R., Unterweger, H., Janko, C., Civelek, M., Cicha, I., Spielvogel, H., & Alexiou, C. (2023). Orally administered nanoparticles for gastrointestinal applications. Nanomedicine. https://doi.org/10.2217/nnm-2022-0324
- Unterweger, H., Janko, C., Civelek, M., Cicha, I., Spielvogel, H., Tietze, R.,... Alexiou, C. (2023). Nanomaterial-based ophthalmic therapies. Nanomedicine, 18(10), 783-788. https://doi.org/10.2217/nnm-2023-0109
- Unterweger, H., Janko, C., Folk, T., Cicha, I., Kovacs, N., Gyebnar, G.,... Lyer, S. (2023). Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety. International Journal of Nanomedicine, 18, 2071-2086. https://doi.org/10.2147/IJN.S402320
- Wirthl, B., Janko, C., Lyer, S., Schrefler, B.A., Alexiou, C., & Wall, W.A. (2023). An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow. Biomedical Microdevices, 26(1), 1-. https://doi.org/10.1007/s10544-023-00685-9
- Zschiesche, L., Janko, C., Friedrich, B., Frey, B., Band, J., Lyer, S.,... Unterweger, H. (2023). Biocompatibility of Dextran-Coated 30 nm and 80 nm Sized SPIONs towards Monocytes, Dendritic Cells and Lymphocytes. Nanomaterials, 13(1). https://doi.org/10.3390/nano13010014
2022
- Alexiou, C. (2022). Emerging applications of magnetic nanoparticles in medicine – A personal perspective. Biochemical and Biophysical Research Communications, 633, 52-54. https://doi.org/10.1016/j.bbrc.2022.09.020
- Behr, J., Carnell, L.R.R., Stein, R., Pfister, F., Friedrich, B., Huber, C.,... Janko, C. (2022). In Vitro Setup for Determination of Nanoparticle-Mediated Magnetic Cell and Drug Accumulation in Tumor Spheroids under Flow Conditions. Cancers, 14(23). https://doi.org/10.3390/cancers14235978
- Cicha, I., Tietze, R., Unterweger, H., Lyer, S., Janko, C., Civelek, M., & Alexiou, C. (2022). Stimuli-responsive nanosystems for enhanced drug delivery and diagnosis. Nanomedicine. https://doi.org/10.2217/nnm-2022-0193
- Fauck, V., Schinz, K., Alexiou, C., Mantsopoulos, K., Iro, H., & Müller, S.K. (2022). Abscesstonsillectomy: Uni- or bilateral? Laryngo-Rhino-Otologie. https://doi.org/10.1055/a-1841-6419
- Friedrich, B., Eichermüller, J., Bogdan, C., Cunningham, S., Hackstein, H., Strauss, R.,... Tietze, R. (2022). Biomimetic Magnetic Particles for the Removal of Gram-Positive Bacteria and Lipoteichoic Acid. Pharmaceutics, 14(11). https://doi.org/10.3390/pharmaceutics14112356
- Friedrich, B., Lyer, S., Janko, C., Unterweger, H., Brox, R., Cunningham, S.,... Tietze, R. (2022). Scavenging of bacteria or bacterial products by magnetic particles functionalized with a broad-spectrum pathogen recognition receptor motif offers diagnostic and therapeutic applications. Acta Biomaterialia, 141, 418-428. https://doi.org/10.1016/j.actbio.2022.01.001
- Friedrich, R.P., Cicha, I., Tietze, R., Unterweger, H., Lyer, S., Janko, C., & Alexiou, C. (2022). Intranasal delivery of nanoparticles. Nanomedicine. https://doi.org/10.2217/nnm-2021-0418
- Friedrich, R.P., Kappes, M., Cicha, I., Tietze, R., Braun, C., Schneider-Stock, R.,... Janko, C. (2022). Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles. International Journal of Nanomedicine, Volume 17, 2139-2163. https://doi.org/10.2147/IJN.S355007
- Gill, D., Lyer, S., Alexiou, C., Fried, F., Buder, T., Neuhuber, W.,... Arkudas, A. (2022). Anatomical study of all carpal and adjoining bones of the wrist using 3D CT reconstruction –Finding the ultimate biomechanical theory. Annals of Anatomy-Anatomischer Anzeiger, 242. https://doi.org/10.1016/j.aanat.2022.151909
- Holler, A., Cicha, I., Eckstein, M., Haderlein, M., Poettler, M., Rappl, A.,... Alexiou, C. (2022). Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts-A follow-up. Cancer Medicine. https://doi.org/10.1002/cam4.4816
- Kappes, M., Friedrich, B., Pfister, F., Huber, C., Friedrich, R.P., Stein, R.,... Janko, C. (2022). Superparamagnetic Iron Oxide Nanoparticles for Targeted Cell Seeding: Magnetic Patterning and Magnetic 3D Cell Culture. Advanced Functional Materials. https://doi.org/10.1002/adfm.202203672
- Ryma, M., Genc, H., Nadernezhad, A., Paulus, I., Schneidereit, D., Friedrich, O.,... Groll, J. (2022). A Print-and-Fuse Strategy for Sacrificial Filaments Enables Biomimetically Structured Perfusable Microvascular Networks with Functional Endothelium Inside 3D Hydrogels. Advanced Materials. https://doi.org/10.1002/adma.202200653
- Stein, R., Pfister, F., Friedrich, B., Blersch, P.-R., Unterweger, H., Arkhypov, A.,... Tietze, R. (2022). Plasmid-DNA Delivery by Covalently Functionalized PEI-SPIONs as a Potential ‘Magnetofection’ Agent. Molecules, 27(21). https://doi.org/10.3390/molecules27217416
- Tietze, R., & Alexiou, C. (2022). SPION based nanoformulations: bio-inspired design and functionalization strategies for applications in medicine. Precision Nanomedicine, 5(2), 897-910. https://doi.org/10.33218/001c.35650
- Vogel, P., Rückert, M.A., Friedrich, B., Tietze, R., Lyer, S., Kampf, T.,... Behr, V.C. (2022). Critical Offset Magnetic PArticle SpectroScopy for rapid and highly sensitive medical point-of-care diagnostics. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-34941-y
- Xu, H., Reshetnikov, V., Wondrak, M., Eckhardt, L., Kunz-Schughart, L.A., Janko, C.,... Mokhir, A. (2022). Intracellular amplifiers of reactive oxygen species affecting mitochondria as radiosensitizers. Cancers, 14(1). https://doi.org/10.3390/cancers14010208
2021
- Balk, M., Haus, T., Band, J., Unterweger, H., Schreiber, E., Friedrich, R.P.,... Gostian, A.O. (2021). Cellular spion uptake and toxicity in various head and neck cancer cell lines. Nanomaterials, 11(3), 1-19. https://doi.org/10.3390/nano11030726
- Blumler, P., Friedrich, R.P., Pereira, J., Baun, O., Alexiou, C., & Mailander, V. (2021). Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields. Nanotechnology, Science and Applications, 14, 91-100. https://doi.org/10.2147/NSA.S298003
- Boosz, P., Pfister, F., Stein, R., Friedrich, B., Fester, L., Band, J.,... Janko, C. (2021). Citrate-coated superparamagnetic iron oxide nanoparticles enable a stable non-spilling loading of t cells and their magnetic accumulation. Cancers, 13(16). https://doi.org/10.3390/cancers13164143
- Cicha, I., & Alexiou, C. (2021). Cardiovascular applications of magnetic particles. Journal of Magnetism and Magnetic Materials, 518. https://doi.org/10.1016/j.jmmm.2020.167428
- Friedrich, B., Auger, J.-P., Dutz, S., Cicha, I., Schreiber, E., Band, J.,... Tietze, R. (2021). Hydroxyapatite-Coated SPIONs and Their Influence on Cytokine Release. International Journal of Molecular Sciences, 22(8). https://doi.org/10.3390/ijms22084143
- Friedrich, R.P., Cicha, I., & Alexiou, C. (2021). Iron oxide nanoparticles in regenerative medicine and tissue engineering. Nanomaterials, 11(9). https://doi.org/10.3390/nano11092337
- Friedrich, R.P., Janko, C., Unterweger, H., Lyer, S., & Alexiou, C. (2021). SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications. Physical Sciences Review. https://doi.org/10.1515/psr-2019-0093
- Genc, H., Hazur, J., Karakaya, E., Dietel, B., Bider, F., Groll, J.,... Cicha, I. (2021). Differential responses to bioink‐induced oxidative stress in endothelial cells and fibroblasts. International Journal of Molecular Sciences, 22(5), 1-21. https://doi.org/10.3390/ijms22052358
- Gresing, L.J., Radon, P., Friedrich, R.P., Zahn, D., Raasch, M., Mosig, A.S.,... Clement, J.H. (2021). Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner. Journal of Magnetism and Magnetic Materials, 521. https://doi.org/10.1016/j.jmmm.2020.167535
- Gräfe, C., Müller, E.K., Gresing, L., Weidner, A., Radon, P., Friedrich, R.P.,... Clement, J.H. (2021). Magnetic hybrid materials interact with biological matrices. Physical Sciences Review. https://doi.org/10.1515/psr-2019-0114
- Gräfe, C., Müller, E.K., Gresing, L., Weidner, A., Radon, P., Friedrich, R.P.,... Clement, J.H. (2021). Magnetic hybrid materials interact with biological matrices. In Stefan Odenbach (Eds.), Magnetic Hybrid-Materials: Multi-scale Modelling, Synthesis, and Applications. (pp. 681 - 738). De Gruyter.
- Janko, C., Friedrich, R.P., Cicha, I., Unterweger, H., Lyer, S., & Alexiou, C. (2021). Modulation of immune responses by nanoparticles. Nanomedicine. https://doi.org/10.2217/nnm-2021-0198
- Kopeć, K., Wojasiński, M., Eichler, M., Genc, H., Friedrich, R.P., Stein, R.,... Cicha, I. (2021). Polydopamine and gelatin coating for rapid endothelialization of vascular scaffolds. Materials Science and Engineering C. https://doi.org/10.1016/j.msec.2021.112544
- Lyer, S., Janko, C., Friedrich, R.P., Cicha, I., Tietze, R., Unterweger, H., & Alexiou, C. (2021). Nanomedicine for vaccination and diagnosis of diseases. Nanomedicine, 16(3), 165-169. https://doi.org/10.2217/nnm-2020-0483
- Sarcletti, M., Park, H., Wirth, J., Englisch, S., Eigen, A., Drobek, D.,... Halik, M. (2021). The remediation of nano-/microplastics from water. Materials Today. https://doi.org/10.1016/j.mattod.2021.02.020
- Wicke, W., Unterweger, H., Kirchner, J., Brand, L., Ahmadzadeh, A., Ahmed, D.,... Schober, R. (2021). Experimental System for Molecular Communication in Pipe Flow With Magnetic Nanoparticles. IEEE Transactions on Molecular, Biological and Multi-Scale Communications. https://doi.org/10.1109/TMBMC.2021.3099399
- Xu, H., Schikora, M., Sisa, M., Daum, S., Klemt, I., Janko, C.,... Mokhir, A. (2021). An Endoplasmic Reticulum Specific Pro-amplifier of Reactive Oxygen Species in Cancer Cells. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202100054
2020
- Bartunik, M., Unterweger, H., Alexiou, C., Schober, R., Lübke, M., Fischer, G., & Kirchner, J. (2020). Comparative Evaluation of a New Sensor for Superparamagnetic Iron Oxide Nanoparticles in a Molecular Communication Setting. In Springer International Publishing (Eds.), Proceedings of the EAI BICT 2020 - 12th EAI International Conference on Bio-inspired Information and Communications Technologies (pp. 303-316). Online.
- Corek, E., Rodgers, G., Siegrist, S., Einfalt, T., Detampel, P., Schleputz, C.M.,... Huwyler, J. (2020). Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution. Small, e2000746-. https://doi.org/10.1002/smll.202000746
- Fadeel, B., & Alexiou, C. (2020). Brave new world revisited: Focus on nanomedicine. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2020.08.046
- Friedrich, R.P., Schreiber, E., Tietze, R., Yang, H., Pilarsky, C., & Alexiou, C. (2020). Intracellular Quantification and Localization of Label-Free Iron Oxide Nanoparticles by Holotomographic Microscopy. Nanotechnology, Science and Applications, 13, 119-130. https://doi.org/10.2147/NSA.S282204
- Lenz, T., Nicol, P., Castellanos, M.I., Engel, L.C., Lahmann, A.L., Alexiou, C., & Joner, M. (2020). Small dimension–Big impact! Nanoparticle-enhanced non-invasive and intravascular molecular imaging of atherosclerosis in vivo. Molecules, 25(5). https://doi.org/10.3390/molecules25051029
- Mühlberger, M., Unterweger, H., Band, J., Lehmann, C., Heger, L., Dudziak, D.,... Janko, C. (2020). Loading of Primary Human T Lymphocytes with Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Does Not Impair Their Activation after Polyclonal Stimulation. Cells, 9(2). https://doi.org/10.3390/cells9020342
- Nguyen, K., Nuß, B., Mühlberger, M., Unterweger, H., Friedrich, R.P., Alexiou, C., & Janko, C. (2020). Superparamagnetic iron oxide nanoparticles carrying chemotherapeutics improve drug efficacy in monolayer and spheroid cell culture by enabling active accumulation. Nanomaterials, 10(8), 1-21. https://doi.org/10.3390/nano10081577
- Podolska, M., Barras, A., Alexiou, C., Frey, B., Gaipl, U., Boukherroub, R.,... Munoz, L.E. (2020). Graphene Oxide Nanosheets for Localized Hyperthermia-Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death. Cells, 9(3). https://doi.org/10.3390/cells9030776
- Ratschker, T., Egenberger, L., Alev, M., Zschiesche, L., Band, J., Schreiber, E.,... Janko, C. (2020). Mitoxantrone-loaded nanoparticles for magnetically controlled tumor therapy–induction of tumor cell death, release of danger signals and activation of immune cells. Pharmaceutics, 12(10), 1-19. https://doi.org/10.3390/pharmaceutics12100923
- Reshetnikov, V., Özkan, H., Daum, S., Janko, C., Alexiou, C., Sauer, C.,... Mokhir, A. (2020). N-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells. Molecules, 25(11). https://doi.org/10.3390/molecules25112545
- Schapher, M., Koch, M., Weidner, D., Scholz, M., Wirtz, S., Mahajan, A.,... Schauer, C. (2020). Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones. Cells, 9(9). https://doi.org/10.3390/cells9092139
- Singh, R., Eitler, D., Morelle, R., Friedrich, R.P., Dietel, B., Alexiou, C.,... Cicha, I. (2020). Optimization of cell seeding on electrospun PCL-silk fibroin scaffolds. European Polymer Journal, 134. https://doi.org/10.1016/j.eurpolymj.2020.109838
- Stein, R., Friedrich, B., Mühlberger, M., Cebulla, N., Schreiber, E., Tietze, R.,... Unterweger, H. (2020). Synthesis and characterization of citrate-stabilized gold-coated superparamagnetic iron oxide nanoparticles for biomedical applications. Molecules, 25(19). https://doi.org/10.3390/molecules25194425
- Unterweger, H., Lyer, S., Janko, C., Friedrich, R.P., Cicha, I., Tietze, R., & Alexiou, C. (2020). Nanomedicine for infectious diseases. Nanomedicine, 15(13), 1263-1267. https://doi.org/10.2217/NNM-2020-0098
- Zeh, G., Haines, P., Miehlich, M., Kienz, T., Neidlinger, A., Friedrich, R.P.,... Mokhir, A. (2020). Anticancer Effect of an Electronically Coupled Oligoferrocene. Organometallics. https://doi.org/10.1021/acs.organomet.0c00306