The Section of Experimental Oncology and Nanomedicine develops and applies iron oxide nanoparticles in Oncology, Cardiovascular diseases, Regenerative Medicine and infectious diseases. Furthermore artificial intelligence based procedures including robotics are performed in vitro and in vivo.
Research projects
Nanomedicine
Oncology
Cardiovascular diseases
Infectious diseases
Artifical Intelligence
Robotics
Current projects Current projects
Recent publications Recent publications
2022
Friedrich, B., Lyer, S., Janko, C., Unterweger, H., Brox, R., Cunningham, S.,... Tietze, R. (2022). Scavenging of bacteria or bacterial products by magnetic particles functionalized with a broad-spectrum pathogen recognition receptor motif offers diagnostic and therapeutic applications . Acta Biomaterialia , 141 , 418-428. https://dx.doi.org/10.1016/j.actbio.2022.01.001
Friedrich, R.P., Kappes, M., Cicha, I., Tietze, R., Braun, C., Schneider-Stock, R.,... Janko, C. (2022). Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles . International Journal of Nanomedicine , Volume 17 , 2139-2163. https://dx.doi.org/10.2147/IJN.S355007
Xu, H., Reshetnikov, V., Wondrak, M., Eckhardt, L., Kunz-Schughart, L.A., Janko, C.,... Mokhir, A. (2022). Intracellular amplifiers of reactive oxygen species affecting mitochondria as radiosensitizers . Cancers , 14 (1). https://dx.doi.org/10.3390/cancers14010208
2021
Balk, M., Haus, T., Band, J., Unterweger, H., Schreiber, E., Friedrich, R.P.,... Gostian, A.O. (2021). Cellular spion uptake and toxicity in various head and neck cancer cell lines . Nanomaterials , 11 (3), 1-19. https://dx.doi.org/10.3390/nano11030726
Blumler, P., Friedrich, R.P., Pereira, J., Baun, O., Alexiou, C., & Mailander, V. (2021). Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields. Nanotechnology, Science and Applications , 14 , 91-100. https://dx.doi.org/10.2147/NSA.S298003
Cicha, I., & Alexiou, C. (2021). Cardiovascular applications of magnetic particles . Journal of Magnetism and Magnetic Materials , 518 . https://dx.doi.org/10.1016/j.jmmm.2020.167428
Friedrich, B., Auger, J.-P., Dutz, S., Cicha, I., Schreiber, E., Band, J.,... Tietze, R. (2021). Hydroxyapatite-Coated SPIONs and Their Influence on Cytokine Release . International Journal of Molecular Sciences , 22 (8). https://dx.doi.org/10.3390/ijms22084143
Friedrich, R.P., Janko, C., Unterweger, H., Lyer, S., & Alexiou, C. (2021). SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications . Physical Sciences Review . https://dx.doi.org/10.1515/psr-2019-0093
Genc, H., Hazur, J., Karakaya, E., Dietel, B., Bider, F., Groll, J.,... Cicha, I. (2021). Differential responses to bioink‐induced oxidative stress in endothelial cells and fibroblasts . International Journal of Molecular Sciences , 22 (5), 1-21. https://dx.doi.org/10.3390/ijms22052358
Gresing, L.J., Radon, P., Friedrich, R.P., Zahn, D., Raasch, M., Mosig, A.S.,... Clement, J.H. (2021). Negatively charged magnetic nanoparticles pass the blood-placenta barrier under continuous flow conditions in a time-dependent manner . Journal of Magnetism and Magnetic Materials , 521 . https://dx.doi.org/10.1016/j.jmmm.2020.167535
Janko, C., Friedrich, R.P., Cicha, I., Unterweger, H., Lyer, S., & Alexiou, C. (2021). Modulation of immune responses by nanoparticles . Nanomedicine . https://dx.doi.org/10.2217/nnm-2021-0198
Lyer, S., Janko, C., Friedrich, R.P., Cicha, I., Tietze, R., Unterweger, H., & Alexiou, C. (2021). Nanomedicine for vaccination and diagnosis of diseases . Nanomedicine , 16 (3), 165-169. https://dx.doi.org/10.2217/nnm-2020-0483
Sarcletti, M., Park, H., Wirth, J., Englisch, S., Eigen, A., Drobek, D.,... Halik, M. (2021). The remediation of nano-/microplastics from water . Materials Today . https://dx.doi.org/10.1016/j.mattod.2021.02.020
Wicke, W., Unterweger, H., Kirchner, J., Brand, L., Ahmadzadeh, A., Ahmed, D.,... Schober, R. (2021). Experimental System for Molecular Communication in Pipe Flow With Magnetic Nanoparticles . IEEE Transactions on Molecular, Biological and Multi-Scale Communications . https://dx.doi.org/10.1109/TMBMC.2021.3099399
Xu, H., Schikora, M., Sisa, M., Daum, S., Klemt, I., Janko, C.,... Mokhir, A. (2021). An Endoplasmic Reticulum Specific Pro-amplifier of Reactive Oxygen Species in Cancer Cells . Angewandte Chemie International Edition . https://dx.doi.org/10.1002/anie.202100054
2020
Bartunik, M., Unterweger, H., Alexiou, C., Schober, R., Lübke, M., Fischer, G., & Kirchner, J. (2020). Comparative Evaluation of a New Sensor for Superparamagnetic Iron Oxide Nanoparticles in a Molecular Communication Setting . In Springer International Publishing (Eds.), Proceedings of the EAI BICT 2020 - 12th EAI International Conference on Bio-inspired Information and Communications Technologies (pp. 303-316). Online.
Corek, E., Rodgers, G., Siegrist, S., Einfalt, T., Detampel, P., Schleputz, C.M.,... Huwyler, J. (2020). Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution . Small , e2000746-. https://dx.doi.org/10.1002/smll.202000746
Fadeel, B., & Alexiou, C. (2020). Brave new world revisited: Focus on nanomedicine . Biochemical and Biophysical Research Communications . https://dx.doi.org/10.1016/j.bbrc.2020.08.046
Friedrich, R.P., Schreiber, E., Tietze, R., Yang, H., Pilarsky, C., & Alexiou, C. (2020). Intracellular Quantification and Localization of Label-Free Iron Oxide Nanoparticles by Holotomographic Microscopy . Nanotechnology, Science and Applications , 13 , 119-130. https://dx.doi.org/10.2147/NSA.S282204
Gräfe, C., Müller, E.K., Gresing, L., Weidner, A., Radon, P., Friedrich, R.P.,... Clement, J.H. (2020). Magnetic hybrid materials interact with biological matrices . Physical Sciences Review . https://dx.doi.org/10.1515/psr-2019-0114
Lenz, T., Nicol, P., Castellanos, M.I., Engel, L.C., Lahmann, A.L., Alexiou, C., & Joner, M. (2020). Small dimension–Big impact! Nanoparticle-enhanced non-invasive and intravascular molecular imaging of atherosclerosis in vivo . Molecules , 25 (5). https://dx.doi.org/10.3390/molecules25051029
Mühlberger, M., Unterweger, H., Band, J., Lehmann, C., Heger, L., Dudziak, D.,... Janko, C. (2020). Loading of Primary Human T Lymphocytes with Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Does Not Impair Their Activation after Polyclonal Stimulation . Cells , 9 (2). https://dx.doi.org/10.3390/cells9020342
Nguyen, K., Nuß, B., Mühlberger, M., Unterweger, H., Friedrich, R.P., Alexiou, C., & Janko, C. (2020). Superparamagnetic iron oxide nanoparticles carrying chemotherapeutics improve drug efficacy in monolayer and spheroid cell culture by enabling active accumulation . Nanomaterials , 10 (8), 1-21. https://dx.doi.org/10.3390/nano10081577
Podolska, M., Barras, A., Alexiou, C., Frey, B., Gaipl, U., Boukherroub, R.,... Munoz, L.E. (2020). Graphene Oxide Nanosheets for Localized Hyperthermia-Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death . Cells , 9 (3). https://dx.doi.org/10.3390/cells9030776
Ratschker, T., Egenberger, L., Alev, M., Zschiesche, L., Band, J., Schreiber, E.,... Janko, C. (2020). Mitoxantrone-loaded nanoparticles for magnetically controlled tumor therapy–induction of tumor cell death, release of danger signals and activation of immune cells . Pharmaceutics , 12 (10), 1-19. https://dx.doi.org/10.3390/pharmaceutics12100923
Reshetnikov, V., Özkan, H., Daum, S., Janko, C., Alexiou, C., Sauer, C.,... Mokhir, A. (2020). N-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells . Molecules , 25 (11). https://dx.doi.org/10.3390/molecules25112545
Schapher, M., Koch, M., Weidner, D., Scholz, M., Wirtz, S., Mahajan, A.,... Herrmann, M. (2020). Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones . Cells , 9 (9). https://dx.doi.org/10.3390/cells9092139
Singh, R., Eitler, D., Morelle, R., Friedrich, R.P., Dietel, B., Alexiou, C.,... Cicha, I. (2020). Optimization of cell seeding on electrospun PCL-silk fibroin scaffolds . European Polymer Journal , 134 . https://dx.doi.org/10.1016/j.eurpolymj.2020.109838
Stein, R., Friedrich, B., Mühlberger, M., Cebulla, N., Schreiber, E., Tietze, R.,... Unterweger, H. (2020). Synthesis and characterization of citrate-stabilized gold-coated superparamagnetic iron oxide nanoparticles for biomedical applications . Molecules , 25 (19). https://dx.doi.org/10.3390/molecules25194425
Zeh, G., Haines, P., Miehlich, M., Kienz, T., Neidlinger, A., Friedrich, R.P.,... Mokhir, A. (2020). Anticancer Effect of an Electronically Coupled Oligoferrocene . Organometallics . https://dx.doi.org/10.1021/acs.organomet.0c00306
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The Section of Experimental Oncology and Nanomedicine develops and applies iron oxide nanoparticles in Oncology, Cardiovascular diseases, Regenerative Medicine and infectious diseases. Furthermore artificial intelligence based procedures including robotics are performed in vitro and in vivo.
Research projects
Current projects
No projects found.
Recent publications
2022
2021
2020
Related Research Fields
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